Items where Author is "Furnham, N"
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Number of items: 23.
2019
Tyzack, JD;
Furnham, N;
Sillitoe, I;
Orengo, CM;
Thornton, JM;
(2019)
Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function.
Methods in molecular biology (Clifton, NJ), 1851.
pp. 263-275.
ISSN 1064-3745
DOI: https://doi.org/10.1007/978-1-4939-8736-8_14
Full text not available from this repository.
2018
Coll, F;
Phelan, J;
Hill-Cawthorne, GA;
Nair, MB;
Mallard, K;
Ali, S;
Abdallah, AM;
Alghamdi, S;
Alsomali, M;
Ahmed, AO;
+41 more...
Portelli, S;
Oppong, Y;
Alves, A;
Bessa, TB;
Campino, S;
Caws, M;
Chatterjee, A;
Crampin, AC;
Dheda, K;
Furnham, N;
Glynn, JR;
Grandjean, L;
Ha, DM;
Hasan, R;
Hasan, Z;
Hibberd, ML;
Joloba, M;
Jones-López, EC;
Matsumoto, T;
Miranda, A;
Moore, DJ;
Mocillo, N;
Panaiotov, S;
Parkhill, J;
Penha, C;
Perdigão, J;
Portugal, I;
Rchiad, Z;
Robledo, J;
Sheen, P;
Shesha, NT;
Sirgel, FA;
Sola, C;
Sousa, EO;
Streicher, EM;
Van Helden, P;
Viveiros, M;
Warren, RM;
McNerney, R;
Pain, A;
Clark, TG;
(2018)
Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
Nature genetics.
ISSN 1061-4036
DOI: https://doi.org/10.1038/s41588-018-0074-3
Full text not available from this repository.
Coll, F;
Phelan, J;
Hill-Cawthorne, GA;
Nair, MB;
Mallard, K;
Ali, S;
Abdallah, AM;
Alghamdi, S;
Alsomali, M;
Ahmed, AO;
+41 more...
Portelli, S;
Oppong, Y;
Alves, A;
Bessa, TB;
Campino, S;
Caws, M;
Chatterjee, A;
Crampin, AC;
Dheda, K;
Furnham, N;
Glynn, JR;
Grandjean, L;
Minh Ha, D;
Hasan, R;
Hasan, Z;
Hibberd, ML;
Joloba, M;
Jones-López, EC;
Matsumoto, T;
Miranda, A;
Moore, DJ;
Mocillo, N;
Panaiotov, S;
Parkhill, J;
Penha, C;
Perdigão, J;
Portugal, I;
Rchiad, Z;
Robledo, J;
Sheen, P;
Shesha, NT;
Sirgel, FA;
Sola, C;
Oliveira Sousa, E;
Streicher, EM;
Helden, PV;
Viveiros, M;
Warren, RM;
McNerney, R;
Pain, A;
Clark, TG;
(2018)
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
Nature genetics.
ISSN 1061-4036
DOI: https://doi.org/10.1038/s41588-017-0029-0
Giuliani, S;
Silva, AC;
Borba, JVVB;
Ramos, PIP;
Paveley, RA;
Muratov, EN;
Andrade, CH;
Furnham, N;
(2018)
Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents.
PLoS computational biology, 14 (10).
e1006515.
ISSN 1553-734X
DOI: https://doi.org/10.1371/journal.pcbi.1006515
Full text not available from this repository.
Portelli, S;
Phelan, JE;
Ascher, DB;
Clark, TG;
Furnham, N;
(2018)
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.
Scientific reports, 8 (1).
p. 15356.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-33370-6
Full text not available from this repository.
2017
Furnham, N;
(2017)
Complementary Sources of Protein Functional Information: The Far Side of GO.
In: UNSPECIFIED, (ed.)
The Gene Ontology Handbook.
Humana Press, pp. 263-274.
ISBN 1940-6029
DOI: https://doi.org/10.1007/978-1-4939-3743-1_19
Ribeiro, AJM;
Holliday, GL;
Furnham, N;
Tyzack, JD;
Ferris, K;
Thornton, JM;
(2017)
Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites.
Nucleic acids research.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkx1012
Tyzack, JD;
Furnham, N;
Sillitoe, I;
Orengo, CM;
Thornton, JM;
(2017)
Understanding enzyme function evolution from a computational perspective.
Current opinion in structural biology, 47.
pp. 131-139.
ISSN 0959-440X
DOI: https://doi.org/10.1016/j.sbi.2017.08.003
Valasatava, Y;
Rosato, A;
Furnham, N;
Thornton, JM;
Andreini, C;
(2017)
To what extent do structural changes in catalytic metal sites affect enzyme function?
Journal of inorganic biochemistry, 179.
pp. 40-53.
ISSN 0162-0134
DOI: https://doi.org/10.1016/j.jinorgbio.2017.11.002
2016
Mascotti, ML;
Juri Ayub, M;
Furnham, N;
Thornton, JM;
Laskowski, RA;
(2016)
Chopping and changing: The evolution of the flavin-dependent monooxygenases.
Journal of molecular biology, 428 (15).
pp. 3131-46.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2016.07.003
Full text not available from this repository.
