Afolabi, Muhammed O; Bojang, Kalifa; D'Alessandro, Umberto; Ota, Martin OC; Imoukhuede, Egeruan B; Ravinetto, Raffaella; Larson, Heidi J; McGrath, Nuala; Chandramohan, Daniel; (2014) Digitised audio questionnaire for assessment of informed consent comprehension in a low-literacy African research population: development and psychometric evaluation. BMJ open, 4 (6). e004817-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2014-004817

Afolabi, Muhammed Olanrewaju; Bojang, Kalifa; D'Alessandro, Umberto; Imoukhuede, Egeruan Babatunde; Ravinetto, Raffaella M; Larson, Heidi Jane; McGrath, Nuala; Chandramohan, Daniel; (2014) Multimedia Informed Consent Tool for a Low Literacy African Research Population: Development and Pilot-Testing. Journal of clinical research & bioethics, 5 (3). 178-. ISSN 2155-9627 DOI: https://doi.org/10.4172/2155-9627.1000178

Baraka, Vito; Tinto, Halidou; Valea, Innocent; Fitzhenry, Robert; Delgado-Ratto, Christopher; Mbonye, Martin K; Van Overmeir, Chantal; Rosanas-Urgell, Anna; Van Geertruyden, Jean-Pierre; D'Alessandro, Umberto; +1 more... Erhart, Annette; (2014) In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso. Antimicrobial agents and chemotherapy, 59 (1). pp. 734-737. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.03647-14 Full text not available from this repository.

Delgado-Ratto, Christopher; Soto-Calle, Veronica E; Van den Eede, Peter; Gamboa, Dionicia; Rosas, Angel; Abatih, Emmanuel N; Rodriguez Ferrucci, Hugo; Llanos-Cuentas, Alejandro; Van Geertruyden, Jean-Pierre; Erhart, Annette; +1 more... D'Alessandro, Umberto; (2014) Population structure and spatio-temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon. MALARIA JOURNAL, 13 (1). 8-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-8

Dial, Natalie J; Ceesay, Serign J; Gosling, Roly D; D'Alessandro, Umberto; Baltzell, Kimberly A; (2014) A qualitative study to assess community barriers to malaria mass drug administration trials in The Gambia. MALARIA JOURNAL, 13 (1). 47-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-47

Jasseh, Momodou; Howie, Stephen RC; Gomez, Pierre; Scott, Susana; Roca, Anna; Cham, Mamady; Greenwood, Brian; Corrah, Tumani; D'Alessandro, Umberto; (2014) Disease-specific mortality burdens in a rural Gambian population using verbal autopsy, 1998-2007. Global health action, 7 (1). 25598-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25598

Kajungu, Dan K; Erhart, Annette; Talisuna, Ambrose Otau; Bassat, Quique; Karema, Corine; Nabasumba, Carolyn; Nambozi, Michael; Tinto, Halidou; Kremsner, Peter; Meremikwu, Martin; +2 more... D'Alessandro, Umberto; Speybroeck, Niko; (2014) Paediatric pharmacovigilance: use of pharmacovigilance data mining algorithms for signal detection in a safety dataset of a paediatric clinical study conducted in seven African countries. PLOS ONE, 9 (5). e96388-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0096388

Livio, Sofie; Strockbine, Nancy A; Panchalingam, Sandra; Tennant, Sharon M; Barry, Eileen M; Marohn, Mark E; Antonio, Martin; Hossain, Anowar; Mandomando, Inacio; Ochieng, John B; +26 more... Oundo, Joseph O; Qureshi, Shahida; Ramamurthy, Thandavarayan; Tamboura, Boubou; Adegbola, Richard A; Hossain, Mohammed Jahangir; Saha, Debasish; Sen, Sunil; Faruque, Abu Syed Golam; Alonso, Pedro L; Breiman, Robert F; Zaidi, Anita KM; Sur, Dipika; Sow, Samba O; Berkeley, Lynette Y; O'Reilly, Ciara E; Mintz, Eric D; Biswas, Kousick; Cohen, Dani; Farag, Tamer H; Nasrin, Dilruba; Wu, Yukun; Blackwelder, William C; Kotloff, Karen L; Nataro, James P; Levine, Myron M; (2014) Shigella isolates from the global enteric multicenter study inform vaccine development. CLINICAL INFECTIOUS DISEASES, 59 (7). pp. 933-941. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/ciu468

