Items where Author is "Alsford, S"
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Article
Alsford, NS;
Navarro, M;
Jamnadass, HR;
Dunbar, H;
Ackroyd, M;
Murphy, NB;
Gull, K;
Ersfeld, K;
(2003)
The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei.
Molecular microbiology, 47 (2).
pp. 277-89.
ISSN 0950-382X
DOI: https://doi.org/10.1046/j.1365-2958.2003.03266.x
Full text not available from this repository.
Alsford, S;
(2015)
Subverting lysosomal function in Trypanosoma brucei.
Microbial cell (Graz, Austria), 2 (8).
pp. 259-261.
ISSN 2311-2638
DOI: https://doi.org/10.15698/mic2015.08.222
Alsford, S;
(2014)
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis.
Microbial cell (Graz, Austria), 1 (8).
pp. 270-272.
ISSN 2311-2638
DOI: https://doi.org/10.15698/mic2014.08.162
Alsford, S;
Currier, RB;
Guerra-Assunção, JA;
Clark, TG;
Horn, D;
(2014)
Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei.
PLoS pathogens, 10 (5).
e1004130.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1004130
Alsford, S;
Dubois, K;
Horn, D;
Field, MC;
(2012)
Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.
Expert reviews in molecular medicine, 14.
e13.
ISSN 1462-3994
DOI: https://doi.org/10.1017/erm.2012.7
Full text not available from this repository.
Alsford, S;
Eckert, S;
Baker, N;
Glover, L;
Sanchez-Flores, A;
Leung, KF;
Turner, DJ;
Field, MC;
Berriman, M;
Horn, D;
(2012)
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature, 482 (7384).
pp. 232-6.
ISSN 0028-0836
DOI: https://doi.org/10.1038/nature10771
Alsford, S;
Field, MC;
Horn, D;
(2013)
Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.
Trends in parasitology.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2013.03.004
Full text not available from this repository.
Alsford, S;
Glover, L;
Horn, D;
(2005)
Multiplex analysis of RNA interference defects in Trypanosoma brucei.
Molecular and biochemical parasitology, 139 (1).
pp. 129-32.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2004.11.001
Alsford, S;
Horn, D;
(2011)
Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes.
Molecular and cellular biology, 31 (9).
pp. 1822-32.
ISSN 0270-7306
DOI: https://doi.org/10.1128/MCB.01026-10
Alsford, S;
Horn, D;
(2008)
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei.
Molecular and biochemical parasitology, 161 (1).
pp. 76-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2008.05.006
Alsford, S;
Horn, D;
(2007)
RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.
Molecular and biochemical parasitology, 153 (1).
pp. 77-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2007.01.013
Alsford, S;
Horn, D;
(2004)
Trypanosomatid histones.
Molecular microbiology, 53 (2).
pp. 365-72.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2004.04151.x
Full text not available from this repository.
Alsford, S;
Horn, D;
(2012)
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.
Nucleic acids research, 40 (20).
pp. 10150-60.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gks813
Alsford, S;
Horn, D;
Glover, L;
(2009)
DNA breaks as triggers for antigenic variation in African trypanosomes.
Genome biology, 10 (6).
p. 223.
ISSN 1465-6906
DOI: https://doi.org/10.1186/gb-2009-10-6-223
Alsford, S;
Kawahara, T;
Glover, L;
Horn, D;
(2005)
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.
Molecular and biochemical parasitology, 144 (2).
pp. 142-8.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.08.009
Alsford, S;
Kawahara, T;
Isamah, C;
Horn, D;
(2007)
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.
Molecular microbiology, 63 (3).
pp. 724-36.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2006.05553.x
Alsford, S;
Kelly, JM;
Baker, N;
Horn, D;
(2013)
Genetic dissection of drug resistance in trypanosomes.
Parasitology.
pp. 1-14.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S003118201300022X
Alsford, S;
Kemp, LE;
Kawahara, T;
Horn, D;
(2010)
RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.
Molecular and biochemical parasitology, 174 (1).
pp. 70-3.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2010.06.006
Alsford, S;
Turner, DJ;
Obado, SO;
Sanchez-Flores, A;
Glover, L;
Berriman, M;
Hertz-Fowler, C;
Horn, D;
(2011)
High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.
Genome research, 21 (6).
pp. 915-24.
ISSN 1088-9051
DOI: https://doi.org/10.1101/gr.115089.110
Alsford, S;
Wickstead, B;
Ersfeld, K;
Gull, K;
(2001)
Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei.
Molecular and biochemical parasitology, 113 (1).
pp. 79-88.
ISSN 0166-6851
DOI: https://doi.org/10.1016/S0166-6851(00)00388-1
Full text not available from this repository.
