Cobelens, F; Nagelkerke, N; Fletcher, H; (2018) The convergent epidemiology of tuberculosis and human cytomegalovirus infection. F1000Research, 7. p. 280. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14184.1

Dowd, JB; Fletcher, HA; Boccia, D; (2018) Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention. F1000Research, 7. p. 224. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14085.1

Fletcher, HA; (2018) Systems approaches to correlates of protection and progression to TB disease. Seminars in immunology. ISSN 1044-5323 DOI: https://doi.org/10.1016/j.smim.2018.10.001 Full text not available from this repository.

Fletcher, HA; Chatterjee, M; Cooper, A; Hussell, T; Kaye, PM; Prior, J; Reljic, R; Vermaak, S; Vordermeier, M; Williams, A; +1 more... McShane, H; (2018) VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. F1000Research, 7. p. 485. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14386.1

Gupta-Wright, A; Tomlinson, GS; Rangaka, MX; Fletcher, HA; (2018) World TB Day 2018: The Challenge of Drug Resistant Tuberculosis. F1000Research, 7. p. 217. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14088.1

Kewcharoenwong, C; Prabowo, SA; Bancroft, GJ; Fletcher, HA; Lertmemongkolchai, G; (2018) Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization. Frontiers in immunology, 9. p. 2109. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2018.02109 Full text not available from this repository.

Rhodes, SJ; Guedj, J; Fletcher, HA; Lindenstrøm, T; Scriba, TJ; Evans, TG; Knight, GM; White, RG; (2018) Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. NPJ Vaccines, 3. p. 36. ISSN 2059-0105 DOI: https://doi.org/10.1038/s41541-018-0075-3 Full text not available from this repository.

Stockdale, L; Nash, S; Nalwoga, A; Painter, H; Asiki, G; Fletcher, H; Newton, R; (2018) Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort. PloS one, 13 (2). ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0192086

Voss, G; Casimiro, D; Neyrolles, O; Williams, A; Kaufmann, SHE; McShane, H; Hatherill, M; Fletcher, HA; (2018) Progress and challenges in TB vaccine development. F1000Research, 7. p. 199. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.13588.1

Zelmer, A; Stockdale, L; Prabowo, SA; Cia, F; Spink, N; Gibb, M; Eddaoudi, A; Fletcher, HA; (2018) High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis. F1000Research, 7. p. 296. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14239.1

Andrews, JR; Nemes, E; Tameris, M; Landry, BS; Mahomed, H; McClain, JB; Fletcher, HA; Hanekom, WA; Wood, R; McShane, H; +2 more... Scriba, TJ; Hatherill, M; (2017) Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study. The lancet Respiratory medicine, 5 (4). pp. 282-290. ISSN 2213-2600 DOI: https://doi.org/10.1016/S2213-2600(17)30060-7

Brennan, MJ; Tanner, R; Morris, S; Scriba, TJ; Achkar, JM; Zelmer, A; Hokey, D; Izzo, A; Sharpe, S; Williams, A; +6 more... Penn-Nicholson, A; Erasmus, M; Stylianou, E; Hoft, DF; McShane, H; Fletcher, HA; (2017) The Cross-species Mycobacterial Growth Inhibition Assay (MGIA) Project 2010-2014. Clinical and vaccine immunology. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00142-17

Rhodes, SJ; Sarfas, C; Knight, GM; White, A; Pathan, AA; McShane, H; Evans, TG; Fletcher, H; Sharpe, S; White, RG; (2017) Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods. Clinical and vaccine immunology. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00525-16

Tanner, R; O'Shea, MK; White, AD; Müller, J; Harrington-Kandt, R; Matsumiya, M; Dennis, MJ; Parizotto, EA; Harris, S; Stylianou, E; +6 more... Naranbhai, V; Bettencourt, P; Drakesmith, H; Sharpe, S; Fletcher, HA; McShane, H; (2017) The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays. Scientific reports, 7. p. 43478. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep43478

Abubakar, I; Lipman, M; McHugh, TD; Fletcher, H; (2016) Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment. BMC medicine, 14 (1). p. 47. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0599-1

Chen, T; Blanc, C; Eder, AZ; Prados-Rosales, R; Souza, AC; Kim, RS; Glatman-Freedman, A; Joe, M; Bai, Y; Lowary, TL; +6 more... Tanner, R; Brennan, MJ; Fletcher, HA; McShane, H; Casadevall, A; Achkar, JM; (2016) Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction. The Journal of infectious diseases, 214 (2). pp. 300-10. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiw141 Full text not available from this repository.

Fletcher, HA; (2016) Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine. mBio, 7 (4). ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.01370-16

Fletcher, HA; Dockrell, HM; (2016) Human biomarkers: can they help us to develop a new tuberculosis vaccine? Future microbiology, 11. pp. 781-7. ISSN 1746-0913 DOI: https://doi.org/10.2217/fmb.16.15 Full text not available from this repository.

