Human biomarkers: can they help us to develop a new tuberculosis vaccine?


Fletcher, HA; Dockrell, HM; (2016) Human biomarkers: can they help us to develop a new tuberculosis vaccine? Future microbiology, 11. pp. 781-7. ISSN 1746-0913 DOI: 10.2217/fmb.16.15

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Abstract

: The most effective intervention for the control of infectious disease is vaccination. The BCG vaccine, the only licensed vaccine for the prevention of tuberculosis (TB) disease, is only partially effective and a new vaccine is urgently needed. Biomarkers can aid the development of new TB vaccines through discovery of immune mechanisms, early assessment of vaccine immunogenicity or vaccine take and identification of those at greatest risk of disease progression for recruitment into smaller, targeted efficacy trials. The ultimate goal, however, remains a biomarker of TB vaccine efficacy that can be used as a surrogate for a TB disease end point and there remains an urgent need for further research in this area.<br/>

Item Type: Article
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
PubMed ID: 27203133
Web of Science ID: 376677500009
URI: http://researchonline.lshtm.ac.uk/id/eprint/2551681

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