Koussis, Konstantinos; Haase, Silvia; Withers-Martinez, Chrislaine; Flynn, Helen R; Kunzelmann, Simone; Christodoulou, Evangelos; Ibrahim, Fairouz; Skehel, Mark; Baker, David A; Blackman, Michael J; (2024) Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites. PLoS pathogens, 20 (6). e1012360-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1012360

Patel, Avnish; Fréville, Aline; Rey, Joshua A; Flynn, Helen R; Koussis, Konstantinos; Skehel, Mark J; Blackman, Michael J; Baker, David A; (2024) Plasmodium falciparum protein phosphatase PP7 is required for early ring-stage development. mBio. e0253924-. ISSN 2150-7511 DOI: https://doi.org/10.1128/mbio.02539-24

Platon, Lucien; Baker, David A; Ménard, Didier; (2023) Modified Plasmodium falciparum Ring-Stage Survival Assay with ML10 Kinase Inhibitor. Antimicrobial agents and chemotherapy, 67 (5). e0001723-. ISSN 0066-4804 DOI: https://doi.org/10.1128/aac.00017-23

Sparkes, PC; (2023) Exploring energy metabolism in male and female Plasmodium falciparum gametocytes. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04671600

Patel, Avnish; Nofal, Stephanie D; Blackman, Michael J; Baker, David A; (2022) CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. mBio, 13 (4). e0163522-. ISSN 2161-2129 DOI: https://doi.org/10.1128/mbio.01635-22

Stewart, Lindsay B; Freville, Aline; Voss, Till S; Baker, David A; Awandare, Gordon A; Conway, David J; (2022) Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines. Microbiology spectrum, 10 (6). e0223422-. ISSN 2165-0497 DOI: https://doi.org/10.1128/spectrum.02234-22

Balestra, Aurélia C; Koussis, Konstantinos; Klages, Natacha; Howell, Steven A; Flynn, Helen R; Bantscheff, Marcus; Pasquarello, Carla; Perrin, Abigail J; Brusini, Lorenzo; Arboit, Patrizia; +9 more... Sanz, Olalla; Castaño, Laura Peces-Barba; Withers-Martinez, Chrislaine; Hainard, Alexandre; Ghidelli-Disse, Sonja; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J; Brochet, Mathieu; (2021) Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. Science advances, 7 (13). eabe5396-. ISSN 2375-2548 DOI: https://doi.org/10.1126/sciadv.abe5396

Nofal, Stephanie D; Patel, Avnish; Blackman, Michael J; Flueck, Christian; Baker, David A; (2021) Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress. mBio, 12 (1). pp. 1-19. ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.02694-20

Perrin, Abigail J; Bisson, Claudine; Faull, Peter A; Renshaw, Matthew J; Lees, Rebecca A; Fleck, Roland A; Saibil, Helen R; Snijders, Ambrosius P; Baker, David A; Blackman, Michael J; (2021) Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony. mBio, 12 (2). e03377-20. ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.03377-20

Baker, David A; Matralis, Alexios N; Osborne, Simon A; Large, Jonathan M; Penzo, Maria; (2020) Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs. FRONTIERS IN MICROBIOLOGY, 11. 602803-. ISSN 1664-302X DOI: https://doi.org/10.3389/fmicb.2020.602803

Henrici, Ryan C; Edwards, Rachel L; Zoltner, Martin; van Schalkwyk, Donelly A; Hart, Melissa N; Mohring, Franziska; Moon, Robert W; Nofal, Stephanie D; Patel, Avnish; Flueck, Christian; +4 more... Baker, David A; Odom John, Audrey R; Field, Mark C; Sutherland, Colin J; (2020) The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. mBio, 11 (1). ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.02918-19

Henrici, Ryan C; Edwards, Rachel L; Zoltner, Martin; van Schalkwyk, Donelly A; Hart, Melissa N; Mohring, Franziska; Moon, Robert W; Nofal, Stephanie D; Patel, Avnish; Flueck, Christian; +4 more... Baker, David A; Odom John, Audrey R; Field, Mark C; Sutherland, Colin J; (2020) The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. mBio, 11 (1). e02918-19. DOI: https://doi.org/10.1128/mBio.02918-19

