Trypanocidal drugs: mechanisms, resistance and new targets


Wilkinson, SR; Kelly, JM; (2009) Trypanocidal drugs: mechanisms, resistance and new targets. Expert Reviews in Molecular Medicine, 11. ISSN 1462-3994 DOI: 10.1017/S1462399409001252

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Abstract

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating infections that exert a considerable health burden on some of the poorest people on the planet. Treatment of trypanosome infections is dependent on a small number of drugs that have limited efficacy and can cause severe side effects. Here, we review the properties of these drugs and describe new findings on their modes of action and the mechanisms by which resistance can arise. We further outline how a greater understanding of parasite biology is being exploited in the search for novel chemotherapeutic agents. This effort is being facilitated by new research networks that involve academic and biotechnology/pharmaceutical organisations, supported by public-private partnerships, and are bringing a new dynamism and purpose to the search for trypanocidal agents.

Item Type: Article
Keywords: trypanosoma-brucei-brucei, s-adenosylmethionine decarboxylase, cruzi, trypanothione reductase, human african trypanosomiasis, cysteine, protease inhibitors, gambiense sleeping sickness, experimental, chagas-disease, eflornithine combination therapy, oxidosqualene cyclase, inhibitors, melamine-based nitroheterocycles, Chagas Disease, drug therapy, parasitology, Humans, Nitrofurans, metabolism, Nitroreductases, metabolism, Protozoan Proteins, metabolism, Trypanocidal Agents, administration & dosage, chemistry, pharmacokinetics, therapeutic use, Trypanosoma brucei brucei, drug effects, Trypanosoma cruzi, drug effects, Trypanosomiasis, African, drug therapy, parasitology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 19863838
Web of Science ID: 276249900001
URI: http://researchonline.lshtm.ac.uk/id/eprint/3847

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