Items where Author or Contributor is "Taylor, Martin C"
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Number of items: 94.
2024
Khan, Archie A;
Langston, Harry C;
Walsh, Louis;
Roscoe, Rebecca;
Jayawardhana, Shiromani;
Francisco, Amanda Fortes;
Taylor, Martin C;
McCann, Conor J;
Kelly, John M;
Lewis, Michael D;
(2024)
Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy.
Nature Communications, 15 (1).
4400-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-024-48749-5
Khan, Archie A;
Taylor, Martin C;
Fortes Francisco, Amanda;
Jayawardhana, Shiromani;
Atherton, Richard L;
Olmo, Francisco;
Lewis, Michael D;
Kelly, John M;
(2024)
Animal models for exploring Chagas disease pathogenesis and supporting drug discovery.
Clinical microbiology reviews.
e0015523-.
ISSN 0893-8512
DOI: https://doi.org/10.1128/cmr.00155-23
Langston, Harry;
Fortes Francisco, Amanda;
Doidge, Ciaran;
Roberts, Chrissy H;
Khan, Archie A;
Jayawardhana, Shiromani;
Taylor, Martin C;
Kelly, John M;
Lewis, Michael D;
(2024)
Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction.
PLoS neglected tropical diseases, 18 (6).
e0012278-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0012278
Olmo, Francisco;
Jayawardhana, Shiromani;
Khan, Archie A;
Langston, Harry C;
Francisco, Amanda Fortes;
Atherton, Richard L;
Ward, Alex I;
Taylor, Martin C;
Kelly, John M;
Lewis, Michael D;
(2024)
A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research.
PLoS Neglected Tropical Diseases, 18 (5).
e0012106-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0012106
2023
Francisco, Amanda Fortes;
Sousa, Giovane R;
Vaughan, Mhairi;
Langston, Harry;
Khan, Archie;
Jayawardhana, Shiromani;
Taylor, Martin C;
Lewis, Michael D;
Kelly, John M;
(2023)
Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease.
Pathogens, 12 (11).
p. 1364.
DOI: https://doi.org/10.3390/pathogens12111364
Jayawardhana, Shiromani;
Ward, Alexander I;
Francisco, Amanda F;
Lewis, Michael D;
Taylor, Martin C;
Kelly, John M;
Olmo, Francisco;
(2023)
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
PLoS Pathogens, 19 (11).
e1011627-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1011627
Martinez, Monica Zavala;
Olmo, Francisco;
Taylor, Martin C;
Caudron, Fabrice;
Wilkinson, Shane R;
(2023)
Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi.
DNA repair, 125.
103485-.
ISSN 1568-7864
DOI: https://doi.org/10.1016/j.dnarep.2023.103485
Pardali, Vasiliki;
Giannakopoulou, Erofili;
Mpekoulis, George;
Tsopela, Vassilina;
Panos, Georgios;
Taylor, Martin C;
Kelly, John M;
Vassilaki, Niki;
Zoidis, Grigoris;
(2023)
Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity.
Pharmaceuticals, 16 (7).
p. 1046.
ISSN 1424-8247
DOI: https://doi.org/10.3390/ph16071046
Racané, Livio;
Ptiček, Lucija;
Kostrun, Sanja;
Raić-Malić, Silvana;
Taylor, Martin Craig;
Delves, Michael;
Alsford, Sam;
Olmo, Francisco;
Francisco, Amanda Fortes;
Kelly, John M;
(2023)
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose.
Journal of medicinal chemistry, 66 (18).
pp. 13043-13057.
ISSN 0022-2623
DOI: https://doi.org/10.1021/acs.jmedchem.3c01051
Racané, Livio;
Zlatić, Katarina;
Cindrić, Maja;
Mehić, Emina;
Karminski-Zamola, Grace;
Taylor, Martin C;
Kelly, John M;
Malić, Silvana Raić;
Stojković, Marijana Radić;
Kralj, Marijeta;
+1 more...
Hranjec, Marijana;
(2023)
Synthesis and Biological Activity of 2-Benzo[b]thienyl and 2-Bithienyl Amidino-Substituted Benzothiazole and Benzimidazole Derivatives.
ChemMedChem, 18 (18).
e202300261-.
