%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Lisa Stockdale, Stephen Nash, Angela Nalwoga, Hannah Painter, Gershim Asiki, Helen Fletcher, Robert Newton
Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref004)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref005)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref006)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref007)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref008)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref009)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref012)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref013)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref014)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref015)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref016)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref017)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref018)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref020)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref021)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref024)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref025)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.ref025)>>
endobj
36 0 obj
<>/Border[0 0 0]/A 37 0 R>>
endobj
37 0 obj
<>
endobj
15 0 obj
[38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R]
endobj
38 0 obj
<>stream
q
0.83 0.64 0.02 0 k
256.252 693.2976 m
261.0142 693.2976 l
h
f*
452.9764 680.315 m
457.6819 680.315 l
h
f*
203.4142 628.3276 m
208.1764 628.3276 l
h
f*
483.4205 615.3449 m
488.126 615.3449 l
h
f*
490.3937 615.3449 m
495.1559 615.3449 l
h
f*
385.115 602.3055 m
389.8772 602.3055 l
h
f*
419.4709 589.3228 m
428.9953 589.3228 l
h
f*
459.326 563.3008 m
468.8504 563.3008 l
h
f*
471.1181 563.3008 m
480.6425 563.3008 l
h
f*
304.1575 524.2961 m
313.6819 524.2961 l
h
f*
309.0331 511.3134 m
318.5575 511.3134 l
h
f*
249.9024 498.3307 m
259.4268 498.3307 l
h
f*
388.4031 485.348 m
397.9276 485.348 l
h
f*
331.3134 472.3087 m
340.8378 472.3087 l
h
f*
384.2646 446.3433 m
393.789 446.3433 l
h
f*
398.948 446.3433 m
408.4724 446.3433 l
h
f*
502.6961 407.3386 m
512.2205 407.3386 l
h
f*
517.3795 407.3386 m
526.9039 407.3386 l
h
f*
203.4142 242.1354 m
212.9386 242.1354 l
h
f*
364.5354 177.1087 m
374.0598 177.1087 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(reactivation,)Tj
5.1703 0 Td
(especially)Tj
4.0195 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(trimester,)Tj
4.0762 0 Td
(is)Tj
0.8504 0 Td
(particularly)Tj
4.8132 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(adverse)Tj
3.2145 0 Td
(neona-)Tj
-34.5994 -1.3039 Td
(tal)Tj
1.1962 0 Td
(outcomes)Tj
4.0875 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7801 0 Td
(incidence)Tj
4.0706 0 Td
(of)Tj
1.0148 0 Td
(congenital)Tj
4.3823 0 Td
(HCMV)Tj
3.2428 0 Td
(infection)Tj
3.7871 0 Td
(is)Tj
0.8504 0 Td
(estimated)Tj
4.0705 0 Td
(at)Tj
0.9524 0 Td
(between)Tj
3.532 0 Td
(0.7)Tj
1.3946 0 Td
(and)Tj
-35.9657 -1.2982 Td
(5%)Tj
1.4513 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(births)Tj
2.5511 0 Td
(in)Tj
1.0375 0 Td
(low-)Tj
2.0069 0 Td
(and)Tj
1.7348 0 Td
(middle-income)Tj
6.3666 0 Td
(countries)Tj
3.9515 0 Td
(\(LMICs\))Tj
3.6963 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
-23.7598 -1.2983 Td
(In)Tj
1.1111 0 Td
(immunocompetent)Tj
7.971 0 Td
(adults,)Tj
2.8403 0 Td
(HCMV)Tj
3.2372 0 Td
(infection)Tj
3.7927 0 Td
(rarely)Tj
2.5171 0 Td
(causes)Tj
2.7553 0 Td
(disease;)Tj
3.2428 0 Td
(however,)Tj
3.8324 0 Td
(once)Tj
-32.4961 -1.2983 Td
(infected,)Tj
3.6396 0 Td
(the)Tj
1.4683 0 Td
(virus)Tj
2.1941 0 Td
(remains)Tj
3.4412 0 Td
(latent)Tj
2.4661 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.652 0 Td
(wide)Tj
2.1203 0 Td
(range)Tj
2.4548 0 Td
(of)Tj
1.0148 0 Td
(cell)Tj
1.5533 0 Td
(types,)Tj
2.4945 0 Td
(including)Tj
4.0365 0 Td
(lymphocytes)Tj
5.2498 0 Td
(and)Tj
1.7291 0 Td
(mye-)Tj
-35.5462 -1.3039 Td
(loid)Tj
1.7688 0 Td
(lineage)Tj
3.0273 0 Td
(cells,)Tj
2.143 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(smooth)Tj
3.2429 0 Td
(muscle)Tj
3.0217 0 Td
(cells)Tj
1.9218 0 Td
(and)Tj
1.7292 0 Td
(endothelial)Tj
4.6714 0 Td
(cells)Tj
1.9162 0 Td
(which)Tj
2.6533 0 Td
(line)Tj
1.7064 0 Td
(blood)Tj
2.5115 0 Td
(vessels)Tj
-34.1629 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(HCMV/HIV)Tj
5.3688 0 Td
(co-infection)Tj
5.0739 0 Td
(is)Tj
0.8504 0 Td
(common)Tj
3.8438 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
0.8504 0 Td
(an)Tj
1.2019 0 Td
(important)Tj
4.2803 0 Td
(cause)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(HCMV)Tj
3.2371 0 Td
(retinitis)Tj
3.3222 0 Td
(and)Tj
-34.7638 -1.2983 Td
(severe)Tj
2.6758 0 Td
(non-AIDS)Tj
4.4107 0 Td
(events,)Tj
2.9537 0 Td
(including)Tj
4.0422 0 Td
(death,)Tj
2.6589 0 Td
(in)Tj
1.0374 0 Td
(HIV-infected)Tj
5.5729 0 Td
(individuals)Tj
4.6488 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
2.3017 0 Td
(HCMV)Tj
3.2372 0 Td
(infection)Tj
-33.5393 -1.3039 Td
(is)Tj
0.8447 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0012 0 Td
(chronic)Tj
3.2882 0 Td
(immune)Tj
3.6226 0 Td
(activation)Tj
4.1556 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(])Tj
1.372 0 Td
(and)Tj
1.7348 0 Td
