Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis


Alsford, S; (2014) Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. Microbial Cell, 1 (8). pp. 270-272. ISSN 2311-2638 DOI: https://doi.org/10.15698/mic2014.08.162

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Abstract

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum’s trypanolytic action.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
URI: http://researchonline.lshtm.ac.uk/id/eprint/2551635

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