ISSN 1860-7179
DOI: https://doi.org/10.1002/cmdc.202300261
Roscoe, RB;
(2023)
Characterising kinetoplastid pantothenate kinase, a multifunctional enzyme of the CoA biosynthesis pathway.
PhD thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04670994
2022
Abacha, Yabalu Z;
Forkuo, Arnold Donkor;
Gbedema, Stephen Y;
Mittal, Nimisha;
Ottilie, Sabine;
Rocamora, Frances;
Winzeler, Elizabeth A;
van Schalkwyk, Donelly A;
Kelly, John M;
Taylor, Martin C;
+9 more...
Reader, Janette;
Birkholtz, Lyn-Marie;
Lisgarten, David R;
Cockcroft, Jeremy K;
Lisgarten, John N;
Palmer, Rex A;
Talbert, Rosemary C;
Shnyder, Steven D;
Wright, Colin W;
(2022)
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.
Frontiers in Pharmacology, 13.
875647-.
ISSN 1663-9812
DOI: https://doi.org/10.3389/fphar.2022.875647
Foscolos, Angeliki Sofia;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
Papanastasiou, Ioannis P;
(2022)
Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi.
Molbank, 2022 (2).
M1363-M1363.
ISSN 1422-8599
DOI: https://doi.org/10.3390/m1363
Macleod, Olivia JS;
Cook, Alexander D;
Webb, Helena;
Crow, Mandy;
Burns, Roisin;
Redpath, Maria;
Seisenberger, Stefanie;
Trevor, Camilla E;
Peacock, Lori;
Schwede, Angela;
+9 more...
Kimblin, Nicola;
Francisco, Amanda F;
Pepperl, Julia;
Rust, Steve;
Voorheis, Paul;
Gibson, Wendy;
Taylor, Martin C;
Higgins, Matthew K;
Carrington, Mark;
(2022)
Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Nature Communications, 13 (1).
5085-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-022-32728-9
Ward, Alexander I;
Lewis, Michael D;
Taylor, Martin C;
Kelly, John M;
(2022)
Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon.
Infection and Immunity, 90 (2).
e0038221-.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.00382-21
2021
Khan, Archie A;
Langston, Harry C;
Costa, Fernanda C;
Olmo, Francisco;
Taylor, Martin C;
McCann, Conor J;
Kelly, John M;
Lewis, Michael D;
(2021)
Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.
PLoS pathogens, 17 (8).
e1009864-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1009864
Racané, Livio;
Rep, Valentina;
Kraljević Pavelić, Sandra;
Grbčić, Petra;
Zonjić, Iva;
Radić Stojković, Marijana;
Taylor, Martin C;
Kelly, John M;
Raić-Malić, Silvana;
(2021)
Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles.
Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1).
pp. 1952-1967.
ISSN 1475-6366
DOI: https://doi.org/10.1080/14756366.2021.1959572
Ward, A;
(2021)
Trypanosoma cruzi : Where is it? Does it ever sleep? Why is a sterile outcome rarely achieved?
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04661782
2020
Francisco, Amanda F;
Jayawardhana, Shiromani;
Olmo, Francisco;
Lewis, Michael D;
Wilkinson, Shane R;
Taylor, Martin C;
Kelly, John M;
(2020)
Challenges in Chagas Disease Drug Development.
MOLECULES, 25 (12).
p. 2799.
ISSN 1420-3049
DOI: https://doi.org/10.3390/molecules25122799
Macleod, Olivia JS;
Bart, Jean-Mathieu;
MacGregor, Paula;
Peacock, Lori;
Savill, Nicholas J;
Hester, Svenja;
Ravel, Sophie;
Sunter, Jack D;
Trevor, Camilla;
Rust, Steven;
+7 more...
Vaughan, Tristan J;
Minter, Ralph;
Mohammed, Shabaz;
Gibson, Wendy;
Taylor, Martin C;
Higgins, Matthew K;
Carrington, Mark;
(2020)
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Nature communications, 11 (1).
1326-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-020-15125-y
Mann, GS;
(2020)
Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging.
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04655803
Mann, Gurdip Singh;
Francisco, Amanda F;
Jayawardhana, Shiromani;
Taylor, Martin C;
Lewis, Michael D;
Olmo, Francisco;
de Freitas, Elisangela Oliveira;
Leoratti, Fabiana MS;
López-Camacho, Cesar;
Reyes-Sandoval, Arturo;
+1 more...
