Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.


Papanastasiou, I; Tsotinis, A; Zoidis, G; Kolocouris, N; Prathalingam, SR; Kelly, JM; (2009) Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. ChemMedChem, 4 (7). pp. 1059-62. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.200900019

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Abstract

Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 19422003
Web of Science ID: 267893000004
URI: http://researchonline.lshtm.ac.uk/id/eprint/5116

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