Baker, N;
Alsford, S;
Horn, D;
(2010)
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Molecular and biochemical parasitology.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2010.11.010
Currier, RB;
Cooper, A;
Burrell-Saward, H;
MacLeod, A;
Alsford, S;
(2018)
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.
PLoS pathogens, 14 (1).
e1006855.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1006855
DuBois, KN;
Alsford, S;
Holden, JM;
Buisson, J;
Swiderski, M;
Bart, JM;
Ratushny, AV;
Wan, Y;
Bastin, P;
Barry, JD;
+5 more...
Navarro, M;
Horn, D;
Aitchison, JD;
Rout, MP;
Field, MC;
(2012)
NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions.
PLoS biology, 10 (3).
e1001287.
ISSN 1544-9173
DOI: https://doi.org/10.1371/journal.pbio.1001287
Field, MC;
Horn, D;
Alsford, S;
Koreny, L;
Rout, MP;
(2012)
Telomeres, tethers and trypanosomes.
Nucleus (Austin, Tex), 3 (6).
pp. 478-486.
ISSN 1949-1034
DOI: https://doi.org/10.4161/nucl.22167
Glover, L;
Alsford, S;
Baker, N;
Turner, DJ;
Sanchez-Flores, A;
Hutchinson, S;
Hertz-Fowler, C;
Berriman, M;
Horn, D;
(2014)
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes.
Nature protocols, 10 (1).
pp. 106-133.
ISSN 1754-2189
DOI: https://doi.org/10.1038/nprot.2015.005
Full text not available from this repository.
Glover, L;
Alsford, S;
Beattie, C;
Horn, D;
(2007)
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.
Nucleic acids research, 35 (3).
pp. 872-80.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkl1100
Glover, L;
Alsford, S;
Horn, D;
(2013)
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in african trypanosomes.
PLoS pathogens, 9 (3).
e1003260.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1003260
Glover, L;
Hutchinson, S;
Alsford, S;
Horn, D;
(2016)
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1600344113
Glover, L;
Hutchinson, S;
Alsford, S;
McCulloch, R;
Field, MC;
Horn, D;
(2013)
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.
Cellular microbiology, 15 (12).
pp. 1984-93.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12215
Full text not available from this repository.
Gould, MK;
Bachmaier, S;
Ali, JA;
Alsford, S;
Tagoe, DN;
Munday, JC;
Schnaufer, AC;
Horn, D;
Boshart, M;
de Koning, HP;
(2013)
Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA.
Antimicrobial agents and chemotherapy, 57 (10).
pp. 4882-93.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00508-13
Kawahara, T;
Siegel, TN;
Ingram, AK;
Alsford, S;
Cross, GA;
Horn, D;
(2008)
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
Molecular microbiology, 69 (4).
pp. 1054-68.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2008.06346.x
Macedo, JP;
Currier, RB;
Wirdnam, C;
Horn, D;
Alsford, S;
Rentsch, D;
(2017)
Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.
FASEB journal.
ISSN 0892-6638
DOI: https://doi.org/10.1096/fj.201700311R
Maishman, L;
Obado, SO;
Alsford, S;
Bart, JM;
Chen, WM;
Ratushny, AV;
Navarro, M;
Horn, D;
Aitchison, JD;
Chait, BT;
+2 more...
Rout, MP;
Field, MC;
(2016)
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.
Nucleic acids research.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkw751
Meredith, EL;
Kumar, A;
Konno, A;
Szular, J;
Alsford, S;
Seifert, K;
Horn, D;
Wilkinson, SR;
(2017)
Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.
Molecular microbiology.
ISSN 0950-382X
DOI: https://doi.org/10.1111/mmi.13767
Stortz, JA;
Serafim, TD;
Alsford, S;
Wilkes, J;
Fernandez-Cortes, F;
Hamilton, G;
Briggs, E;
Lemgruber, L;
Horn, D;
Mottram, JC;
+1 more...
McCulloch, R;
(2017)
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.
PLoS pathogens, 13 (7).
e1006477.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1006477
Thomas, James;
Baker, Nicola;
Hutchinson, Sebastian;
Dominicus, Caia;
Trenaman, Anna;
Glover, Lucy;
Alsford, Sam;
Horn, David;
(2018)
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
PLOS NEGLECTED TROPICAL DISEASES, 12 (11).
ISSN 1935-2735
DOI: https://doi.org/10.1371/journal.pntd.0006980
Zoltner, M;
Leung, KF;
Alsford, S;
Horn, D;
Field, MC;
(2015)
Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.
PLoS pathogens, 11 (10).
e1005236.
ISSN 1553-7366
DOI: https://doi.org/10.1371/journal.ppat.1005236