Kelly, John M;
(2020)
Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.
PLoS neglected tropical diseases, 14 (4).
e0007717-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0007717
Pardali, Vasiliki;
Giannakopoulou, Erofili;
Balourdas, Dimitrios-Ilias;
Myrianthopoulos, Vassilios;
Taylor, Martin C;
Šekutor, Marina;
Mlinarić-Majerski, Kata;
Kelly, John M;
Zoidis, Grigoris;
(2020)
Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study.
CURRENT PHARMACEUTICAL DESIGN, 26 (8).
pp. 838-866.
ISSN 1381-6128
DOI: https://doi.org/10.2174/1381612826666200210150127
Popov, Andrea Bistrović;
Krstulović, Luka;
Koštrun, Sanja;
Jelić, Dubravko;
Bokulić, Ana;
Stojković, Marijana Radić;
Zonjić, Iva;
Taylor, Martin C;
Kelly, John M;
Bajić, Miroslav;
+1 more...
Raić-Malić, Silvana;
(2020)
Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles.
European journal of medicinal chemistry, 207.
112802-.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2020.112802
Taylor, Martin C;
Ward, Alexander I;
Olmo, Francisco;
Francisco, Amanda F;
Jayawardhana, Shiromani;
Costa, Fernanda C;
Lewis, Michael D;
Kelly, John M;
(2020)
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity.
Current pharmaceutical design, 27 (14).
pp. 1733-1740.
ISSN 1381-6128
DOI: https://doi.org/10.2174/1381612826666201124113214
Taylor, Martin C;
Ward, Alexander;
Olmo, Francisco;
Jayawardhana, Shiromani;
Francisco, Amanda F;
Lewis, Michael D;
Kelly, John M;
(2020)
Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.
PLoS neglected tropical diseases, 14 (3).
e0008007-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0008007
Taylor, Martin Craig;
Lander, Noelia;
Yoshida, Nobuko;
(2020)
Editorial: Unravelling T. cruzi Biology.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10.
382-.
ISSN 2235-2988
DOI: https://doi.org/10.3389/fcimb.2020.00382
Ward, Alexander I;
Lewis, Michael D;
Khan, Archie A;
McCann, Conor J;
Francisco, Amanda F;
Jayawardhana, Shiromani;
Taylor, Martin C;
Kelly, John M;
(2020)
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution.
mBio, 11 (4).
pp. 1-13.
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.01242-20
Ward, Alexander I;
Olmo, Francisco;
Atherton, Richard L;
Taylor, Martin C;
Kelly, John M;
(2020)
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate.
OPEN BIOLOGY, 10 (12).
200261-.
ISSN 2046-2441
DOI: https://doi.org/10.1098/rsob.200261
2019
Foscolos, Angeliki-Sofia;
Papanastasiou, Ioannis;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
(2019)
Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity.
ChemMedChem, 14 (13).
pp. 1227-1231.
ISSN 1860-7179
DOI: https://doi.org/10.1002/cmdc.201900165
Fytas, George;
Zoidis, Grigoris;
Taylor, Martin C;
Kelly, John M;
Tsatsaroni, Alexandra;
Tsotinis, Andrew;
(2019)
Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents.
FUTURE MEDICINAL CHEMISTRY, 11 (11).
pp. 1259-1266.
ISSN 1756-8919
DOI: https://doi.org/10.4155/fmc-2018-0599
Georgiadis, Markos-Orestis;
Kourbeli, Violeta;
Ioannidou, Vaya;
Karakitsios, Evangelos;
Papanastasiou, Ioannis;
Tsotinis, Andrew;
Komiotis, Dimitri;
Vocat, Anthony;
Cole, Stewart T;
Taylor, Martin C;
+1 more...
Kelly, John M;
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2019.04.010
Georgiadis, Markos-Orestis;
Kourbeli, Violeta;
Papanastasiou, Ioannis P;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
(2019)
Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei.
RSC Medicinal Chemistry, 11 (1).
pp. 72-84.
DOI: https://doi.org/10.1039/c9md00478e
Giannakopoulou, Erofili;
Pardali, Vasiliki;
Frakolaki, Efseveia;
Siozos, Vasileios;
Myrianthopoulos, Vassilios;
Mikros, Emmanuel;
Taylor, Martin C;
Kelly, John M;
Vassilaki, Niki;
Zoidis, Grigoris;
(2019)
Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.
