Brown, S; Everett, CC; Naraghi, K; Davies, C; Dawkins, B; Hulme, C; McCabe, C; Pavitt, S; Emery, P; Sharples, L; +1 more... Buch, MH; (2018) Alternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT. Technical Report. NIHR Journals Library. DOI: https://doi.org/10.3310/hta22340

Nair, SK; Sudarshan, CD; Thorpe, BS; Singh, J; Pillay, T; Catarino, P; Valchanov, K; Codispoti, M; Dunning, J; Abu-Omar, Y; +5 more... Moorjani, N; Matthews, C; Freeman, CJ; Fox-Rushby, JA; Sharples, LD; (2018) Mini-Stern Trial: A randomized trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement. The Journal of thoracic and cardiovascular surgery. ISSN 0022-5223 DOI: https://doi.org/10.1016/j.jtcvs.2018.05.057 Full text not available from this repository.

Nair, SK; Sudarshan, CD; Thorpe, BS; Singh, J; Pillay, T; Catarino, P; Valchanov, K; Codispoti, M; Dunning, J; Abu-Omar, Y; +5 more... Moorjani, N; Matthews, C; Freeman, CJ; Fox-Rushby, JA; Sharples, LD; (2018) Mini-Stern Trial: A randomised trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement. The Journal of thoracic and cardiovascular surgery. ISSN 0022-5223 DOI: https://doi.org/10.1016/j.jtcvs.2018.05.057 Item availability may be restricted.

Nashef, SAM; Fynn, S; Abu-Omar, Y; Spyt, TJ; Mills, C; Everett, CC; Fox-Rushby, J; Singh, J; Dalrymple-Hay, M; Sudarshan, C; +4 more... Codispoti, M; Braidley, P; Wells, FC; Sharples, LD; (2018) Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation. European journal of cardio-thoracic surgery. ISSN 1010-7940 DOI: https://doi.org/10.1093/ejcts/ezy165

Papachristofi, O; Klein, AA; Mackay, J; Nashef, S; Fletcher, NS; Sharples, LD; Association for Cardiothoracic Anaesthesia and Critical Care (AC; (2018) Does the "Weekend Effect" for Postoperative Mortality Stand Up to Scrutiny? Association for Cardiothoracic Anesthesia and Critical Care Cohort Study of 110,728 Cardiac Surgical Patients. Journal of cardiothoracic and vascular anesthesia. ISSN 1053-0770 DOI: https://doi.org/10.1053/j.jvca.2018.04.015 Item availability may be restricted.

Sharples, L; Everett, C; Singh, J; Mills, C; Spyt, T; Abu-Omar, Y; Fynn, S; Thorpe, B; Stoneman, V; Goddard, H; +2 more... Fox-Rushby, J; Nashef, S; (2018) Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation. Health technology assessment (Winchester, England), 22 (19). pp. 1-132. ISSN 1366-5278 DOI: https://doi.org/10.3310/hta22190

Sharples, LD; (2018) The role of statistics in the era of big data: Electronic health records for healthcare research. Statistics & probability letters, 136. pp. 105-110. ISSN 0167-7152 DOI: https://doi.org/10.1016/j.spl.2018.02.044 Item availability may be restricted.

Soares, MO; Sharples, L; Morton, A; Claxton, K; Bojke, L; (2018) Experiences of Structured Elicitation for Model-Based Cost-Effectiveness Analyses. Value in health, 21 (6). pp. 715-723. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2018.01.019

Abu-Omar, Y; Thorpe, BS; Freeman, C; Mills, C; Stoneman, VEA; Gopalan, D; Rana, B; Spyt, TJ; Sharples, LD; Nashef, SAM; (2017) Recovery of Left Atrial Contractile Function After Maze Surgery in Persistent Longstanding Atrial Fibrillation. Journal of the American College of Cardiology, 70 (18). pp. 2309-2311. ISSN 0735-1097 DOI: https://doi.org/10.1016/j.jacc.2017.08.073

