Contemporary roles of registries in clinical cardiology: when do we need randomized trials?


Ieva, F; Gale, CP; Sharples, LD; (2014) Contemporary roles of registries in clinical cardiology: when do we need randomized trials? Expert review of cardiovascular therapy, 12 (12). pp. 1383-6. ISSN 1477-9072 DOI: https://doi.org/10.1586/14779072.2015.982096

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Abstract

Clinical registries are established as tools for auditing clinical standards and benchmarking quality improvement initiatives. They also have an emerging role (as electronic health records) in cardiovascular research and, in particular, the conduct of RCTs. While the RCT is accepted as the most robust experimental design, observational data from clinical registries has become increasingly valuable for RCTs. Data from clinical registries may be used to augment results from RCTs, identify patients for recruitment and as an alternative when randomization is not practically possible or ethically desirable. Here the authors appraise the advantages and disadvantages of both methodologies, with the aim of clarifying when their joint use may be successful.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 25418756
URI: http://researchonline.lshtm.ac.uk/id/eprint/4224346

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