Items where Author is "Horn, D"
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Number of items: 59.
2014
Glover, L;
Alsford, S;
Baker, N;
Turner, DJ;
Sanchez-Flores, A;
Hutchinson, S;
Hertz-Fowler, C;
Berriman, M;
Horn, D;
(2014)
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes.
Nature protocols, 10 (1).
pp. 106-133.
ISSN 1754-2189
DOI: https://doi.org/10.1038/nprot.2015.005
Full text not available from this repository.
2013
Alsford, S;
Field, MC;
Horn, D;
(2013)
Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.
Trends in parasitology.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2013.03.004
Full text not available from this repository.
Alsford, S;
Kelly, JM;
Baker, N;
Horn, D;
(2013)
Genetic dissection of drug resistance in trypanosomes.
Parasitology.
pp. 1-14.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S003118201300022X
Baker, N;
de Koning, HP;
Mäser, P;
Horn, D;
(2013)
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.
Trends in parasitology.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2012.12.005
Glover, L;
Alsford, S;
Horn, D;
(2013)
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in african trypanosomes.
PLoS pathogens, 9 (3).
e1003260.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1003260
Glover, L;
Hutchinson, S;
Alsford, S;
McCulloch, R;
Field, MC;
Horn, D;
(2013)
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.
Cellular microbiology, 15 (12).
pp. 1984-93.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12215
Full text not available from this repository.
Gould, MK;
Bachmaier, S;
Ali, JA;
Alsford, S;
Tagoe, DN;
Munday, JC;
Schnaufer, AC;
Horn, D;
Boshart, M;
de Koning, HP;
(2013)
Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA.
Antimicrobial agents and chemotherapy, 57 (10).
pp. 4882-93.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00508-13
Horn, D;
(2013)
High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes.
Parasitology.
pp. 1-6.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182013000243
2012
Alsford, S;
Dubois, K;
Horn, D;
Field, MC;
(2012)
Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.
Expert reviews in molecular medicine, 14.
e13.
ISSN 1462-3994
DOI: https://doi.org/10.1017/erm.2012.7
Full text not available from this repository.
Alsford, S;
Eckert, S;
Baker, N;
Glover, L;
Sanchez-Flores, A;
Leung, KF;
Turner, DJ;
Field, MC;
Berriman, M;
Horn, D;
(2012)
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature, 482 (7384).
pp. 232-6.
ISSN 0028-0836
DOI: https://doi.org/10.1038/nature10771
Alsford, S;
Horn, D;
(2012)
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.
Nucleic acids research, 40 (20).
pp. 10150-60.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gks813
Baker, N;
Glover, L;
Munday, JC;
Aguinaga Andrés, D;
Barrett, MP;
de Koning, HP;
Horn, D;
(2012)
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1202885109
Full text not available from this repository.
DuBois, KN;
Alsford, S;
Holden, JM;
Buisson, J;
Swiderski, M;
Bart, JM;
Ratushny, AV;
Wan, Y;
Bastin, P;
Barry, JD;
+5 more...
Navarro, M;
Horn, D;
Aitchison, JD;
Rout, MP;
Field, MC;
(2012)
NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions.
PLoS biology, 10 (3).
e1001287.
ISSN 1544-9173
DOI: https://doi.org/10.1371/journal.pbio.1001287
Field, MC;
Horn, D;
Alsford, S;
Koreny, L;
Rout, MP;
(2012)
Telomeres, tethers and trypanosomes.
Nucleus (Austin, Tex), 3 (6).
pp. 478-486.
ISSN 1949-1034
DOI: https://doi.org/10.4161/nucl.22167
Glover, L;
Horn, D;
(2012)
Trypanosomal histone ?H2A and the DNA damage response.
Molecular and biochemical parasitology.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2012.01.008
Kelly, JM;
Taylor, MC;
Horn, D;
Loza, E;
Kalvinsh, I;
Björkling, F;
(2012)
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorganic & medicinal chemistry letters, 22 (5).
pp. 1886-90.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2012.01.072
2011
Alsford, S;
Horn, D;
(2011)
Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes.
Molecular and cellular biology, 31 (9).
pp. 1822-32.
ISSN 0270-7306
DOI: https://doi.org/10.1128/MCB.01026-10
Alsford, S;
Turner, DJ;
Obado, SO;
Sanchez-Flores, A;
Glover, L;
Berriman, M;
Hertz-Fowler, C;
Horn, D;
(2011)
High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.