Bowman, SJ; Everett, CC; O'Dwyer, JL; Emery, P; Pitzalis, C; Ng, WF; Pease, CT; Price, EJ; Sutcliffe, N; St Gendi, N; +13 more... Hall, FC; Ruddock, SP; Fernandez, C; Reynolds, C; Hulme, CT; Davies, KA; Edwards, CJ; Lanyon, PC; Moots, RJ; Roussou, E; Giles, IP; Sharples, LD; Bombardieri, M; (2017) Randomized Controlled Trial of Rituximab and cost-effectiveness analysis in treating fatigue and oral dryness in primary Sjogren's Syndrome. Arthritis & rheumatology (Hoboken, NJ). ISSN 2326-5191 DOI: https://doi.org/10.1002/art.40093

Clayton, GL; Smith, IL; Higgins, JPT; Mihaylova, B; Thorpe, B; Cicero, R; Lokuge, K; Forman, JR; Tierney, JF; White, IR; +2 more... Sharples, LD; Jones, HE; (2017) The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials. Trials, 18 (1). p. 219. ISSN 1745-6215 DOI: https://doi.org/10.1186/s13063-017-1955-y

Fisher, BA; Everett, CC; Rout, J; O'Dwyer, JL; Emery, P; Pitzalis, C; Ng, WF; Carr, A; Pease, CT; Price, EJ; +17 more... Sutcliffe, N; Makdissi, J; Tappuni, AR; Gendi, NST; Hall, FC; Ruddock, SP; Fernandez, C; Hulme, CT; Davies, KA; Edwards, CJ; Lanyon, PC; Moots, RJ; Roussou, E; Richards, A; Sharples, LD; Bombardieri, M; Bowman, SJ; (2017) Effect of rituximab on a salivary gland ultrasound score in primary Sjögren's syndrome: results of the TRACTISS randomised double-blind multicentre substudy. Annals of the rheumatic diseases. ISSN 0003-4967 DOI: https://doi.org/10.1136/annrheumdis-2017-212268

Papachristofi, O; Klein, AA; Mackay, J; Nashef, S; Fletcher, N; Sharples, LD; Association of Cardiothoracic Anaesthesia and Critical Care (ACT; (2017) Effect of individual patient risk, centre, surgeon and anaesthetist on length of stay in hospital after cardiac surgery: Association of Cardiothoracic Anaesthesia and Critical Care (ACTACC) consecutive cases series study of 10 UK specialist centres. BMJ open, 7 (9). e016947. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2017-016947

Thom, H; Jackson, C; Welton, N; Sharples, L; (2017) Using Parameter Constraints to Choose State Structures in Cost-Effectiveness Modelling. PharmacoEconomics. ISSN 1170-7690 DOI: https://doi.org/10.1007/s40273-017-0501-9

Thom, H; Jackson, C; Welton, N; Sharples, L; (2017) Erratum to: Using Parameter Constraints to Choose State Structures in Cost-Effectiveness Modelling. Springer Verlag. DOI: https://doi.org/10.1007/s40273-017-0520-6

Thorpe, B; Carroll, O; Sharples, L; (2017) Methods for Handling Unobserved Covariates in a Bayesian Update of a Cost-Effectiveness Model. Medical decision making. 272989X17736780. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X17736780

Barr, AJ; Dube, B; Hensor, EM; Kingsbury, SR; Peat, G; Bowes, MA; Sharples, LD; Conaghan, PG; (2016) The relationship between three-dimensional knee MRI bone shape and total knee replacement-a case control study: data from the Osteoarthritis Initiative. Rheumatology (Oxford, England), 55 (9). pp. 1585-93. ISSN 1462-0324 DOI: https://doi.org/10.1093/rheumatology/kew191