Fletcher, HA; Filali-Mouhim, A; Nemes, E; Hawkridge, A; Keyser, A; Njikan, S; Hatherill, M; Scriba, TJ; Abel, B; Kagina, BM; +32 more... Veldsman, A; Agudelo, NM; Kaplan, G; Hussey, GD; Sekaly, RP; Hanekom, WA; BCG study team; , COLLABORATORS; Minnies, D; Tanner, R; Chung, CK; Cameron, MJ; Goulet, JP; Gaujoux, R; Hughes, J; Gelderbloem, S; Iloni, K; Buchanan, M; van der Merwe, L; Burger, A; Denation, L; Mlanjeni, S; Abrahams, S; Shepherd, R; Geldenhuys, M; Seoighe, C; Soares, A; Gamieldien, H; Sidibana, M; Mahomed, H; McShane, H; Hill, AV; (2016) Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study. BMC medicine, 14 (1). p. 76. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0617-3

Fletcher, HA; Schrager, L; (2016) TB vaccine development and the End TB Strategy: importance and current status. Transactions of the Royal Society of Tropical Medicine and Hygiene, 110 (4). pp. 212-8. ISSN 0035-9203 DOI: https://doi.org/10.1093/trstmh/trw016

Fletcher, HA; Snowden, MA; Landry, B; Rida, W; Satti, I; Harris, SA; Matsumiya, M; Tanner, R; O'Shea, MK; Dheenadhayalan, V; +20 more... Bogardus, L; Stockdale, L; Marsay, L; Chomka, A; Harrington-Kandt, R; Manjaly-Thomas, ZR; Naranbhai, V; Stylianou, E; Darboe, F; Penn-Nicholson, A; Nemes, E; Hatheril, M; Hussey, G; Mahomed, H; Tameris, M; McClain, JB; Evans, TG; Hanekom, WA; Scriba, TJ; McShane, H; (2016) T-cell activation is an immune correlate of risk in BCG vaccinated infants. Nature communications, 7. p. 11290. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms11290

Khan, MS; Fletcher, H; London School of Hygiene and Tropical Medicine TB Centre Steerin; Coker, R; (2016) Investments in tuberculosis research - what are the gaps? BMC medicine, 14 (1). p. 123. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0644-0

Phillips, PP; Fletcher, HA; Abubakar, I; Lipman, MC; McHugh, TD; (2016) World TB Day 2016: an interview with leading experts in tuberculosis research. BMC medicine, 14 (1). p. 55. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0591-9

Rhodes, SJ; Zelmer, A; Knight, GM; Prabowo, SA; Stockdale, L; Evans, TG; Lindenstrøm, T; White, RG; Fletcher, H; (2016) The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2016.10.060

Smith, SG; Zelmer, A; Blitz, R; Fletcher, HA; Dockrell, HM; (2016) Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2016.09.002

Tanner, R; O'Shea, MK; Fletcher, HA; McShane, H; (2016) In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy. Vaccine, 34 (39). pp. 4656-4665. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2016.07.058

Vainieri, ML; Blagborough, AM; MacLean, AL; Haltalli, ML; Ruivo, N; Fletcher, HA; Stumpf, MP; Sinden, RE; Celso, CL; (2016) Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points. Open biology, 6 (6). ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.160038

Zelmer, A; Tanner, R; Stylianou, E; Damelang, T; Morris, S; Izzo, A; Williams, A; Sharpe, S; Pepponi, I; Walker, B; +4 more... Hokey, DA; McShane, H; Brennan, M; Fletcher, H; (2016) A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. BMC infectious diseases, 16. p. 412. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-016-1751-4

Dunachie, S; Berthoud, T; Hill, AV; Fletcher, HA; (2015) Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.07.087

Dunachie, S; Hill, AV; Fletcher, HA; (2015) Profiling the host response to malaria vaccination and malaria challenge. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.07.107

Fletcher, H; (2015) Profiling the host immune response to tuberculosis vaccines. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.07.090 Full text not available from this repository.

Jenjaroen, K; Chumseng, S; Sumonwiriya, M; Ariyaprasert, P; Chantratita, N; Sunyakumthorn, P; Hongsuwan, M; Wuthiekanun, V; Fletcher, HA; Teparrukkul, P; +3 more... Limmathurotsakul, D; Day, NP; Dunachie, SJ; (2015) T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. PLoS neglected tropical diseases, 9 (10). e0004152. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0004152

Kaufmann, SH; Fletcher, HA; Guzman, CA; Ottenhoff, TH; (2015) Introduction and section summaries. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.04.078 Full text not available from this repository.

Naranbhai, V; Fletcher, HA; Tanner, R; O'Shea, MK; McShane, H; Fairfax, BP; Knight, JC; Hill, AV; (2015) Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. EBioMedicine, 2 (11). pp. 1619-1626. ISSN 2352-3964 DOI: https://doi.org/10.1016/j.ebiom.2015.09.027

Rhodes, SJ; Knight, GM; Fielding, K; Scriba, TJ; Pathan, AA; McShane, H; Fletcher, H; White, RG; (2015) Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status. Tuberculosis (Edinburgh, Scotland), 96. pp. 37-43. ISSN 1472-9792 DOI: https://doi.org/10.1016/j.tube.2015.10.002

Schito, M; Migliori, GB; Fletcher, HA; McNerney, R; Centis, R; D'Ambrosio, L; Bates, M; Kibiki, G; Kapata, N; Corrah, T; +6 more... Bomanji, J; Vilaplana, C; Johnson, D; Mwaba, P; Maeurer, M; Zumla, A; (2015) Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines. Clinical infectious diseases, 61 (suppl 3). S102-S118. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/civ609 Full text not available from this repository.

