Items where Author is "Kelly, JM"
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Number of items: 91.
Article
Adjogatse, E;
Erskine, P;
Wells, SA;
Kelly, JM;
Wilden, JD;
Chan, AWE;
Selwood, D;
Coker, A;
Wood, S;
Cooper, JB;
(2018)
Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta crystallographica Section D, Structural biology, 74 (Pt 9).
pp. 861-876.
ISSN 2059-7983
DOI: https://doi.org/10.1107/S2059798318009208
Item availability may be restricted.
Allen, CL;
Kelly, JM;
(2001)
Trypanosoma cruzi: mucin pseudogenes organized in a tandem array.
Experimental parasitology, 97 (3).
pp. 173-7.
ISSN 0014-4894
DOI: https://doi.org/10.1006/expr.2001.4600
Full text not available from this repository.
Alsford, S;
Kelly, JM;
Baker, N;
Horn, D;
(2013)
Genetic dissection of drug resistance in trypanosomes.
Parasitology.
pp. 1-14.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S003118201300022X
Baker, DA;
Kelly, JM;
(2004)
Structure, function and evolution of microbial adenylyl and guanylyl cyclases.
Molecular microbiology, 52 (5).
pp. 1229-42.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2004.04067.x
Full text not available from this repository.
Baker, DA;
Kelly, JM;
(2004)
Purine nucleotide cyclases in the malaria parasite.
Trends in parasitology, 20 (5).
pp. 227-32.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2004.02.007
Full text not available from this repository.
Bistrović, A;
Krstulović, L;
Stolić, I;
Drenjančević, D;
Talapko, J;
Taylor, MC;
Kelly, JM;
Bajić, M;
Raić-Malić, S;
(2018)
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.
Journal of enzyme inhibition and medicinal chemistry, 33 (1).
pp. 1323-1334.
ISSN 1475-6366
DOI: https://doi.org/10.1080/14756366.2018.1484733
Brand, S;
Ko, EJ;
Viayna, E;
Thompson, S;
Spinks, D;
Thomas, M;
Sandberg, L;
Francisco, AF;
Jayawardhana, S;
Smith, VC;
+26 more...
Jansen, C;
De Rycker, M;
Thomas, J;
MacLean, L;
Osuna-Cabello, M;
Riley, J;
Scullion, P;
Stojanovski, L;
Simeons, FRC;
Epemolu, O;
Shishikura, Y;
Crouch, SD;
Bakshi, TS;
Nixon, CJ;
Reid, IH;
Hill, AP;
Underwood, TZ;
Hindley, SJ;
Robinson, SA;
Kelly, JM;
Fiandor, JM;
Wyatt, PG;
Marco, M;
Miles, TJ;
Read, KD;
Gilbert, IH;
(2017)
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Journal of medicinal chemistry.
ISSN 0022-2623
DOI: https://doi.org/10.1021/acs.jmedchem.7b00463
Bromley, EV;
Taylor, MC;
Wilkinson, SR;
Kelly, JM;
(2004)
The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal.
International journal for parasitology, 34 (1).
pp. 63-71.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ipara.2003.09.004
Full text not available from this repository.
Campos, MC;
Leon, LL;
Taylor, MC;
Kelly, JM;
(2014)
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.
Molecular and biochemical parasitology, 193 (1).
pp. 17-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002
Campos, MC;
Phelan, J;
Francisco, AF;
Taylor, MC;
Lewis, MD;
Pain, A;
Clark, TG;
Kelly, JM;
(2017)
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Scientific reports, 7 (1).
p. 14407.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-017-14986-6
Camps, P;
Duque, MD;
Vázquez, S;
Naesens, L;
Clercq, ED;
Sureda, FX;
López-Querol, M;
Camins, A;
Pallàs, M;
Prathalingam, SR;
+4 more...
Kelly, JM;
Romero, V;
Ivorra, D;
Cortés, D;
(2008)
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Bioorganic & medicinal chemistry, 16 (23).
pp. 9925-36.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2008.10.028
Full text not available from this repository.
