Items where Author or Contributor is "Taylor, Martin C"

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Number of items: 66.

2020

Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M; (2020) Challenges in Chagas Disease Drug Development. MOLECULES, 25 (12). ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules25122799
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Macleod, Olivia JS; Bart, Jean-Mathieu; MacGregor, Paula; Peacock, Lori; Savill, Nicholas J; Hester, Svenja; Ravel, Sophie; Sunter, Jack D; Trevor, Camilla; Rust, Steven; +7 more... Vaughan, Tristan J; Minter, Ralph; Mohammed, Shabaz; Gibson, Wendy; Taylor, Martin C; Higgins, Matthew K; Carrington, Mark; (2020) A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies. Nature communications, 11 (1). 1326-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-020-15125-y
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Mann, GS; (2020) Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging. PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04655803 Item availability may be restricted.
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Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; +1 more... Kelly, John M; (2020) Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. PLoS neglected tropical diseases, 14 (4). e0007717-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0007717
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2019

Foscolos, Angeliki-Sofia; Papanastasiou, Ioannis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity. ChemMedChem, 14 (13). pp. 1227-1231. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.201900165
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Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; +1 more... Kelly, John M; (2019) Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. Bioorganic & medicinal chemistry letters, 29 (11). pp. 1278-1281. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2019.04.010
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Georgiadis, Markos-Orestis; Kourbeli, Violeta; Papanastasiou, Ioannis P; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. RSC Medicinal Chemistry, 11 (1). pp. 72-84. DOI: https://doi.org/10.1039/c9md00478e
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MacGregor, Paula; Gonzalez-Munoz, Andrea L; Jobe, Fatoumatta; Taylor, Martin C; Rust, Steven; Sandercock, Alan M; Macleod, Olivia JS; Van Bocxlaer, Katrien; Francisco, Amanda F; D'Hooge, Francois; +7 more... Tiberghien, Arnaud; Barry, Conor S; Howard, Philip; Higgins, Matthew K; Vaughan, Tristan J; Minter, Ralph; Carrington, Mark; (2019) A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. PLoS neglected tropical diseases, 13 (5). e0007373-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0007373
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2018

Bistrović, Andrea; Krstulović, Luka; Stolić, Ivana; Drenjančević, Domagoj; Talapko, Jasminka; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; Raić-Malić, Silvana; (2018) Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. Journal of enzyme inhibition and medicinal chemistry, 33 (1). pp. 1323-1334. ISSN 1475-6366 DOI: https://doi.org/10.1080/14756366.2018.1484733
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Ghashghaei, Ouldouz; Kielland, Nicola; Revés, Marc; Taylor, Martin C; Kelly, John M; Di Pietro, Ornella; Muñoz-Torrero, Diego; Pérez, Belén; Lavilla, Rodolfo; (2018) Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. Molecules (Basel, Switzerland), 23 (1). p. 177. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules23010177
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2017

Taylor, Martin C; Ward, Theresa H; (2017) Pathogen imaging applications. Methods (San Diego, Calif), 127. pp. 1-2. ISSN 1046-2023 DOI: https://doi.org/10.1016/j.ymeth.2017.08.011
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Zoidis, Grigoris; Tsotinis, Andrew; Tsatsaroni, Alexandra; Taylor, Martin C; Kelly, John M; Efstathiou, Antonia; Smirlis, Despina; Fytas, George; (2017) Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. Chemical biology & drug design, 91 (2). pp. 408-421. ISSN 1747-0277 DOI: https://doi.org/10.1111/cbdd.13088
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2016

Sola, Irene; Artigas, Albert; Taylor, Martin C; Pérez-Areales, F Javier; Viayna, Elisabet; Clos, M Victòria; Pérez, Belén; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2016) Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic & medicinal chemistry, 24 (21). pp. 5162-5171. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2016.08.036
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2015

Di Pietro, Ornella; Vicente-García, Esther; Taylor, Martin C; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; +5 more... Clos, M Victòria; Pérez, Belén; Kelly, John M; Lavilla, Rodolfo; Muñoz-Torrero, Diego; (2015) Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. European journal of medicinal chemistry, 105. pp. 120-137. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2015.10.007
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Sola, Irene; Castellà, Sílvia; Viayna, Elisabet; Galdeano, Carles; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Jones, Deuan C; Fairlamb, Alan H; +3 more... Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2015) Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic & medicinal chemistry, 23 (16). pp. 5156-5167. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2015.01.031 Full text not available from this repository.