Dobson, LE; Fairbairn, TA; Musa, TA; Uddin, A; Mundie, CA; Swoboda, PP; Ripley, DP; McDiarmid, AK; Erhayiem, B; Garg, P; +5 more... Malkin, CJ; Blackman, DJ; Sharples, LD; Plein, S; Greenwood, JP; (2016) Sex-related differences in left ventricular remodeling in severe aortic stenosis and reverse remodeling after aortic valve replacement: A cardiovascular magnetic resonance study. American heart journal, 175. pp. 101-11. ISSN 0002-8703 DOI: https://doi.org/10.1016/j.ahj.2016.02.010

Giraud, K; Pontin, M; Sharples, LD; Fletcher, P; Dalgleish, T; Eden, A; Jenkins, DP; Vuylsteke, A; (2016) Use of a Structured Mirrors Intervention Does Not Reduce Delirium Incidence But May Improve Factual Memory Encoding in Cardiac Surgical ICU Patients Aged Over 70 Years: A Pilot Time-Cluster Randomized Controlled Trial. Frontiers in aging neuroscience, 8. p. 228. ISSN 1663-4365 DOI: https://doi.org/10.3389/fnagi.2016.00228

Greenwood, JP; Ripley, DP; Berry, C; McCann, GP; Plein, S; Bucciarelli-Ducci, C; Dall'Armellina, E; Prasad, A; Bijsterveld, P; Foley, JR; +8 more... Mangion, K; Sculpher, M; Walker, S; Everett, CC; Cairns, DA; Sharples, LD; Brown, JM; CE-MARC 2 Investigators; (2016) Effect of Care Guided by Cardiovascular Magnetic Resonance, Myocardial Perfusion Scintigraphy, or NICE Guidelines on Subsequent Unnecessary Angiography Rates: The CE-MARC 2 Randomized Clinical Trial. JAMA, 316 (10). pp. 1051-60. ISSN 0098-7484 DOI: https://doi.org/10.1001/jama.2016.12680

Jackson, C; Stevens, J; Ren, S; Latimer, N; Bojke, L; Manca, A; Sharples, L; (2016) Extrapolating Survival from Randomized Trials Using External Data: A Review of Methods. Medical decision making, 37 (4). pp. 377-390. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X16639900

Mackay, JH; Nashef, SA; Klein, AA; Papachristofi, O; Sharples, LD; Fletcher, SN; Association of Cardiothoracic Anaesthetists (ACTA); (2016) Anaesthetist contribution to mortality after cardiac surgery - a reply. Anaesthesia, 71 (5). pp. 599-601. ISSN 0003-2409 DOI: https://doi.org/10.1111/anae.13475 Full text not available from this repository.

Papachristofi, O; Jenkins, D; Sharples, LD; (2016) Assessment of learning curves in complex surgical interventions: a consecutive case-series study. Trials, 17 (1). p. 266. ISSN 1745-6215 DOI: https://doi.org/10.1186/s13063-016-1383-4

Papachristofi, O; Klein, A; Sharples, L; (2016) Evaluation of the effects of multiple providers in complex surgical interventions. Statistics in medicine, 35 (28). pp. 5222-5246. ISSN 0277-6715 DOI: https://doi.org/10.1002/sim.7057 Full text not available from this repository.

Blencowe, NS; Brown, JM; Cook, JA; Metcalfe, C; Morton, DG; Nicholl, J; Sharples, LD; Treweek, S; Blazeby, JM; Members of the MRC Hub for Trials Methodology Research Network W; +29 more... , COLLABORATORS; Bach, S; Beard, D; Campbell, MK; Carr, A; Conroy, EJ; Costa, M; Davidson, P; Donovan, J; Doré, CJ; Groves, T; Hutchison, I; Jain, A; Jayne, D; Kolias, AG; Lamb, S; McCaul, J; Mehanna, H; Montgomery, AA; Pinkney, T; Potter, S; Rangan, A; Rogers, C; Sasieni, P; Stenning, S; Smith, CT; White, I; Williams, B; Williamson, PR; (2015) Interventions in randomised controlled trials in surgery: issues to consider during trial design. Trials, 16. p. 392. ISSN 1745-6215 DOI: https://doi.org/10.1186/s13063-015-0918-4