Genome research, 21 (6).
pp. 915-24.
ISSN 1088-9051
DOI: https://doi.org/10.1101/gr.115089.110
2010
Alsford, S;
Kemp, LE;
Kawahara, T;
Horn, D;
(2010)
RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.
Molecular and biochemical parasitology, 174 (1).
pp. 70-3.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2010.06.006
Baker, N;
Alsford, S;
Horn, D;
(2010)
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Molecular and biochemical parasitology.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2010.11.010
Glover, L;
Jun, J;
Horn, D;
(2010)
Microhomology-mediated deletion and gene conversion in African trypanosomes.
Nucleic acids research.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkq981
Horn, D;
McCulloch, R;
(2010)
Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.
Current opinion in microbiology.
ISSN 1369-5274
DOI: https://doi.org/10.1016/j.mib.2010.08.009
Wang, QP;
Kawahara, T;
Horn, D;
(2010)
Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.
Molecular microbiology, 77 (5).
pp. 1237-45.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2010.07284.x
2009
Alsford, S;
Horn, D;
Glover, L;
(2009)
DNA breaks as triggers for antigenic variation in African trypanosomes.
Genome biology, 10 (6).
p. 223.
ISSN 1465-6906
DOI: https://doi.org/10.1186/gb-2009-10-6-223
Glover, L;
Horn, D;
(2009)
Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei.
Molecular and biochemical parasitology, 166 (2).
pp. 194-7.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2009.03.010
Horn, D;
(2009)
Antigenic variation: extending the reach of telomeric silencing.
Current biology, 19 (12).
R496-8.
ISSN 0960-9822
DOI: https://doi.org/10.1016/j.cub.2009.04.049
Full text not available from this repository.
2008
Alsford, S;
Horn, D;
(2008)
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei.
Molecular and biochemical parasitology, 161 (1).
pp. 76-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2008.05.006
Field, MC;
Horn, D;
Carrington, M;
(2008)
Analysis of small GTPase function in trypanosomes.
In: Balch, WE; Der, CJ; Hall, A, (eds.)
Small GTPases in Disease, Part A.
Elsevier Academic Press Inc, San Diego, pp. 57-76.
ISBN 9780123739681
DOI: https://doi.org/10.1016/S0076-6879(07)38005-1
Full text not available from this repository.
Glover, L;
McCulloch, R;
Horn, D;
(2008)
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes.
Nucleic acids research, 36 (8).
pp. 2608-18.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkn104
Horn, D;
(2008)
Histone deacetylases.
Advances in experimental medicine and biology, 625.
pp. 81-6.
ISSN 0065-2598
http://researchonline.lshtm.ac.uk/id/eprint/8082
Full text not available from this repository.
Horn, D;
(2008)
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids.
BMC genomics, 9.
p. 2.
ISSN 1471-2164
DOI: https://doi.org/10.1186/1471-2164-9-2
Kawahara, T;
Siegel, TN;
Ingram, AK;
Alsford, S;
Cross, GA;
Horn, D;
(2008)
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
Molecular microbiology, 69 (4).
pp. 1054-68.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2008.06346.x
Siegel, TN;
Kawahara, T;
Degrasse, JA;
Janzen, CJ;
Horn, D;
Cross, GAM;
(2008)
Acetylation of histone H4K4 is cell cycle regulated and mediated by HAD in Trypanosoma brucei.
Molecular microbiology, 67 (4).
pp. 762-771.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2007.06079.x
Wilkinson, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
Cheeseman, I;
(2008)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America, 105 (13).
pp. 5022-7.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0711014105
Full text not available from this repository.
2007
Alsford, S;
Horn, D;
(2007)
RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.
Molecular and biochemical parasitology, 153 (1).
pp. 77-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2007.01.013
Alsford, S;
Kawahara, T;
Isamah, C;
Horn, D;
(2007)
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.
Molecular microbiology, 63 (3).
pp. 724-36.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2006.05553.x
Glover, L;
Alsford, S;
Beattie, C;
Horn, D;
(2007)
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.
Nucleic acids research, 35 (3).
pp. 872-80.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkl1100
Horn, D;
(2007)
Introducing histone modification in trypanosomes.
Trends in parasitology, 23 (6).
pp. 239-42.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2007.03.009
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-758.
ISSN 0066-4804
DOI: https://doi.org/10.1128/aac.01360-06
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-8.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.01360-06
Full text not available from this repository.