MEDCHEMCOMM, 10 (6).
pp. 991-1006.
ISSN 2040-2503
DOI: https://doi.org/10.1039/c9md00200f
MacGregor, Paula;
Gonzalez-Munoz, Andrea L;
Jobe, Fatoumatta;
Taylor, Martin C;
Rust, Steven;
Sandercock, Alan M;
Macleod, Olivia JS;
Van Bocxlaer, Katrien;
Francisco, Amanda F;
D'Hooge, Francois;
+7 more...
Tiberghien, Arnaud;
Barry, Conor S;
Howard, Philip;
Higgins, Matthew K;
Vaughan, Tristan J;
Minter, Ralph;
Carrington, Mark;
(2019)
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.
PLoS neglected tropical diseases, 13 (5).
e0007373-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0007373
Popov, A Bistrović;
Stolić, I;
Krstulović, L;
Taylor, MC;
Kelly, JM;
Tomić, S;
Tumir, L;
Bajić, M;
Raić-Malić, S;
(2019)
Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 173.
pp. 63-75.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2019.04.007
Taylor, Martin C;
Francisco, Amanda F;
Jayawardhana, Shiromani;
Mann, Gurdip Singh;
Ward, Alexander I;
Olmo, Francisco;
Lewis, Michael D;
Kelly, John M;
(2019)
Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions.
Springer New York, pp. 147-163.
ISBN 9781493991471
DOI: https://doi.org/10.1007/978-1-4939-9148-8_11
2018
Bistrović, Andrea;
Krstulović, Luka;
Stolić, Ivana;
Drenjančević, Domagoj;
Talapko, Jasminka;
Taylor, Martin C;
Kelly, John M;
Bajić, Miroslav;
Raić-Malić, Silvana;
(2018)
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.
Journal of enzyme inhibition and medicinal chemistry, 33 (1).
pp. 1323-1334.
ISSN 1475-6366
DOI: https://doi.org/10.1080/14756366.2018.1484733
Costa, Fernanda Cristina;
Francisco, Amanda Fortes;
Jayawardhana, Shiromani;
Calderano, Simone Guedes;
Lewis, Michael D;
Olmo, Francisco;
Beneke, Tom;
Gluenz, Eva;
Sunter, Jack;
Dean, Samuel;
+2 more...
Kelly, John Morrison;
Taylor, Martin Craig;
(2018)
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
PLoS neglected tropical diseases, 12 (4).
e0006388-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0006388
Francisco, Amanda Fortes;
Jayawardhana, Shiromani;
Taylor, Martin C;
Lewis, Michael D;
Kelly, John M;
(2018)
Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.
Antimicrobial agents and chemotherapy, 62 (10).
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00832-18
Ghashghaei, Ouldouz;
Kielland, Nicola;
Revés, Marc;
Taylor, Martin C;
Kelly, John M;
Di Pietro, Ornella;
Muñoz-Torrero, Diego;
Pérez, Belén;
Lavilla, Rodolfo;
(2018)
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.
Molecules (Basel, Switzerland), 23 (1).
p. 177.
ISSN 1420-3049
DOI: https://doi.org/10.3390/molecules23010177
Lewis, Michael D;
Francisco, Amanda F;
Jayawardhana, Shiromani;
Langston, Harry;
Taylor, Martin C;
Kelly, John M;
(2018)
Imaging the development of chronic Chagas disease after oral transmission.
Scientific reports, 8 (1).
11292-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-29564-7
Olmo, Francisco;
Costa, Fernanda C;
Mann, Gurdip Singh;
Taylor, Martin C;
Kelly, John M;
(2018)
Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation.
Molecular and biochemical parasitology, 226.
pp. 34-36.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2018.07.002
2017
Campos, Mônica C;
Phelan, Jody;
Francisco, Amanda F;
Taylor, Martin C;
Lewis, Michael D;
Pain, Arnab;
Clark, Taane G;
Kelly, John M;
(2017)
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Scientific reports, 7 (1).
14407-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-017-14986-6
Francisco, Amanda F;
Jayawardhana, Shiromani;
Lewis, Michael D;
Taylor, Martin C;
Kelly, John M;
(2017)
Biological factors that impinge on Chagas disease drug development.