Geneletti, S; O'Keeffe, AG; Sharples, LD; Richardson, S; Baio, G; (2015) Bayesian regression discontinuity designs: incorporating clinical knowledge in the causal analysis of primary care data. Statistics in medicine, 34 (15). pp. 2334-52. ISSN 0277-6715 DOI: https://doi.org/10.1002/sim.6486

Ieva, F; Jackson, CH; Sharples, LD; (2015) Multi-state modelling of repeated hospitalisation and death in patients with heart failure: The use of large administrative databases in clinical epidemiology. Statistical methods in medical research, 26 (3). pp. 1350-1372. ISSN 0962-2802 DOI: https://doi.org/10.1177/0962280215578777 Full text not available from this repository.

Ortmann, E; Besser, MW; Sharples, LD; Gerrard, C; Berman, M; Jenkins, DP; Klein, AA; (2015) An exploratory cohort study comparing prothrombin complex concentrate and fresh frozen plasma for the treatment of coagulopathy after complex cardiac surgery. Anesthesia and analgesia, 121 (1). pp. 26-33. ISSN 0003-2999 DOI: https://doi.org/10.1213/ANE.0000000000000689 Full text not available from this repository.

Papachristofi, O; Sharples, LD; Mackay, JH; Nashef, SA; Fletcher, SN; Klein, AA; Association of Cardiothoracic Anaesthetists (ACTA); , COLLABORATORS; Lau, G; Woodward, D; +7 more... Hillier, J; Ware, M; Agarwal, S; Bill, M; Gill, R; Duthie, D; Skinner, H; (2015) The contribution of the anaesthetist to risk-adjusted mortality after cardiac surgery. Anaesthesia, 71 (2). pp. 138-46. ISSN 0003-2409 DOI: https://doi.org/10.1111/anae.13291

Sastry, P; Hughes, V; Hayes, P; Vallabhaneni, S; Sharples, L; Thompson, M; Catarino, P; Moorjani, N; Vale, L; Gray, J; +21 more... Cook, A; Elefteriades, JA; Large, SR; ETTAA Collaborators; , COLLABORATORS; Rajakaruna, C; Chetter, I; Bicknell, C; Spyt, T; Oo, A; Dayer, M; Freeman, L; Unsworth-White, J; Quarmby, J; Vallabhaneni, SR; Cooper, G; Tsang, G; Loftus, I; McCollum, C; Thompson, A; Elefteriades, J; (2015) The ETTAA study protocol: a UK-wide observational study of 'Effective Treatments for Thoracic Aortic Aneurysm'. BMJ open, 5 (6). e008147. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2015-008147

Sharples, LD; Clutterbuck-James, AL; Glover, MJ; Bennett, MS; Chadwick, R; Pittman, MA; Quinnell, TG; (2015) Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea. Sleep medicine reviews, 27. pp. 108-24. ISSN 1087-0792 DOI: https://doi.org/10.1016/j.smrv.2015.05.003

Sharples, LD; Quinnell, TG; TOMADO investigators; (2015) Response to comments on "Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea". Sleep medicine reviews, 27. pp. 41-2. ISSN 1087-0792 DOI: https://doi.org/10.1016/j.smrv.2015.08.001 Full text not available from this repository.

Thom, HH; Jackson, CH; Commenges, D; Sharples, LD; (2015) State selection in Markov models for panel data with application to psoriatic arthritis. Statistics in medicine, 34 (16). pp. 2456-75. ISSN 0277-6715 DOI: https://doi.org/10.1002/sim.6460 Full text not available from this repository.

Benaglia, T; Jackson, CH; Sharples, LD; (2014) Survival extrapolation in the presence of cause specific hazards. Statistics in medicine, 34 (5). pp. 796-811. ISSN 0277-6715 DOI: https://doi.org/10.1002/sim.6375

Ieva, F; Gale, CP; Sharples, LD; (2014) Contemporary roles of registries in clinical cardiology: when do we need randomized trials? Expert review of cardiovascular therapy, 12 (12). pp. 1383-6. ISSN 1477-9072 DOI: https://doi.org/10.1586/14779072.2015.982096 Full text not available from this repository.