Costa, FC;
Francisco, AF;
Jayawardhana, S;
Calderano, SG;
Lewis, MD;
Olmo, F;
Beneke, T;
Gluenz, E;
Sunter, J;
Dean, S;
+2 more...
Kelly, JM;
Taylor, MC;
(2018)
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
PLoS neglected tropical diseases, 12 (4).
e0006388.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0006388
Defaux, J;
Sala, M;
Formosa, X;
Galdeano, C;
Taylor, MC;
Alobaid, WAA;
Kelly, JM;
Wright, CW;
Camps, P;
Munoz-Torrero, D;
(2011)
Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.
Bioorganic & medicinal chemistry, 19 (5).
pp. 1702-1707.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2011.01.028
Di Pietro, O;
Vicente-García, E;
Taylor, MC;
Berenguer, D;
Viayna, E;
Lanzoni, A;
Sola, I;
Sayago, H;
Riera, C;
Fisa, R;
+5 more...
Clos, MV;
Pérez, B;
Kelly, JM;
Lavilla, R;
Muñoz-Torrero, D;
(2015)
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
European journal of medicinal chemistry, 105.
pp. 120-137.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2015.10.007
Duque, MD;
Camps, P;
Profire, L;
Montaner, S;
Vázquez, S;
Sureda, FX;
Mallol, J;
López-Querol, M;
Naesens, L;
De Clercq, E;
+2 more...
Prathalingam, SR;
Kelly, JM;
(2009)
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
Bioorganic & medicinal chemistry, 17 (8).
pp. 3198-206.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2009.02.007
Full text not available from this repository.
Duque, MD;
Camps, P;
Torres, E;
Valverde, E;
Sureda, FX;
Lopez-Querol, M;
Camins, A;
Prathalingam, SR;
Kelly, JM;
Vazquez, S;
(2010)
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
Bioorganic & medicinal chemistry, 18 (1).
pp. 46-57.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2009.11.017
Full text not available from this repository.
Echeverry, MC;
Bot, C;
Obado, SO;
Taylor, MC;
Kelly, JM;
(2012)
Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted.
BMC Genomics, 13.
p. 29.
ISSN 1471-2164
DOI: https://doi.org/10.1186/1471-2164-13-29
Fortes Francisco, A;
Jayawardhana, S;
Taylor, MC;
Lewis, MD;
Kelly, JM;
(2018)
Assessing the effectiveness of curative benznidazole treatment in preventing chronic cardiac pathology in experimental models of Chagas disease.
Antimicrobial agents and chemotherapy.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00832-18
Fortes Francisco, A;
Lewis, MD;
Jayawardhana, S;
Taylor, MC;
Chatelain, E;
Kelly, JM;
(2015)
The limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging.
Antimicrobial agents and chemotherapy.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00520-15
Francisco, AF;
Jayawardhana, S;
Lewis, MD;
Taylor, MC;
Kelly, JM;
(2017)
Biological factors that impinge on Chagas disease drug development.
Parasitology.
pp. 1-10.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182017001469
Francisco, AF;
Jayawardhana, S;
Lewis, MD;
White, KL;
Shackleford, DM;
Chen, G;
Saunders, J;
Osuna-Cabello, M;
Read, KD;
Charman, SA;
+2 more...
Chatelain, E;
Kelly, JM;
(2016)
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Scientific reports, 6.
p. 35351.
ISSN 2045-2322
DOI: https://doi.org/10.1038/srep35351
Francisco, AF;
Lewis, MD;
Jayawardhana, S;
Taylor, MC;
Chatelain, E;
Kelly, JM;
(2015)
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".
Antimicrobial agents and chemotherapy, 59 (12).
p. 7925.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.02022-15
Full text not available from this repository.
Fytas, C;
Zoidis, G;
Tzoutzas, N;
Taylor, MC;
Fytas, G;
Kelly, JM;
(2011)
Novel Lipophilic Acetohydroxamic Acid Derivatives Based on Conformationally Constrained Spiro Carbocyclic 2,6-Diketopiperazine Scaffolds with Potent Trypanocidal Activity.
