Items where Author or Contributor is "Blackman, MJ"
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Number of items: 114.
2023
Pietsch, Emma;
Ramaprasad, Abhinay;
Bielfeld, Sabrina;
Wohlfarter, Yvonne;
Maco, Bohumil;
Niedermüller, Korbinian;
Wilcke, Louisa;
Kloehn, Joachim;
Keller, Markus A;
Soldati-Favre, Dominique;
+3 more...
Blackman, Michael J;
Gilberger, Tim-Wolf;
Burda, Paul-Christian;
(2023)
A patatin-like phospholipase is important for mitochondrial function in malaria parasites.
mBio, 14 (6).
e0171823-.
ISSN 2150-7511
DOI: https://doi.org/10.1128/mbio.01718-23
Ramaprasad, Abhinay;
Burda, Paul-Christian;
Koussis, Konstantinos;
Thomas, James A;
Pietsch, Emma;
Calvani, Enrica;
Howell, Steven A;
MacRae, James I;
Snijders, Ambrosius P;
Gilberger, Tim-Wolf;
+1 more...
Blackman, Michael J;
(2023)
A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
PLoS pathogens, 19 (6).
e1011449-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1011449
2022
Patel, Avnish;
Nofal, Stephanie D;
Blackman, Michael J;
Baker, David A;
(2022)
CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation.
mBio, 13 (4).
e0163522-.
ISSN 2161-2129
DOI: https://doi.org/10.1128/mbio.01635-22
Ramaprasad, Abhinay;
Burda, Paul-Christian;
Calvani, Enrica;
Sait, Aaron J;
Palma-Duran, Susana Alejandra;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Macrae, James;
Collinson, Lucy;
Gilberger, Tim Wolf;
+1 more...
Blackman, Michael J;
(2022)
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite.
eLife, 11.
e82207-.
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.82207
2021
Balestra, Aurélia C;
Koussis, Konstantinos;
Klages, Natacha;
Howell, Steven A;
Flynn, Helen R;
Bantscheff, Marcus;
Pasquarello, Carla;
Perrin, Abigail J;
Brusini, Lorenzo;
Arboit, Patrizia;
+9 more...
Sanz, Olalla;
Castaño, Laura Peces-Barba;
Withers-Martinez, Chrislaine;
Hainard, Alexandre;
Ghidelli-Disse, Sonja;
Snijders, Ambrosius P;
Baker, David A;
Blackman, Michael J;
Brochet, Mathieu;
(2021)
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.
Science advances, 7 (13).
eabe5396-.
ISSN 2375-2548
DOI: https://doi.org/10.1126/sciadv.abe5396
Lidumniece, Elina;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Collins, Christine R;
Perrin, Abigail J;
Koussis, Konstantinos;
Bisson, Claudine;
Blackman, Michael J;
Jirgensons, Aigars;
(2021)
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.
Proceedings of the National Academy of Sciences of the United States of America, 118 (20).
e2022696118-e2022696118.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.2022696118
Nofal, Stephanie D;
Patel, Avnish;
Blackman, Michael J;
Flueck, Christian;
Baker, David A;
(2021)
Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress.
mBio, 12 (1).
pp. 1-19.
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.02694-20
Perrin, Abigail J;
Bisson, Claudine;
Faull, Peter A;
Renshaw, Matthew J;
Lees, Rebecca A;
Fleck, Roland A;
Saibil, Helen R;
Snijders, Ambrosius P;
Baker, David A;
Blackman, Michael J;
(2021)
Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony.
mBio, 12 (2).
e03377-20.
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.03377-20
Prior, Kimberley F;
Middleton, Benita;
Owolabi, Alíz TY;
Westwood, Mary L;
Holland, Jacob;
O'Donnell, Aidan J;
Blackman, Michael J;
Skene, Debra J;
Reece, Sarah E;
(2021)
Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid.
Wellcome Open Research, 6.
186-.
DOI: https://doi.org/10.12688/wellcomeopenres.16894.2
Tan, Michele SY;
Blackman, Michael J;
(2021)
Malaria parasite egress at a glance.
Journal of cell science, 134 (5).
jcs257345.
ISSN 0021-9533
DOI: https://doi.org/10.1242/jcs.257345
Tan, Michele SY;
Koussis, Konstantinos;
Withers-Martinez, Chrislaine;
Howell, Steven A;
Thomas, James A;
Hackett, Fiona;
Knuepfer, Ellen;
Shen, Min;
Hall, Matthew D;
Snijders, Ambrosius P;
+1 more...
Blackman, Michael J;
(2021)
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.
The EMBO journal, 40 (11).
e107226-.
ISSN 0261-4189
DOI: https://doi.org/10.15252/embj.2020107226
2020
Collins, Christine R;
Hackett, Fiona;
Howell, Steven A;
Snijders, Ambrosius P;
Russell, Matthew Rg;
Collinson, Lucy M;
Blackman, Michael J;
(2020)
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion.
eLife, 9.
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.61121
Koussis, Konstantinos;
Withers-Martinez, Chrislaine;
Baker, David A;
Blackman, Michael J;
(2020)
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function.
LIFE SCIENCE ALLIANCE, 3 (4).
e201900626-e201900626.
ISSN 2575-1077
DOI: https://doi.org/10.26508/lsa.201900626
Matz, Joachim M;
Beck, Josh R;
Blackman, Michael J;
(2020)
The parasitophorous vacuole of the blood-stage malaria parasite.
NATURE REVIEWS MICROBIOLOGY, 18 (7).
pp. 379-391.
