Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Markos-Orestis
Georgiadis
;
Violeta
Kourbeli
;
Vaya
Ioannidou
;
Evangelos
Karakitsios
;
Ioannis
Papanastasiou
;
Andrew
Tsotinis
;
Dimitri
Komiotis
;
Anthony
Vocat
;
Stewart T
Cole
;
Martin C
Taylor
;
+1 more...
John M
Kelly
;
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2019.04.010
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.
Item Type | Article |
---|---|
Elements ID | 127620 |
Date Deposited | 20 May 2019 09:00 |
ORCID: https://orcid.org/0000-0003-4147-0693
ORCID: https://orcid.org/0000-0003-4305-5258