DNA breaks as triggers for antigenic variation in African trypanosomes.


Alsford, S; Horn, D; Glover, L; (2009) DNA breaks as triggers for antigenic variation in African trypanosomes. Genome biology, 10 (6). p. 223. ISSN 1465-6906 DOI: https://doi.org/10.1186/gb-2009-10-6-223

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Abstract

ABSTRACT: The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 19519956
Web of Science ID: 267604300004
URI: http://researchonline.lshtm.ac.uk/id/eprint/5272

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