ISSN 1740-1526
DOI: https://doi.org/10.1038/s41579-019-0321-3
Matz, Joachim M;
Drepper, Benjamin;
Blum, Thorsten B;
van Genderen, Eric;
Burrell, Alana;
Martin, Peer;
Stach, Thomas;
Collinson, Lucy M;
Abrahams, Jan Pieter;
Matuschewski, Kai;
+1 more...
Blackman, Michael J;
(2020)
A lipocalin mediates unidirectional heme biomineralization in malaria parasites.
Proc Natl Acad Sci U S A, 117 (28).
pp. 16546-16556.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.2001153117
Perrin, Abigail J;
Patel, Avnish;
Flueck, Christian;
Blackman, Michael J;
Baker, David A;
(2020)
cAMP signalling and its role in host cell invasion by malaria parasites.
CURRENT OPINION IN MICROBIOLOGY, 58.
pp. 69-74.
ISSN 1369-5274
DOI: https://doi.org/10.1016/j.mib.2020.09.003
Tarr, Sarah J;
Withers-Martinez, Chrislaine;
Flynn, Helen R;
Snijders, Ambrosius P;
Masino, Laura;
Koussis, Konstantinos;
Conway, David J;
Blackman, Michael J;
(2020)
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.
The Biochemical journal, 477 (2).
pp. 525-540.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BCJ20190918
2019
El Bakkouri, Majida;
Kouidmi, Imène;
Wernimont, Amy K;
Amani, Mehrnaz;
Hutchinson, Ashley;
Loppnau, Peter;
Kim, Jeong Joo;
Flueck, Christian;
Walker, John R;
Seitova, Alma;
+7 more...
Senisterra, Guillermo;
Kakihara, Yoshito;
Kim, Choel;
Blackman, Michael J;
Calmettes, Charles;
Baker, David A;
Hui, Raymond;
(2019)
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proceedings of the National Academy of Sciences of the United States of America, 116 (28).
pp. 14164-14173.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1905558116
Flueck, Christian;
Drought, Laura G;
Jones, Andrew;
Patel, Avnish;
Perrin, Abigail J;
Walker, Eloise M;
Nofal, Stephanie D;
Snijders, Ambrosius P;
Blackman, Michael J;
Baker, David A;
(2019)
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.
PLoS Biology, 17 (2).
e3000154-.
ISSN 1544-9173
DOI: https://doi.org/10.1371/journal.pbio.3000154
Flueck, Christian;
Drought, Laura G;
Jones, Andrew;
Patel, Avnish;
Perrin, Abigail J;
Walker, Eloise M;
Nofal, Stephanie D;
Snijders, Ambrosius P;
Blackman, Michael J;
Baker, David A;
(2019)
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.
PLoS biology, 17 (2).
e3000154-.
ISSN 1544-9173
DOI: https://doi.org/10.1371/journal.pbio.3000154
Low, Leanne M;
Azasi, Yvonne;
Sherling, Emma S;
Garten, Matthias;
Zimmerberg, Joshua;
Tsuboi, Takafumi;
Brzostowski, Joseph;
Mu, Jianbing;
Blackman, Michael J;
Miller, Louis H;
(2019)
Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake.
mBio, 10 (4).
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.01460-19
Nofal, SD;
(2019)
Investigation of the role of GCα in activating cGMP signalling in Plasmodium falciparum and how cyclic nucleotide signalling modulates molecular motor function.
PhD thesis, London School of Hygiene & Tropical Medicine.
DOI: https://doi.org/10.17037/PUBS.04655674
Pace, Tomasino;
Grasso, Felicia;
Camarda, Grazia;
Suarez, Catherine;
Blackman, Michael J;
Ponzi, Marta;
Olivieri, Anna;
(2019)
The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress.
Cellular microbiology, 21 (7).
e13028-.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.13028
Patel, Avnish;
Perrin, Abigail J;
Flynn, Helen R;
Bisson, Claudine;
Withers-Martinez, Chrislaine;
Treeck, Moritz;
Flueck, Christian;
Nicastro, Giuseppe;
Martin, Stephen R;
Ramos, Andres;
+4 more...
Gilberger, Tim W;
Snijders, Ambrosius P;
Blackman, Michael J;
Baker, David A;
(2019)
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.
PLoS biology, 17 (5).
e3000264-.
ISSN 1544-9173
DOI: https://doi.org/10.1371/journal.pbio.3000264
Sherling, Emma S;
Perrin, Abigail J;
Knuepfer, Ellen;
Russell, Matthew RG;
Collinson, Lucy M;
Miller, Louis H;
Blackman, Michael J;
(2019)
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion.
PLoS pathogens, 15 (9).
e1008049-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1008049
Zogota, Rimants;
Kinena, Linda;
Withers-Martinez, Chrislaine;
Blackman, Michael J;
Bobrovs, Raitis;
Pantelejevs, Teodors;
Kanepe-Lapsa, Iveta;
Ozola, Vita;
Jaudzems, Kristaps;
Suna, Edgars;
+1 more...
Jirgensons, Aigars;
(2019)
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.
European Journal of Medicinal Chemistry, 163.
pp. 344-352.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2018.11.068
2018
Boonyalai, Nonlawat;
Collins, Christine R;
Hackett, Fiona;
Withers-Martinez, Chrislaine;
Blackman, Michael J;
(2018)
Essentiality of Plasmodium falciparum plasmepsin V.
PloS one, 13 (12).
e0207621-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0207621
Boonyalai, Nonlawat;
Collins, Christine R;
Hackett, Fiona;
Withers-Martinez, Chrislaine;
Blackman, Michael J;
(2018)
Function and essentiality of <i>Plasmodium falciparum</i> plasmepsin V.
BioRxiv.
