Nuclear gene transcription and chromatin in Trypanosoma brucei


Horn, D; (2001) Nuclear gene transcription and chromatin in Trypanosoma brucei. International journal for parasitology, 31 (11). pp. 1157-65. ISSN 0020-7519

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Abstract

As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells. Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins.

Item Type: Article
Keywords: Amino Acid Sequence, Animal, Chromatin/*genetics, DNA-Directed RNA Polymerases/physiology, Gene Expression Regulation, Histones/chemistry/genetics, Molecular Sequence Data, Promoter Regions (Genetics)/physiology, Support, Non-U.S. Gov't, Transcription Factors/physiology, *Transcription, Genetic, Trypanosoma brucei brucei/*genetics, Trypanosomiasis/parasitology, Variant Surface Glycoproteins, Trypanosoma/*genetics, Amino Acid Sequence, Animal, Chromatin, genetics, DNA-Directed RNA Polymerase, physiology, Gene Expression Regulation, Histones, chemistry, genetics, Molecular Sequence Data, Promoter Regions (Genetics), physiology, Support, Non-U.S. Gov't, Transcription Factors, physiology, Transcription, Genetic, Trypanosoma brucei brucei, genetics, Trypanosomiasis, parasitology, Variant Surface Glycoproteins, Trypanosoma, genetics
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 11513885
Web of Science ID: 170803600001
URI: http://researchonline.lshtm.ac.uk/id/eprint/17258

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