Parasitology, 144 (14).
pp. 1871-1880.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182017001469
Taylor, Martin C;
Ward, Theresa H;
(2017)
Pathogen imaging applications.
Methods (San Diego, Calif), 127.
pp. 1-2.
ISSN 1046-2023
DOI: https://doi.org/10.1016/j.ymeth.2017.08.011
Zoidis, Grigoris;
Tsotinis, Andrew;
Tsatsaroni, Alexandra;
Taylor, Martin C;
Kelly, John M;
Efstathiou, Antonia;
Smirlis, Despina;
Fytas, George;
(2017)
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study.
Chemical biology & drug design, 91 (2).
pp. 408-421.
ISSN 1747-0277
DOI: https://doi.org/10.1111/cbdd.13088
2016
Lewis, Michael D;
Francisco, Amanda Fortes;
Taylor, Martin C;
Jayawardhana, Shiromani;
Kelly, John M;
(2016)
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Cellular microbiology, 18 (10).
pp. 1429-1443.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12584
Sola, Irene;
Artigas, Albert;
Taylor, Martin C;
Pérez-Areales, F Javier;
Viayna, Elisabet;
Clos, M Victòria;
Pérez, Belén;
Wright, Colin W;
Kelly, John M;
Muñoz-Torrero, Diego;
(2016)
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Bioorganic & medicinal chemistry, 24 (21).
pp. 5162-5171.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2016.08.036
2015
Campos, MCO;
Leon, LL;
Taylor, MC;
Kelly, JM;
(2015)
"Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert'' [Mol. Biochem. Parasit. (2014) 193, 17-19].
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 201 (1).
83-.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2015.05.006
Di Pietro, Ornella;
Vicente-García, Esther;
Taylor, Martin C;
Berenguer, Diana;
Viayna, Elisabet;
Lanzoni, Anna;
Sola, Irene;
Sayago, Helena;
Riera, Cristina;
Fisa, Roser;
+5 more...
Clos, M Victòria;
Pérez, Belén;
Kelly, John M;
Lavilla, Rodolfo;
Muñoz-Torrero, Diego;
(2015)
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
European journal of medicinal chemistry, 105.
pp. 120-137.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2015.10.007
Francisco, Amanda Fortes;
Lewis, Michael D;
Jayawardhana, Shiromani;
Taylor, Martin C;
Chatelain, Eric;
Kelly, John M;
(2015)
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".
Antimicrobial agents and chemotherapy, 59 (12).
7925-.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.02022-15
Francisco, Amanda Fortes;
Lewis, Michael D;
Jayawardhana, Shiromani;
Taylor, Martin C;
Chatelain, Eric;
Kelly, John M;
(2015)
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Antimicrobial agents and chemotherapy, 59 (8).
pp. 4653-4661.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00520-15
Sola, Irene;
Castellà, Sílvia;
Viayna, Elisabet;
Galdeano, Carles;
Taylor, Martin C;
Gbedema, Stephen Y;
Pérez, Belén;
Clos, M Victòria;
Jones, Deuan C;
Fairlamb, Alan H;
+3 more...
Wright, Colin W;
Kelly, John M;
Muñoz-Torrero, Diego;
(2015)
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorganic & medicinal chemistry, 23 (16).
pp. 5156-5167.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2015.01.031
Full text not available from this repository.
Taylor, Martin C;
Lewis, Michael D;
Fortes Francisco, Amanda;
Wilkinson, Shane R;
Kelly, John M;
(2015)
The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence.
PLoS neglected tropical diseases, 9 (4).
e0003707-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0003707
2014
Campos, Mônica CO;
Leon, Leonor L;
Taylor, Martin C;
Kelly, John M;
(2014)
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.
Molecular and biochemical parasitology, 193 (1).
pp. 17-19.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002
Lewis, Michael D;
Fortes Francisco, Amanda;
Taylor, Martin C;
Burrell-Saward, Hollie;
McLatchie, Alex P;
Miles, Michael A;
Kelly, John M;
(2014)
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Cellular microbiology, 16 (9).
pp. 1285-1300.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12297
Lewis, Michael D;
Francisco, Amanda Fortes;
Taylor, Martin C;
Kelly, John M;
(2014)
A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging.