Nambozi, Michael; Malunga, Phidelis; Mulenga, Modest; Van Geertruyden, Jean-Pierre; D'Alessandro, Umberto; (2014) Defining the malaria burden in Nchelenge District, northern Zambia using the World Health Organization malaria indicators survey. MALARIA JOURNAL, 13 (1). 220-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-220

Noulin, Florian; Manesia, Javed Karim; Rosanas-Urgell, Anna; Erhart, Annette; Borlon, Céline; Van Den Abbeele, Jan; d'Alessandro, Umberto; Verfaillie, Catherine M; (2014) Hematopoietic stem/progenitor cell sources to generate reticulocytes for Plasmodium vivax culture. PLOS ONE, 9 (11). e112496-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0112496

Okebe, Joseph; Affara, Muna; Correa, Simon; Muhammad, Abdul Khalie; Nwakanma, Davis; Drakeley, Chris; D'Alessandro, Umberto; (2014) School-based countrywide seroprevalence survey reveals spatial heterogeneity in malaria transmission in the Gambia. PloS one, 9 (10). e110926-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0110926

Okebe, Joseph; Amambua-Ngwa, Alfred; Parr, Jason; Nishimura, Sei; Daswani, Melissa; Takem, Ebako N; Affara, Muna; Ceesay, Serign J; Nwakanma, Davis; D'Alessandro, Umberto; (2014) The prevalence of glucose-6-phosphate dehydrogenase deficiency in Gambian school children. MALARIA JOURNAL, 13 (1). 148-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-148

Okell, Lucy C; Cairns, Matthew; Griffin, Jamie T; Ferguson, Neil M; Tarning, Joel; Jagoe, George; Hugo, Pierre; Baker, Mark; D'Alessandro, Umberto; Bousema, Teun; +2 more... Ubben, David; Ghani, Azra C; (2014) Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis. Nature communications, 5 (1). 5606-. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms6606

Payne, Sarah; Townend, John; Jasseh, Momodou; Lowe Jallow, Yamundow; Kampmann, Beate; (2014) Achieving comprehensive childhood immunization: an analysis of obstacles and opportunities in The Gambia. HEALTH POLICY AND PLANNING, 29 (2). pp. 193-203. ISSN 0268-1080 DOI: https://doi.org/10.1093/heapol/czt004

Peeters Grietens, Koen; Ribera, Joan Muela; Erhart, Annette; Hoibak, Sarah; Ravinetto, Raffaella M; Gryseels, Charlotte; Dierickx, Susan; O'Neill, Sarah; Muela, Susanna Hausmann; D'Alessandro, Umberto; (2014) Doctors and vampires in sub-Saharan Africa: ethical challenges in clinical trial research. The American journal of tropical medicine and hygiene, 91 (2). pp. 213-215. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.13-0630

Pinder, Margaret; Jawara, Musa; Jarju, Lamin BS; Salami, Kolawole; Jeffries, David; Adiamoh, Majidah; Bojang, Kalifa; Correa, Simon; Kandeh, Balla; Kaur, Harparkash; +3 more... Conway, David J; D'Alessandro, Umberto; Lindsay, Steve W; (2014) Efficacy of indoor residual spraying with dichlorodiphenyltrichloroethane against malaria in Gambian communities with high usage of long-lasting insecticidal mosquito nets: a cluster-randomised controlled trial. Lancet, 385 (9976). pp. 1436-1446. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(14)61007-2 Full text not available from this repository.

Ravinetto, Raffaella M; Afolabi, Muhammed O; Okebe, Joseph; Van Nuil, Jennifer Ilo; Lutumba, Pascal; Mavoko, Hypolite Muhindo; Nahum, Alain; Tinto, Halidou; Addissie, Adamu; D'Alessandro, Umberto; +1 more... Grietens, Koen Peeters; (2014) Participation in medical research as a resource-seeking strategy in socio-economically vulnerable communities: call for research and action. Tropical medicine & international health, 20 (1). pp. 63-66. ISSN 1360-2276 DOI: https://doi.org/10.1111/tmi.12396 Full text not available from this repository.