Koussis, Konstantinos; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J; (2020) Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function. LIFE SCIENCE ALLIANCE, 3 (4). e201900626-e201900626. ISSN 2575-1077 DOI: https://doi.org/10.26508/lsa.201900626

Marr, Edward J; Milne, Rachel M; Anar, Burcu; Girling, Gareth; Schwach, Frank; Mooney, Jason P; Nahrendorf, Wiebke; Spence, Philip J; Cunningham, Deirdre; Baker, David A; +5 more... Langhorne, Jean; Rayner, Julian C; Billker, Oliver; Bushell, Ellen S; Thompson, Joanne; (2020) An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi. Wellcome open research, 5. 71-. ISSN 2398-502X DOI: https://doi.org/10.12688/wellcomeopenres.15587.2

Mohring, Franziska; Hart, Melissa N; Patel, Avnish; Baker, David A; Moon, Robert W; (2020) CRISPR-Cas9 Genome Editing of Plasmodium knowlesi. BIO-PROTOCOL, 10 (4). e3522-. ISSN 2331-8325 DOI: https://doi.org/10.21769/BioProtoc.3522

Perrin, Abigail J; Patel, Avnish; Flueck, Christian; Blackman, Michael J; Baker, David A; (2020) cAMP signalling and its role in host cell invasion by malaria parasites. CURRENT OPINION IN MICROBIOLOGY, 58. pp. 69-74. ISSN 1369-5274 DOI: https://doi.org/10.1016/j.mib.2020.09.003

Ressurreição, Margarida; Thomas, James A; Nofal, Stephanie D; Flueck, Christian; Moon, Robert W; Baker, David A; van Ooij, Christiaan; (2020) Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites. PloS one, 15 (7). e0235798-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0235798

Sherratt, Samuel; Patel, Avnish; Baker, David A; Riley, Eleanor M; Goodier, Martin R; (2020) Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum. Frontiers in immunology, 11. 533-. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2020.00533

Camarda, Grazia; Jirawatcharadech, Piyaporn; Priestley, Richard S; Saif, Ahmed; March, Sandra; Wong, Michael HL; Leung, Suet; Miller, Alex B; Baker, David A; Alano, Pietro; +5 more... Paine, Mark JI; Bhatia, Sangeeta N; O'Neill, Paul M; Ward, Stephen A; Biagini, Giancarlo A; (2019) Antimalarial activity of primaquine operates via a two-step biochemical relay. Nature Communications, 10 (1). 3226-. DOI: https://doi.org/10.1038/s41467-019-11239-0

El Bakkouri, Majida; Kouidmi, Imène; Wernimont, Amy K; Amani, Mehrnaz; Hutchinson, Ashley; Loppnau, Peter; Kim, Jeong Joo; Flueck, Christian; Walker, John R; Seitova, Alma; +7 more... Senisterra, Guillermo; Kakihara, Yoshito; Kim, Choel; Blackman, Michael J; Calmettes, Charles; Baker, David A; Hui, Raymond; (2019) Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proceedings of the National Academy of Sciences of the United States of America, 116 (28). pp. 14164-14173. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1905558116

Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A; (2019) Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. PLoS Biology, 17 (2). e3000154-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.3000154

Flueck, Christian; Drought, Laura G; Jones, Andrew; Patel, Avnish; Perrin, Abigail J; Walker, Eloise M; Nofal, Stephanie D; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A; (2019) Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. PLoS biology, 17 (2). e3000154-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.3000154

Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; +5 more... Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A; (2019) Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty. Bioorganic & medicinal chemistry letters, 29 (19). 126610-. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2019.08.014

Matralis, Alexios N; Malik, Adnan; Penzo, Maria; Moreno, Inmaculada; Almela, Maria J; Camino, Isabel; Crespo, Benigno; Saadeddin, Anas; Ghidelli-Disse, Sonja; Rueda, Lourdes; +7 more... Calderon, Felix; Osborne, Simon A; Drewes, Gerard; Böesche, Markus; Fernández-Álvaro, Elena; Martin Hernando, Jose Ignacio; Baker, David A; (2019) Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites. Journal of medicinal chemistry, 62 (20). pp. 9217-9235. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.9b01099