Renauld, H;
Kelly, JM;
Horn, D;
(2007)
Chromosome structure and dynamics.
In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.)
Trypanosomes - After the Genome.
Horizon Scientific Press, Norwich, UK., pp. 91-132.
http://researchonline.lshtm.ac.uk/id/eprint/11566
Full text not available from this repository.
2006
Glover, L;
Horn, D;
(2006)
Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres.
EMBO reports, 7 (1).
pp. 93-9.
ISSN 1469-221X
DOI: https://doi.org/10.1038/sj.embor.7400575
Full text not available from this repository.
Subramaniam, C;
Veazey, P;
Seth, R;
Hayes-Sinclair, J;
Chambers, E;
Carrington, M;
Gull, K;
Matthews, K;
Horn, D;
Field, MC;
(2006)
Chromosome-wide analysis of gene function by RNA interference in the African trypanosome.
Eukaryotic cell, 5 (9).
pp. 1539-1549.
ISSN 1535-9778
DOI: https://doi.org/10.1128/EC.00141-06
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Ahmed, A;
Horn, D;
Kelly, JM;
(2006)
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
Free radical biology & medicine, 40 (2).
pp. 198-209.
ISSN 0891-5849
DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022
Full text not available from this repository.
2005
Alibu, VP;
Storm, L;
Haile, S;
Clayton, C;
Horn, D;
(2005)
A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei.
Molecular and biochemical parasitology.
p. 75.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2004.10.002
Full text not available from this repository.
Alsford, S;
Glover, L;
Horn, D;
(2005)
Multiplex analysis of RNA interference defects in Trypanosoma brucei.
Molecular and biochemical parasitology, 139 (1).
pp. 129-32.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2004.11.001
Alsford, S;
Kawahara, T;
Glover, L;
Horn, D;
(2005)
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.
Molecular and biochemical parasitology, 144 (2).
pp. 142-8.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.08.009
Clayton, CE;
Esteacutevez, AM;
Hartmann, C;
Alibu, VP;
Field, M;
Horn, D;
(2005)
Down-regulating gene expression by RNA interference in Trypanosoma brucei.
Methods in molecular biology (Clifton, NJ), 309.
pp. 39-60.
ISSN 1064-3745
DOI: https://doi.org/10.1385/1-59259-935-4:039
Full text not available from this repository.
Horn, D;
(2005)
Directional enrichment of directly cloned PCR products.
BioTechniques, 39 (1).
40, 42, 44, 46.
ISSN 0736-6205
DOI: https://doi.org/10.2144/05391BM03
Full text not available from this repository.
Horn, D;
Barry, JD;
(2005)
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.
Chromosome research, 13 (5).
pp. 525-33.
ISSN 0967-3849
DOI: https://doi.org/10.1007/s10577-005-0991-8
Full text not available from this repository.
Ivens, AC;
Peacock, CS;
Worthey, EA;
Murphy, L;
Aggarwal, G;
Berriman, M;
Sisk, E;
Rajandream, MA;
Adlem, E;
Aert, R;
+90 more...
Anupama, A;
Apostolou, Z;
Attipoe, P;
Bason, N;
Bauser, C;
Beck, A;
Beverley, SM;
Bianchettin, G;
Borzym, K;
Bothe, G;
Bruschi, CV;
Collins, M;
Cadag, E;
Ciarloni, L;
Clayton, C;
Coulson, RMR;
Cronin, A;
Cruz, AK;
Davies, RM;
de Gaudenzi, J;
Dobson, DE;
Duesterhoeft, A;
Fazelina, G;
Fosker, N;
Frasch, AC;
Fraser, A;
Fuchs, M;
Gabel, C;
Goble, A;
Goffeau, A;
Harris, D;
Hertz-Fowler, C;
Hilbert, H;
Horn, D;
Huang, YT;
Klages, S;
Knights, A;
Kube, M;
Larke, N;
Litvin, L;
Lord, A;
Louie, T;
Marra, M;
Masuy, D;
Matthews, K;
Michaeli, S;
Mottram, JC;
Muller-Auer, S;
Munden, H;
Norbertczak, H;
Oliver, K;
O'Neil, S;
Pentony, M;
Pohl, TM;
Price, C;
Purnelle, B;
Quail, MA;
Rabbinowitsch, E;
Reinhardt, R;
Rieger, M;
Rinta, J;
Robben, J;
Robertson, L;
Ruiz, JC;
Rutter, S;
Saunders, D;
Schafer, M;
Schein, J;
Schwartz, DC;
Seeger, K;
Seyler, A;
Sharp, S;
Shin, H;
Sivam, D;
Squares, R;
Squares, S;
Tosato, V;
Vogt, C;
Volckaert, G;
Wambutt, R;
Warren, T;
Wedler, H;
Woodward, J;
Zhou, SG;
Zimmermann, W;
Smith, DF;
Blackwell, JM;
Stuart, KD;
Barrell, B;
Myler, PJ;
(2005)
The genome of the kinetoplastid parasite, Leishmania major.