Journal of medicinal chemistry, 54 (14).
pp. 5250-5254.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm200217m
Ghashghaei, O;
Kielland, N;
Revés, M;
Taylor, MC;
Kelly, JM;
Di Pietro, O;
Muñoz-Torrero, D;
Pérez, B;
Lavilla, R;
(2018)
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.
Molecules (Basel, Switzerland), 23 (1).
ISSN 1420-3049
DOI: https://doi.org/10.3390/molecules23010177
Gluenz, E;
Taylor, MC;
Kelly, JM;
(2007)
The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements.
International journal for parasitology, 37 (6).
pp. 617-25.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ijpara.2006.11.016
Howard, SL;
Jagannathan, A;
Soo, EC;
Hui, JP;
Aubry, AJ;
Ahmed, I;
Karlyshev, A;
Kelly, JF;
Jones, MA;
Stevens, MP;
+2 more...
Logan, SM;
Wren, BW;
(2009)
A Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis and colonisation of chickens.
Infection and immunity, 77 (6).
pp. 2544-56.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.01425-08
Full text not available from this repository.
Kelly, JM;
McRobert, L;
Baker, DA;
(2006)
Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage.
Proceedings of the National Academy of Sciences of the United States of America, 103 (17).
pp. 6706-11.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0510363103
Full text not available from this repository.
Kelly, JM;
Quack, G;
Miles, MM;
(2001)
In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei.
Antimicrobial agents and chemotherapy, 45 (5).
pp. 1360-6.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.45.5.1360-1366.2001
Full text not available from this repository.
Kelly, JM;
Taylor, MC;
Horn, D;
Loza, E;
Kalvinsh, I;
Björkling, F;
(2012)
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorganic & medicinal chemistry letters, 22 (5).
pp. 1886-90.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2012.01.072
Kishore, KG;
Ghashghaei, O;
Estarellas, C;
Mestre, MM;
Monturiol, C;
Kielland, N;
Kelly, JM;
Francisco, AF;
Jayawardhana, S;
Muñoz-Torrero, D;
+4 more...
Pérez, B;
Luque, FJ;
Gámez-Montaño, R;
Lavilla, R;
(2016)
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds.
Angewandte Chemie (International ed in English), 55 (31).
pp. 8994-8.
ISSN 1433-7851
DOI: https://doi.org/10.1002/anie.201604109
Full text not available from this repository.
Kolocouris, N;
Zoidis, G;
Foscolos, GB;
Fytas, G;
Prathalingham, SR;
Kelly, JM;
Naesens, L;
De Clercq, E;
(2007)
Design and synthesis of bioactive adamantane spiro heterocycles.
Bioorganic & medicinal chemistry letters, 17 (15).
pp. 4358-62.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2007.04.108
Full text not available from this repository.
Koperniku, A;
Papanastasiou, I;
Foscolos, GB;
Tsotinis, A;
Taylor, MC;
Kelly, JM;
(2013)
Synthesis and trypanocidal action of new adamantane substituted imidazolines.
MedChemComm, 4 (5).
pp. 856-859.
ISSN 2040-2503
DOI: https://doi.org/10.1039/c3md00081h
Full text not available from this repository.
Lewis, MD;
Fortes Francisco, A;
Taylor, MC;
Burrell-Saward, H;
McLatchie, AP;
Miles, MA;
Kelly, JM;
(2014)
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Cellular microbiology, 16 (9).
pp. 1285-300.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12297
Lewis, MD;
Francisco, AF;
Jayawardhana, S;
Langston, H;
Taylor, MC;
Kelly, JM;
(2018)
Imaging the development of chronic Chagas disease after oral transmission.
Scientific reports, 8 (1).
p. 11292.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-29564-7
Lewis, MD;
Francisco, AF;
Taylor, MC;
Jayawardhana, S;
Kelly, JM;
(2016)
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Cellular microbiology.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12584
Lewis, MD;
Francisco, AF;
Taylor, MC;
Kelly, JM;
(2014)
A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging.
