An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tsatsaroni, Alexandra;
Zoidis, Grigoris;
Zoumpoulakis, Panagiotis;
Tsotinis, Andrew;
Taylor, Martin C;
Kelly, John M;
Fytas, George;
(2013)
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tetrahedron letters, 54 (25).
pp. 3238-3240.
ISSN 0040-4039
DOI: https://doi.org/10.1016/j.tetlet.2013.03.128
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.
