The role of glutathione peroxidases in trypanosomatids


Wilkinson, SR; Kelly, JM; (2003) The role of glutathione peroxidases in trypanosomatids. Biological chemistry, 384 (4). pp. 517-25. ISSN 1431-6730 DOI: https://doi.org/10.1515/BC.2003.060

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Abstract

Reactive oxygen species are the unwanted by-products of aerobic metabolism. To protect cells against their potentially lethal effects a series of pathways have evolved that are collectively called the oxidative defence system. In most eukaryotes, catalases and selenium-dependent glutathione peroxidases form the front line of defence against hydroperoxide-mediated damage. However, these activities are lacking in members of the Trypanosomatidae family of protozoan parasites. Instead these organisms contain several enzyme-mediated pathways for removal of hydroperoxides that are centred upon the unusual thiol trypanothione. Here we discuss the biochemical properties of one group of these enzymes, the non-selenium glutathione-dependent peroxidases, and outline the roles that they play in protecting the parasite against hydroperoxides associated with biological membranes.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 12751782
Web of Science ID: 182158100004
URI: http://researchonline.lshtm.ac.uk/id/eprint/16482

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