Journal of biomolecular screening, 20 (1).
pp. 36-43.
ISSN 1087-0571
DOI: https://doi.org/10.1177/1087057114552623
Lewis, MD;
Kelly, JM;
(2016)
Putting Infection Dynamics at the Heart of Chagas Disease.
Trends in parasitology.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2016.08.009
Logan, FJ;
Taylor, MC;
Wilkinson, SR;
Kaur, H;
Kelly, JM;
(2007)
The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.
The Biochemical journal, 407 (3).
pp. 419-26.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20070766
Full text not available from this repository.
MacRae, JI;
Obado, SO;
Turnock, DC;
Roper, JR;
Kierans, M;
Kelly, JM;
Ferguson, MAJ;
(2006)
The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.
Molecular and biochemical parasitology, 147 (1).
pp. 126-136.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2006.02.011
Full text not available from this repository.
McLatchie, AP;
Burrell-Saward, H;
Myburgh, E;
Lewis, MD;
Ward, TH;
Mottram, JC;
Croft, SL;
Kelly, JM;
Taylor, MC;
(2013)
Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing "Red-Shifted" Luciferase.
PLoS neglected tropical diseases, 7 (11).
e2571.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0002571
Mejia, AM;
Hall, BS;
Taylor, MC;
Gómez-Palacio, A;
Wilkinson, SR;
Triana-Chávez, O;
Kelly, JM;
(2012)
Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population.
The Journal of infectious diseases, 206 (2).
pp. 220-8.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jis331
Muhia, DK;
Swales, CA;
Deng, W;
Kelly, JM;
Baker, DA;
(2001)
The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum.
Molecular microbiology, 42 (2).
pp. 553-60.
ISSN 0950-382X
DOI: https://doi.org/10.1046/j.1365-2958.2001.02665.x
Full text not available from this repository.
Muhia, DK;
Swales, CA;
Eckstein-Ludwig, U;
Saran, S;
Polley, SD;
Kelly, JM;
Schaap, P;
Krishna, S;
Baker, DA;
(2003)
Multiple Splice Variants Encode a Novel Adenylyl Cyclase of Possible Plastid Origin Expressed in the Sexual Stage of the Malaria Parasite Plasmodium falciparum.
The Journal of biological chemistry, 278 (24).
pp. 22014-22.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M301639200
Full text not available from this repository.
Obado, SO;
Bot, C;
Echeverry, MC;
Bayona, JC;
Alvarez, VE;
Taylor, MC;
Kelly, JM;
(2011)
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.
Nucleic acids research, 39 (3).
pp. 1023-33.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkq839
Obado, SO;
Bot, C;
Nilsson, D;
Andersson, B;
Kelly, JM;
(2007)
Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi.
Genome biology, 8 (3).
R37.
ISSN 1465-6906
DOI: https://doi.org/10.1186/gb-2007-8-3-r37
Obado, SO;
Taylor, MC;
Wilkinson, SR;
Bromley, EV;
Kelly, JM;
(2005)
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.
Genome research, 15 (1).
pp. 36-43.
ISSN 1088-9051
DOI: https://doi.org/10.1101/gr.2895105
Olmo, F;
Costa, FC;
Mann, GS;
Taylor, MC;
Kelly, JM;
(2018)
Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation.
Molecular and biochemical parasitology.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2018.07.002
Full text not available from this repository.
Papanastasiou, I;
Foscolos, GB;
Tsotinis, A;
Olah, J;
Ovadi, J;
Prathalingam, SR;
Kelly, JM;
(2008)
Conformationally constrained adamantane-oxazolines of pharmacological interest.
Heterocycles, 75 (8).
pp. 2043-2061.
ISSN 0385-5414
http://researchonline.lshtm.ac.uk/id/eprint/6841
Full text not available from this repository.
Papanastasiou, I;
Tsotinis, A;
Foscolos, GB;
Prathalingam, SR;
Kelly, JM;
(2008)
Synthesis of conformationally constrained adamantane imidazolines with trypanocidal activity.