(recent)Tj
2.7042 0 Td
(evidence)Tj
3.7134 0 Td
(implicates)Tj
4.2803 0 Td
(immune)Tj
3.6226 0 Td
(acti-)Tj
-35.5972 -1.2983 Td
(vation)Tj
2.7269 0 Td
(with)Tj
2.0012 0 Td
(increased)Tj
3.9968 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(tuberculosis)Tj
5.04 0 Td
(\(TB\))Tj
2.0919 0 Td
(disease)Tj
3.0161 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-20.4093 -1.2983 Td
(Epidemiological)Tj
6.7124 0 Td
(studies)Tj
2.982 0 Td
(in)Tj
1.0375 0 Td
(high-income)Tj
5.3461 0 Td
(countries)Tj
3.9514 0 Td
(\(HICs\))Tj
3.0331 0 Td
(have)Tj
2.0579 0 Td
(found)Tj
2.6192 0 Td
(associations)Tj
4.989 0 Td
(between)Tj
-33.9248 -1.3039 Td
(HCMV)Tj
3.2371 0 Td
(infection)Tj
3.7927 0 Td
(and)Tj
1.7291 0 Td
(increased)Tj
4.0025 0 Td
(risk)Tj
1.7122 0 Td
(of)Tj
1.0148 0 Td
(mortality)Tj
3.9174 0 Td
(in)Tj
1.0375 0 Td
(older)Tj
2.296 0 Td
(people)Tj
2.8517 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
3.2541 0 Td
(Further)Tj
3.2712 0 Td
(studies)Tj
2.982 0 Td
(have)Tj
-35.0983 -1.2982 Td
(implicated)Tj
4.4446 0 Td
(chronic)Tj
3.2882 0 Td
(HCMV)Tj
3.2372 0 Td
(infection)Tj
3.7927 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(risk)Tj
1.7177 0 Td
(factor)Tj
2.5399 0 Td
(for)Tj
1.3889 0 Td
(cardiovascular)Tj
6.0038 0 Td
(disease)Tj
3.016 0 Td
(\(CVD\);)Tj
3.2202 0 Td
(a)Tj
0.6519 0 Td
(recent)Tj
-34.9679 -1.2983 Td
(meta-analysis)Tj
5.6522 0 Td
(of)Tj
1.0148 0 Td
(studies)Tj
2.9877 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0318 0 Td
(HICs,)Tj
2.5795 0 Td
(estimated)Tj
4.0705 0 Td
(a)Tj
0.6577 0 Td
(22%)Tj
1.9275 0 Td
(increased)Tj
3.9968 0 Td
(relative)Tj
3.1408 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(CVD)Tj
-34.2196 -1.3039 Td
(with)Tj
1.9955 0 Td
(exposure)Tj
3.8154 0 Td
(to)Tj
1.0262 0 Td
(HCMV)Tj
3.2371 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0806 0 Td
(In)Tj
1.1055 0 Td
(a)Tj
0.6577 0 Td
(UK)Tj
1.627 0 Td
(setting,)Tj
3.1068 0 Td
(HCMV)Tj
3.2371 0 Td
(infection)Tj
3.7928 0 Td
(was)Tj
1.7008 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(devel-)Tj
-35.104 -1.2983 Td
(opment)Tj
3.3335 0 Td
(of)Tj
1.0148 0 Td
(arteriosclerosis)Tj
6.2135 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
1.8538 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(3mmHg)Tj
3.566 0 Td
(increase)Tj
3.4752 0 Td
(in)Tj
1.0375 0 Td
(systolic)Tj
3.1351 0 Td
(blood)Tj
2.5171 0 Td
(pressure)Tj
3.5773 0 Td
(among)Tj
2.9934 0 Td
(older)Tj
-35.0983 -1.2982 Td
(individuals)Tj
4.6487 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.075 0 Td
(As)Tj
1.2642 0 Td
(Africa)Tj
2.6873 0 Td
(undergoes)Tj
4.3766 0 Td
(what)Tj
2.1657 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(described)Tj
4.0535 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(`epidemiological)Tj
6.7918 0 Td
(shift')Tj
-33.9418 -1.2983 Td
(from)Tj
2.2053 0 Td
(infectious)Tj
4.1329 0 Td
(to)Tj
1.0204 0 Td
(non-communicabl)Tj
7.4835 0 Td
(e)Tj
0.6406 0 Td
(disease)Tj
3.016 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(],)Tj
2.0806 0 Td
(an)Tj
1.2019 0 Td
(estimated)Tj
4.0706 0 Td
(1.2)Tj
1.4003 0 Td
(million)Tj
3.1181 0 Td
(deaths)Tj
2.7949 0 Td
(in)Tj
1.0318 0 Td
(Africa)Tj
-34.1969 -1.3039 Td
(were)Tj
2.1203 0 Td
(attributed)Tj
4.1725 0 Td
(to)Tj
1.0262 0 Td
(CVD)Tj
2.313 0 Td
(in)Tj
1.0375 0 Td
(2004)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-11.5936 -1.2983 Td
(Associations)Tj
5.244 0 Td
(of)Tj
1.0148 0 Td
(HCMV)Tj
3.2372 0 Td
(and)Tj
1.7291 0 Td
(CVD)Tj
2.313 0 Td
(have)Tj
2.0637 0 Td
(not)Tj
1.5703 0 Td
(been)Tj
2.126 0 Td
(fully)Tj
1.9786 0 Td
(investigated)Tj
4.9889 0 Td
(in)Tj
1.0375 0 Td
(LMICs)Tj
3.016 0 Td
(where)Tj
2.6476 0 Td
(HCMV)Tj
-34.1629 -1.2983 Td
(infection)Tj
3.7927 0 Td
(rates)Tj
2.1033 0 Td
(are)Tj
1.4513 0 Td
(much)Tj
2.5172 0 Td
(higher)Tj
2.8062 0 Td
(than)Tj
2.024 0 Td
(in)Tj
1.0374 0 Td
(HICs)Tj
2.3528 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
3.5433 0 Td
(Studies)Tj
3.101 0 Td
(from)Tj
2.2054 0 Td
(other)Tj
2.3527 0 Td
(herpes)Tj
2.8403 0 Td
(viruses)Tj
2.9877 0 Td
(asso-)Tj
-35.1153 -1.3039 Td
(ciated)Tj
2.5908 0 Td
(with)Tj
2.0012 0 Td
(non-communicable)Tj
8.1184 0 Td
(disease)Tj
3.0217 0 Td
(\(NCD\))Tj
3.0331 0 Td
(in)Tj
1.0375 0 Td
(areas)Tj
2.245 0 Td
(where)Tj
2.6475 0 Td
(infection)Tj
3.7928 0 Td
(is)Tj
0.8447 0 Td
(ubiquitous)Tj
4.5184 0 Td
(\(such)Tj
2.4037 0 Td
(as)Tj
-36.2548 -1.2982 Td
(EBV)Tj
2.0636 0 Td
(in)Tj
1.0374 0 Td
(relation)Tj
3.3109 0 Td
(to)Tj
1.0261 0 Td
(African)Tj
3.2372 0 Td
(Burkitt)Tj
3.0614 0 Td
(lymphoma)Tj
4.5467 0 Td
(and)Tj
1.7291 0 Td
(KSHV)Tj
2.829 0 Td
(in)Tj
1.0375 0 Td
(relation)Tj
3.3165 0 Td
(to)Tj
1.0261 0 Td
(African)Tj
3.2371 0 Td
(Kaposi)Tj
2.9764 0 Td
(Sar-)Tj
-34.435 -1.2983 Td
(coma\),)Tj
2.9706 0 Td
(show)Tj
2.2961 0 Td
(that)Tj
1.7801 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(NCD)Tj
2.3528 0 Td
(increases)Tj
3.8324 0 Td
(with)Tj
2.0012 0 Td
(increasing)Tj
4.3257 0 Td
(viral)Tj
1.9955 0 Td
(antibody)Tj
3.7644 0 Td
(titre)Tj
1.8766 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
-28.7318 -1.3039 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(study,)Tj
2.6192 0 Td
(we)Tj
1.3266 0 Td
(investigate)Tj
4.4617 0 Td
(HCMV)Tj
3.2371 0 Td
(seroprevalence)Tj