DOI: https://doi.org/10.1101/404798
Deligianni, Elena;
Silmon de Monerri, Natalie C;
McMillan, Paul J;
Bertuccini, Lucia;
Superti, Fabiana;
Manola, Maria;
Spanos, Lefteris;
Louis, Christos;
Blackman, Michael J;
Tilley, Leann;
+1 more...
Siden-Kiamos, Inga;
(2018)
Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.
PloS one, 13 (8).
e0201651-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0201651
Herman, Lou S;
Fornace, Kimberly;
Phelan, Jody;
Grigg, Matthew J;
Anstey, Nicholas M;
William, Timothy;
Moon, Robert W;
Blackman, Michael J;
Drakeley, Chris J;
Tetteh, Kevin KA;
(2018)
Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure.
PLoS neglected tropical diseases, 12 (6).
e0006457-.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0006457
Perrin, Abigail J;
Collins, Christine R;
Russell, Matthew RG;
Collinson, Lucy M;
Baker, David A;
Blackman, Michael J;
(2018)
The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress.
mBio, 9 (4).
ISSN 2150-7511
DOI: https://doi.org/10.1128/mBio.00905-18
Thomas, James A;
Tan, Michele SY;
Bisson, Claudine;
Borg, Aaron;
Umrekar, Trishant R;
Hackett, Fiona;
Hale, Victoria L;
Vizcay-Barrena, Gema;
Fleck, Roland A;
Snijders, Ambrosius P;
+2 more...
Saibil, Helen R;
Blackman, Michael J;
(2018)
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.
Nature microbiology, 3 (4).
pp. 447-455.
ISSN 2058-5276
DOI: https://doi.org/10.1038/s41564-018-0111-0
2017
Benavente, Ernest Diez;
de Sessions, Paola Florez;
Moon, Robert W;
Grainger, Munira;
Holder, Anthony A;
Blackman, Michael J;
Roper, Cally;
Drakeley, Christopher J;
Pain, Arnab;
Sutherland, Colin J;
+3 more...
Hibberd, Martin L;
Campino, Susana;
Clark, Taane G;
(2017)
A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line.
International journal for parasitology, 48 (3-4).
pp. 191-196.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ijpara.2017.09.008
Collins, Christine R;
Hackett, Fiona;
Atid, Jonathan;
Tan, Michele Ser Ying;
Blackman, Michael J;
(2017)
The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.
PLoS pathogens, 13 (7).
e1006453-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1006453
Diez Benavente, Ernest;
Florez de Sessions, Paola;
Moon, Robert W;
Holder, Anthony A;
Blackman, Michael J;
Roper, Cally;
Drakeley, Christopher J;
Pain, Arnab;
Sutherland, Colin J;
Hibberd, Martin L;
+2 more...
Campino, Susana;
Clark, Taane G;
(2017)
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations.
PLoS genetics, 13 (9).
e1007008-.
ISSN 1553-7390
DOI: https://doi.org/10.1371/journal.pgen.1007008
Hale, Victoria L;
Watermeyer, Jean M;
Hackett, Fiona;
Vizcay-Barrena, Gema;
van Ooij, Christiaan;
Thomas, James A;
Spink, Matthew C;
Harkiolaki, Maria;
Duke, Elizabeth;
Fleck, Roland A;
+2 more...
Blackman, Michael J;
Saibil, Helen R;
(2017)
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.
Proceedings of the National Academy of Sciences of the United States of America, 114 (13).
pp. 3439-3444.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1619441114
Pino, P;
Caldelari, R;
Mukherjee, B;
Vahokoski, J;
Klages, N;
Maco, B;
Collins, CR;
Blackman, MJ;
Kursula, I;
Heussler, V;
+2 more...
Brochet, M;
Soldati-Favre, D;
(2017)
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.
Technical Report.
American Association for the Advancement of Science.
DOI: https://doi.org/10.1126/science.aaf8675
Sherling, Emma S;
Knuepfer, Ellen;
Brzostowski, Joseph A;
Miller, Louis H;
Blackman, Michael J;
van Ooij, Christiaan;
(2017)
The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake.
eLife, 6.
ISSN 2050-084X
DOI: https://doi.org/10.7554/eLife.23239
2016
Hill, Ross J;
Ringel, Alessa;
Knuepfer, Ellen;
Moon, Robert W;
Blackman, Michael J;
van Ooij, Christiaan;
(2016)
Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites.
The Journal of biological chemistry, 291 (46).
pp. 24280-24292.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M116.740506
Jones, Matthew L;
Das, Sujaan;
Belda, Hugo;
Collins, Christine R;
Blackman, Michael J;
Treeck, Moritz;
(2016)
A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum.
Scientific reports, 6 (1).
21800-.
ISSN 2045-2322
DOI: https://doi.org/10.1038/srep21800
Moon, RW;
Sharaf, H;
Hastings, CH;
Ho, YS;
Nair, MB;
Rchiad, Z;
Knuepfer, E;
Ramaprasad, A;
Mohring, F;
Amir, A;
+7 more...
Yusuf, NA;
Hall, J;
Almond, N;
Lau, YL;
Pain, A;
Blackman, MJ;
Holder, AA;
(2016)
Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1522469113
Thomas, James A;
Collins, Christine R;
Das, Sujaan;
Hackett, Fiona;
Graindorge, Arnault;
Bell, Donald;
Deu, Edgar;
Blackman, Michael J;
(2016)
Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum.
PloS one, 11 (6).
e0157873-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0157873
2015
Das, Sujaan;
Hertrich, Nadine;
Perrin, Abigail J;
Withers-Martinez, Chrislaine;
Collins, Christine R;
Jones, Matthew L;
Watermeyer, Jean M;
Fobes, Elmar T;
Martin, Stephen R;
Saibil, Helen R;
+4 more...