2014

Campos, Mônica CO; Leon, Leonor L; Taylor, Martin C; Kelly, John M; (2014) Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. Molecular and biochemical parasitology, 193 (1). pp. 17-19. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002
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Shameer, Sanu; Logan-Klumpler, Flora J; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; +31 more... Bütikofer, Peter; Cattanach, Amy M; Bannerman-Chukualim, Bridget; Creek, Darren J; Crouch, Kathryn; de Koning, Harry P; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H; Ferguson, Michael AJ; Ginger, Michael L; Hertz-Fowler, Christiane; Kerkhoven, Eduard J; Mäser, Pascal; Michels, Paul AM; Nayak, Archana; Nes, David W; Nolan, Derek P; Olsen, Christian; Silva-Franco, Fatima; Smith, Terry K; Taylor, Martin C; Tielens, Aloysius GM; Urbaniak, Michael D; van Hellemond, Jaap J; Vincent, Isabel M; Wilkinson, Shane R; Wyllie, Susan; Opperdoes, Fred R; Barrett, Michael P; Jourdan, Fabien; (2014) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic acids research, 43 (Databa). D637-D644. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gku944
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Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2014) Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & medicinal chemistry letters, 24 (23). pp. 5435-5438. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2014.10.025 Full text not available from this repository.

Taylor, Martin C; Kelly, John M; (2014) Optimizing bioluminescence imaging to study protozoan parasite infections. Trends in parasitology, 30 (4). pp. 161-162. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2014.01.006 Full text not available from this repository.

2013

Koperniku, Ana; Papanastasiou, Ioannis; Foscolos, George B; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2013) Synthesis and trypanocidal action of new adamantane substituted imidazolines. MedChemComm, 4 (5). p. 856. ISSN 2040-2503 DOI: https://doi.org/10.1039/c3md00081h Full text not available from this repository.

Myburgh, E; Coles, J; Ritchie, R; Kennedy, PGE; McLatchie, AP; Rodgers, R; Taylor, MC; Barrett, MP; Brewer, JM; Mottram, JC; (2013) In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis. PLoS neglected tropical diseases, 7 (8). ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0002384.
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Tsatsaroni, Alexandra; Zoidis, Grigoris; Zoumpoulakis, Panagiotis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Fytas, George; (2013) An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. Tetrahedron letters, 54 (25). pp. 3238-3240. ISSN 0040-4039 DOI: https://doi.org/10.1016/j.tetlet.2013.03.128
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2012

Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik; (2012) Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorganic & medicinal chemistry letters, 22 (5). pp. 1886-1890. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.01.072
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Mejia, Ana Maria; Hall, Belinda S; Taylor, Martin C; Gómez-Palacio, Andrés; Wilkinson, Shane R; Triana-Chávez, Omar; Kelly, John M; (2012) Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. The Journal of infectious diseases, 206 (2). pp. 220-228. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jis331
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Torres, Eva; Duque, María D; López-Querol, Marta; Taylor, Martin C; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H; Sureda, Francesc X; Kelly, John M; Vázquez, Santiago; (2012) Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & medicinal chemistry, 20 (2). pp. 942-948. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.11.050 Full text not available from this repository.

2011

Defaux, Julien; Sala, Marta; Formosa, Xavier; Galdeano, Carles; Taylor, Martin C; Alobaid, Waleed AA; Kelly, John M; Wright, Colin W; Camps, Pelayo; Muñoz-Torrero, Diego; (2011) Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorganic & medicinal chemistry, 19 (5). pp. 1702-1707. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.01.028
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Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M; (2011) Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. Journal of medicinal chemistry, 54 (14). pp. 5250-5254. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm200217m
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Obado, Samson O; Bot, Christopher; Echeverry, Maria C; Bayona, Julio C; Alvarez, Vanina E; Taylor, Martin C; Kelly, John M; (2011) Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. Nucleic acids research, 39 (3). pp. 1023-1033. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkq839
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Taylor, Martin C; Huang, Huan; Kelly, John M; (2011) Genetic techniques in Trypanosoma cruzi. Advances in parasitology, 75. pp. 231-250. ISSN 0065-308X DOI: https://doi.org/10.1016/B978-0-12-385863-4.00011-3 Full text not available from this repository.