Melo-Filho, CC;
Dantas, RF;
Braga, RC;
Neves, BJ;
Senger, MR;
Valente, WC;
Rezende-Neto, JM;
Chaves, WT;
Muratov, EN;
Paveley, RA;
+5 more...
Furnham, N;
Kamentsky, L;
Carpenter, AE;
Silva-Junior, FP;
Andrade, CH;
(2016)
QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni.
Journal of chemical information and modeling, 56 (7).
pp. 1357-72.
ISSN 1549-9596
DOI: https://doi.org/10.1021/acs.jcim.6b00055
Neves, BJ;
Dantas, RF;
Senger, MR;
Melo-Filho, CC;
Valente, WC;
de Almeida, AC;
Rezende-Neto, JM;
Lima, EF;
Paveley, R;
Furnham, N;
+6 more...
Muratov, E;
Kamentsky, L;
Carpenter, AE;
Braga, RC;
Silva-Junior, FP;
Andrade, CH;
(2016)
Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening.
Journal of medicinal chemistry, 59 (15).
pp. 7075-88.
ISSN 0022-2623
DOI: https://doi.org/10.1021/acs.jmedchem.5b02038
Phelan, J;
Coll, F;
McNerney, R;
Ascher, DB;
Pires, DE;
Furnham, N;
Coeck, N;
Hill-Cawthorne, GA;
Nair, MB;
Mallard, K;
+6 more...
Ramsay, A;
Campino, S;
Hibberd, ML;
Pain, A;
Rigouts, L;
Clark, TG;
(2016)
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
BMC medicine, 14 (1).
p. 31.
ISSN 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0575-9
2015
Farnell, EJ;
Tyagi, N;
Ryan, S;
Chalmers, IW;
Pinot de Moira, A;
Jones, FM;
Wawrzyniak, J;
Fitzsimmons, CM;
Tukahebwa, EM;
Furnham, N;
+2 more...
Maizels, RM;
Dunne, DW;
(2015)
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.
Frontiers in immunology, 6.
p. 26.
ISSN 1664-3224
DOI: https://doi.org/10.3389/fimmu.2015.00026
Furnham, N;
Dawson, NL;
Rahman, SA;
Thornton, JM;
Orengo, CA;
(2015)
Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies.
Journal of molecular biology, 428 (2 Pt A).
pp. 253-67.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2015.11.010
Martínez Cuesta, S;
Rahman, SA;
Furnham, N;
Thornton, JM;
(2015)
The Classification and Evolution of Enzyme Function.
Biophysical journal, 109 (6).
pp. 1082-6.
ISSN 0006-3495
DOI: https://doi.org/10.1016/j.bpj.2015.04.020
Sillitoe, I;
Furnham, N;
(2015)
FunTree: advances in a resource for exploring and contextualising protein function evolution.
Nucleic acids research, 44 (D1).
D317-23.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gkv1274
Tyagi, N;
Farnell, EJ;
Fitzsimmons, CM;
Ryan, S;
Tukahebwa, E;
Maizels, RM;
Dunne, DW;
Thornton, JM;
Furnham, N;
(2015)
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.
PLoS computational biology, 11 (10).
e1004546.
ISSN 1553-734X
DOI: https://doi.org/10.1371/journal.pcbi.1004546
2014
Holliday, GL;
Rahman, SA;
Furnham, N;
Thornton, JM;
(2014)
Exploring the biological and chemical complexity of the ligases.
Journal of molecular biology, 426 (10).
pp. 2098-111.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2014.03.008
Martinez Cuesta, S;
Furnham, N;
Rahman, SA;
Sillitoe, I;
Thornton, JM;
(2014)
The evolution of enzyme function in the isomerases.
Current opinion in structural biology, 26C.
pp. 121-130.
ISSN 0959-440X
DOI: https://doi.org/10.1016/j.sbi.2014.06.002
Rahman, SA;
Cuesta, SM;
Furnham, N;
Holliday, GL;
Thornton, JM;
(2014)
EC-BLAST: a tool to automatically search and compare enzyme reactions.
Nature methods, 11 (2).
pp. 171-4.
ISSN 1548-7091
DOI: https://doi.org/10.1038/nmeth.2803
Sillitoe, I;
Lewis, TE;
Cuff, A;
Das, S;
Ashford, P;
Dawson, NL;
Furnham, N;
Laskowski, RA;
Lee, D;
Lees, JG;
+4 more...
Lehtinen, S;
Studer, RA;
Thornton, J;
Orengo, CA;
(2014)
CATH: comprehensive structural and functional annotations for genome sequences.
Nucleic acids research.
ISSN 0305-1048
DOI: https://doi.org/10.1093/nar/gku947
2008
Pietras, Z;
Bavro, VN;
Furnham, N;
Pellegrini-Calace, M;
Milner-White, EJ;
Luisi, BF;
(2008)
Structure and mechanism of drug efflux machinery in Gram negative bacteria.
Current drug targets, 9 (9).
pp. 719-28.
ISSN 1389-4501
http://researchonline.lshtm.ac.uk/id/eprint/2551706
Full text not available from this repository.