6.1455 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(large)Tj
2.1657 0 Td
(cross-sectional)Tj
6.1001 0 Td
(rural)Tj
2.1713 0 Td
(Ugandan)Tj
-33.8964 -1.2983 Td
(cohort)Tj
2.8516 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7993 0 Td
(2,174\))Tj
2.6873 0 Td
(and)Tj
1.7291 0 Td
(investigate)Tj
4.4617 0 Td
(associations)Tj
4.9889 0 Td
(with)Tj
2.0013 0 Td
(co-infections,)Tj
5.6579 0 Td
(clinical)Tj
3.0727 0 Td
(measurements)Tj
6.0321 0 Td
(and)Tj
-35.3931 -1.2983 Td
(demographic)Tj
5.5048 0 Td
(information.)Tj
5.3008 0 Td
(As)Tj
1.2642 0 Td
(a)Tj
0.652 0 Td
(secondary)Tj
4.2746 0 Td
(analysis,)Tj
3.5489 0 Td
(we)Tj
1.3266 0 Td
(link)Tj
1.7802 0 Td
(cardiovascular)Tj
6.0037 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(to)Tj
-34.2763 -1.2982 Td
(HCMV)Tj
3.2371 0 Td
(antibody)Tj
3.7644 0 Td
(levels.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 330.1795 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Material)Tj
3.959 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F12 1 Tf
-5.948 -1.4976 Td
(Study)Tj
2.6173 0 Td
(area)Tj
1.9843 0 Td
(and)Tj
1.7953 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 295.2 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(General)Tj
3.3845 0 Td
(Population)Tj
4.6318 0 Td
(Cohort)Tj
3.0954 0 Td
(\(GPC\))Tj
2.8347 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(population-based)Tj
7.1943 0 Td
(open)Tj
2.2167 0 Td
(cohort)Tj
2.8573 0 Td
(study,)Tj
2.6135 0 Td
(set)Tj
1.3039 0 Td
(up)Tj
1.2643 0 Td
(in)Tj
-34.6788 -1.2982 Td
(1990)Tj
2.1203 0 Td
(by)Tj
1.1848 0 Td
(the)Tj
1.4684 0 Td
(Medical)Tj
3.4355 0 Td
(Research)Tj
3.8041 0 Td
(Council)Tj
3.4016 0 Td
(\(MRC\))Tj
3.0784 0 Td
(UK)Tj
1.6327 0 Td
(in)Tj
1.0318 0 Td
(collaboration)Tj
5.5219 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4684 0 Td
(Uganda)Tj
3.3675 0 Td
(Virus)Tj
-33.5109 -1.3039 Td
(Research)Tj
3.804 0 Td
(Institute)Tj
3.583 0 Td
(\(UVRI\).)Tj
3.5206 0 Td
(Initially)Tj
3.3222 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
3.6 0 Td
(trends)Tj
2.7496 0 Td
(in)Tj
1.0375 0 Td
(HIV)Tj
2.0182 0 Td
(prevalence)Tj
4.4901 0 Td
(and)Tj
1.7291 0 Td
(incidence,)Tj
4.2973 0 Td
(the)Tj
-35.1777 -1.2983 Td
(GPC)Tj
2.1543 0 Td
(is)Tj
0.8504 0 Td
(located)Tj
3.0784 0 Td
(in)Tj
1.0374 0 Td
(Kyamulibwa)Tj
5.2668 0 Td
(sub-county)Tj
4.7281 0 Td
(of)Tj
1.0148 0 Td
(Kalungu)Tj
3.6397 0 Td
(district,)Tj
3.2598 0 Td
(rural)Tj
2.1713 0 Td
(south-western)Tj
5.9017 0 Td
(Uganda)Tj
-33.1027 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7801 0 Td
(cohort)Tj
2.8573 0 Td
(now)Tj
1.9616 0 Td
(comprises)Tj
4.269 0 Td
(a)Tj
0.6519 0 Td
(cluster)Tj
2.8743 0 Td
(of)Tj
1.0148 0 Td
(25)Tj
1.1736 0 Td
(neighboring)Tj
5.1136 0 Td
(villages)Tj
3.1181 0 Td
(with)Tj
2.0013 0 Td
(approximately)Tj
5.9754 0 Td
(20,000)Tj
-34.8659 -1.3039 Td
(residents)Tj
3.7984 0 Td
(\(52%)Tj
2.2733 0 Td
(aged)Tj
/F13 1 Tf
0 Tc
2.0693 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
(13)Tj
1.9389 0 Td
(years\))Tj
2.6078 0 Td
(from)Tj
2.2054 0 Td
(three)Tj
2.262 0 Td
(ethnic)Tj
2.7099 0 Td
(groups,)Tj
3.1975 0 Td
(the)Tj
1.4683 0 Td
(majority)Tj
3.6283 0 Td
(\(75%\))Tj
2.6079 0 Td
(being)Tj
2.4321 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
-35.4045 -1.2982 Td
(Baganda)Tj
3.6396 0 Td
(tribe,)Tj
2.3131 0 Td
(the)Tj
1.474 0 Td
(main)Tj
2.2847 0 Td
(tribal)Tj
2.3471 0 Td
(group)Tj
2.6078 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(region.)Tj
-15.9759 -1.2983 Td
(Blood)Tj
2.5908 0 Td
(samples)Tj
3.3846 0 Td
(are)Tj
1.4456 0 Td
(transported)Tj
4.8812 0 Td
(to)Tj
1.0205 0 Td
(MRC/UVRI)Tj
5.1194 0 Td
(laboratories)Tj
4.9492 0 Td
(in)Tj
1.0375 0 Td
(Entebbe)Tj
3.4979 0 Td
(where)Tj
2.6476 0 Td
(a)Tj
0.6576 0 Td
(portion)Tj
3.2315 0 Td
(of)Tj
-35.6596 -1.2983 Td
(the)Tj
1.4683 0 Td
(venous)Tj
3.0444 0 Td
(blood)Tj
2.5115 0 Td
(sample)Tj
3.0217 0 Td
(is)Tj
0.8504 0 Td
(analysed)Tj
3.651 0 Td
(according)Tj
4.1839 0 Td
(to)Tj
1.0261 0 Td
(protocol)Tj
3.6 0 Td
(guidelines.)Tj
4.5014 0 Td
(Remaining)Tj
4.6147 0 Td
(samples)Tj
3.3846 0 Td
(are)Tj
-35.858 -1.3039 Td
(stored)Tj
2.7099 0 Td
(at)Tj
0.9524 0 Td
(80C)Tj
2.7439 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(biobank)Tj
3.4866 0 Td
(in)Tj
1.0318 0 Td
(Entebbe)Tj
3.498 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
-0.01 Tc
-14.9158 -1.2983 Td
(The)Tj
1.7688 0 Td
(majority)Tj
3.5773 0 Td
(of)Tj
1.0034 0 Td
(samples)Tj
3.3392 0 Td
(tested)Tj
2.5172 0 Td
(for)Tj
1.3719 0 Td
(HCMV)Tj
3.2145 0 Td
(in)Tj
1.0205 0 Td
(this)Tj
1.6497 0 Td
(study)Tj
2.3641 0 Td
(were)Tj
2.0976 0 Td
(taken)Tj
2.3868 0 Td
(from)Tj
2.1826 0 Td
(2011.)Tj
2.3188 0 Td
(Samples)Tj
3.4582 0 Td
(from)Tj
-35.4668 -1.2982 Td
(TB)Tj
1.4003 0 Td
(cases)Tj
2.1883 0 Td
(were)Tj
2.1033 0 Td
(from)Tj
2.177 0 Td
(a)Tj
0.6519 0 Td
(range)Tj
2.4322 0 Td
(of)Tj
1.0034 0 Td
(GPC)Tj
2.1373 0 Td
(rounds)Tj
3.0274 0 Td
(sampled)Tj
3.5093 0 Td
(between)Tj
3.4866 0 Td
(1999)Tj
2.0976 0 Td
(and)Tj
1.7121 0 Td
(2014.)Tj
2.3187 0 Td
(Active)Tj
2.7326 0 Td
(pulmonary)Tj
-32.978 -1.3039 Td
(TB)Tj
1.4003 0 Td
(was)Tj
1.6781 0 Td
(diagnosed)Tj
4.2292 0 Td
(through)Tj
3.4016 0 Td
(positive)Tj
3.2711 0 Td
(sputum)Tj
3.2315 0 Td
(smear)Tj
2.6022 0 Td
(microscopy)Tj
4.8132 0 Td
(after)Tj
2.0012 0 Td
(passive)Tj
2.9991 0 Td