Mohring, Franziska; Hart, Melissa Natalie; Rawlinson, Thomas A; Henrici, Ryan; Charleston, James A; Diez Benavente, Ernest; Patel, Avnish; Hall, Joanna; Almond, Neil; Campino, Susana; +5 more... Clark, Taane G; Sutherland, Colin J; Baker, David A; Draper, Simon J; Moon, Robert William; (2019) Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research. eLife, 8. ISSN 2050-084X DOI: https://doi.org/10.7554/eLife.45829

Nofal, SD; (2019) Investigation of the role of GCα in activating cGMP signalling in Plasmodium falciparum and how cyclic nucleotide signalling modulates molecular motor function. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04655674

Patel, Avnish; Perrin, Abigail J; Flynn, Helen R; Bisson, Claudine; Withers-Martinez, Chrislaine; Treeck, Moritz; Flueck, Christian; Nicastro, Giuseppe; Martin, Stephen R; Ramos, Andres; +4 more... Gilberger, Tim W; Snijders, Ambrosius P; Blackman, Michael J; Baker, David A; (2019) Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery. PLoS biology, 17 (5). e3000264-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.3000264

Penzo, Maria; de Las Heras-Dueña, Laura; Mata-Cantero, Lydia; Diaz-Hernandez, Beatriz; Vazquez-Muñiz, Maria-Jesus; Ghidelli-Disse, Sonja; Drewes, Gerard; Fernandez-Alvaro, Elena; Baker, David A; (2019) High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites. Scientific reports, 9 (1). 7005-. DOI: https://doi.org/10.1038/s41598-019-42801-x

Ravenhall, Matt; Benavente, Ernest Diez; Sutherland, Colin J; Baker, David A; Campino, Susana; Clark, Taane G; (2019) An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene. Scientific reports, 9 (1). 8287-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-019-44599-0

Benavente, Ernest Diez; Oresegun, Damilola R; de Sessions, Paola Florez; Walker, Eloise M; Roper, Cally; Dombrowski, Jamille G; de Souza, Rodrigo M; Marinho, Claudio RF; Sutherland, Colin J; Hibberd, Martin L; +4 more... Mohareb, Fady; Baker, David A; Clark, Taane G; Campino, Susana; (2018) Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development. Scientific reports, 8 (1). 15429-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-018-33767-3

Fang, Hanwei; Gomes, Ana Rita; Klages, Natacha; Pino, Paco; Maco, Bohumil; Walker, Eloise M; Zenonos, Zenon A; Angrisano, Fiona; Baum, Jake; Doerig, Christian; +3 more... Baker, David A; Billker, Oliver; Brochet, Mathieu; (2018) Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites. Nature communications, 9 (1). 4248-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-018-06733-w

Large, Jonathan M; Birchall, Kristian; Bouloc, Nathalie S; Merritt, Andy T; Smiljanic-Hurley, Ela; Tsagris, Denise J; Wheldon, Mary C; Ansell, Keith H; Coombs, Peter J; Kettleborough, Catherine A; +5 more... Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A; (2018) Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines. Bioorganic & medicinal chemistry letters, 29 (3). pp. 509-514. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2018.11.039

Meerstein-Kessel, Lisette; van der Lee, Robin; Stone, Will; Lanke, Kjerstin; Baker, David A; Alano, Pietro; Silvestrini, Francesco; Janse, Chris J; Khan, Shahid M; van de Vegte-Bolmer, Marga; +10 more... Graumans, Wouter; Siebelink-Stoter, Rianne; Kooij, Taco WA; Marti, Matthias; Drakeley, Chris; Campo, Joseph J; van Dam, Teunis JP; Sauerwein, Robert; Bousema, Teun; Huynen, Martijn A; (2018) Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites. Scientific reports, 8 (1). 410-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-017-18840-7