Sankoh, Osman; Sharrow, David; Herbst, Kobus; Whiteson Kabudula, Chodziwadziwa; Alam, Nurul; Kant, Shashi; Ravn, Henrik; Bhuiya, Abbas; Thi Vui, Le; Darikwa, Timotheus; +24 more... Gyapong, Margaret; Jasseh, Momodou; Chuc Thi Kim, Nguyen; Abdullah, Salim; Crampin, Amelia; Ojal, John; Owusu-Agyei, Seth; Odhiambo, Frank; Urassa, Mark; Streatfield, Kim; Shimada, Masaaki; Sacoor, Charfudin; Beguy, Donatien; Derra, Karim; Wak, George; Delaunay, Valerie; Sie, Ali; Soura, Abdramane; Diallo, Diadier; Wilopo, Siswanto; Masanja, Honorati; Bonfoh, Bassirou; Phuanukoonnon, Suparat; Clark, Samuel J; (2014) The INDEPTH standard population for low- and middle-income countries, 2013. Global health action, 7 (1). 23286-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.23286

Scott, Susana; Mens, Petra F; Tinto, Halidou; Nahum, Alain; Ruizendaal, Esmée; Pagnoni, Franco; Grietens, Koen Peeters; Kendall, Lindsay; Bojang, Kalifa; Schallig, Henk; +1 more... D'Alessandro, Umberto; (2014) Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health in The Gambia, Burkina Faso and Benin: study protocol for a randomized controlled trial. Trials, 15 (1). 340-. ISSN 1745-6215 DOI: https://doi.org/10.1186/1745-6215-15-340

Scott, Susana; Odutola, Aderonke; Mackenzie, Grant; Fulford, Tony; Afolabi, Muhammed O; Lowe Jallow, Yamundow; Jasseh, Momodou; Jeffries, David; Dondeh, Bai Lamin; Howie, Stephen RC; +1 more... D'Alessandro, Umberto; (2014) Coverage and timing of children's vaccination: an evaluation of the expanded programme on immunisation in The Gambia. PloS one, 9 (9). e107280-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0107280

Shimakawa, Yusuke; Lemoine, Maud; Mendy, Maimuna; Njai, Harr Freeya; D'Alessandro, Umberto; Hall, Andrew; Thursz, Mark; Njie, Ramou; (2014) Population-based interventions to reduce the public health burden related with hepatitis B virus infection in the gambia, west Africa. Tropical medicine and health, 42 (2 Supp). pp. 59-64. ISSN 1348-8945 DOI: https://doi.org/10.2149/tmh.2014-S08

Shimakawa, Yusuke; Takao, Yuki; Anderson, Suzanne T; Taal, Makie; Yamaguchi, Takashi; Giana, Lamin; Ndow, Gibril; Sarr, Louise; Kambi, Abubacarr; Njai, Harr Freeya; +8 more... Bottomley, Christian; Nyan, Ousman; Sabally, Saihou; D'Alessandro, Umberto; Taylor-Robinson, Simon D; Thursz, Mark; Lemoine, Maud; Njie, Ramou; (2014) The prevalence and burden of symptoms in patients with chronic liver diseases in The Gambia, West Africa. Palliative medicine, 29 (2). pp. 184-185. ISSN 0269-2163 DOI: https://doi.org/10.1177/0269216314547103 Full text not available from this repository.

Sonko, Sheriff T; Jaiteh, Malanding; Jafali, James; Jarju, Lamin BS; D'Alessandro, Umberto; Camara, Abu; Komma-Bah, Musu; Saho, Alieu; (2014) Does socio-economic status explain the differentials in malaria parasite prevalence? Evidence from The Gambia. MALARIA JOURNAL, 13 (1). 449-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-449

Streatfield, P Kim; Alam, Nurul; Compaoré, Yacouba; Rossier, Clementine; Soura, Abdramane B; Bonfoh, Bassirou; Jaeger, Fabienne; Ngoran, Eliezer K; Utzinger, Juerg; Gomez, Pierre; +34 more... Jasseh, Momodou; Ansah, Akosua; Debpuur, Cornelius; Oduro, Abraham; Williams, John; Addei, Sheila; Gyapong, Margaret; Kukula, Vida A; Bauni, Evasius; Mochamah, George; Ndila, Carolyne; Williams, Thomas N; Desai, Meghna; Moige, Hellen; Odhiambo, Frank O; Ogwang, Sheila; Beguy, Donatien; Ezeh, Alex; Oti, Samuel; Chihana, Menard; Crampin, Amelia; Price, Alison; Delaunay, Valérie; Diallo, Aldiouma; Douillot, Laetitia; Sokhna, Cheikh; Collinson, Mark A; Kahn, Kathleen; Tollman, Stephen M; Herbst, Kobus; Mossong, Joël; Emina, Jacques BO; Sankoh, Osman A; Byass, Peter; (2014) Pregnancy-related mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites. Global health action, 7 (1). 25368-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25368