(case)Tj
1.8368 0 Td
(detection.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Sampling)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Individuals)Tj
4.7224 0 Td
(were)Tj
2.1203 0 Td
(selected)Tj
3.3449 0 Td
(at)Tj
0.9524 0 Td
(random,)Tj
3.6567 0 Td
(having)Tj
2.9197 0 Td
(been)Tj
2.1203 0 Td
(stratified)Tj
3.753 0 Td
(by)Tj
1.1849 0 Td
(age)Tj
1.542 0 Td
(and)Tj
1.7292 0 Td
(sex.)Tj
1.6951 0 Td
(Infants)Tj
3.0387 0 Td
(under)Tj
2.6192 0 Td
(5)Tj
-35.3988 -1.2982 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(were)Tj
2.126 0 Td
(oversampled)Tj
5.3064 0 Td
(in)Tj
1.0318 0 Td
(anticipation)Tj
5.0343 0 Td
(of)Tj
1.0148 0 Td
(high)Tj
2.0069 0 Td
(age-dependent)Tj
6.1285 0 Td
(HCMV)Tj
3.2428 0 Td
(seropositivity)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 505.3039 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HCMV,)Tj
3.4086 0 Td
(TB)Tj
1.4882 0 Td
(and)Tj
1.8497 0 Td
(CVD)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01920)Tj
4.089 0 Td
(86)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(6,)Tj
1.0417 0 Td
(2018)Tj
33.7042 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(16)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
BT
10.3394 82.7156 Td
(exist.)Tj
ET
Q
endstream
endobj
61 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 62 0 R/Contents 63 0 R/TrimBox[0 0 612 792]>>
endobj
62 0 obj
[64 0 R 65 0 R 66 0 R 67 0 R]
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192086.t001)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Lpone.0192086.t001)>>
endobj
66 0 obj
<>/Border[0 0 0]/A 68 0 R>>
endobj
68 0 obj
<>
endobj
67 0 obj
<>/Border[0 0 0]/A 69 0 R>>
endobj
69 0 obj
<>
endobj
63 0 obj
[70 0 R 71 0 R 72 0 R 73 0 R 74 0 R]
endobj
70 0 obj
<>stream
q
0.83 0.64 0.02 0 k
229.4929 667.3323 m
258.6331 667.3323 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(based)Tj
2.4717 0 Td
(on)Tj
1.2756 0 Td
(evidence)Tj
3.7134 0 Td
(from)Tj
2.2053 0 Td
(other)Tj
2.3471 0 Td
(sub-Saharan)Tj
5.193 0 Td
(countries.)Tj
4.1726 0 Td
(A)Tj
0.9014 0 Td
(target)Tj
2.5115 0 Td
(sample)Tj
3.0217 0 Td
(size)Tj
1.6838 0 Td
(of)Tj
1.0148 0 Td
(approximately)Tj
-30.5119 -1.3039 Td
(100)Tj
1.644 0 Td
(individuals)Tj
4.6488 0 Td
(per)Tj
1.5364 0 Td
(year)Tj
1.8992 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(from)Tj
2.211 0 Td
(under)Tj
2.6136 0 Td
(1)Tj
0.6973 0 Td
(year)Tj
1.9049 0 Td
(to)Tj
1.0261 0 Td
(5)Tj
0.6916 0 Td
(year)Tj
1.9049 0 Td
(were)Tj
2.126 0 Td
(sampled)Tj
3.5489 0 Td
(and)Tj
1.7292 0 Td
(200)Tj
1.644 0 Td
(individuals)Tj
-32.3827 -1.2982 Td
(in)Tj
1.0318 0 Td
(5)Tj
0.6973 0 Td
(to)Tj
1.0261 0 Td
(10)Tj
1.1735 0 Td
(year)Tj
1.8992 0 Td
(age)Tj
1.5421 0 Td
(groups)Tj
2.9707 0 Td
(thereafter.)Tj
4.3086 0 Td
(The)Tj
1.7802 0 Td
(sex)Tj
1.4683 0 Td
(ratio)Tj
2.0976 0 Td
(was)Tj
1.7008 0 Td
(approximately)Tj
5.9754 0 Td
(equal)Tj
2.3584 0 Td
(within)Tj
2.8119 0 Td
(each)Tj
2.0296 0 Td
(age)Tj
-34.8715 -1.2983 Td
(group)Tj
2.6078 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
-4.1952 -1.2983 Td
(The)Tj
1.7858 0 Td
(age)Tj
1.542 0 Td
(structure)Tj
3.8211 0 Td
(of)Tj
1.0148 0 Td
(sampling)Tj
3.8778 0 Td
(for)Tj
1.3889 0 Td
(this)Tj
1.6725 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(determined)Tj
4.8529 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(Ugandan)Tj
3.9174 0 Td
(demo-)Tj
-32.9043 -1.3039 Td
(graphics;)Tj
3.8097 0 Td
(49%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(Ugandans)Tj
4.2803 0 Td
(are)Tj
1.4457 0 Td
(under)Tj
2.6192 0 Td
(14)Tj
1.1735 0 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(age,)Tj
1.7689 0 Td
(21%)Tj
1.9275 0 Td
(are)Tj
1.4513 0 Td
(between)Tj
3.5263 0 Td
(1524)Tj
2.6419 0 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(age,)Tj
-34.1402 -1.2982 Td
(28%)Tj
1.9275 0 Td
(between)Tj
3.5263 0 Td
(25)Tj
1.1735 0 Td
(and)Tj
1.7291 0 Td
(64)Tj
1.1736 0 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(and)Tj
1.7292 0 Td
(only)Tj
1.9785 0 Td
(2%)Tj
1.4514 0 Td
(over)Tj
1.9785 0 Td
(65.)Tj
1.3947 0 Td
(The)Tj
1.7858 0 Td
(sampling)Tj
3.8778 0 Td
(here)Tj
1.9672 0 Td
(was)Tj
1.6951 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
-36.2208 -1.2983 Td
(Ugandan)Tj
3.9117 0 Td
(demographic)Tj
5.5049 0 Td
(with)Tj
1.9956 0 Td
(45%)Tj
1.9332 0 Td
(under)Tj
2.6135 0 Td
(14)Tj
1.1735 0 Td
(years,)Tj
2.4888 0 Td
(18%)Tj
1.9276 0 Td
(1524,)Tj
2.8686 0 Td
(32%)Tj
1.9276 0 Td
(2564)Tj
2.6419 0 Td
(and)Tj
1.7291 0 Td
(5%)Tj
1.4513 0 Td
(over)Tj
1.9786 0 Td
(65)Tj
1.1678 0 Td
(years)Tj
-35.3137 -1.3039 Td
(of)Tj
1.0147 0 Td
(age.)Tj
0.1815 -1.2983 Td
(Being)Tj
2.5058 0 Td
(a)Tj
0.6576 0 Td
(cross-sectional)Tj
6.1001 0 Td
(study,)Tj
2.6136 0 Td
(each)Tj
2.0295 0 Td
(individual)Tj
4.286 0 Td
(was)Tj
1.7008 0 Td
(only)Tj
1.9786 0 Td
(sampled)Tj
3.5489 0 Td
(once.)Tj
2.3471 0 Td
(Siblings)Tj
3.3562 0 Td
(and)Tj
1.7291 0 Td
(parent-)Tj
-34.0495 -1.2983 Td
(child)Tj
2.211 0 Td
(pairs)Tj
2.1713 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.576 0 Td
(excluded.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 547.37 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 530.3622 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Written)Tj
3.3902 0 Td
(consent)Tj