Perrin, Abigail J; Collins, Christine R; Russell, Matthew RG; Collinson, Lucy M; Baker, David A; Blackman, Michael J; (2018) The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. mBio, 9 (4). ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.00905-18

Tsagris, Denise J; Birchall, Kristian; Bouloc, Nathalie; Large, Jonathan M; Merritt, Andy; Smiljanic-Hurley, Ela; Wheldon, Mary; Ansell, Keith H; Kettleborough, Catherine; Whalley, David; +4 more... Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A; (2018) Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG). Bioorganic & medicinal chemistry letters, 28 (19). pp. 3168-3173. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2018.08.028

Walker, EM; (2018) Investigation of the Relationship between CGMP Signalling and Calcium Mobilisation in Plasmodium Falciparum with a Focus on the Role of Phosphodiesterases in Sexual Development. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04646920

Baker, David A; Drought, Laura G; Flueck, Christian; Nofal, Stephanie D; Patel, Avnish; Penzo, Maria; Walker, Eloise M; (2017) Cyclic nucleotide signalling in malaria parasites. Open biology, 7 (12). p. 170213. ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.170213

Baker, David A; Stewart, Lindsay B; Large, Jonathan M; Bowyer, Paul W; Ansell, Keith H; Jiménez-Díaz, María B; El Bakkouri, Majida; Birchall, Kristian; Dechering, Koen J; Bouloc, Nathalie S; +19 more... Coombs, Peter J; Whalley, David; Harding, Denise J; Smiljanic-Hurley, Ela; Wheldon, Mary C; Walker, Eloise M; Dessens, Johannes T; Lafuente, María José; Sanz, Laura M; Gamo, Francisco-Javier; Ferrer, Santiago B; Hui, Raymond; Bousema, Teun; Angulo-Barturén, Iñigo; Merritt, Andy T; Croft, Simon L; Gutteridge, Winston E; Kettleborough, Catherine A; Osborne, Simon A; (2017) A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. Nature communications, 8 (1). 430-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-017-00572-x

Ganter, M; Goldberg, JM; Dvorin, JD; Paulo, JA; King, JG; Tripathi, AK; Paul, AS; Yang, J; Coppens, I; Jiang, RH; +5 more... Elsworth, B; Baker, DA; Dinglasan, RR; Gygi, SP; Duraisingh, MT; (2017) Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nature microbiology, 2. p. 17017. ISSN 2058-5276 DOI: https://doi.org/10.1038/nmicrobiol.2017.17

Campino, Susana; Benavente, Ernest Diez; Assefa, Samuel; Thompson, Eloise; Drought, Laura G; Taylor, Catherine J; Gorvett, Zaria; Carret, Celine K; Flueck, Christian; Ivens, Al C; +4 more... Kwiatkowski, Dominic P; Alano, Pietro; Baker, David A; Clark, Taane G; (2016) Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines. Malaria journal, 15 (1). 229-. ISSN 1475-2875 DOI: https://doi.org/10.1186/s12936-016-1254-1

LSHTM; (2015) May 2015 - predicting pandemics, the impact of cold weather, and using viagra to control malaria. [Podcast] http://soundcloud.com/lshtm/may-2015-predicting-pa...

LSHTM; (2015) David Baker - Using Viagra to control malaria. [Podcast] http://soundcloud.com/lshtm/david-baker-using-viag...

Alam, Mahmood M; Solyakov, Lev; Bottrill, Andrew R; Flueck, Christian; Siddiqui, Faiza A; Singh, Shailja; Mistry, Sharad; Viskaduraki, Maria; Lee, Kate; Hopp, Christine S; +7 more... Chitnis, Chetan E; Doerig, Christian; Moon, Robert W; Green, Judith L; Holder, Anthony A; Baker, David A; Tobin, Andrew B; (2015) Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion. Nature communications, 6 (1). 7285-. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms8285

Drought, LG; (2015) Investigations into Phosphodieterases as Targets for Antimalarial Drug Discovery. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.02305376