Streatfield, P Kim; Khan, Wasif A; Bhuiya, Abbas; Alam, Nurul; Sié, Ali; Soura, Abdramane B; Bonfoh, Bassirou; Ngoran, Eliezer K; Weldearegawi, Berhe; Jasseh, Momodou; +18 more... Oduro, Abraham; Gyapong, Margaret; Kant, Shashi; Juvekar, Sanjay; Wilopo, Siswanto; Williams, Thomas N; Odhiambo, Frank O; Beguy, Donatien; Ezeh, Alex; Kyobutungi, Catherine; Crampin, Amelia; Delaunay, Valérie; Tollman, Stephen M; Herbst, Kobus; Chuc, Nguyen TK; Sankoh, Osman A; Tanner, Marcel; Byass, Peter; (2014) Cause-specific mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites. Global health action, 7 (1). 25362-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25362

Streatfield, P Kim; Khan, Wasif A; Bhuiya, Abbas; Hanifi, Syed MA; Alam, Nurul; Bagagnan, Cheik H; Sié, Ali; Zabré, Pascal; Lankoandé, Bruno; Rossier, Clementine; +49 more... Soura, Abdramane B; Bonfoh, Bassirou; Kone, Siaka; Ngoran, Eliezer K; Utzinger, Juerg; Haile, Fisaha; Melaku, Yohannes A; Weldearegawi, Berhe; Gomez, Pierre; Jasseh, Momodou; Ansah, Patrick; Debpuur, Cornelius; Oduro, Abraham; Wak, George; Adjei, Alexander; Gyapong, Margaret; Sarpong, Doris; Kant, Shashi; Misra, Puneet; Rai, Sanjay K; Juvekar, Sanjay; Lele, Pallavi; Bauni, Evasius; Mochamah, George; Ndila, Carolyne; Williams, Thomas N; Laserson, Kayla F; Nyaguara, Amek; Odhiambo, Frank O; Phillips-Howard, Penelope; Ezeh, Alex; Kyobutungi, Catherine; Oti, Samuel; Crampin, Amelia; Nyirenda, Moffat; Price, Alison; Delaunay, Valérie; Diallo, Aldiouma; Douillot, Laetitia; Sokhna, Cheikh; Gómez-Olivé, F Xavier; Kahn, Kathleen; Tollman, Stephen M; Herbst, Kobus; Mossong, Joël; Chuc, Nguyen TK; Bangha, Martin; Sankoh, Osman A; Byass, Peter; (2014) Adult non-communicable disease mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites. Global health action, 7 (1). 25365-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25365

Streatfield, P Kim; Khan, Wasif A; Bhuiya, Abbas; Hanifi, Syed MA; Alam, Nurul; Diboulo, Eric; Niamba, Louis; Sié, Ali; Lankoandé, Bruno; Millogo, Roch; +45 more... Soura, Abdramane B; Bonfoh, Bassirou; Kone, Siaka; Ngoran, Eliezer K; Utzinger, Juerg; Ashebir, Yemane; Melaku, Yohannes A; Weldearegawi, Berhe; Gomez, Pierre; Jasseh, Momodou; Azongo, Daniel; Oduro, Abraham; Wak, George; Wontuo, Peter; Attaa-Pomaa, Mary; Gyapong, Margaret; Manyeh, Alfred K; Kant, Shashi; Misra, Puneet; Rai, Sanjay K; Juvekar, Sanjay; Patil, Rutuja; Wahab, Abdul; Wilopo, Siswanto; Bauni, Evasius; Mochamah, George; Ndila, Carolyne; Williams, Thomas N; Khaggayi, Christine; Nyaguara, Amek; Obor, David; Odhiambo, Frank O; Ezeh, Alex; Oti, Samuel; Wamukoya, Marylene; Chihana, Menard; Crampin, Amelia; Collinson, Mark A; Kabudula, Chodziwadziwa W; Wagner, Ryan; Herbst, Kobus; Mossong, Joël; Emina, Jacques BO; Sankoh, Osman A; Byass, Peter; (2014) Mortality from external causes in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System Sites. Global health action, 7 (1). 25366-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25366

