Histone deacetylases.


Horn, D; (2008) Histone deacetylases. Advances in experimental medicine and biology, 625. pp. 81-6. ISSN 0065-2598

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Abstract

Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 18365660
Web of Science ID: 253022600007
URI: http://researchonline.lshtm.ac.uk/id/eprint/8082

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