Khan, Archie A; Langston, Harry C; Walsh, Louis; Roscoe, Rebecca; Jayawardhana, Shiromani; Francisco, Amanda Fortes; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D; (2024) Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy. Nature Communications, 15 (1). 4400-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-024-48749-5

Langston, Harry; Fortes Francisco, Amanda; Doidge, Ciaran; Roberts, Chrissy H; Khan, Archie A; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M; Lewis, Michael D; (2024) Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction. PLoS neglected tropical diseases, 18 (6). e0012278-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0012278

Olmo, Francisco; Jayawardhana, Shiromani; Khan, Archie A; Langston, Harry C; Francisco, Amanda Fortes; Atherton, Richard L; Ward, Alex I; Taylor, Martin C; Kelly, John M; Lewis, Michael D; (2024) A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research. PLoS Neglected Tropical Diseases, 18 (5). e0012106-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0012106

Francisco, Amanda Fortes; Sousa, Giovane R; Vaughan, Mhairi; Langston, Harry; Khan, Archie; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M; (2023) Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease. Pathogens, 12 (11). p. 1364. DOI: https://doi.org/10.3390/pathogens12111364

Jayawardhana, Shiromani; Ward, Alexander I; Francisco, Amanda F; Lewis, Michael D; Taylor, Martin C; Kelly, John M; Olmo, Francisco; (2023) Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice. PLoS Pathogens, 19 (11). e1011627-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1011627

Martinez, Monica Zavala; Olmo, Francisco; Taylor, Martin C; Caudron, Fabrice; Wilkinson, Shane R; (2023) Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi. DNA repair, 125. 103485-. ISSN 1568-7864 DOI: https://doi.org/10.1016/j.dnarep.2023.103485

Pardali, Vasiliki; Giannakopoulou, Erofili; Mpekoulis, George; Tsopela, Vassilina; Panos, Georgios; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris; (2023) Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity. Pharmaceuticals, 16 (7). p. 1046. ISSN 1424-8247 DOI: https://doi.org/10.3390/ph16071046

Racané, Livio; Ptiček, Lucija; Kostrun, Sanja; Raić-Malić, Silvana; Taylor, Martin Craig; Delves, Michael; Alsford, Sam; Olmo, Francisco; Francisco, Amanda Fortes; Kelly, John M; (2023) Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose. Journal of medicinal chemistry, 66 (18). pp. 13043-13057. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.3c01051

Racané, Livio; Zlatić, Katarina; Cindrić, Maja; Mehić, Emina; Karminski-Zamola, Grace; Taylor, Martin C; Kelly, John M; Malić, Silvana Raić; Stojković, Marijana Radić; Kralj, Marijeta; +1 more... Hranjec, Marijana; (2023) Synthesis and Biological Activity of 2-Benzo[b]thienyl and 2-Bithienyl Amidino-Substituted Benzothiazole and Benzimidazole Derivatives. ChemMedChem, 18 (18). e202300261-. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.202300261

Roscoe, RB; (2023) Characterising kinetoplastid pantothenate kinase, a multifunctional enzyme of the CoA biosynthesis pathway. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04670994

Abacha, Yabalu Z; Forkuo, Arnold Donkor; Gbedema, Stephen Y; Mittal, Nimisha; Ottilie, Sabine; Rocamora, Frances; Winzeler, Elizabeth A; van Schalkwyk, Donelly A; Kelly, John M; Taylor, Martin C; +9 more... Reader, Janette; Birkholtz, Lyn-Marie; Lisgarten, David R; Cockcroft, Jeremy K; Lisgarten, John N; Palmer, Rex A; Talbert, Rosemary C; Shnyder, Steven D; Wright, Colin W; (2022) Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. Frontiers in Pharmacology, 13. 875647-. ISSN 1663-9812 DOI: https://doi.org/10.3389/fphar.2022.875647

Foscolos, Angeliki Sofia; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Papanastasiou, Ioannis P; (2022) Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi. Molbank, 2022 (2). M1363-M1363. ISSN 1422-8599 DOI: https://doi.org/10.3390/m1363