3.3335 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5364 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0727 0 Td
(records)Tj
3.2088 0 Td
(and)Tj
1.7291 0 Td
(biological)Tj
4.0876 0 Td
(samples)Tj
3.3845 0 Td
(for)Tj
1.3833 0 Td
(research)Tj
3.5603 0 Td
(purposes)Tj
-32.5528 -1.2982 Td
(was)Tj
1.6951 0 Td
(obtained)Tj
3.736 0 Td
(from)Tj
2.2053 0 Td
(all)Tj
1.1452 0 Td
(GPC)Tj
2.16 0 Td
(participants)Tj
4.9549 0 Td
(following)Tj
3.9799 0 Td
(Uganda)Tj
3.3675 0 Td
(National)Tj
3.6907 0 Td
(Council)Tj
3.4015 0 Td
(of)Tj
1.0148 0 Td
(Science)Tj
3.2088 0 Td
(and)Tj
-34.5597 -1.2983 Td
(Technology)Tj
4.9322 0 Td
(guidelines.)Tj
-3.736 -1.3039 Td
(Ethical)Tj
2.9763 0 Td
(approval)Tj
3.6964 0 Td
(for)Tj
1.3719 0 Td
(the)Tj
1.4627 0 Td
(use)Tj
1.525 0 Td
(of)Tj
1.0035 0 Td
(samples)Tj
3.3732 0 Td
(for)Tj
1.3776 0 Td
(this)Tj
1.6611 0 Td
(study)Tj
2.3811 0 Td
(was)Tj
1.6894 0 Td
(obtained)Tj
3.7247 0 Td
(from)Tj
2.194 0 Td
(The)Tj
1.7745 0 Td
(UVRI)Tj
2.6022 0 Td
(Research)Tj
-34.0098 -1.2983 Td
(and)Tj
1.7291 0 Td
(Ethics)Tj
2.6645 0 Td
(Committee)Tj
4.7452 0 Td
(and)Tj
1.7291 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(Uganda)Tj
3.3675 0 Td
(Council)Tj
3.4016 0 Td
(for)Tj
1.3889 0 Td
(Science)Tj
3.2032 0 Td
(and)Tj
1.7291 0 Td
(Technology,)Tj
5.159 0 Td
(in)Tj
1.0375 0 Td
(addition)Tj
-33.8284 -1.2982 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(London)Tj
3.3959 0 Td
(School)Tj
2.9083 0 Td
(of)Tj
1.0148 0 Td
(Hygiene)Tj
3.5717 0 Td
(&)Tj
0.9241 0 Td
(Tropical)Tj
3.5943 0 Td
(Medicine,)Tj
4.2179 0 Td
(London,)Tj
3.6226 0 Td
(UK.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 435.3448 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(HCMV)Tj
3.2551 0 Td
(serology)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 418.337 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Serum)Tj
2.8346 0 Td
(samples)Tj
3.3845 0 Td
(were)Tj
2.1203 0 Td
(tested)Tj
2.5569 0 Td
(for)Tj
1.3833 0 Td
(antibodies)Tj
4.3596 0 Td
(against)Tj
3.0274 0 Td
(HCMV)Tj
3.2428 0 Td
(using)Tj
2.3868 0 Td
(standard,)Tj
3.9514 0 Td
(validated)Tj
3.8325 0 Td
(and)Tj
1.7291 0 Td
(com-)Tj
-34.8092 -1.2982 Td
(mercially)Tj
3.9061 0 Td
(available)Tj
3.668 0 Td
(enzyme-linked)Tj
6.1625 0 Td
(immunosorbent)Tj
6.7237 0 Td
(assay)Tj
2.2677 0 Td
(\(ELISA\))Tj
3.5036 0 Td
(against)Tj
3.0274 0 Td
(HCMV)Tj
3.2428 0 Td
(IgG)Tj
1.7405 0 Td
(\(IBL)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
200.0001 377.2514 m
576 377.2514 l
576 376.7513 l
200.0001 376.7513 l
f*
427.9139 376.7513 m
427.9139 364.2514 l
427.4138 364.2514 l
427.4138 376.7513 l
f*
427.4138 364.2514 m
200.0001 364.2514 l
200.0001 364.7514 l
427.4138 364.7514 l
f*
575.9997 364.2514 m
427.9139 364.2514 l
427.9139 364.7514 l
575.9997 364.7514 l
f*
427.9139 364.2514 m
427.9139 351.7515 l
427.4138 351.7515 l
427.4138 364.2514 l
f*
427.4138 351.7515 m
200.0001 351.7515 l
200.0001 352.2515 l
427.4138 352.2515 l
f*
575.9997 351.7515 m
427.9139 351.7515 l
427.9139 352.2515 l
575.9997 352.2515 l
f*
427.9139 351.7515 m
427.9139 339.2515 l
427.4138 339.2515 l
427.4138 351.7515 l
f*
427.4138 339.2515 m
200.0001 339.2515 l
200.0001 339.7516 l
427.4138 339.7516 l
f*
575.9997 339.2515 m
427.9139 339.2515 l
427.9139 339.7516 l
575.9997 339.7516 l
f*
427.9139 339.2515 m
427.9139 326.7516 l
427.4138 326.7516 l
427.4138 339.2515 l
f*
427.4138 326.7516 m
200.0001 326.7516 l
200.0001 327.2516 l
427.4138 327.2516 l
f*
575.9997 326.7516 m
427.9139 326.7516 l
427.9139 327.2516 l
575.9997 327.2516 l
f*
427.9139 326.7516 m
427.9139 314.2517 l
427.4138 314.2517 l
427.4138 326.7516 l
f*
427.4138 314.2517 m
200.0001 314.2517 l
200.0001 314.7517 l
427.4138 314.7517 l
f*
575.9997 314.2517 m
427.9139 314.2517 l
427.9139 314.7517 l
575.9997 314.7517 l
f*
427.9139 314.2517 m
427.9139 301.7517 l
427.4138 301.7517 l
427.4138 314.2517 l
f*
427.4138 301.7517 m
200.0001 301.7517 l
200.0001 302.2517 l
427.4138 302.2517 l
f*
575.9997 301.7517 m
427.9139 301.7517 l
427.9139 302.2517 l
575.9997 302.2517 l
f*
427.9139 301.7517 m
427.9139 289.2518 l
427.4138 289.2518 l
427.4138 301.7517 l
f*
427.4138 289.2518 m
200.0001 289.2518 l
200.0001 289.7518 l
427.4138 289.7518 l
f*
575.9997 289.2518 m
427.9139 289.2518 l
427.9139 289.7518 l
575.9997 289.7518 l
f*
427.9139 289.2518 m
427.9139 276.7518 l
427.4138 276.7518 l
427.4138 289.2518 l
f*
427.4138 276.7518 m
200.0001 276.7518 l
200.0001 277.2519 l
427.4138 277.2519 l
f*
575.9997 276.7518 m
427.9139 276.7518 l
427.9139 277.2519 l
575.9997 277.2519 l
f*
427.9139 276.7518 m
427.9139 264.2519 l
427.4138 264.2519 l
427.4138 276.7518 l
f*
427.4138 264.2519 m
200.0001 264.2519 l
200.0001 264.7519 l
427.4138 264.7519 l
f*
575.9997 264.2519 m
427.9139 264.2519 l
427.9139 264.7519 l
575.9997 264.7519 l
f*
427.9139 264.2519 m
427.9139 251.752 l
427.4138 251.752 l
427.4138 264.2519 l
f*
427.4138 251.752 m
200.0001 251.752 l
200.0001 252.252 l
427.4138 252.252 l
f*
575.9997 251.752 m
427.9139 251.752 l
427.9139 252.252 l
575.9997 252.252 l
f*
427.9139 251.752 m
427.9139 239.252 l
427.4138 239.252 l
427.4138 251.752 l
f*
427.4138 239.252 m
200.0001 239.252 l
200.0001 239.7521 l
427.4138 239.7521 l
f*
575.9997 239.252 m
427.9139 239.252 l
427.9139 239.7521 l
575.9997 239.7521 l
f*
427.9139 239.252 m