Journal of heterocyclic chemistry, 45 (5).
pp. 1401-1406.
ISSN 0022-152X
http://researchonline.lshtm.ac.uk/id/eprint/6842
Full text not available from this repository.
Papanastasiou, I;
Tsotinis, A;
Kolocouris, N;
Prathalingam, SR;
Kelly, JM;
(2008)
Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives.
Journal of medicinal chemistry, 51 (5).
pp. 1496-1500.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm7014292
Full text not available from this repository.
Papanastasiou, I;
Tsotinis, A;
Zoidis, G;
Kolocouris, N;
Prathalingam, SR;
Kelly, JM;
(2009)
Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
ChemMedChem, 4 (7).
pp. 1059-62.
ISSN 1860-7179
DOI: https://doi.org/10.1002/cmdc.200900019
Full text not available from this repository.
Patel, S;
Hussain, S;
Harris, R;
Sardiwal, S;
Kelly, JM;
Wilkinson, SR;
Driscoll, PC;
Djordjevic, S;
(2010)
Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
The Biochemical journal, 425 (3).
pp. 513-22.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20091167
Full text not available from this repository.
Piacenza, L;
Irigoin, F;
Alvarez, MN;
Peluffo, G;
Taylor, MC;
Kelly, JM;
Wilkinson, SR;
Radi, R;
(2007)
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.
The Biochemical journal, 403 (2).
pp. 323-34.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20061281
Full text not available from this repository.
Piacenza, L;
Peluffo, G;
Alvarez, MN;
Kelly, JM;
Wilkinson, SR;
Radi, R;
(2008)
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite.
The Biochemical journal, 410 (2).
pp. 359-68.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20071138
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-758.
ISSN 0066-4804
DOI: https://doi.org/10.1128/aac.01360-06
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-8.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.01360-06
Full text not available from this repository.
Richards, T;
Clevenger, B;
Keidan, J;
Collier, T;
Klein, AA;
Anker, SD;
Kelly, JD;
(2015)
PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial.
Trials, 16 (1).
p. 254.
ISSN 1745-6215
DOI: https://doi.org/10.1186/s13063-015-0774-2
Sola, I;
Artigas, A;
Taylor, MC;
Gbedema, SY;
Pérez, B;
Clos, MV;
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2014)
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Bioorganic & medicinal chemistry letters, 24 (23).
pp. 5435-5438.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2014.10.025
Full text not available from this repository.
Sola, I;
Artigas, A;
Taylor, MC;
Pérez-Areales, FJ;
Viayna, E;
Clos, MV;
Pérez, B;
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2016)
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Bioorganic & medicinal chemistry.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2016.08.036
Sola, I;
Castellà, S;
Viayna, E;
Galdeano, C;
Taylor, MC;
Gbedema, SY;
Pérez, B;
Clos, MV;
Jones, DC;
Fairlamb, AH;
+3 more...
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2015)
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorganic & medicinal chemistry, 23 (16).
pp. 5156-67.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2015.01.031
Full text not available from this repository.
Taylor, MC;
Huang, H;
Kelly, JM;
(2011)
Genetic Techniques in Trypanosoma cruzi.
Advances in parasitology, 75.
pp. 231-50.
ISSN 0065-308X
DOI: https://doi.org/10.1016/B978-0-12-385863-4.00011-3
Full text not available from this repository.
Taylor, MC;
Kaur, H;
Blessington, B;
Kelly, JM;
Wilkinson, SR;
(2008)
Validation of spermidine synthase as a drug target in African trypanosomes.
The Biochemical journal, 409 (2).
pp. 563-9.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20071185
Full text not available from this repository.
Taylor, MC;
Kelly, JM;
(2014)
Optimizing bioluminescence imaging to study protozoan parasite infections.
Trends in parasitology, 30 (4).
pp. 161-2.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2014.01.006
Full text not available from this repository.
Taylor, MC;
Kelly, JM;
(2010)
Iron metabolism in trypanosomatids, and its crucial role in infection.