Wright, Gavin J;
Treeck, Moritz;
Epp, Christian;
Blackman, Michael J;
(2015)
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.
Cell host & microbe, 18 (4).
pp. 433-444.
ISSN 1931-3128
DOI: https://doi.org/10.1016/j.chom.2015.09.007
Pieperhoff, Manuela S;
Pall, Gurman S;
Jiménez-Ruiz, Elena;
Das, Sujaan;
Melatti, Carmen;
Gow, Matthew;
Wong, Eleanor H;
Heng, Joanne;
Müller, Sylke;
Blackman, Michael J;
+1 more...
Meissner, Markus;
(2015)
Conditional U1 Gene Silencing in Toxoplasma gondii.
PloS one, 10 (6).
e0130356-.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0130356
Stallmach, Robert;
Kavishwar, Manoli;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Collins, Christine R;
Howell, Steven A;
Yeoh, Sharon;
Knuepfer, Ellen;
Atid, Avshalom J;
Holder, Anthony A;
+1 more...
Blackman, Michael J;
(2015)
Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
Molecular microbiology, 96 (2).
pp. 368-387.
ISSN 0950-382X
DOI: https://doi.org/10.1111/mmi.12941
Watermeyer, Jean M;
Hale, Victoria L;
Hackett, Fiona;
Clare, Daniel K;
Cutts, Erin E;
Vakonakis, Ioannis;
Fleck, Roland A;
Blackman, Michael J;
Saibil, Helen R;
(2015)
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.
Blood, 127 (3).
pp. 343-351.
ISSN 0006-4971
DOI: https://doi.org/10.1182/blood-2015-10-674002
2014
Giovani, Simone;
Penzo, Maria;
Brogi, Simone;
Brindisi, Margherita;
Gemma, Sandra;
Novellino, Ettore;
Savini, Luisa;
Blackman, Michael J;
Campiani, Giuseppe;
Butini, Stefania;
(2014)
Rational design of the first difluorostatone-based PfSUB1 inhibitors.
Bioorganic & medicinal chemistry letters, 24 (15).
pp. 3582-3586.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2014.05.044
Full text not available from this repository.
Grüring, Christof;
Moon, Robert W;
Lim, Caeul;
Holder, Anthony A;
Blackman, Michael J;
Duraisingh, Manoj T;
(2014)
Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.
Cellular microbiology, 16 (5).
pp. 612-620.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12275
Full text not available from this repository.
Jaudzems, Kristaps;
Tars, Kaspars;
Maurops, Gundars;
Ivdra, Natalija;
Otikovs, Martins;
Leitans, Janis;
Kanepe-Lapsa, Iveta;
Domraceva, Ilona;
Mutule, Ilze;
Trapencieris, Peteris;
+2 more...
Blackman, Michael J;
Jirgensons, Aigars;
(2014)
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.
ACS medicinal chemistry letters, 5 (4).
pp. 373-377.
ISSN 1948-5875
DOI: https://doi.org/10.1021/ml4004952
Full text not available from this repository.
Kher, Samir S;
Penzo, Maria;
Fulle, Simone;
Finn, Paul W;
Blackman, Michael J;
Jirgensons, Aigars;
(2014)
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.
Bioorganic & medicinal chemistry letters, 24 (18).
pp. 4486-4489.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2014.07.086
Withers-Martinez, Chrislaine;
Strath, Malcolm;
Hackett, Fiona;
Haire, Lesley F;
Howell, Steven A;
Walker, Philip A;
Christodoulou, Evangelos;
Dodson, Guy G;
Blackman, Michael J;
(2014)
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nature communications, 5 (1).
3726-.
ISSN 2041-1723
DOI: https://doi.org/10.1038/ncomms4726
2013
Blackman, Michael J;
Carruthers, Vern B;
(2013)
Recent insights into apicomplexan parasite egress provide new views to a kill.
Current opinion in microbiology, 16 (4).
pp. 459-464.
ISSN 1369-5274
DOI: https://doi.org/10.1016/j.mib.2013.04.008
Full text not available from this repository.
Child, Matthew A;
Harris, Philippa K;
Collins, Christine R;
Withers-Martinez, Chrislaine;
Yeoh, Sharon;
Blackman, Michael J;
(2013)
Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.
Traffic (Copenhagen, Denmark), 14 (10).
pp. 1053-1064.
ISSN 1398-9219
DOI: https://doi.org/10.1111/tra.12092
Collins, Christine R;
Das, Sujaan;
Wong, Eleanor H;
Andenmatten, Nicole;
Stallmach, Robert;
Hackett, Fiona;
Herman, Jean-Paul;
Müller, Sylke;
Meissner, Markus;
Blackman, Michael J;
(2013)
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Molecular microbiology, 88 (4).
pp. 687-701.
ISSN 0950-382X
DOI: https://doi.org/10.1111/mmi.12206
Collins, Christine R;
Hackett, Fiona;
Strath, Malcolm;
Penzo, Maria;
Withers-Martinez, Chrislaine;
Baker, David A;
Blackman, Michael J;
(2013)
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.
PLoS pathogens, 9 (5).
e1003344-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1003344
Deligianni, Elena;
Morgan, Rhiannon N;
Bertuccini, Lucia;
Wirth, Christine C;
Silmon de Monerri, Natalie C;
Spanos, Lefteris;
Blackman, Michael J;
Louis, Christos;
Pradel, Gabriele;
Siden-Kiamos, Inga;
(2013)
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes.