Smith, SG; Smits, K; Joosten, SA; van Meijgaarden, KE; Satti, I; Fletcher, HA; Caccamo, N; Dieli, F; Mascart, F; McShane, H; +3 more... Dockrell, HM; Ottenhoff, TH; TBVI TB Biomarker Working Group; (2015) Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines. PloS one, 10 (9). e0138042. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0138042

Dutruel, C; Thole, J; Geels, M; Mollenkopf, HJ; Ottenhoff, T; Guzman, CA; Fletcher, HA; Leroy, O; Kaufmann, SH; (2014) TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'How can big data help?'. Vaccine. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2014.06.014

Harris, SA; Satti, I; Matsumiya, M; Stockdale, L; Chomka, A; Tanner, R; O'Shea, MK; Manjaly Thomas, ZR; Tameris, M; Mahomed, H; +4 more... Scriba, TJ; Hanekom, WA; Fletcher, HA; McShane, H; (2014) Process of Assay Selection and Optimization for the Study of Case and Control Samples from a Phase IIb Efficacy Trial of a Candidate Tuberculosis Vaccine, MVA85A. Clinical and vaccine immunology, 21 (7). pp. 1005-11. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00128-14

Matsumiya, M; Harris, SA; Satti, I; Stockdale, L; Tanner, R; O'Shea, MK; Tameris, M; Mahomed, H; Hatherill, M; Scriba, TJ; +3 more... Hanekom, WA; McShane, H; Fletcher, HA; (2014) Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response. BMC infectious diseases, 14 (1). p. 314. ISSN 1471-2334 DOI: https://doi.org/10.1186/1471-2334-14-314

Matsumiya, M; Satti, I; Chomka, A; Harris, SA; Stockdale, L; Meyer, J; Fletcher, HA; McShane, H; (2014) Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model. The Journal of infectious diseases. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiu615

Naranbhai, V; Kim, S; Fletcher, H; Cotton, MF; Violari, A; Mitchell, C; Nachman, S; McSherry, G; McShane, H; Hill, A; +1 more... Madhi, SA; (2014) The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. BMC medicine, 12 (1). p. 120. ISSN 1741-7015 DOI: https://doi.org/10.1186/PREACCEPT-2435299671185919

Naranbhai, V; Moodley, D; Chipato, T; Stranix-Chibanda, L; Nakabaiito, C; Kamateeka, M; Musoke, P; Manji, K; George, K; Emel, LM; +8 more... Richardson, P; Andrew, P; Fowler, M; Fletcher, H; Mcshane, H; Coovadia, HM; Hill, AV; for the HPTN 046 protocol team; (2014) The association between the ratio of monocytes: lymphocytes and risk of tuberculosis(TB) amongst HIV infected postpartum women. Journal of acquired immune deficiency syndromes (1999). ISSN 1525-4135 DOI: https://doi.org/10.1097/QAI.0000000000000353 Full text not available from this repository.

Tanner, R; Kakalacheva, K; Miller, E; Pathan, AA; Chalk, R; Sander, CR; Scriba, T; Tameris, M; Hawkridge, T; Mahomed, H; +5 more... Hussey, G; Hanekom, W; Checkley, A; McShane, H; Fletcher, HA; (2014) Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. BMC infectious diseases, 14. p. 660. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-014-0660-7

Griffiths, KL; Pathan, AA; Minassian, AM; Sander, CR; Beveridge, NE; Hill, AV; Fletcher, HA; McShane, H; (2011) Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS One, 6 (8). e23463. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0023463

Fletcher, HA; Hawkridge, T; McShane, H; (2009) A New Vaccine for Tuberculosis: The Challenges of Development and Deployment. Journal of bioethical inquiry, 6 (2). pp. 219-228. ISSN 1176-7529 DOI: https://doi.org/10.1007/s11673-009-9153-6

Wassie, L; Demissie, A; Aseffa, A; Abebe, M; Yamuah, L; Tilahun, H; Petros, B; Rook, G; Zumla, A; Andersen, P; +3 more... Doherty, TM; VACSEL Study Group, . (inc. Fletcher, H; ); (2008) Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time. PLoS One, 3 (1). e1522. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0001522

Demissie, A; Leyten, EM; Abebe, M; Wassie, L; Aseffa, A; Abate, G; Fletcher, H; Owiafe, P; Hill, PC; Brookes, R; +8 more... Rook, G; Zumla, A; Arend, SM; Klein, M; Ottenhoff, TH; Andersen, P; Doherty, TM; VACSEL Study Group; (2006) Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. Clinical and vaccine immunology, 13 (2). pp. 179-86. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.13.2.179-186.2006 Full text not available from this repository.