Green, Judith L; Moon, Robert W; Whalley, David; Bowyer, Paul W; Wallace, Claire; Rochani, Ankit; Nageshan, Rishi K; Howell, Steven A; Grainger, Munira; Jones, Hayley M; +7 more... Ansell, Keith H; Chapman, Timothy M; Taylor, Debra L; Osborne, Simon A; Baker, David A; Tatu, Utpal; Holder, Anthony A; (2015) Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development. Antimicrobial agents and chemotherapy, 60 (3). pp. 1464-1475. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01748-15

Guenot, Marianne; Loizon, Séverine; Howard, Jennifer; Costa, Giulia; Baker, David A; Mohabeer, Shaneel Y; Troye-Blomberg, Marita; Moreau, Jean-François; Déchanet-Merville, Julie; Mercereau-Puijalon, Odile; +2 more... Mamani-Matsuda, Maria; Behr, Charlotte; (2015) Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells. Infection and immunity, 83 (10). pp. 3816-3824. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.00446-15

Henriques, Gisela; van Schalkwyk, Donelly A; Burrow, Rebekah; Warhurst, David C; Thompson, Eloise; Baker, David A; Fidock, David A; Hallett, Rachel; Flueck, Christian; Sutherland, Colin J; (2015) The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine. Antimicrobial agents and chemotherapy, 59 (5). pp. 2540-2547. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.04067-14

Kim, Jeong Joo; Flueck, Christian; Franz, Eugen; Sanabria-Figueroa, Eduardo; Thompson, Eloise; Lorenz, Robin; Bertinetti, Daniela; Baker, David A; Herberg, Friedrich W; Kim, Choel; (2015) Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress. PLoS pathogens, 11 (2). e1004639-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1004639

Ramdani, Ghania; Naissant, Bernina; Thompson, Eloise; Breil, Florence; Lorthiois, Audrey; Dupuy, Florian; Cummings, Ross; Duffier, Yoann; Corbett, Yolanda; Mercereau-Puijalon, Odile; +5 more... Vernick, Kenneth; Taramelli, Donatella; Baker, David A; Langsley, Gordon; Lavazec, Catherine; (2015) cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. PLoS pathogens, 11 (5). e1004815-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1004815

Brochet, Mathieu; Collins, Mark O; Smith, Terry K; Thompson, Eloise; Sebastian, Sarah; Volkmann, Katrin; Schwach, Frank; Chappell, Lia; Gomes, Ana Rita; Berriman, Matthew; +4 more... Rayner, Julian C; Baker, David A; Choudhary, Jyoti; Billker, Oliver; (2014) Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites. PLoS biology, 12 (3). e1001806-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.1001806

Flueck, Christian; Baker, David A; (2014) Malaria parasite epigenetics: when virulence and romance collide. Cell host & microbe, 16 (2). pp. 148-150. ISSN 1931-3128 DOI: https://doi.org/10.1016/j.chom.2014.07.012 Full text not available from this repository.

Kafsack, BF; Rovira-Graells, N; Clark, TG; Bancells, C; Crowley, VM; Campino, SG; Williams, AE; Drought, LG; Kwiatkowski, DP; Baker, DA; +2 more... Cortés, A; Llinás, M; (2014) A transcriptional switch underlies commitment tosexual development in malaria parasites. Nature, 507 (7491). pp. 248-52. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature12920

Kafsack, Björn FC; Rovira-Graells, Núria; Clark, Taane G; Bancells, Cristina; Crowley, Valerie M; Campino, Susana G; Williams, April E; Drought, Laura G; Kwiatkowski, Dominic P; Baker, David A; +2 more... Cortés, Alfred; Llinás, Manuel; (2014) A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature, 507 (7491). pp. 248-252. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature12920 Full text not available from this repository.

Lavogina, Darja; Budu, Alexandre; Enkvist, Erki; Hopp, Christine S; Baker, David A; Langsley, Gordon; Garcia, Celia RS; Uri, Asko; (2014) Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates. Experimental parasitology, 138 (1). pp. 55-62. ISSN 0014-4894 DOI: https://doi.org/10.1016/j.exppara.2014.02.001 Full text not available from this repository.

