Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Georgiadis, M; Kourbeli, V; Ioannidou, V; Karakitsios, E; Papanastasiou, I; Tsotinis, A; Komiotis, D; Vocat, A; Cole, ST; Taylor, MC
; +1 more...Kelly, JM and
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2019.04.010
; +1 more...Kelly, JM and
(2019)
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.
Bioorganic & medicinal chemistry letters, 29 (11).
pp. 1278-1281.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2019.04.010
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.
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picture_as_pdf - Synthesis.pdf
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subject - Accepted Version
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- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0
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