The genome of the kinetoplastid parasite, Leishmania major
Ivens, AC; Peacock, CS; Worthey, EA; Murphy, L; Aggarwal, G; Berriman, M; Sisk, E; Rajandream, MA; Adlem, E; Aert, R; Anupama, A; Apostolou, Z; Attipoe, P; Bason, N; Bauser, C; Beck, A; Beverley, SM; Bianchettin, G; Borzym, K; Bothe, G; Bruschi, CV; Collins, M; Cadag, E; Ciarloni, L; Clayton, C; Coulson, RMR; Cronin, A; Cruz, AK; Davies, RM; de Gaudenzi, J; Dobson, DE; Duesterhoeft, A; Fazelina, G; Fosker, N; Frasch, AC; Fraser, A; Fuchs, M; Gabel, C; Goble, A; Goffeau, A; Harris, D; Hertz-Fowler, C; Hilbert, H; Horn, D; Huang, YT; Klages, S; Knights, A; Kube, M; Larke, N; Litvin, L; Lord, A; Louie, T; Marra, M; Masuy, D; Matthews, K; Michaeli, S; Mottram, JC; Muller-Auer, S; Munden, H; Norbertczak, H; Oliver, K; O'Neil, S; Pentony, M; Pohl, TM; Price, C; Purnelle, B; Quail, MA; Rabbinowitsch, E; Reinhardt, R; Rieger, M; Rinta, J; Robben, J; Robertson, L; Ruiz, JC; Rutter, S; Saunders, D; Schafer, M; Schein, J; Schwartz, DC; Seeger, K; Seyler, A; Sharp, S; Shin, H; Sivam, D; Squares, R; Squares, S; Tosato, V; Vogt, C; Volckaert, G; Wambutt, R; Warren, T; Wedler, H; Woodward, J; Zhou, SG; Zimmermann, W; Smith, DF; Blackwell, JM; Stuart, KD; Barrell, B; Myler, PJ; (2005) The genome of the kinetoplastid parasite, Leishmania major. Science (New York, NY), 309 (5733). p. 436. ISSN 0036-8075 DOI: 10.1126/science.1112680Full text not available from this repository.
Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
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