The association between the ratio of monocytes: lymphocytes and risk of tuberculosis(TB) amongst HIV infected postpartum women.


Naranbhai, V; Moodley, D; Chipato, T; Stranix-Chibanda, L; Nakabaiito, C; Kamateeka, M; Musoke, P; Manji, K; George, K; Emel, LM; Richardson, P; Andrew, P; Fowler, M; Fletcher, H; Mcshane, H; Coovadia, HM; Hill, AV; for the HPTN 046 protocol team, ; (2014) The association between the ratio of monocytes: lymphocytes and risk of tuberculosis(TB) amongst HIV infected postpartum women. Journal of acquired immune deficiency syndromes (1999). ISSN 1525-4135 DOI: https://doi.org/10.1097/QAI.0000000000000353

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Abstract

SUMMARY Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte:lymphocyte(ML) ratio and tuberculosis(TB) disease. To evaluate generalizability of this finding, we modelled the association between peripartum ML ratio and incident TB disease within 18 months postpartum amongst 1202 HIV-infected women in South Africa, Tanzania, Uganda and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral-therapy(cART), WHO stage or CD4 count(HRadjusted=1.22;95%CI 1.07-1.4;p=0.003 per 0.1 unit increase in ML ratio).

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 25247435
Web of Science ID: 344772300021
URI: http://researchonline.lshtm.ac.uk/id/eprint/1954718

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