427.9139 226.7521 l
427.4138 226.7521 l
427.4138 239.252 l
f*
427.4138 226.7521 m
200.0001 226.7521 l
200.0001 227.2521 l
427.4138 227.2521 l
f*
575.9997 226.7521 m
427.9139 226.7521 l
427.9139 227.2521 l
575.9997 227.2521 l
f*
427.9139 226.7521 m
427.9139 214.2522 l
427.4138 214.2522 l
427.4138 226.7521 l
f*
427.4138 214.2522 m
200.0001 214.2522 l
200.0001 214.7522 l
427.4138 214.7522 l
f*
575.9997 214.2522 m
427.9139 214.2522 l
427.9139 214.7522 l
575.9997 214.7522 l
f*
427.9139 214.2522 m
427.9139 201.7522 l
427.4138 201.7522 l
427.4138 214.2522 l
f*
427.4138 201.7522 m
200.0001 201.7522 l
200.0001 202.2523 l
427.4138 202.2523 l
f*
575.9997 201.7522 m
427.9139 201.7522 l
427.9139 202.2523 l
575.9997 202.2523 l
f*
427.9139 201.7522 m
427.9139 189.2523 l
427.4138 189.2523 l
427.4138 201.7522 l
f*
427.4138 189.2523 m
200.0001 189.2523 l
200.0001 189.7523 l
427.4138 189.7523 l
f*
575.9997 189.2523 m
427.9139 189.2523 l
427.9139 189.7523 l
575.9997 189.7523 l
f*
427.9139 189.2523 m
427.9139 176.7523 l
427.4138 176.7523 l
427.4138 189.2523 l
f*
427.4138 176.7523 m
200.0001 176.7523 l
200.0001 177.2524 l
427.4138 177.2524 l
f*
575.9997 176.7523 m
427.9139 176.7523 l
427.9139 177.2524 l
575.9997 177.2524 l
f*
575.9997 95.0026 m
200.0001 95.0026 l
200.0001 95.5026 l
575.9997 95.5026 l
f*
0.83 0.64 0.02 0 k
200.0126 81.9213 m
350.7591 81.9213 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 382.1102 cm
BT
/F12 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(General)Tj
3.5009 0 Td
(populati)Tj
3.5079 0 Td
(on)Tj
1.2897 0 Td
(cohort)Tj
2.9552 0 Td
(character)Tj
3.8764 0 Td
(istics)Tj
2.3102 0 Td
(of)Tj
1.063 0 Td
(individu)Tj
3.5079 0 Td
(als)Tj
1.3394 0 Td
(included)Tj
3.8268 0 Td
(in)Tj
1.0559 0 Td
(this)Tj
1.7717 0 Td
(study.)Tj
/F6 1 Tf
0 Tc
-33.7325 -1.8567 Td
(Age,)Tj
2.0338 0 Td
(mean)Tj
2.4662 0 Td
(\(range\))Tj
24.364 0 Td
(22.7)Tj
1.8921 0 Td
(\(0.08100)Tj
3.9544 0 Td
(.75\))Tj
-34.7105 -1.5661 Td
(Sex,)Tj
1.8283 0 Td
(percentage)Tj
4.578 0 Td
(female)Tj
2.8772 0 Td
(\(number/tot)Tj
4.9961 0 Td
(al\))Tj
14.5844 0 Td
(50.2%)Tj
2.6504 0 Td
(\(1,091/2,)Tj
3.515 0 Td
(174\))Tj
-35.0294 -1.5591 Td
(HIV)Tj
2.0338 0 Td
(prevalence)Tj
4.2875 0 Td
(,)Tj
0.4606 0 Td
(percentage)Tj
4.578 0 Td
(\(number/tot)Tj
4.9961 0 Td
(al\))Tj
12.508 0 Td
(4.6%)Tj
2.1685 0 Td
(\(100/2,134\))Tj
-31.0325 -1.5661 Td
(Body)Tj
2.3031 0 Td
(mass)Tj
2.2181 0 Td
(index)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 254.0976 332.674 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 257.3858 329.7259 cm
BT
/F6 1 Tf
1 TL
0 0 Td
(,)Tj
0.4606 0 Td
(percentage)Tj
4.578 0 Td
(\(number/tot)Tj
4.9961 0 Td
(al\))Tj
-16.2851 -1.559 Td
(-)Tj
0.5811 0 Td
(Underweig)Tj
4.4646 0 Td
(ht)Tj
22.8969 0 Td
(21%)Tj
1.9418 0 Td
(\(237/1,150)Tj
4.2449 0 Td
(\))Tj
-34.1293 -1.5662 Td
(-)Tj
0.5811 0 Td
(Normal)Tj
27.3615 0 Td
(69%)Tj
1.9418 0 Td
(\(797/1,150)Tj
4.2449 0 Td
(\))Tj
-34.1293 -1.559 Td
(-)Tj
0.5811 0 Td
(Overweig)Tj
3.8481 0 Td
(ht)Tj
23.5134 0 Td
(8%)Tj
1.467 0 Td
(\(97/1,150\))Tj
-29.4096 -1.5591 Td
(-)Tj
0.5811 0 Td
(Obese)Tj
27.3615 0 Td
(2%)Tj
1.467 0 Td
(\(19/1,150\))Tj
-30.3309 -1.5662 Td
(Hyperte)Tj
3.267 0 Td
(nsion)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 244.1196 270.1417 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
0.5871 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 250.696 267.2503 cm
BT
/F6 1 Tf
1 TL
0 0 Td
(,)Tj
0.4606 0 Td
(percen)Tj
2.7142 0 Td
(tage)Tj
1.8638 0 Td
(\(number/t)Tj
4.1811 0 Td
(otal\))Tj
-14.6339 -1.559 Td
(-)Tj
0.5811 0 Td
(Normal)Tj
27.3616 0 Td
(46%)Tj
1.9417 0 Td
(\(552/1,187)Tj
4.2449 0 Td
(\))Tj
-34.1293 -1.5662 Td
(-)Tj
0.5811 0 Td
(Pre-hypert)Tj
4.3158 0 Td
(ension)Tj
23.0458 0 Td
(39%)Tj
1.9417 0 Td
(\(460/1,187)Tj
4.2449 0 Td
(\))Tj
-34.1293 -1.559 Td
(-)Tj
0.5811 0 Td
(Hyperte)Tj
3.267 0 Td
(nsion)Tj
24.0946 0 Td
(15%)Tj
1.9417 0 Td
(\(175/1,187)Tj
4.2449 0 Td
(\))Tj
-35.0505 -1.5662 Td
(Tribe,)Tj
2.6504 0 Td
(percentage)Tj
4.5779 0 Td
(\(number/to)Tj
4.6913 0 Td
(tal\))Tj
-10.9984 -1.5591 Td
(-)Tj
0.5811 0 Td
(Baganda)Tj
27.3616 0 Td
(75%)Tj
1.9417 0 Td
(\(1,524/2,035)Tj
4.9536 0 Td
(\))Tj
-34.838 -1.5661 Td
(-)Tj
0.5811 0 Td
(Rwandese)Tj
4.2662 0 Td
(Ugandan)Tj
23.0954 0 Td
(16%)Tj
1.9417 0 Td
(\(319/2,035)Tj
4.2449 0 Td
(\))Tj
-34.1293 -1.5591 Td
(-)Tj
0.5811 0 Td
(Other)Tj
2.6079 0 Td
()Tj
24.7537 0 Td
(9%)Tj
1.4669 0 Td
(\(192/2,035)Tj
4.2449 0 Td
(\))Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 200.0125 163.8992 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 203.3007 161.0078 cm
BT
/F6 1 Tf
1 TL
0 0 Td
(body)Tj
2.2323 0 Td
(mass)Tj
2.211 0 Td
(index)Tj
2.4732 0 Td
(18.4)Tj
1.8922 0 Td
(and)Tj
1.7504 0 Td
(below)Tj
2.6079 0 Td
(is)Tj
0.8575 0 Td
(underweight)Tj
5.0882 0 Td
(,)Tj
0.4606 0 Td
(18.524.9)Tj
4.0749 0 Td
(is)Tj
0.8645 0 Td
(normal,)Tj
3.3946 0 Td
(25.029.9)Tj
4.0677 0 Td
(is)Tj
0.8646 0 Td
(overweight)Tj
4.4433 0 Td
(,)Tj
0.4607 0 Td
(and)Tj
1.7504 0 Td
(30)Tj
1.1834 0 Td
(and)Tj
1.7434 0 Td
(above)Tj
2.5653 0 Td
(is)Tj
-45.3971 -1.5023 Td
(obese.)Tj
ET
Q
q
1 j
1 J
0 w
5.5998 0 0 5.5998 200.0125 139.9181 cm
BT
/F13 1 Tf
1 TL
0 0 Td
()Tj
0.5871 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 208.4031 137.0267 cm
BT
/F6 1 Tf
1 TL