Journal of biomolecular screening, 20 (1).
pp. 36-43.
ISSN 1087-0571
DOI: https://doi.org/10.1177/1087057114552623
Shameer, Sanu;
Logan-Klumpler, Flora J;
Vinson, Florence;
Cottret, Ludovic;
Merlet, Benjamin;
Achcar, Fiona;
Boshart, Michael;
Berriman, Matthew;
Breitling, Rainer;
Bringaud, Frédéric;
+31 more...
Bütikofer, Peter;
Cattanach, Amy M;
Bannerman-Chukualim, Bridget;
Creek, Darren J;
Crouch, Kathryn;
de Koning, Harry P;
Denise, Hubert;
Ebikeme, Charles;
Fairlamb, Alan H;
Ferguson, Michael AJ;
Ginger, Michael L;
Hertz-Fowler, Christiane;
Kerkhoven, Eduard J;
Mäser, Pascal;
Michels, Paul AM;
Nayak, Archana;
Nes, David W;
Nolan, Derek P;
Olsen, Christian;
Silva-Franco, Fatima;
Smith, Terry K;
Taylor, Martin C;
Tielens, Aloysius GM;
Urbaniak, Michael D;
van Hellemond, Jaap J;
Vincent, Isabel M;
Wilkinson, Shane R;
Wyllie, Susan;
Opperdoes, Fred R;
Barrett, Michael P;
Jourdan, Fabien;
(2014)
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Nucleic acids research, 43 (Databa).
D637-D644.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gku944
Sola, Irene;
Artigas, Albert;
Taylor, Martin C;
Gbedema, Stephen Y;
Pérez, Belén;
Clos, M Victòria;
Wright, Colin W;
Kelly, John M;
Muñoz-Torrero, Diego;
(2014)
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Bioorganic & medicinal chemistry letters, 24 (23).
pp. 5435-5438.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2014.10.025
Full text not available from this repository.
Taylor, Martin C;
Kelly, John M;
(2014)
Optimizing bioluminescence imaging to study protozoan parasite infections.
Trends in parasitology, 30 (4).
pp. 161-162.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2014.01.006
Full text not available from this repository.
2013
Koperniku, Ana;
Papanastasiou, Ioannis;
Foscolos, George B;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
(2013)
Synthesis and trypanocidal action of new adamantane substituted imidazolines.
MedChemComm, 4 (5).
p. 856.
ISSN 2040-2503
DOI: https://doi.org/10.1039/c3md00081h
Full text not available from this repository.
McLatchie, Alex P;
Burrell-Saward, Hollie;
Myburgh, Elmarie;
Lewis, Michael D;
Ward, Theresa H;
Mottram, Jeremy C;
Croft, Simon L;
Kelly, John M;
Taylor, Martin C;
(2013)
Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase.
PLoS neglected tropical diseases, 7 (11).
e2571-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0002571
Myburgh, E;
Coles, J;
Ritchie, R;
Kennedy, PGE;
McLatchie, AP;
Rodgers, R;
Taylor, MC;
Barrett, MP;
Brewer, JM;
Mottram, JC;
(2013)
In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis.
PLoS neglected tropical diseases, 7 (8).
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0002384.
Myburgh, Elmarie;
Coles, Jonathan A;
Ritchie, Ryan;
Kennedy, Peter GE;
McLatchie, Alex P;
Rodgers, Jean;
Taylor, Martin C;
Barrett, Michael P;
Brewer, James M;
Mottram, Jeremy C;
(2013)
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.
PLOS NEGLECTED TROPICAL DISEASES, 7 (8).
e2384-.
ISSN 1935-2735
DOI: https://doi.org/10.1371/journal.pntd.0002384
Taylor, Martin C;
McLatchie, Alex P;
Kelly, John M;
(2013)
Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.
Molecular microbiology, 89 (3).
pp. 420-432.
ISSN 0950-382X
DOI: https://doi.org/10.1111/mmi.12285
Tsatsaroni, Alexandra;
Zoidis, Grigoris;
Zoumpoulakis, Panagiotis;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
Fytas, George;
(2013)
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tetrahedron letters, 54 (25).
pp. 3238-3240.