Cellular microbiology, 15 (8).
pp. 1438-1455.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12131
Full text not available from this repository.
Fulle, Simone;
Withers-Martinez, Chrislaine;
Blackman, Michael J;
Morris, Garrett M;
Finn, Paul W;
(2013)
Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.
Journal of chemical information and modeling, 53 (3).
pp. 573-583.
ISSN 1549-9596
DOI: https://doi.org/10.1021/ci300581z
Suarez, Catherine;
Volkmann, Katrin;
Gomes, Ana Rita;
Billker, Oliver;
Blackman, Michael J;
(2013)
The malarial serine protease SUB1 plays an essential role in parasite liver stage development.
PLoS pathogens, 9 (12).
e1003811-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1003811
van Ooij, Christiaan;
Withers-Martinez, Chrislaine;
Ringel, Alessa;
Cockcroft, Shamshad;
Haldar, Kasturi;
Blackman, Michael J;
(2013)
Identification of a Plasmodium falciparum phospholipid transfer protein.
The Journal of biological chemistry, 288 (44).
pp. 31971-31983.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M113.474189
2012
Cruz, Laura Nogueira;
Juliano, Maria Aparecida;
Budu, Alexandre;
Juliano, Luiz;
Holder, Anthony A;
Blackman, Michael J;
Garcia, Célia Rs;
(2012)
Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
Malaria journal, 11 (1).
69-.
ISSN 1475-2875
DOI: https://doi.org/10.1186/1475-2875-11-69
Gemma, Sandra;
Giovani, Simone;
Brindisi, Margherita;
Tripaldi, Pierangela;
Brogi, Simone;
Savini, Luisa;
Fiorini, Isabella;
Novellino, Ettore;
Butini, Stefania;
Campiani, Giuseppe;
+2 more...
Penzo, Maria;
Blackman, Michael J;
(2012)
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & medicinal chemistry letters, 22 (16).
pp. 5317-5321.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2012.06.023
Full text not available from this repository.
Moon, Robert W;
Hall, Joanna;
Rangkuti, Farania;
Ho, Yung Shwen;
Almond, Neil;
Mitchell, Graham H;
Pain, Arnab;
Holder, Anthony A;
Blackman, Michael J;
(2012)
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America, 110 (2).
pp. 531-536.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1216457110
Full text not available from this repository.
Ruecker, Andrea;
Shea, Michael;
Hackett, Fiona;
Suarez, Catherine;
Hirst, Elizabeth MA;
Milutinovic, Katarina;
Withers-Martinez, Chrislaine;
Blackman, Michael J;
(2012)
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
The Journal of biological chemistry, 287 (45).
pp. 37949-37963.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M112.400820
Withers-Martinez, Chrislaine;
Suarez, Catherine;
Fulle, Simone;
Kher, Samir;
Penzo, Maria;
Ebejer, Jean-Paul;
Koussis, Kostas;
Hackett, Fiona;
Jirgensons, Aigars;
Finn, Paul;
+1 more...
Blackman, Michael J;
(2012)
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
International journal for parasitology, 42 (6).
pp. 597-612.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ijpara.2012.04.005
2011
Collins, Christine R;
Blackman, Michael J;
(2011)
Apicomplexan AMA1 in host cell invasion: a model at the junction?
Cell host & microbe, 10 (6).
pp. 531-533.
ISSN 1931-3128
DOI: https://doi.org/10.1016/j.chom.2011.11.006
Full text not available from this repository.
Olivieri, Anna;
Collins, Christine R;
Hackett, Fiona;
Withers-Martinez, Chrislaine;
Marshall, Joshua;
Flynn, Helen R;
Skehel, J Mark;
Blackman, Michael J;
(2011)
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.
PLoS pathogens, 7 (12).
e1002448-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1002448
Santos, Joana M;
Ferguson, David JP;
Blackman, Michael J;
Soldati-Favre, Dominique;
(2011)
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.
Science (New York, NY), 331 (6016).
pp. 473-477.
ISSN 0036-8075
DOI: https://doi.org/10.1126/science.1199284
Full text not available from this repository.
Silmon de Monerri, Natalie C;
Flynn, Helen R;
Campos, Marta G;
Hackett, Fiona;
Koussis, Konstantinos;
Withers-Martinez, Chrislaine;
Skehel, J Mark;
Blackman, Michael J;
(2011)
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
Infection and immunity, 79 (3).
pp. 1086-1097.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.00902-10
Full text not available from this repository.
2010
Child, Matthew A;
Epp, Christian;
Bujard, Hermann;
Blackman, Michael J;
(2010)
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth.
Molecular microbiology, 78 (1).
pp. 187-202.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2010.07324.x
Dvorin, Jeffrey D;
Martyn, Derek C;
Patel, Saurabh D;
Grimley, Joshua S;
Collins, Christine R;
Hopp, Christine S;
Bright, A Taylor;
Westenberger, Scott;
Winzeler, Elizabeth;
Blackman, Michael J;
+3 more...
Baker, David A;
Wandless, Thomas J;
Duraisingh, Manoj T;
(2010)
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.
Science (New York, NY), 328 (5980).
pp. 910-912.
ISSN 0036-8075
DOI: https://doi.org/10.1126/science.1188191
Full text not available from this repository.
Friedrich, Nikolas;
Santos, Joana M;
Liu, Yan;
Palma, Angelina S;
Leon, Ester;
Saouros, Savvas;
Kiso, Makoto;
Blackman, Michael J;
Matthews, Stephen;
Feizi, Ten;
+1 more...
Soldati-Favre, Dominique;
(2010)
Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites.