Tewari, Rita; Patzewitz, Eva-Maria; Poulin, Benoit; Stewart, Lindsay; Baker, David A; (2014) Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target. PloS one, 9 (5). e96923-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0096923

Collins, Christine R; Hackett, Fiona; Strath, Malcolm; Penzo, Maria; Withers-Martinez, Chrislaine; Baker, David A; Blackman, Michael J; (2013) Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. PLoS pathogens, 9 (5). e1003344-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1003344

Hopp, Christine S; Bowyer, Paul W; Baker, David A; (2012) The role of cGMP signalling in regulating life cycle progression of Plasmodium. Microbes and infection / Institut Pasteur, 14 (10). pp. 831-837. ISSN 1286-4579 DOI: https://doi.org/10.1016/j.micinf.2012.04.011

Hopp, Christine S; Flueck, Christian; Solyakov, Lev; Tobin, Andrew; Baker, David A; (2012) Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. PloS one, 7 (11). e48206-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0048206

Baker, David A; (2010) Cyclic nucleotide signalling in malaria parasites. Cellular microbiology, 13 (3). pp. 331-339. ISSN 1462-5814 DOI: https://doi.org/10.1111/j.1462-5822.2010.01561.x Full text not available from this repository.

Baker, David A; (2010) Malaria gametocytogenesis. Molecular and biochemical parasitology, 172 (2). pp. 57-65. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2010.03.019

Dvorin, Jeffrey D; Martyn, Derek C; Patel, Saurabh D; Grimley, Joshua S; Collins, Christine R; Hopp, Christine S; Bright, A Taylor; Westenberger, Scott; Winzeler, Elizabeth; Blackman, Michael J; +3 more... Baker, David A; Wandless, Thomas J; Duraisingh, Manoj T; (2010) A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, NY), 328 (5980). pp. 910-912. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.1188191 Full text not available from this repository.

Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Dhar Kumar, S; Heussler, V; Holder, AA; Kocken, C; Krishna, S; +11 more... Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U; Alano, P; (2009) Signalling in malaria parasites. The MALSIG consortium. Parasite (Paris, France), 16 (3). pp. 169-182. ISSN 1252-607X DOI: https://doi.org/10.1051/parasite/2009163169 Full text not available from this repository.

Leber, Werner; Skippen, Alison; Fivelman, Quinton L; Bowyer, Paul W; Cockcroft, Shamshad; Baker, David A; (2009) A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum. International journal for parasitology, 39 (6). pp. 645-653. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2008.11.015 Full text not available from this repository.

Moon, Robert W; Taylor, Cathy J; Bex, Claudia; Schepers, Rebecca; Goulding, David; Janse, Chris J; Waters, Andrew P; Baker, David A; Billker, Oliver; (2009) A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS pathogens, 5 (9). e1000599-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1000599

Schnick, Claudia; Polley, Spencer D; Fivelman, Quinton L; Ranford-Cartwright, Lisa C; Wilkinson, Shane R; Brannigan, James A; Wilkinson, Anthony J; Baker, David A; (2009) Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages. Molecular microbiology, 71 (2). pp. 533-545. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2008.06544.x

Taylor, Helen M; McRobert, Louisa; Grainger, Munira; Sicard, Audrey; Dluzewski, Anton R; Hopp, Christine S; Holder, Anthony A; Baker, David A; (2009) The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryotic cell, 9 (1). pp. 37-45. ISSN 1535-9778 DOI: https://doi.org/10.1128/EC.00186-09 Full text not available from this repository.

McRobert, L; Taylor, CJ; Deng, W; Fivelman, Q; Cummings, R; Billker, O; Baker, DA; (2008) P-falciparum gametogenesis is mediated by cGMPdependent protein kinase. [Conference or Workshop Item] https://researchonline.lshtm.ac.uk/id/eprint/7854 Full text not available from this repository.