Science (New York, NY), 309 (5733).
p. 436.
ISSN 0036-8075
DOI: https://doi.org/10.1126/science.1112680
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
(2005)
Vitamin C biosynthesis in trypanosomes: A role for the glycosome.
Proceedings of the National Academy of Sciences of the United States of America, 102.
pp. 11645-11650.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0504251102
Full text not available from this repository.
el-Sayed, NM;
Myler, PJ;
Bartholomeu, DC;
Nilsson, D;
Aggarwal, G;
Tran, AN;
Ghedin, E;
Worthey, EA;
Delcher, AL;
Blandin, G;
+72 more...
Westenberger, SJ;
Caler, E;
Cerqueira, GC;
Branche, C;
Haas, B;
Anupama, A;
Arner, E;
Aslund, L;
Attipoe, P;
Bontempi, E;
Bringaud, F;
Burton, P;
Cadag, E;
Campbell, DA;
Carrington, M;
Crabtree, J;
Darban, H;
da Silveira, JF;
de Jong, P;
Edwards, K;
Englund, PT;
Fazelina, G;
Feldblyum, T;
Ferella, M;
Frasch, AC;
Gull, K;
Horn, D;
Hou, LH;
Huang, YT;
Kindlund, E;
Ktingbeil, M;
Kluge, S;
Koo, H;
Lacerda, D;
Levin, MJ;
Lorenzi, H;
Louie, T;
Machado, CR;
McCulloch, R;
McKenna, A;
Mizuno, Y;
Mottram, JC;
Nelson, S;
Ochaya, S;
Osoegawa, K;
Pai, G;
Parsons, M;
Pentony, M;
Pettersson, U;
Pop, M;
Ramirez, JL;
Rinta, J;
Robertson, L;
Salzberg, SL;
Sanchez, DO;
Seyler, A;
Sharma, R;
Shetty, J;
Simpson, AJ;
Sisk, E;
Tammi, MT;
Tarteton, R;
Teixeira, S;
van Aken, S;
Vogt, C;
Ward, PN;
Wickstead, B;
Wortman, J;
White, O;
Fraser, CM;
Stuart, KD;
Andersson, B;
(2005)
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
Science (New York, NY), 309 (5733).
p. 409.
ISSN 0036-8075
DOI: https://doi.org/10.1126/science.1112631
Full text not available from this repository.
2004
Alsford, S;
Horn, D;
(2004)
Trypanosomatid histones.
Molecular microbiology, 53 (2).
pp. 365-72.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2004.04151.x
Full text not available from this repository.
Horn, D;
(2004)
The molecular control of antigenic variation in Trypanosoma brucei.
Current molecular medicine, 4 (6).
pp. 563-76.
ISSN 1566-5240
DOI: https://doi.org/10.2174/1566524043360078
Full text not available from this repository.
2003
Wilkinson, SR;
Horn, D;
Prathalingam, R;
Kelly, JM;
(2003)
RNAi identifies two hydroperoxide metabolising enzymes that are essential to the bloodstream form of the African trypanosome.
The Journal of biological chemistry, 278 (34).
pp. 31640-6.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M303035200
Full text not available from this repository.
2002
Ingram, AK;
Horn, D;
(2002)
Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression.
Molecular microbiology, 45 (1).
pp. 89-97.
ISSN 0950-382X
DOI: https://doi.org/10.1046/j.1365-2958.2002.03018.x
Full text not available from this repository.
2001
Horn, D;
(2001)
Nuclear gene transcription and chromatin in Trypanosoma brucei.
International journal for parasitology, 31 (11).
pp. 1157-65.
ISSN 0020-7519
http://researchonline.lshtm.ac.uk/id/eprint/17258
Full text not available from this repository.