ISSN 0040-4039
DOI: https://doi.org/10.1016/j.tetlet.2013.03.128
2012
Echeverry, Maria C;
Bot, Christopher;
Obado, Samson O;
Taylor, Martin C;
Kelly, John M;
(2012)
Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted.
BMC genomics, 13 (1).
29-.
ISSN 1471-2164
DOI: https://doi.org/10.1186/1471-2164-13-29
Kelly, John M;
Taylor, Martin C;
Horn, David;
Loza, Einars;
Kalvinsh, Ivars;
Björkling, Fredrik;
(2012)
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorganic & medicinal chemistry letters, 22 (5).
pp. 1886-1890.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2012.01.072
Mejia, Ana Maria;
Hall, Belinda S;
Taylor, Martin C;
Gómez-Palacio, Andrés;
Wilkinson, Shane R;
Triana-Chávez, Omar;
Kelly, John M;
(2012)
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
The Journal of infectious diseases, 206 (2).
pp. 220-228.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jis331
Torres, Eva;
Duque, María D;
López-Querol, Marta;
Taylor, Martin C;
Naesens, Lieve;
Ma, Chunlong;
Pinto, Lawrence H;
Sureda, Francesc X;
Kelly, John M;
Vázquez, Santiago;
(2012)
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Bioorganic & medicinal chemistry, 20 (2).
pp. 942-948.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2011.11.050
Full text not available from this repository.
2011
Defaux, Julien;
Sala, Marta;
Formosa, Xavier;
Galdeano, Carles;
Taylor, Martin C;
Alobaid, Waleed AA;
Kelly, John M;
Wright, Colin W;
Camps, Pelayo;
Muñoz-Torrero, Diego;
(2011)
Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.
Bioorganic & medicinal chemistry, 19 (5).
pp. 1702-1707.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2011.01.028
Fytas, Christos;
Zoidis, Grigoris;
Tzoutzas, Nikolaos;
Taylor, Martin C;
Fytas, George;
Kelly, John M;
(2011)
Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity.
Journal of medicinal chemistry, 54 (14).
pp. 5250-5254.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm200217m
Obado, Samson O;
Bot, Christopher;
Echeverry, Maria C;
Bayona, Julio C;
Alvarez, Vanina E;
Taylor, Martin C;
Kelly, John M;
(2011)
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.
Nucleic acids research, 39 (3).
pp. 1023-1033.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkq839
Taylor, Martin C;
Huang, Huan;
Kelly, John M;
(2011)
Genetic techniques in Trypanosoma cruzi.
Advances in parasitology, 75.
pp. 231-250.
ISSN 0065-308X
DOI: https://doi.org/10.1016/B978-0-12-385863-4.00011-3
Full text not available from this repository.
2010
Bot, Chris;
Hall, Belinda S;
Bashir, Noosheen;
Taylor, Martin C;
Helsby, Nuala A;
Wilkinson, Shane R;
(2010)
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.
Antimicrobial agents and chemotherapy, 54 (10).
pp. 4246-4252.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00800-10
Full text not available from this repository.
Taylor, MC;
Kelly, JM;
(2010)
Iron metabolism in trypanosomatids, and its crucial role in infection.
Parasitology, 137 (6).
pp. 899-917.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182009991880
2008
Taylor, Martin C;
Kaur, Harparkash;
Blessington, Bernard;
Kelly, John M;
Wilkinson, Shane R;
(2008)
Validation of spermidine synthase as a drug target in African trypanosomes.
The Biochemical journal, 409 (2).
pp. 563-569.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20071185
Full text not available from this repository.
Wilkinson, Shane R;
Taylor, Martin C;
Horn, David;
Kelly, John M;
Cheeseman, Ian;
(2008)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America, 105 (13).
pp. 5022-5027.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0711014105
Full text not available from this repository.
2007
Gluenz, Eva;
Taylor, Martin C;
Kelly, John M;
(2007)
The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements.
International journal for parasitology, 37 (6).
pp. 617-625.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ijpara.2006.11.016
Logan, Flora J;
Taylor, Martin C;
Wilkinson, Shane R;
Kaur, Harparkash;
Kelly, John M;
(2007)
The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.
The Biochemical journal, 407 (3).
pp. 419-426.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20070766
Full text not available from this repository.
Piacenza, Lucía;
Irigoín, Florencia;
Alvarez, María Noel;
Peluffo, Gonzalo;
Taylor, Martin C;
Kelly, John M;
Wilkinson, Shane R;
Radi, Rafael;
(2007)
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.