Macleod, Olivia JS; Cook, Alexander D; Webb, Helena; Crow, Mandy; Burns, Roisin; Redpath, Maria; Seisenberger, Stefanie; Trevor, Camilla E; Peacock, Lori; Schwede, Angela; +9 more... Kimblin, Nicola; Francisco, Amanda F; Pepperl, Julia; Rust, Steve; Voorheis, Paul; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark; (2022) Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor. Nature Communications, 13 (1). 5085-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-022-32728-9

Ward, Alexander I; Lewis, Michael D; Taylor, Martin C; Kelly, John M; (2022) Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon. Infection and Immunity, 90 (2). e0038221-. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.00382-21

Khan, Archie A; Langston, Harry C; Costa, Fernanda C; Olmo, Francisco; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D; (2021) Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale. PLoS pathogens, 17 (8). e1009864-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1009864

Racané, Livio; Rep, Valentina; Kraljević Pavelić, Sandra; Grbčić, Petra; Zonjić, Iva; Radić Stojković, Marijana; Taylor, Martin C; Kelly, John M; Raić-Malić, Silvana; (2021) Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles. Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1). pp. 1952-1967. ISSN 1475-6366 DOI: https://doi.org/10.1080/14756366.2021.1959572

Ward, A; (2021) Trypanosoma cruzi : Where is it? Does it ever sleep? Why is a sterile outcome rarely achieved? PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04661782

Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M; (2020) Challenges in Chagas Disease Drug Development. MOLECULES, 25 (12). p. 2799. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules25122799

Macleod, Olivia JS; Bart, Jean-Mathieu; MacGregor, Paula; Peacock, Lori; Savill, Nicholas J; Hester, Svenja; Ravel, Sophie; Sunter, Jack D; Trevor, Camilla; Rust, Steven; +7 more... Vaughan, Tristan J; Minter, Ralph; Mohammed, Shabaz; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark; (2020) A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies. Nature communications, 11 (1). 1326-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-020-15125-y

Mann, GS; (2020) Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging. PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04655803

Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; +1 more... Kelly, John M; (2020) Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. PLoS neglected tropical diseases, 14 (4). e0007717-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0007717

Pardali, Vasiliki; Giannakopoulou, Erofili; Balourdas, Dimitrios-Ilias; Myrianthopoulos, Vassilios; Taylor, Martin C; Šekutor, Marina; Mlinarić-Majerski, Kata; Kelly, John M; Zoidis, Grigoris; (2020) Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study. CURRENT PHARMACEUTICAL DESIGN, 26 (8). pp. 838-866. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612826666200210150127

Popov, Andrea Bistrović; Krstulović, Luka; Koštrun, Sanja; Jelić, Dubravko; Bokulić, Ana; Stojković, Marijana Radić; Zonjić, Iva; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; +1 more... Raić-Malić, Silvana; (2020) Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. European journal of medicinal chemistry, 207. 112802-. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2020.112802

Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M; (2020) Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. Current pharmaceutical design, 27 (14). pp. 1733-1740. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612826666201124113214

Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M; (2020) Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. PLoS neglected tropical diseases, 14 (3). e0008007-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0008007

Taylor, Martin Craig; Lander, Noelia; Yoshida, Nobuko; (2020) Editorial: Unravelling T. cruzi Biology. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10. 382-. ISSN 2235-2988 DOI: https://doi.org/10.3389/fcimb.2020.00382

Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M; (2020) In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. mBio, 11 (4). pp. 1-13. ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.01242-20

Ward, Alexander I; Olmo, Francisco; Atherton, Richard L; Taylor, Martin C; Kelly, John M; (2020) Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate. OPEN BIOLOGY, 10 (12). 200261-. ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.200261

Foscolos, Angeliki-Sofia; Papanastasiou, Ioannis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity. ChemMedChem, 14 (13). pp. 1227-1231. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.201900165

Fytas, George; Zoidis, Grigoris; Taylor, Martin C; Kelly, John M; Tsatsaroni, Alexandra; Tsotinis, Andrew; (2019) Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents. FUTURE MEDICINAL CHEMISTRY, 11 (11). pp. 1259-1266. ISSN 1756-8919 DOI: https://doi.org/10.4155/fmc-2018-0599

Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; +1 more... Kelly, John M; (2019) Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. Bioorganic & medicinal chemistry letters, 29 (11). pp. 1278-1281. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2019.04.010

Georgiadis, Markos-Orestis; Kourbeli, Violeta; Papanastasiou, Ioannis P; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. RSC Medicinal Chemistry, 11 (1). pp. 72-84. DOI: https://doi.org/10.1039/c9md00478e

Giannakopoulou, Erofili; Pardali, Vasiliki; Frakolaki, Efseveia; Siozos, Vasileios; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris; (2019) Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species. MEDCHEMCOMM, 10 (6). pp. 991-1006. ISSN 2040-2503 DOI: https://doi.org/10.1039/c9md00200f

MacGregor, Paula; Gonzalez-Munoz, Andrea L; Jobe, Fatoumatta; Taylor, Martin C; Rust, Steven; Sandercock, Alan M; Macleod, Olivia JS; Van Bocxlaer, Katrien; Francisco, Amanda F; D'Hooge, Francois; +7 more... Tiberghien, Arnaud; Barry, Conor S; Howard, Philip; Higgins, Matthew K; Vaughan, Tristan J; Minter, Ralph; Carrington, Mark; (2019) A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. PLoS neglected tropical diseases, 13 (5). e0007373-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0007373

Popov, A Bistrović; Stolić, I; Krstulović, L; Taylor, MC; Kelly, JM; Tomić, S; Tumir, L; Bajić, M; Raić-Malić, S; (2019) Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 173. pp. 63-75. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2019.04.007

Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M; (2019) Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. Springer New York, pp. 147-163. ISBN 9781493991471 DOI: https://doi.org/10.1007/978-1-4939-9148-8_11

Bistrović, Andrea; Krstulović, Luka; Stolić, Ivana; Drenjančević, Domagoj; Talapko, Jasminka; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; Raić-Malić, Silvana; (2018) Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. Journal of enzyme inhibition and medicinal chemistry, 33 (1). pp. 1323-1334. ISSN 1475-6366 DOI: https://doi.org/10.1080/14756366.2018.1484733

Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; +2 more... Kelly, John Morrison; Taylor, Martin Craig; (2018) Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. PLoS neglected tropical diseases, 12 (4). e0006388-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0006388

Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M; (2018) Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. Antimicrobial agents and chemotherapy, 62 (10). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00832-18

Ghashghaei, Ouldouz; Kielland, Nicola; Revés, Marc; Taylor, Martin C; Kelly, John M; Di Pietro, Ornella; Muñoz-Torrero, Diego; Pérez, Belén; Lavilla, Rodolfo; (2018) Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. Molecules (Basel, Switzerland), 23 (1). p. 177. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules23010177

Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M; (2018) Imaging the development of chronic Chagas disease after oral transmission. Scientific reports, 8 (1). 11292-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-018-29564-7

Olmo, Francisco; Costa, Fernanda C; Mann, Gurdip Singh; Taylor, Martin C; Kelly, John M; (2018) Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation. Molecular and biochemical parasitology, 226. pp. 34-36. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2018.07.002

Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M; (2017) Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. Scientific reports, 7 (1). 14407-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-017-14986-6

Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M; (2017) Biological factors that impinge on Chagas disease drug development. Parasitology, 144 (14). pp. 1871-1880. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182017001469

Taylor, Martin C; Ward, Theresa H; (2017) Pathogen imaging applications. Methods (San Diego, Calif), 127. pp. 1-2. ISSN 1046-2023 DOI: https://doi.org/10.1016/j.ymeth.2017.08.011

Zoidis, Grigoris; Tsotinis, Andrew; Tsatsaroni, Alexandra; Taylor, Martin C; Kelly, John M; Efstathiou, Antonia; Smirlis, Despina; Fytas, George; (2017) Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. Chemical biology & drug design, 91 (2). pp. 408-421. ISSN 1747-0277 DOI: https://doi.org/10.1111/cbdd.13088

Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M; (2016) Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. Cellular microbiology, 18 (10). pp. 1429-1443. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12584

Sola, Irene; Artigas, Albert; Taylor, Martin C; Pérez-Areales, F Javier; Viayna, Elisabet; Clos, M Victòria; Pérez, Belén; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2016) Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic & medicinal chemistry, 24 (21). pp. 5162-5171. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2016.08.036

Campos, MCO; Leon, LL; Taylor, MC; Kelly, JM; (2015) "Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert'' [Mol. Biochem. Parasit. (2014) 193, 17-19]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 201 (1). 83-. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2015.05.006

Di Pietro, Ornella; Vicente-García, Esther; Taylor, Martin C; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; +5 more... Clos, M Victòria; Pérez, Belén; Kelly, John M; Lavilla, Rodolfo; Muñoz-Torrero, Diego; (2015) Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. European journal of medicinal chemistry, 105. pp. 120-137. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2015.10.007

Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M; (2015) Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". Antimicrobial agents and chemotherapy, 59 (12). 7925-. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02022-15

Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M; (2015) Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrobial agents and chemotherapy, 59 (8). pp. 4653-4661. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00520-15

Sola, Irene; Castellà, Sílvia; Viayna, Elisabet; Galdeano, Carles; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Jones, Deuan C; Fairlamb, Alan H; +3 more... Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2015) Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic & medicinal chemistry, 23 (16). pp. 5156-5167. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2015.01.031 Full text not available from this repository.

Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M; (2015) The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. PLoS neglected tropical diseases, 9 (4). e0003707-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0003707

Campos, Mônica CO; Leon, Leonor L; Taylor, Martin C; Kelly, John M; (2014) Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. Molecular and biochemical parasitology, 193 (1). pp. 17-19. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002

Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M; (2014) Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. Cellular microbiology, 16 (9). pp. 1285-1300. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12297

Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M; (2014) A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. Journal of biomolecular screening, 20 (1). pp. 36-43. ISSN 1087-0571 DOI: https://doi.org/10.1177/1087057114552623

Shameer, Sanu; Logan-Klumpler, Flora J; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; +31 more... Bütikofer, Peter; Cattanach, Amy M; Bannerman-Chukualim, Bridget; Creek, Darren J; Crouch, Kathryn; de Koning, Harry P; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H; Ferguson, Michael AJ; Ginger, Michael L; Hertz-Fowler, Christiane; Kerkhoven, Eduard J; Mäser, Pascal; Michels, Paul AM; Nayak, Archana; Nes, David W; Nolan, Derek P; Olsen, Christian; Silva-Franco, Fatima; Smith, Terry K; Taylor, Martin C; Tielens, Aloysius GM; Urbaniak, Michael D; van Hellemond, Jaap J; Vincent, Isabel M; Wilkinson, Shane R; Wyllie, Susan; Opperdoes, Fred R; Barrett, Michael P; Jourdan, Fabien; (2014) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic acids research, 43 (Databa). D637-D644. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gku944

Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2014) Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & medicinal chemistry letters, 24 (23). pp. 5435-5438. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2014.10.025 Full text not available from this repository.

Taylor, Martin C; Kelly, John M; (2014) Optimizing bioluminescence imaging to study protozoan parasite infections. Trends in parasitology, 30 (4). pp. 161-162. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2014.01.006 Full text not available from this repository.

Koperniku, Ana; Papanastasiou, Ioannis; Foscolos, George B; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2013) Synthesis and trypanocidal action of new adamantane substituted imidazolines. MedChemComm, 4 (5). p. 856. ISSN 2040-2503 DOI: https://doi.org/10.1039/c3md00081h Full text not available from this repository.

McLatchie, Alex P; Burrell-Saward, Hollie; Myburgh, Elmarie; Lewis, Michael D; Ward, Theresa H; Mottram, Jeremy C; Croft, Simon L; Kelly, John M; Taylor, Martin C; (2013) Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. PLoS neglected tropical diseases, 7 (11). e2571-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0002571

Myburgh, E; Coles, J; Ritchie, R; Kennedy, PGE; McLatchie, AP; Rodgers, R; Taylor, MC; Barrett, MP; Brewer, JM; Mottram, JC; (2013) In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis. PLoS neglected tropical diseases, 7 (8). ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0002384.