0 0 Td
(Pre-hypertens)Tj
5.6622 0 Td
(ion)Tj
1.5591 0 Td
(is)Tj
0.8645 0 Td
(systolic)Tj
3.1678 0 Td
(blood)Tj
2.537 0 Td
(pressure)Tj
3.6 0 Td
(\(SBP\))Tj
2.5371 0 Td
(between)Tj
3.5504 0 Td
(120mmHg)Tj
4.5425 0 Td
(and)Tj
1.7434 0 Td
(140)Tj
1.6653 0 Td
(mmHg,)Tj
3.3308 0 Td
(and)Tj
1.7504 0 Td
(a)Tj
0.6661 0 Td
(diastolic)Tj
3.5859 0 Td
(blood)Tj
-41.8113 -1.5023 Td
(pressure)Tj
3.6 0 Td
(\(DBP\))Tj
2.7992 0 Td
(between)Tj
3.5504 0 Td
(80)Tj
1.1835 0 Td
(mmHg)Tj
3.111 0 Td
(and)Tj
1.7434 0 Td
(90)Tj
1.1834 0 Td
(mmHg.)Tj
3.3378 0 Td
(Hypertens)Tj
4.1812 0 Td
(ion)Tj
1.559 0 Td
(is)Tj
0.8646 0 Td
(defined)Tj
3.2528 0 Td
(as)Tj
1.0276 0 Td
(SBP)Tj
/F13 1 Tf
1.8496 0 Td
()Tj
/F6 1 Tf
(140mmHg)Tj
5.3079 0 Td
(and)Tj
1.7504 0 Td
(DBP)Tj
/F13 1 Tf
-40.3018 -1.5024 Td
()Tj
/F6 1 Tf
(90mmH)Tj
4.1315 0 Td
(g.)Tj
-4.1315 -1.4953 Td
()Tj
0.7087 0 Td
(Other)Tj
2.6078 0 Td
(tribes)Tj
2.4732 0 Td
(include)Tj
3.2103 0 Td
(Bakiga,)Tj
3.1465 0 Td
(Batooro,)Tj
3.678 0 Td
(Banyankol)Tj
4.2661 0 Td
(e,)Tj
0.8859 0 Td
(Basoga,)Tj
3.2527 0 Td
(Bafumb)Tj
3.1607 0 Td
(ira,)Tj
1.5449 0 Td
(Tanzani)Tj
3.267 0 Td
(an,)Tj
1.4456 0 Td
(Barundi)Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-33.6474 -2.2535 Td
(https://d)Tj
3.0826 0 Td
(oi.org/10.1371/j)Tj
5.9174 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0192086.t00)Tj
5.3859 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 505.3039 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HCMV,)Tj
3.4086 0 Td
(TB)Tj
1.4882 0 Td
(and)Tj
1.8497 0 Td
(CVD)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01920)Tj
4.089 0 Td
(86)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(6,)Tj
1.0417 0 Td
(2018)Tj
33.7042 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
BT
66.402 0 Td
(16)Tj
ET
Q
endstream
endobj
75 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 79 0 R/Contents 80 0 R/TrimBox[0 0 612 792]>>
endobj
76 0 obj
<>
endobj
81 0 obj
<>
endobj
84 0 obj
<>stream
MinionPro-Regular 6 )
H? HD H\ ' - 3 > H N T Z ` j q t { +2=CIU[cnz~
"(.9CIOU[elov|&-8>DPV^iuy &+/49@DGLPU[]_ahjmru|
&-4;BIPW^elsz
")07>ELSZahov} %,3:AHOV]dkry#/;JTey ! ( / 6 = D K R Y ` g n u |
$
+
2
9
@
G
N
U
\
c
j
q
x
'.5<CJQX_fmt{ #*18?FMT[bkry
"
)
0
7
>
E
J
O
W
d
q
v
$+29@GNU\cjqx '.5<CJQX_fmt{ #*18?FMT[bipw~
&-4;BIPW^elsz !(/6=DOVcpuz-B\v$<Tdy*5@Tanz!2>O_fmt{ $-6?HQZclu~ )2;DMV^gpy $-6?HQZclu~ )2;DM\enwcommaaccentAbreveAmacronAogonekAEacuteCacuteCcaronCcircumflexCdotaccentDcaronDcroatEbreveEcaronEdotaccentEmacronEngEogonekGbreveGcircumflexGcommaaccentGdotaccentHbarHcircumflexIbreveIJImacronIogonekItildeJcircumflexKcommaaccentLacuteLcaronLcommaaccentLdotNacuteNcaronNcommaaccentObreveOhungarumlautOmacronOslashacuteRacuteRcaronRcommaaccentSacuteScedillaScircumflexScommaaccentTbarTcaronTcommaaccentUbreveUhungarumlautUmacronUogonekUringUtildeWacuteWcircumflexWdieresisWgraveYcircumflexYgraveZacuteZdotaccentIdotaccentabreveamacronaogonekaeacutecacuteccaronccircumflexcdotaccentdcarondcroatebreveecaronedotaccentemacronengeogonekgbrevegcircumflexgcommaaccentgdotaccenthbarhcircumflexibreveijimacroniogonekitildejcircumflexkcommaaccentlacutelcaronlcommaaccentldotnacutencaronncommaaccentobreveohungarumlautomacronoslashacuteracutercaronrcommaaccentsacutescedillascircumflexscommaaccenttbartcarontcommaaccentubreveuhungarumlautumacronuogonekuringutildewacutewcircumflexwdieresiswgraveycircumflexygravezacutezdotaccentkgreenlandiclongsnapostrophetonosdieresistonosAlphaBetaGammaDeltaEpsilonZetaEtaThetaIotaKappaLambdaMuNuXiOmicronPiRhoSigmaTauUpsilonPhiChiPsiOmegaAlphatonosEpsilontonosEtatonosIotatonosIotadieresisOmicrontonosUpsilontonosUpsilondieresisOmegatonosuni1FBBuni1F09uni1F0Duni1F0Buni1F0Funi1FB8uni1FBAuni1FBCuni1F89uni1F8Duni1F8Buni1F8Funi1F88uni1F8Cuni1F8Auni1F8Euni1F08uni1F0Cuni1F0Auni1F0Euni1FB9uni1FC9uni1F19uni1F1Duni1F1Buni1FC8uni1F18uni1F1Cuni1F1Auni1FCBuni1F29uni1F2Duni1F2Buni1F2Funi1FCAuni1FCCuni1F99uni1F9Duni1F9Buni1F9Funi1F98uni1F9Cuni1F9Auni1F9Euni1F28uni1F2Cuni1F2Auni1F2Euni1FDBuni1F39uni1F3Duni1F3Buni1F3Funi1FD8uni1FDAuni1F38uni1F3Cuni1F3Auni1F3Euni1FD9uni1FFBuni1F69uni1F6Duni1F6Buni1F6Funi1FFAuni1FFCuni1FA9uni1FADuni1FABuni1FAFuni1FA8uni1FACuni1FAAuni1FAEuni1F68uni1F6Cuni1F6Auni1F6Euni1FF9uni1F49uni1F4Duni1F4Buni1FF8uni1F48uni1F4Cuni1F4Auni1FECuni1FEBuni1F59uni1F5Duni1F5Buni1F5Funi1FE8uni1FEAuni1FE9alphabetagammadeltaepsilonzetaetathetaiotakappalambdanuxiomicronpirhosigmatauupsilonphichipsiomegaalphatonosepsilontonosetatonosiotatonosiotadieresisomicrontonosupsilontonosupsilondieresisomegatonosiotadieresistonosupsilondieresistonosuni03C2uni0374uni0375uni037Euni03D0uni03DAuni03DEuni03E0uni03F0uni1FBDuni1FBEuni1FC1uni1FCDuni1FCEuni1FCFuni1FDDuni1FDEuni1FDFuni1FEDuni1FEEuni1FFEuni1F00uni1F01uni1F02uni1F03uni1F04uni1F05uni1F06uni1F07uni1F10uni1F11uni1F12uni1F13uni1F14uni1F15uni1F20uni1F21uni1F22uni1F23uni1F24uni1F25uni1F26uni1F27uni1F30uni1F31uni1F32uni1F33uni1F34uni1F35uni1F36uni1F37uni1F40uni1F41uni1F42uni1F43uni1F44uni1F45uni1F50uni1F51uni1F52uni1F53uni1F54uni1F55uni1F56uni1F57uni1F60uni1F61uni1F62uni1F63uni1F64uni1F65uni1F66uni1F67uni1F70uni1F71uni1F72uni1F73uni1F74uni1F75uni1F76uni1F77uni1F78uni1F79uni1F7Auni1F7Buni1F7Cuni1F7Duni1F80uni1F81uni1F82uni1F83uni1F84uni1F85uni1F86uni1F87uni1F90uni1F91uni