Streatfield, P Kim; Khan, Wasif A; Bhuiya, Abbas; Hanifi, Syed MA; Alam, Nurul; Diboulo, Eric; Sié, Ali; Yé, Maurice; Compaoré, Yacouba; Soura, Abdramane B; +49 more... Bonfoh, Bassirou; Jaeger, Fabienne; Ngoran, Eliezer K; Utzinger, Juerg; Melaku, Yohannes A; Mulugeta, Afework; Weldearegawi, Berhe; Gomez, Pierre; Jasseh, Momodou; Hodgson, Abraham; Oduro, Abraham; Welaga, Paul; Williams, John; Awini, Elizabeth; Binka, Fred N; Gyapong, Margaret; Kant, Shashi; Misra, Puneet; Srivastava, Rahul; Chaudhary, Bharat; Juvekar, Sanjay; Wahab, Abdul; Wilopo, Siswanto; Bauni, Evasius; Mochamah, George; Ndila, Carolyne; Williams, Thomas N; Desai, Meghna; Hamel, Mary J; Lindblade, Kim A; Odhiambo, Frank O; Slutsker, Laurence; Ezeh, Alex; Kyobutungi, Catherine; Wamukoya, Marylene; Delaunay, Valérie; Diallo, Aldiouma; Douillot, Laetitia; Sokhna, Cheikh; Gómez-Olivé, F Xavier; Kabudula, Chodziwadziwa W; Mee, Paul; Herbst, Kobus; Mossong, Joël; Chuc, Nguyen TK; Arthur, Samuelina S; Sankoh, Osman A; Tanner, Marcel; Byass, Peter; (2014) Malaria mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites. Global health action, 7 (1). 25369-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25369

Streatfield, P Kim; Khan, Wasif A; Bhuiya, Abbas; Hanifi, Syed MA; Alam, Nurul; Millogo, Ourohiré; Sié, Ali; Zabré, Pascal; Rossier, Clementine; Soura, Abdramane B; +50 more... Bonfoh, Bassirou; Kone, Siaka; Ngoran, Eliezer K; Utzinger, Juerg; Abera, Semaw F; Melaku, Yohannes A; Weldearegawi, Berhe; Gomez, Pierre; Jasseh, Momodou; Ansah, Patrick; Azongo, Daniel; Kondayire, Felix; Oduro, Abraham; Amu, Alberta; Gyapong, Margaret; Kwarteng, Odette; Kant, Shashi; Pandav, Chandrakant S; Rai, Sanjay K; Juvekar, Sanjay; Muralidharan, Veena; Wahab, Abdul; Wilopo, Siswanto; Bauni, Evasius; Mochamah, George; Ndila, Carolyne; Williams, Thomas N; Khagayi, Sammy; Laserson, Kayla F; Nyaguara, Amek; Van Eijk, Anna M; Ezeh, Alex; Kyobutungi, Catherine; Wamukoya, Marylene; Chihana, Menard; Crampin, Amelia; Price, Alison; Delaunay, Valérie; Diallo, Aldiouma; Douillot, Laetitia; Sokhna, Cheikh; Gómez-Olivé, F Xavier; Mee, Paul; Tollman, Stephen M; Herbst, Kobus; Mossong, Joël; Chuc, Nguyen TK; Arthur, Samuelina S; Sankoh, Osman A; Byass, Peter; (2014) HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites. Global health action, 7 (1). 25370-. ISSN 1654-9716 DOI: https://doi.org/10.3402/gha.v7.25370

Tinto, Halidou; Bonkian, Léa N; Nana, Louis A; Yerbanga, Isidore; Lingani, Moussa; Kazienga, Adama; Valéa, Innocent; Sorgho, Hermann; Kpoda, Hervé; Guiguemdé, Tinga Robert; +4 more... Ouédraogo, Jean Bosco; Mens, Petronella F; Schallig, Henk; D'Alessandro, Umberto; (2014) Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change. MALARIA JOURNAL, 13 (1). 207-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-207

Van Hong, Nguyen; Amambua-Ngwa, Alfred; Tuan, Nguyen Quang; Cuong, Do Duy; Giang, Nguyen Thi Huong; Van Dung, Nguyen; Tinh, Ta Thi; Van Tien, Nguyen; Phuc, Bui Quang; Duong, Tran Thanh; +4 more... Rosanas-Urgell, Anna; D'Alessandro, Umberto; Van Geertruyden, Jean-Pierre; Erhart, Annette; (2014) Severe malaria not responsive to artemisinin derivatives in man returning from Angola to Vietnam. EMERGING INFECTIOUS DISEASES, 20 (7). pp. 1199-1202. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid2007.140155

Zwang, Julien; Dorsey, Grant; Mårtensson, Andreas; d'Alessandro, Umberto; Ndiaye, Jean-Louis; Karema, Corine; Djimde, Abdoulaye; Brasseur, Philippe; Sirima, Sodiomon B; Olliaro, Piero; (2014) Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999-2009. MALARIA JOURNAL, 13 (1). 114-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-13-114