2010

Bot, Chris; Hall, Belinda S; Bashir, Noosheen; Taylor, Martin C; Helsby, Nuala A; Wilkinson, Shane R; (2010) Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrobial agents and chemotherapy, 54 (10). pp. 4246-4252. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00800-10 Full text not available from this repository.

2008

Taylor, Martin C; Kaur, Harparkash; Blessington, Bernard; Kelly, John M; Wilkinson, Shane R; (2008) Validation of spermidine synthase as a drug target in African trypanosomes. The Biochemical journal, 409 (2). pp. 563-569. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20071185 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Horn, David; Kelly, John M; Cheeseman, Ian; (2008) A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 105 (13). pp. 5022-5027. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0711014105 Full text not available from this repository.

2007

Logan, Flora J; Taylor, Martin C; Wilkinson, Shane R; Kaur, Harparkash; Kelly, John M; (2007) The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. The Biochemical journal, 407 (3). pp. 419-426. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20070766 Full text not available from this repository.

Piacenza, Lucía; Irigoín, Florencia; Alvarez, María Noel; Peluffo, Gonzalo; Taylor, Martin C; Kelly, John M; Wilkinson, Shane R; Radi, Rafael; (2007) Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. The Biochemical journal, 403 (2). pp. 323-334. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20061281 Full text not available from this repository.

2006

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Ahmed, Aiyaz; Horn, David; Kelly, John M; (2006) Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free radical biology & medicine, 40 (2). pp. 198-209. ISSN 0891-5849 DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022 Full text not available from this repository.

2005

Kelly, JM; Taylor, MC; Wilkinson, SR; (2005) Trypanosoma cruzi. In: Fuchs, J; Podda, M; Goethe, JW, (eds.) Encyclopedia of Diagnostic Genomics and Proteomics. Marcel Dekker, Inc., New York, USA, pp. 1297-1301. https://researchonline.lshtm.ac.uk/id/eprint/15644 Full text not available from this repository.

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Horn, David; Kelly, John M; (2005) Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proceedings of the National Academy of Sciences of the United States of America, 102 (33). pp. 11645-11650. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0504251102 Full text not available from this repository.

2004

Bromley, Elizabeth V; Taylor, Martin C; Wilkinson, Shane R; Kelly, John M; (2004) The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. International journal for parasitology, 34 (1). pp. 63-71. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2003.09.004 Full text not available from this repository.

McRobert, Louisa; Preiser, Peter; Sharp, Sarah; Jarra, William; Kaviratne, Mallika; Taylor, Martin C; Renia, Laurent; Sutherland, Colin J; (2004) Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle. Infection and immunity, 72 (11). pp. 6597-6602. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.72.11.6597-6602.2004 Full text not available from this repository.

2003

Gaunt, Michael W; Yeo, Matthew; Frame, Iain A; Stothard, J Russell; Carrasco, Hernan J; Taylor, Martin C; Mena, Susana Solis; Veazey, Paul; Miles, Graham AJ; Acosta, Nidia; +2 more... de Arias, Antonieta Rojas; Miles, Michael A; (2003) Mechanism of genetic exchange in American trypanosomes. Nature, 421 (6926). pp. 936-939. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature01438 Full text not available from this repository.

2002

Taylor, MC; Kelly, JM; (2002) Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era. In: Tyler, K; Miles, MA, (eds.) American Trypanosomiasis. Kluwer Academic Publishers, London, pp. 57-68. https://researchonline.lshtm.ac.uk/id/eprint/15544 Full text not available from this repository.

Wilkinson, Shane R; Meyer, David J; Taylor, Martin C; Bromley, Elizabeth V; Miles, Michael A; Kelly, John M; (2002) The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. The Journal of biological chemistry, 277 (19). pp. 17062-17071. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M111126200 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Touitha, Said; Mauricio, Isabel L; Meyer, David J; Kelly, John M; (2002) TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. The Biochemical journal, 364 (Pt 3). pp. 787-794. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20020038 Full text not available from this repository.

This list was generated on Wed Oct 28 06:30:10 2020 GMT.