McRobert, Louisa; Taylor, Cathy J; Deng, Wensheng; Fivelman, Quinton L; Cummings, Ross M; Polley, Spencer D; Billker, Oliver; Baker, David A; (2008) Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. PLoS biology, 6 (6). e139-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.0060139

Taylor, Cathy J; McRobert, Louisa; Baker, David A; (2008) Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis. Molecular microbiology, 69 (1). pp. 110-118. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2008.06267.x

Taylor, HM; McRobert, L; Grainger, M; Holder, AA; Baker, DA; (2008) Plasmodium falciparum cGMP-dependent protein kinase plays a central role in schizogony. [Conference or Workshop Item] https://researchonline.lshtm.ac.uk/id/eprint/7853 Full text not available from this repository.

Fivelman, Quinton L; McRobert, Louisa; Sharp, Sarah; Taylor, Cathy J; Saeed, Maha; Swales, Claire A; Sutherland, Colin J; Baker, David A; (2007) Improved synchronous production of Plasmodium falciparum gametocytes in vitro. Molecular and biochemical parasitology, 154 (1). pp. 119-123. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2007.04.008 Full text not available from this repository.

Kelly, John M; McRobert, Louisa; Baker, David A; (2006) Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. Proceedings of the National Academy of Sciences of the United States of America, 103 (17). pp. 6706-6711. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0510363103 Full text not available from this repository.

Sharp, Sarah; Lavstsen, Thomas; Fivelman, Quinton L; Saeed, Maha; McRobert, Louisa; Templeton, Thomas J; Jensen, Anja TR; Baker, David A; Theander, Thor G; Sutherland, Colin J; (2006) Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes. Eukaryotic cell, 5 (8). pp. 1206-1214. ISSN 1535-9778 DOI: https://doi.org/10.1128/EC.00029-06 Full text not available from this repository.

Baker, David A; Deng, Wensheng; (2005) Cyclic GMP-dependent protein kinases in protozoa. Frontiers in bioscience (Landmark edition), 10 (1-3). pp. 1229-1238. ISSN 1093-4715 DOI: https://doi.org/10.2741/1615 Full text not available from this repository.

Young, Jason A; Fivelman, Quinton L; Blair, Peter L; de la Vega, Patricia; Le Roch, Karine G; Zhou, Yingyao; Carucci, Daniel J; Baker, David A; Winzeler, Elizabeth A; (2005) The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Molecular and biochemical parasitology, 143 (1). pp. 67-79. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2005.05.007 Full text not available from this repository.

Baker, David A; (2004) Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum. IUBMB life, 56 (9). pp. 535-540. ISSN 1521-6543 DOI: https://doi.org/10.1080/15216540400013937 Full text not available from this repository.

Baker, David A; Kelly, John M; (2004) Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Molecular microbiology, 52 (5). pp. 1229-1242. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2004.04067.x Full text not available from this repository.

Baker, David A; Kelly, John M; (2004) Purine nucleotide cyclases in the malaria parasite. Trends in parasitology, 20 (5). pp. 227-232. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2004.02.007 Full text not available from this repository.

Deng, Wensheng; Parbhu-Patel, Asha; Meyer, David J; Baker, David A; (2003) The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum. The Biochemical journal, 374 (Pt 2). pp. 559-565. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20030474 Full text not available from this repository.

Muhia, David K; Swales, Claire A; Eckstein-Ludwig, Ursula; Saran, Shweta; Polley, Spencer D; Kelly, John M; Schaap, Pauline; Krishna, Sanjeev; Baker, David A; (2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. The Journal of biological chemistry, 278 (24). pp. 22014-22022. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M301639200 Full text not available from this repository.

Deng, Wensheng; Baker, David A; (2002) A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle. Molecular microbiology, 44 (5). pp. 1141-1151. ISSN 0950-382X DOI: https://doi.org/10.1046/j.1365-2958.2002.02948.x Full text not available from this repository.

Li, JL; Targett, GA; Baker, DA; (2001) Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum. International journal for parasitology, 31 (4). pp. 387-392. ISSN 0020-7519 DOI: https://doi.org/10.1016/s0020-7519(01)00126-6 Full text not available from this repository.

Muhia, DK; Swales, CA; Deng, W; Kelly, JM; Baker, DA; (2001) The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum. Molecular microbiology, 42 (2). pp. 553-560. ISSN 0950-382X DOI: https://doi.org/10.1046/j.1365-2958.2001.02665.x Full text not available from this repository.