Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment.


Abubakar, I; Lipman, M; McHugh, TD; Fletcher, H; (2016) Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment. BMC medicine, 14 (1). p. 47. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0599-1

[img]
Preview
Text - Published Version
License:

Download (1MB) | Preview

Abstract

Tuberculosis is a major global cause of morbidity and mortality. Despite recent advances in containing the epidemic, several challenges continue to slow progress towards elimination including the continuing impact of drug resistant disease, and the lack of appropriate tools. Curtailing the transmission of tuberculosis remains a challenge especially in high burden countries. New developments in measuring correlates of protection are urgently needed to support the evaluation of vaccines. Similarly, despite progress in molecular diagnostics, better tools are required to identify resistance to antibiotics in multi and extensively drug resistant tuberculosis. Whole Genome Sequencing may lead to the next generation of assays to rapidly detect resistance and evaluate transmission. Advances on shortening treatment are hampered by the lack of a biomarker of cure which obviates the current long wait for relapses in trials. New research is urgently needed to support development of new vaccines and better diagnostics tools and shorter treatment for drug sensitive and resistant tuberculosis.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
PubMed ID: 27004971
Web of Science ID: 373173000003
URI: http://researchonline.lshtm.ac.uk/id/eprint/2535968

Statistics


Download activity - last 12 months
Downloads since deposit
53Downloads
129Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item