1F92uni1F93uni1F94uni1F95uni1F96uni1F97uni1FA0uni1FA1uni1FA2uni1FA3uni1FA4uni1FA5uni1FA6uni1FA7uni1FB0uni1FB1uni1FB2uni1FB3uni1FB6uni1FB7uni1FC2uni1FC3uni1FC4uni1FC6uni1FC7uni1FD0uni1FD1uni1FD2uni1FD3uni1FD6uni1FD7uni1FE0uni1FE1uni1FE2uni1FE3uni1FE4uni1FE5uni1FE6uni1FF2uni1FF3uni1FF4uni1FF6uni1FF7uni1FB4uni1FE7uniEFD5anoteleiauni03D1uni03D5uni03D6franclirapesetaEuroafii61289estimatedpartialdiffproductsummationuni2219radicalinfinityintegralapproxequalnotequallessequalgreaterequallozengeuni02C9uniEFEDuniEFEEuniEFF1uniEFF2uniEFF3uniEFF5uniEFF7AcuteCaronDieresisDieresisAcuteDieresisGraveGraveHungarumlautMacroncyrBrevecyrFlexdblGravecyrbrevecyrflexdblgravedieresisacutedieresisgraveuniF635uniF637uniF638uniF639uniF6DCuniF63AuniF63BuniF63CuniF63DuniF63EuniF63FuniF640uniF641uniF642uniF628uniF643uniF644uniF645uniF646uniF647uniF648uniF649uniF64AuniF64BuniF64CuniF64DuniF64EuniF64FuniF650uniF651uniF652uniF653uniF654uniF655uniF656uniF657uniF658uniF659uniF65AuniF65BuniF65CuniF65DuniF65EuniF65FuniF660uniF629uniF62AuniF62BuniF62CuniF62DuniF661uniF662uniF663uniF664uniF665uniF666uniF667uniF668uniF669uniF66AuniF66BuniF66CuniF62EuniF62FuniF630uniF631uniF632uniF66DuniF66EuniF66FuniF670uniF671uniF672uniF673uniF674uniF675uniF676uniF677uniF678uniF679uniF67AuniF67BuniF67CuniF67DuniF67EuniF67FuniF680uniF681uniF682uniF683uniF684uniF685uniF686uniF687uniF688uniF689uniF68AuniF68BuniF68CuniF68DuniF68EuniF68FuniF690uniF691uniF692uniF693uniF694uniF695uniF696uniF697uniF698uniF699uniF69AuniF69BuniF69CuniF69DuniF69EuniF69FuniF6A0uniF6A1uniF6A2uniF6A3uniF6A4uniF6A5uniF6A6uniF6A7uniF6A8uniF6A9uniF6AAuniF6ABuniF6ACuniF6ADuniF6AEuniF6AFuniF6B0uniF6B1uniF6B2uniF6B3uniF6B4uniF6B5uniF6B6uniF6B7uniF6B8uniF6B9uniF6BAuniF6BBuniF6BCuniF6BDuniF633c_hc_kc_tf_bf_f_bf_f_hf_f_kf_f_tf_hf_jf_f_jf_kf_ts_puniFB06T_hlongs_blongs_hlongs_ilongs_klongs_llongs_longsuniFB05longs_longs_ilongs_longs_la.ende.endm.endn.endr.endK.altR.altk.altcaron.altcommaaccent.altpeseta.altAlphaiotasub.altAlphaiotasubasper.altAlphaiotasubasperacute.altAlphaiotasubaspergrave.altAlphaiotasubaspertilde.altAlphaiotasublenis.altAlphaiotasublenisacute.altAlphaiotasublenisgrave.altAlphaiotasublenistilde.altEtaiotasub.altEtaiotasubasper.altEtaiotasubasperacute.altEtaiotasubaspergrave.altEtaiotasubaspertilde.altEtaiotasublenis.altEtaiotasublenisacute.altEtaiotasublenisgrave.altEtaiotasublenistilde.altOmegaiotasub.altOmegaiotasubasper.altOmegaiotasubasperacute.altOmegaiotasubaspergrave.altOmegaiotasubaspertilde.altOmegaiotasublenis.altOmegaiotasublenisacute.altOmegaiotasublenisgrave.altOmegaiotasublenistilde.altEuro.fittedcent.fittedcolonmonetary.fitteddollar.fittedflorin.fittedfranc.fittedlira.fittednumbersign.fittedsterling.fittedyen.fittedEuro.oldstylecolonmonetary.oldstyleestimated.oldstyleflorin.oldstylefranc.oldstylelira.oldstylenumbersign.oldstylesterling.oldstyleyen.oldstylefranc.taboldstylelira.taboldstyleorn.001orn.002orn.003orn.004orn.005orn.006orn.007orn.008orn.009orn.010orn.011orn.012orn.013orn.014orn.015orn.016orn.017orn.018orn.019orn.020orn.021orn.022orn.023afii10023afii10031afii10022afii10049T_h.caronafii10070afii10196afii10026afii10021afii10846afii10193afii10107afii10024afii10195afii10041afii10037afii10109afii10053afii10045afii10108afii10040afii10104afii10036afii10078afii10074afii10060afii10046afii10052afii10087afii10050afii10145afii10057afii10059afii10146afii10088afii10101afii10054afii10058Rholenisafii10025afii10099afii10068afii10035afii10048afii10089afii10105afii10085afii10020afii10077afii10106afii10019afii10076afii10110afii10100afii10090afii10028afii10095afii10147afii10066afii10098afii10082afii10061afii10103afii10102afii10083afii10027afii10072afii10039afii61352afii10069afii10094afii10038afii10034afii10148afii10032afii10194afii10033afii10075afii10017afii10081afii10056afii10084afii10044afii10030afii10051afii10047afii10018afii10080afii10042afii10071afii10029afii10062afii10065afii10097T_h.commaaccentafii10096afii10079afii10091afii10093afii10064afii10043afii10092uni2215uni021Bafii10073afii10067uni00A0uni021Aafii10086afii10055uni0394uni03BCuni03A9uni00ADCopyright 2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro RegularMinion Pro% i WZ5:`v22> % I
/
2
I
o
#3p~U
D
e
!o#]emE %<Jeov~EMfjtFp|,S-AZ0=DK +^&7NQy(/S_dl 5Rk$=Valsz"'-@T_gos{ ) . > N ^ d n v ~ !!!!'!3!?!H!Q!Z!]!c!i!n!s!x!!!!!!!!!!!!!"""#"'"3"?"K"W"c"k"s"{""""""""""""""c&oEr^7 JB@H *W2c~sp&m!1= 4:$kYyywRvzwrZnon?˘iNUddLoLݪ
~}}vywS6vO(Zp^TrǕ؍8x`?NYwUVYWE}zyMhummR~Kfowx}|txcBzuyBpOwTxql[LPҩy}~Bxxhzqlc#T0@9
5/j,X^M8Uruuoquvqiff{bE<H8XUo^bb_rMG'Н=[W}yQSSۚ$P|TzTyT'
ajqyzx||rrpwttozpj`lWHrʥaiqyo
|rqpxt@tpyqjalVHr]yt/m'mDx]pIsn8AgmxpQAz4wv~s}~vstzf|oęgfeoszvwzxu$wny|YgJO-ʆea]>9+ZhchAB_\?#^|m[5v-<<[FL LHHq˂~XxAo4uFabfqaf%f+rrs}ǔcqW "* ڟŇՊvx|po~}wUJN<0o-כtzr[ {"!coч~^o]/6'orsBp0ZlZqRoGt{_Fpq|iiMkTratap`DabuvCICpAϦ{~{lpˇBDDpӐ qoكtYoNU)gI_Z`yӔodžF/INlw71oC
ŸԱȗГnoՆ3$811xrdcQD:0] ;hJjp~djmplXhZfYxnmmyf^#MR:AgszvT]jjZ?_ynZQ{sNHyZdƨ]O틯֯}ޣDyZ{kvumofFMk_VYЄ#ms^@L A_!Z Z|蒯}~rqyg|usqrwgmazԬqbfZBoل5|%69o<3oZMZJuׇ3c T{ddmvrjY_VpŇkrkGpφ}8Fgsmy]pWSy/OBR7WXjfeolw}v84o~}xUGP~72pC
~㿊IK
NϪb98IPq
`y[~XsłI\FL
ދ.R۲vhl_@oۅ8(85oq͗ƫ>(3XOG7]_\i^%"Ba:Jy.}eu}|wzq]is|~ґϐuCDDEp
ؑ~P|xhcMp^},
qkuGuzwv~s}~ust}e{nęgfR5BcH
蠓`
i
`c
v
y
蠚}xsnyvrpyh&T~Y|S|Q4xrqxvrpyhrqVVrm