Myburgh, Elmarie; Coles, Jonathan A; Ritchie, Ryan; Kennedy, Peter GE; McLatchie, Alex P; Rodgers, Jean; Taylor, Martin C; Barrett, Michael P; Brewer, James M; Mottram, Jeremy C; (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLOS NEGLECTED TROPICAL DISEASES, 7 (8). e2384-. ISSN 1935-2735 DOI: https://doi.org/10.1371/journal.pntd.0002384

Taylor, Martin C; McLatchie, Alex P; Kelly, John M; (2013) Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. Molecular microbiology, 89 (3). pp. 420-432. ISSN 0950-382X DOI: https://doi.org/10.1111/mmi.12285

Tsatsaroni, Alexandra; Zoidis, Grigoris; Zoumpoulakis, Panagiotis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Fytas, George; (2013) An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. Tetrahedron letters, 54 (25). pp. 3238-3240. ISSN 0040-4039 DOI: https://doi.org/10.1016/j.tetlet.2013.03.128

Echeverry, Maria C; Bot, Christopher; Obado, Samson O; Taylor, Martin C; Kelly, John M; (2012) Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. BMC genomics, 13 (1). 29-. ISSN 1471-2164 DOI: https://doi.org/10.1186/1471-2164-13-29

Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik; (2012) Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorganic & medicinal chemistry letters, 22 (5). pp. 1886-1890. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.01.072

Mejia, Ana Maria; Hall, Belinda S; Taylor, Martin C; Gómez-Palacio, Andrés; Wilkinson, Shane R; Triana-Chávez, Omar; Kelly, John M; (2012) Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. The Journal of infectious diseases, 206 (2). pp. 220-228. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jis331

Torres, Eva; Duque, María D; López-Querol, Marta; Taylor, Martin C; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H; Sureda, Francesc X; Kelly, John M; Vázquez, Santiago; (2012) Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & medicinal chemistry, 20 (2). pp. 942-948. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.11.050 Full text not available from this repository.

Defaux, Julien; Sala, Marta; Formosa, Xavier; Galdeano, Carles; Taylor, Martin C; Alobaid, Waleed AA; Kelly, John M; Wright, Colin W; Camps, Pelayo; Muñoz-Torrero, Diego; (2011) Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorganic & medicinal chemistry, 19 (5). pp. 1702-1707. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.01.028

Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M; (2011) Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. Journal of medicinal chemistry, 54 (14). pp. 5250-5254. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm200217m

Obado, Samson O; Bot, Christopher; Echeverry, Maria C; Bayona, Julio C; Alvarez, Vanina E; Taylor, Martin C; Kelly, John M; (2011) Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. Nucleic acids research, 39 (3). pp. 1023-1033. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkq839

Taylor, Martin C; Huang, Huan; Kelly, John M; (2011) Genetic techniques in Trypanosoma cruzi. Advances in parasitology, 75. pp. 231-250. ISSN 0065-308X DOI: https://doi.org/10.1016/B978-0-12-385863-4.00011-3 Full text not available from this repository.

Bot, Chris; Hall, Belinda S; Bashir, Noosheen; Taylor, Martin C; Helsby, Nuala A; Wilkinson, Shane R; (2010) Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrobial agents and chemotherapy, 54 (10). pp. 4246-4252. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00800-10 Full text not available from this repository.

Taylor, MC; Kelly, JM; (2010) Iron metabolism in trypanosomatids, and its crucial role in infection. Parasitology, 137 (6). pp. 899-917. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182009991880

Taylor, Martin C; Kaur, Harparkash; Blessington, Bernard; Kelly, John M; Wilkinson, Shane R; (2008) Validation of spermidine synthase as a drug target in African trypanosomes. The Biochemical journal, 409 (2). pp. 563-569. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20071185 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Horn, David; Kelly, John M; Cheeseman, Ian; (2008) A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 105 (13). pp. 5022-5027. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0711014105 Full text not available from this repository.