The Biochemical journal, 403 (2).
pp. 323-334.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20061281
Full text not available from this repository.
2006
Taylor, Martin C;
Kelly, John M;
(2006)
pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi.
BMC biotechnology, 6 (1).
32-.
ISSN 1472-6750
DOI: https://doi.org/10.1186/1472-6750-6-32
Wilkinson, Shane R;
Prathalingam, S Radhika;
Taylor, Martin C;
Ahmed, Aiyaz;
Horn, David;
Kelly, John M;
(2006)
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
Free radical biology & medicine, 40 (2).
pp. 198-209.
ISSN 0891-5849
DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022
Full text not available from this repository.
2005
Kelly, JM;
Taylor, MC;
Wilkinson, SR;
(2005)
Trypanosoma cruzi.
In: Fuchs, J; Podda, M; Goethe, JW, (eds.)
Encyclopedia of Diagnostic Genomics and Proteomics.
Marcel Dekker, Inc., New York, USA, pp. 1297-1301.
https://researchonline.lshtm.ac.uk/id/eprint/15644
Full text not available from this repository.
Obado, Samson O;
Taylor, Martin C;
Wilkinson, Shane R;
Bromley, Elizabeth V;
Kelly, John M;
(2005)
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.
Genome research, 15 (1).
pp. 36-43.
ISSN 1088-9051
DOI: https://doi.org/10.1101/gr.2895105
Wilkinson, Shane R;
Prathalingam, S Radhika;
Taylor, Martin C;
Horn, David;
Kelly, John M;
(2005)
Vitamin C biosynthesis in trypanosomes: a role for the glycosome.
Proceedings of the National Academy of Sciences of the United States of America, 102 (33).
pp. 11645-11650.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0504251102
Full text not available from this repository.
2004
Bromley, Elizabeth V;
Taylor, Martin C;
Wilkinson, Shane R;
Kelly, John M;
(2004)
The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal.
International journal for parasitology, 34 (1).
pp. 63-71.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ijpara.2003.09.004
Full text not available from this repository.
Kelly, JM;
Obado, SO;
Taylor, MC;
(2004)
Functional mapping of an American trypanosome centromere [Abstract].
Springer Verlag.
https://researchonline.lshtm.ac.uk/id/eprint/19454
Full text not available from this repository.
McRobert, Louisa;
Preiser, Peter;
Sharp, Sarah;
Jarra, William;
Kaviratne, Mallika;
Taylor, Martin C;
Renia, Laurent;
Sutherland, Colin J;
(2004)
Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle.
Infection and immunity, 72 (11).
pp. 6597-6602.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.72.11.6597-6602.2004
Full text not available from this repository.
2003
Gaunt, Michael W;
Yeo, Matthew;
Frame, Iain A;
Stothard, J Russell;
Carrasco, Hernan J;
Taylor, Martin C;
Mena, Susana Solis;
Veazey, Paul;
Miles, Graham AJ;
Acosta, Nidia;
+2 more...
de Arias, Antonieta Rojas;
Miles, Michael A;
(2003)
Mechanism of genetic exchange in American trypanosomes.
Nature, 421 (6926).
pp. 936-939.
ISSN 0028-0836
DOI: https://doi.org/10.1038/nature01438
Full text not available from this repository.
2002
Taylor, MC;
Kelly, JM;
(2002)
Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era.
In: Tyler, K; Miles, MA, (eds.)
American Trypanosomiasis.
Kluwer Academic Publishers, London, pp. 57-68.
https://researchonline.lshtm.ac.uk/id/eprint/15544
Full text not available from this repository.
Wilkinson, Shane R;
Meyer, David J;
Taylor, Martin C;
Bromley, Elizabeth V;
Miles, Michael A;
Kelly, John M;
(2002)
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.
The Journal of biological chemistry, 277 (19).
pp. 17062-17071.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M111126200
Full text not available from this repository.
Wilkinson, Shane R;
Taylor, Martin C;
Touitha, Said;
Mauricio, Isabel L;
Meyer, David J;
Kelly, John M;
(2002)
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.
The Biochemical journal, 364 (Pt 3).
pp. 787-794.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20020038
Full text not available from this repository.