Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Markos-Orestis
Georgiadis
;
Violeta
Kourbeli
;
Vaya
Ioannidou
;
Evangelos
Karakitsios
;
Ioannis
Papanastasiou
;
Andrew
Tsotinis
;
Dimitri
Komiotis
;
Anthony
Vocat
;
Stewart T
Cole
;
Martin C
Taylor
;
+1 more...
John M
Kelly
;
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2019.04.010
;
+1 more...
John M
Kelly
;
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2019.04.010
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.
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picture_as_pdf - Synthesis.pdf
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subject - Accepted Version
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- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0
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