Parasitology.
pp. 1-19.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182009991880
Taylor, MC;
Kelly, JM;
(2006)
pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi.
BMC Biotechnol, 6.
p. 32.
ISSN 1472-6750
DOI: https://doi.org/10.1186/1472-6750-6-32
Taylor, MC;
Lewis, MD;
Francisco, AF;
Wilkinson, SR;
Kelly, JM;
(2015)
The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence.
PLoS neglected tropical diseases, 9 (4).
e0003707.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0003707
Taylor, MC;
McLatchie, AP;
Kelly, JM;
(2013)
Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.
Molecular microbiology, 89 (3).
pp. 420-32.
ISSN 0950-382X
DOI: https://doi.org/10.1111/mmi.12285
Torres, E;
Duque, MD;
Lopez-Querol, M;
Taylor, MC;
Naesens, L;
Ma, CL;
Pinto, LH;
Sureda, FX;
Kelly, JM;
Vazquez, S;
(2012)
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Bioorganic & medicinal chemistry, 20 (2).
pp. 942-948.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2011.11.050
Full text not available from this repository.
Tsatsaroni, A;
Zoidis, G;
Zoumpoulakis, P;
Tsotinis, A;
Taylor, MC;
Kelly, JM;
Fytas, G;
(2013)
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.
Tetrahedron letters, 54 (25).
pp. 3238-3240.
ISSN 0040-4039
DOI: https://doi.org/10.1016/j.tetlet.2013.03.128
Wilkinson, SM;
Meyer, DJ;
Taylor, MC;
Bromley, EV;
Miles, MA;
Kelly, JM;
(2002)
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.
The Journal of biological chemistry, 277 (19).
pp. 17062-17071.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M111126200
Full text not available from this repository.
Wilkinson, SR;
Bot, C;
Kelly, JM;
Hall, BS;
Stro Ja, VP;
(2011)
Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives.
Current topics in medicinal chemistry, 11 (16).
pp. 2072-2084.
ISSN 1568-0266
http://researchonline.lshtm.ac.uk/id/eprint/126
Full text not available from this repository.
Wilkinson, SR;
Horn, D;
Prathalingam, R;
Kelly, JM;
(2003)
RNAi identifies two hydroperoxide metabolising enzymes that are essential to the bloodstream form of the African trypanosome.
The Journal of biological chemistry, 278 (34).
pp. 31640-6.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M303035200
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2009)
Trypanocidal drugs: mechanisms, resistance and new targets.
Expert Reviews in Molecular Medicine, 11.
ISSN 1462-3994
DOI: https://doi.org/10.1017/S1462399409001252
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2003)
The role of glutathione peroxidases in trypanosomatids.
Biological chemistry, 384 (4).
pp. 517-25.
ISSN 1431-6730
DOI: https://doi.org/10.1515/BC.2003.060
Full text not available from this repository.
Wilkinson, SR;
Obado, SO;
Mauricio, IL;
Kelly, JM;
(2002)
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America, 99 (21).
pp. 13453-8.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.202422899
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Ahmed, A;
Horn, D;
Kelly, JM;
(2006)
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
Free radical biology & medicine, 40 (2).
pp. 198-209.
ISSN 0891-5849
DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
(2005)
Vitamin C biosynthesis in trypanosomes: A role for the glycosome.
Proceedings of the National Academy of Sciences of the United States of America, 102.
pp. 11645-11650.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0504251102
Full text not available from this repository.
Wilkinson, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
Cheeseman, I;
(2008)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America, 105 (13).
pp. 5022-7.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0711014105
Full text not available from this repository.
Wilkinson, SR;
Taylor, MC;
Touitha, S;
Mauricio, IL;
Meyer, DJ;
Kelly, JM;
(2002)
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.
The Biochemical journal, 364 (Pt 3).
pp. 787-94.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20020038
Full text not available from this repository.
Wilkinson, SR;
and Kelly, JM;
(2009)
Trypanocidal drugs: mechanisms, resistance and new targets.