Kosmoliaptsis, V; Gjorgjimajkoska, O; Sharples, LD; Chaudhry, AN; Chatzizacharias, N; Peacock, S; Torpey, N; Bolton, EM; Taylor, CJ; Bradley, JA; (2014) Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. Kidney international, 86 (5). pp. 1039-48. ISSN 0085-2538 DOI: https://doi.org/10.1038/ki.2014.106 Full text not available from this repository.

O'Keeffe, AG; Geneletti, S; Baio, G; Sharples, LD; Nazareth, I; Petersen, I; (2014) Regression discontinuity designs: an approach to the evaluation of treatment efficacy in primary care using observational data. BMJ (Clinical research ed), 349. g5293. ISSN 0959-8138 DOI: https://doi.org/10.1136/bmj.g5293 Full text not available from this repository.

Quinnell, TG; Bennett, M; Jordan, J; Clutterbuck-James, AL; Davies, MG; Smith, IE; Oscroft, N; Pittman, MA; Cameron, M; Chadwick, R; +4 more... Morrell, MJ; Glover, MJ; Fox-Rushby, JA; Sharples, LD; (2014) A crossover randomised controlled trial of oral mandibular advancement devices for obstructive sleep apnoea-hypopnoea (TOMADO). Thorax, 69 (10). pp. 938-45. ISSN 0040-6376 DOI: https://doi.org/10.1136/thoraxjnl-2014-205464 Full text not available from this repository.

Rintoul, RC; Ritchie, AJ; Edwards, JG; Waller, DA; Coonar, AS; Bennett, M; Lovato, E; Hughes, V; Fox-Rushby, JA; Sharples, LD; +22 more... MesoVATS Collaborators; , COLLABORATORS; Beckett, P; Lang-Lazdunski, L; Reddy, R; Powrie, D; Lim, E; Martin-Ucar, A; Morgan, I; Chaudhuri, N; Qureshi, N; Tasker, A; Munday, H; Matthews, C; Buttery, R; Slade, M; Slade, G; Rassl, D; Lowry, E; Elliott, J; Laroche, C; Winter, R; (2014) Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma (MesoVATS): an open-label, randomised, controlled trial. Lancet, 384 (9948). pp. 1118-27. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(14)60418-9 Full text not available from this repository.

Thom, H; West, NE; Hughes, V; Dyer, M; Buxton, M; Sharples, LD; Jackson, CH; Crean, AM; CECaT study group; , COLLABORATORS; +17 more... Armstrong, J; Buxton, M; Caine, N; Coulden, R; Crean, A; Dyer, M; Gillham, M; Goddard, H; Goldsmith, K; Hughes, V; Lee, E; Patel, R; Schofield, P; Sharples, L; Sonnex, E; Stone, D; Treacy, C; (2014) Cost-effectiveness of initial stress cardiovascular MR, stress SPECT or stress echocardiography as a gate-keeper test, compared with upfront invasive coronary angiography in the investigation and management of patients with stable chest pain: mid-term outcomes from the CECaT randomised controlled trial. BMJ open, 4 (2). e003419. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2013-003419

Rintoul, RC; Glover, MJ; Jackson, C; Hughes, V; Tournoy, KG; Dooms, C; Annema, JT; Sharples, LD; (2013) Cost effectiveness of endosonography versus surgical staging in potentially resectable lung cancer: a health economics analysis of the ASTER trial from a European perspective. Thorax, 69 (7). pp. 679-81. ISSN 0040-6376 DOI: https://doi.org/10.1136/thoraxjnl-2013-204374 Full text not available from this repository.

Demiris, N; Lunn, D; Sharples, LD; (2011) Survival extrapolation using the poly-Weibull model. Statistical methods in medical research, 24 (2). pp. 287-301. ISSN 0962-2802 DOI: https://doi.org/10.1177/0962280211419645 Full text not available from this repository.