The Journal of biological chemistry, 285 (3).
pp. 2064-2076.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M109.060988
Full text not available from this repository.
Woehlbier, Ute;
Epp, Christian;
Hackett, Fiona;
Blackman, Michael J;
Bujard, Hermann;
(2010)
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion.
Malaria journal, 9 (1).
77-.
ISSN 1475-2875
DOI: https://doi.org/10.1186/1475-2875-9-77
2009
Collins, Christine R;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Blackman, Michael J;
(2009)
An inhibitory antibody blocks interactions between components of the malarial invasion machinery.
PLoS pathogens, 5 (1).
e1000273-.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1000273
Doerig, C;
Baker, D;
Billker, O;
Blackman, MJ;
Chitnis, C;
Dhar Kumar, S;
Heussler, V;
Holder, AA;
Kocken, C;
Krishna, S;
+11 more...
Langsley, G;
Lasonder, E;
Menard, R;
Meissner, M;
Pradel, G;
Ranford-Cartwright, L;
Sharma, A;
Sharma, P;
Tardieux, T;
Tatu, U;
Alano, P;
(2009)
Signalling in malaria parasites. The MALSIG consortium.
Parasite (Paris, France), 16 (3).
pp. 169-182.
ISSN 1252-607X
DOI: https://doi.org/10.1051/parasite/2009163169
Full text not available from this repository.
Koussis, Konstantinos;
Withers-Martinez, Chrislaine;
Yeoh, Sharon;
Child, Matthew;
Hackett, Fiona;
Knuepfer, Ellen;
Juliano, Luiz;
Woehlbier, Ute;
Bujard, Hermann;
Blackman, Michael J;
(2009)
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
The EMBO journal, 28 (6).
pp. 725-735.
ISSN 0261-4189
DOI: https://doi.org/10.1038/emboj.2009.22
Lazarou, Maria;
Guevara Patiño, José A;
Jennings, Richard M;
McIntosh, Richard S;
Shi, Jianguo;
Howell, Steven;
Cullen, Eilish;
Jones, Tarran;
Adame-Gallegos, Jaime R;
Chappel, Jonathan A;
+4 more...
McBride, Jana S;
Blackman, Michael J;
Holder, Anthony A;
Pleass, Richard J;
(2009)
Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies.
Infection and immunity, 77 (12).
pp. 5659-5667.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.00167-09
Full text not available from this repository.
Wanyiri, Jane W;
Techasintana, Patsharaporn;
O'Connor, Roberta M;
Blackman, Michael J;
Kim, Kami;
Ward, Honorine D;
(2009)
Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro.
Eukaryotic cell, 8 (4).
pp. 470-477.
ISSN 1535-9778
DOI: https://doi.org/10.1128/EC.00306-08
Full text not available from this repository.
2008
Blackman, Michael J;
(2008)
Malarial proteases and host cell egress: an 'emerging' cascade.
Cellular microbiology, 10 (10).
pp. 1925-1934.
ISSN 1462-5814
DOI: https://doi.org/10.1111/j.1462-5822.2008.01176.x
Dowse, Timothy J;
Koussis, Konstantinos;
Blackman, Michael J;
Soldati-Favre, Dominique;
(2008)
Roles of proteases during invasion and egress by Plasmodium and Toxoplasma.
Sub-cellular biochemistry, 47.
pp. 121-139.
ISSN 0306-0225
DOI: https://doi.org/10.1007/978-0-387-78267-6_10
Full text not available from this repository.
Sawmynaden, Kovilen;
Saouros, Savvas;
Friedrich, Nikolas;
Marchant, Jan;
Simpson, Peter;
Bleijlevens, Boris;
Blackman, Michael J;
Soldati-Favre, Dominique;
Matthews, Stephen;
(2008)
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.
EMBO reports, 9 (11).
pp. 1149-1155.
ISSN 1469-221X
DOI: https://doi.org/10.1038/embor.2008.179
Full text not available from this repository.
Withers-Martinez, Chrislaine;
Haire, Lesley F;
Hackett, Fiona;
Walker, Philip A;
Howell, Steven A;
Smerdon, Stephen J;
Dodson, Guy G;
Blackman, Michael J;
(2008)
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.
Journal of molecular biology, 375 (3).
pp. 773-781.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.10.071
Full text not available from this repository.
2007
Blumenschein, Tharin MA;
Friedrich, Nikolas;
Childs, Robert A;
Saouros, Savvas;
Carpenter, Elisabeth P;
Campanero-Rhodes, Maria A;
Simpson, Peter;
Chai, Wengang;
Koutroukides, Theodoros;
Blackman, Michael J;
+3 more...
Feizi, Ten;
Soldati-Favre, Dominique;
Matthews, Stephen;
(2007)
Atomic resolution insight into host cell recognition by Toxoplasma gondii.
The EMBO journal, 26 (11).
pp. 2808-2820.
ISSN 0261-4189
DOI: https://doi.org/10.1038/sj.emboj.7601704
Full text not available from this repository.
Collins, Christine R;
Withers-Martinez, Chrislaine;
Bentley, Graham A;
Batchelor, Adrian H;
Thomas, Alan W;
Blackman, Michael J;
(2007)
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.
The Journal of biological chemistry, 282 (10).
pp. 7431-7441.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M610562200
Full text not available from this repository.
Yeoh, Sharon;
O'Donnell, Rebecca A;
Koussis, Konstantinos;
Dluzewski, Anton R;
Ansell, Keith H;
Osborne, Simon A;
Hackett, Fiona;
Withers-Martinez, Chrislaine;
Mitchell, Graham H;
Bannister, Lawrence H;
+3 more...