Gluenz, Eva; Taylor, Martin C; Kelly, John M; (2007) The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. International journal for parasitology, 37 (6). pp. 617-625. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2006.11.016

Logan, Flora J; Taylor, Martin C; Wilkinson, Shane R; Kaur, Harparkash; Kelly, John M; (2007) The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. The Biochemical journal, 407 (3). pp. 419-426. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20070766 Full text not available from this repository.

Piacenza, Lucía; Irigoín, Florencia; Alvarez, María Noel; Peluffo, Gonzalo; Taylor, Martin C; Kelly, John M; Wilkinson, Shane R; Radi, Rafael; (2007) Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. The Biochemical journal, 403 (2). pp. 323-334. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20061281 Full text not available from this repository.

Taylor, Martin C; Kelly, John M; (2006) pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. BMC biotechnology, 6 (1). 32-. ISSN 1472-6750 DOI: https://doi.org/10.1186/1472-6750-6-32

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Ahmed, Aiyaz; Horn, David; Kelly, John M; (2006) Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free radical biology & medicine, 40 (2). pp. 198-209. ISSN 0891-5849 DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022 Full text not available from this repository.

Kelly, JM; Taylor, MC; Wilkinson, SR; (2005) Trypanosoma cruzi. In: Fuchs, J; Podda, M; Goethe, JW, (eds.) Encyclopedia of Diagnostic Genomics and Proteomics. Marcel Dekker, Inc., New York, USA, pp. 1297-1301. https://researchonline.lshtm.ac.uk/id/eprint/15644 Full text not available from this repository.

Obado, Samson O; Taylor, Martin C; Wilkinson, Shane R; Bromley, Elizabeth V; Kelly, John M; (2005) Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome research, 15 (1). pp. 36-43. ISSN 1088-9051 DOI: https://doi.org/10.1101/gr.2895105

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Horn, David; Kelly, John M; (2005) Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proceedings of the National Academy of Sciences of the United States of America, 102 (33). pp. 11645-11650. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0504251102 Full text not available from this repository.

Bromley, Elizabeth V; Taylor, Martin C; Wilkinson, Shane R; Kelly, John M; (2004) The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. International journal for parasitology, 34 (1). pp. 63-71. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2003.09.004 Full text not available from this repository.

Kelly, JM; Obado, SO; Taylor, MC; (2004) Functional mapping of an American trypanosome centromere [Abstract]. Springer Verlag. https://researchonline.lshtm.ac.uk/id/eprint/19454 Full text not available from this repository.

McRobert, Louisa; Preiser, Peter; Sharp, Sarah; Jarra, William; Kaviratne, Mallika; Taylor, Martin C; Renia, Laurent; Sutherland, Colin J; (2004) Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle. Infection and immunity, 72 (11). pp. 6597-6602. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.72.11.6597-6602.2004 Full text not available from this repository.

Gaunt, Michael W; Yeo, Matthew; Frame, Iain A; Stothard, J Russell; Carrasco, Hernan J; Taylor, Martin C; Mena, Susana Solis; Veazey, Paul; Miles, Graham AJ; Acosta, Nidia; +2 more... de Arias, Antonieta Rojas; Miles, Michael A; (2003) Mechanism of genetic exchange in American trypanosomes. Nature, 421 (6926). pp. 936-939. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature01438 Full text not available from this repository.

Taylor, MC; Kelly, JM; (2002) Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era. In: Tyler, K; Miles, MA, (eds.) American Trypanosomiasis. Kluwer Academic Publishers, London, pp. 57-68. https://researchonline.lshtm.ac.uk/id/eprint/15544 Full text not available from this repository.

Wilkinson, Shane R; Meyer, David J; Taylor, Martin C; Bromley, Elizabeth V; Miles, Michael A; Kelly, John M; (2002) The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. The Journal of biological chemistry, 277 (19). pp. 17062-17071. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M111126200 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Touitha, Said; Mauricio, Isabel L; Meyer, David J; Kelly, John M; (2002) TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. The Biochemical journal, 364 (Pt 3). pp. 787-794. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20020038 Full text not available from this repository.