Expert Reviews in Molecular Medicine, 11 (e31).
pp. 1-24.
ISSN 1462-3994
http://researchonline.lshtm.ac.uk/id/eprint/4897
Full text not available from this repository.
Zoidis, G;
Kolocouris, N;
Kelly, JM;
Prathalingam, SR;
Naesens, L;
De Clercq, E;
(2010)
Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines.
European journal of medicinal chemistry, 45 (11).
pp. 5022-30.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2010.08.009
Full text not available from this repository.
Zoidis, G;
Tsotinis, A;
Kolocouris, N;
Kelly, JM;
Prathalingam, SR;
Naesens, L;
De Clercq, E;
(2008)
Design and synthesis of bioactive 1,2-annulated adamantane derivatives.
Organic & biomolecular chemistry, 6 (17).
pp. 3177-85.
ISSN 1477-0520
DOI: https://doi.org/10.1039/b804907f
Full text not available from this repository.
Zoidis, G;
Tsotinis, A;
Tsatsaroni, A;
Taylor, MC;
Kelly, JM;
Efstathiou, A;
Smirlis, D;
Fytas, G;
(2017)
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study.
Chemical biology & drug design.
ISSN 1747-0277
DOI: https://doi.org/10.1111/cbdd.13088
Book Section
Kelly, JM;
Obado, S;
(2002)
Chromosome fragmentation as an approach to whole-genome analysis in trypanosomes.
In: Wren, BW; Dorrell, N, (eds.)
Functional Microbial Genomics.
Academic Press Inc, San Diego, pp. 397-406.
http://researchonline.lshtm.ac.uk/id/eprint/16484
Full text not available from this repository.
Kelly, JM;
Taylor, MC;
Wilkinson, SR;
(2005)
Trypanosoma cruzi.
In: Fuchs, J; Podda, M; Goethe, JW, (eds.)
Encyclopedia of Diagnostic Genomics and Proteomics.
Marcel Dekker, Inc., New York, USA, pp. 1297-1301.
http://researchonline.lshtm.ac.uk/id/eprint/15644
Full text not available from this repository.
Renauld, H;
Kelly, JM;
Horn, D;
(2007)
Chromosome structure and dynamics.
In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.)
Trypanosomes - After the Genome.
Horizon Scientific Press, Norwich, UK., pp. 91-132.
http://researchonline.lshtm.ac.uk/id/eprint/11566
Full text not available from this repository.
Ruben, L;
Kelly, JM;
Chakrabarti, D;
(2002)
Intracellular signalling.
In: Koumuniecki, R; Nilsen, T; Marr, JJ, (eds.)
Molecular Medical Parasitology.
Academic Press, London, pp. 241-276.
http://researchonline.lshtm.ac.uk/id/eprint/15541
Full text not available from this repository.
Taylor, MC;
Kelly, JM;
(2002)
Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era.
In: Tyler, K; Miles, MA, (eds.)
American Trypanosomiasis.
Kluwer Academic Publishers, London, pp. 57-68.
http://researchonline.lshtm.ac.uk/id/eprint/15544
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2003)
How does Trypanosoma cruzi survive the toxic effects of reactive oxygen species?
In: Kelly, JM, (ed.)
Molecular Mechanisms in the Pathogenesis of Chagas? Disease.
Landes Bioscience, Georgetown, Texas, USA, pp. 56-71.
http://researchonline.lshtm.ac.uk/id/eprint/15542
Full text not available from this repository.
Book
Kelly, JM;
(2003)
Molecular Mechanisms in the Pathogenesis of Chagas? Disease.
Landes Bioscience, Georgetown, Texas, USA.
http://researchonline.lshtm.ac.uk/id/eprint/15543
Full text not available from this repository.
Other
Kelly, JM;
Obado, SO;
Taylor, MC;
(2004)
Functional mapping of an American trypanosome centromere [Abstract].
Springer Verlag.
http://researchonline.lshtm.ac.uk/id/eprint/19454
Full text not available from this repository.