Bryans, Justin S;
Kettleborough, Catherine A;
Blackman, Michael J;
(2007)
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Cell, 131 (6).
pp. 1072-1083.
ISSN 0092-8674
DOI: https://doi.org/10.1016/j.cell.2007.10.049
2006
Montero, Estrella;
Gonzalez, Luis Miguel;
Rodriguez, Marilis;
Oksov, Yelena;
Blackman, Michael J;
Lobo, Cheryl A;
(2006)
A conserved subtilisin protease identified in Babesia divergens merozoites.
The Journal of biological chemistry, 281 (47).
pp. 35717-35726.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M604344200
Full text not available from this repository.
O'Donnell, Rebecca A;
Hackett, Fiona;
Howell, Steven A;
Treeck, Moritz;
Struck, Nicole;
Krnajski, Zita;
Withers-Martinez, Chrislaine;
Gilberger, Tim W;
Blackman, Michael J;
(2006)
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.
The Journal of cell biology, 174 (7).
pp. 1023-1033.
ISSN 0021-9525
DOI: https://doi.org/10.1083/jcb.200604136
2005
Carruthers, Vern B;
Blackman, Michael J;
(2005)
A new release on life: emerging concepts in proteolysis and parasite invasion.
Molecular microbiology, 55 (6).
pp. 1617-1630.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2005.04483.x
Full text not available from this repository.
Chesne-Seck, Marie-Laure;
Pizarro, Juan Carlos;
Vulliez-Le Normand, Brigitte;
Collins, Christine R;
Blackman, Michael J;
Faber, Bart W;
Remarque, Edmond J;
Kocken, Clemens HM;
Thomas, Alan W;
Bentley, Graham A;
(2005)
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites.
Molecular and biochemical parasitology, 144 (1).
pp. 55-67.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.07.007
Full text not available from this repository.
Ersmark, Karolina;
Nervall, Martin;
Hamelink, Elizabeth;
Janka, Linda K;
Clemente, Jose C;
Dunn, Ben M;
Blackman, Michael J;
Samuelsson, Bertil;
Aqvist, Johan;
Hallberg, Anders;
(2005)
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.
Journal of medicinal chemistry, 48 (19).
pp. 6090-6106.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm050463l
Full text not available from this repository.
Harris, Philippa K;
Yeoh, Sharon;
Dluzewski, Anton R;
O'Donnell, Rebecca A;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Bannister, Lawrence H;
Mitchell, Graham H;
Blackman, Michael J;
(2005)
Molecular identification of a malaria merozoite surface sheddase.
PLoS pathogens, 1 (3).
pp. 241-251.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.0010029
Howell, Steven A;
Hackett, Fiona;
Jongco, Artemio M;
Withers-Martinez, Chrislaine;
Kim, Kami;
Carruthers, Vern B;
Blackman, Michael J;
(2005)
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.
Molecular microbiology, 57 (5).
pp. 1342-1356.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2005.04772.x
Full text not available from this repository.
Jean, Létitia;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Blackman, Michael J;
(2005)
Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity.
Molecular and biochemical parasitology, 144 (2).
pp. 187-197.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.07.008
Full text not available from this repository.
Johansson, Per-Ola;
Lindberg, Jimmy;
Blackman, Michael J;
Kvarnström, Ingemar;
Vrang, Lotta;
Hamelink, Elizabeth;
Hallberg, Anders;
Rosenquist, Asa;
Samuelsson, Bertil;
(2005)
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
Journal of medicinal chemistry, 48 (13).
pp. 4400-4409.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm040884n
Full text not available from this repository.
O'Donnell, Rebecca A;
Blackman, Michael J;
(2005)
The role of malaria merozoite proteases in red blood cell invasion.
Current opinion in microbiology, 8 (4).
pp. 422-427.
ISSN 1369-5274
DOI: https://doi.org/10.1016/j.mib.2005.06.018
Full text not available from this repository.
Pizarro, Juan Carlos;
Vulliez-Le Normand, Brigitte;
Chesne-Seck, Marie-Laure;
Collins, Christine R;
Withers-Martinez, Chrislaine;
Hackett, Fiona;
Blackman, Michael J;
Faber, Bart W;
Remarque, Edmond J;
Kocken, Clemens HM;
+2 more...
Thomas, Alan W;
Bentley, Graham A;
(2005)
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Science (New York, NY), 308 (5720).
pp. 408-411.
ISSN 0036-8075
DOI: https://doi.org/10.1126/science.1107449
Full text not available from this repository.
Polson, Hannah EJ;
Blackman, Michael J;
(2005)
A role for poly(dA)poly(dT) tracts in directing activity of the Plasmodium falciparum calmodulin gene promoter.
Molecular and biochemical parasitology, 141 (2).
pp. 179-189.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.02.008
Full text not available from this repository.
2004
Blackman, Michael J;
(2004)
Proteases in host cell invasion by the malaria parasite.
Cellular microbiology, 6 (10).
pp. 893-903.
ISSN 1462-5814
DOI: https://doi.org/10.1111/j.1462-5822.2004.00437.x
Full text not available from this repository.
Ersmark, Karolina;
Feierberg, Isabella;
Bjelic, Sinisa;
Hamelink, Elizabeth;
Hackett, Fiona;
Blackman, Michael J;
Hultén, Johan;
Samuelsson, Bertil;
Aqvist, Johan;
Hallberg, Anders;
(2004)
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
Journal of medicinal chemistry, 47 (1).
pp. 110-122.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm030933g
Full text not available from this repository.
Johansson, Per-Ola;
Chen, Yantao;
Belfrage, Anna Karin;
Blackman, Michael J;
Kvarnström, Ingemar;
Jansson, Katarina;
Vrang, Lotta;
Hamelink, Elizabeth;
Hallberg, Anders;
Rosenquist, Asa;
+1 more...
Samuelsson, Bertil;
(2004)
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
Journal of medicinal chemistry, 47 (13).
pp. 3353-3366.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm031106i
Full text not available from this repository.
Silvie, Olivier;
Franetich, Jean-François;
Charrin, Stéphanie;
Mueller, Markus S;
Siau, Anthony;
Bodescot, Myriam;
Rubinstein, Eric;
Hannoun, Laurent;
Charoenvit, Yupin;
Kocken, Clemens H;
+7 more...
Thomas, Alan W;
Van Gemert, Geert-Jan;
Sauerwein, Robert W;
Blackman, Michael J;
Anders, Robin F;
Pluschke, Gerd;
Mazier, Dominique;
(2004)
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
The Journal of biological chemistry, 279 (10).
pp. 9490-9496.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M311331200
Full text not available from this repository.
Withers-Martinez, Chrislaine;
Jean, Létitia;
Blackman, Michael J;
(2004)
Subtilisin-like proteases of the malaria parasite.
Molecular microbiology, 53 (1).
pp. 55-63.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2004.04144.x
Full text not available from this repository.
Zhou, Xing W;
Blackman, Michael J;
Howell, Steven A;
Carruthers, Vern B;
(2004)
Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex.
Molecular & cellular proteomics, 3 (6).
pp. 565-576.
ISSN 1535-9476
DOI: https://doi.org/10.1074/mcp.M300123-MCP200
Full text not available from this repository.
2003
Bannister, Lawrence H;
Hopkins, John M;
Dluzewski, Anton R;
Margos, Gabriele;
Williams, Ian T;
Blackman, Michael J;
Kocken, Clemens H;
Thomas, Alan W;
Mitchell, Graham H;
(2003)
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.
Journal of cell science, 116 (Pt 18).
pp. 3825-3834.
ISSN 0021-9533
DOI: https://doi.org/10.1242/jcs.00665
Full text not available from this repository.
Blackman, Michael J;
(2003)
RNAi in protozoan parasites: what hope for the Apicomplexa?
Protist, 154 (2).
pp. 177-180.
ISSN 1434-4610
DOI: https://doi.org/10.1078/143446103322166482
Full text not available from this repository.
Fleck, Suzanne L;
Birdsall, Berry;
Babon, Jeffrey;
Dluzewski, Anton R;
Martin, Stephen R;
Morgan, William D;
Angov, Evelina;
Kettleborough, Catherine A;
Feeney, James;
Blackman, Michael J;
+1 more...
Holder, Anthony A;
(2003)
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum.
The Journal of biological chemistry, 278 (48).
pp. 47670-47677.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M306603200
Full text not available from this repository.
Howell, Steven A;
Well, Isabelle;
Fleck, Suzanne L;
Kettleborough, Catherine;
Collins, Christine R;
Blackman, Michael J;
(2003)
A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage.
The Journal of biological chemistry, 278 (26).
pp. 23890-23898.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M302160200
Full text not available from this repository.
Jean, Letitia;
Hackett, Fiona;
Martin, Stephen R;
Blackman, Michael J;
(2003)
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1.
The Journal of biological chemistry, 278 (31).
pp. 28572-28579.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M303827200
Full text not available from this repository.
Miller, Steven A;
Thathy, Vandana;
Ajioka, James W;
Blackman, Michael J;
Kim, Kami;
(2003)
TgSUB2 is a Toxoplasma gondii rhoptry organelle processing proteinase.
Molecular microbiology, 49 (4).
pp. 883-894.
ISSN 0950-382X
DOI: https://doi.org/10.1046/j.1365-2958.2003.03604.x
Full text not available from this repository.
2002
Blackman, Michael J;
Corrie, John ET;
Croney, John C;
Kelly, Geoff;
Eccleston, John F;
Jameson, David M;
(2002)
Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate.
Biochemistry, 41 (40).
pp. 12244-12252.
ISSN 0006-2960
DOI: https://doi.org/10.1021/bi0263661
Full text not available from this repository.
Kocken, Clemens HM;
Withers-Martinez, Chrislaine;
Dubbeld, Martin A;
van der Wel, Annemarie;
Hackett, Fiona;
Valderrama, Augusto;
Blackman, Michael J;
Thomas, Alan W;
(2002)
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.
Infection and immunity, 70 (8).
pp. 4471-4476.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.70.8.4471-4476.2002
Full text not available from this repository.
Withers-Martinez, Chrislaine;
Saldanha, José W;
Ely, Barry;
Hackett, Fiona;
O'Connor, Tony;
Blackman, Michael J;
(2002)
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.
The Journal of biological chemistry, 277 (33).
pp. 29698-29709.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M203088200
Full text not available from this repository.
2001
Blackman, MJ;
Bannister, LH;
(2001)
Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation.
Molecular and biochemical parasitology, 117 (1).
pp. 11-25.
ISSN 0166-6851
DOI: https://doi.org/10.1016/s0166-6851(01)00328-0
Full text not available from this repository.
Howell, SA;
Withers-Martinez, C;
Kocken, CH;
Thomas, AW;
Blackman, MJ;
(2001)
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.
The Journal of biological chemistry, 276 (33).
pp. 31311-31320.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M103076200
Full text not available from this repository.
Miller, SA;
Binder, EM;
Blackman, MJ;
Carruthers, VB;
Kim, K;
(2001)
A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii.
The Journal of biological chemistry, 276 (48).
pp. 45341-45348.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M106665200
Full text not available from this repository.