Items where Author or Contributor is "Croft, SL"
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Number of items: 198.
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Addae-Kyereme, J;
Croft, SL;
Kendrick, H;
Wright, CW;
(2001)
Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and of some alkaloids isolated from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine.
Journal of ethnopharmacology, 76 (1).
pp. 99-103.
ISSN 0378-8741
DOI: https://doi.org/10.1016/s0378-8741(01)00212-4
Full text not available from this repository.
Ahmed, A;
Ginn, C;
Croft, SL;
Brocchini, S;
(2013)
Anti-infectives.
In: Uchegbu, IF; Schätzlein, AG; Cheng, WP; Lalatsa, A, (eds.)
Fundamentals of Pharmaceutical Nanoscience.
Springer Science,, New York, pp. 429-464.
ISBN 978-1-4614-9164-4
https://researchonline.lshtm.ac.uk/id/eprint/2961949
Full text not available from this repository.
Alvar, Jorge;
Croft, Simon L;
Kaye, Paul;
Khamesipour, Ali;
Sundar, Shyam;
Reed, Steven G;
(2013)
Case study for a vaccine against leishmaniasis.
Vaccine, 31 Sup (SUPPL2).
B244-B249.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2012.11.080
Full text not available from this repository.
Anao, I;
Houghton, P;
Croft, S;
(2004)
Antiprotozoal activity guided fractionation of Sclerocarya birrea (A. Rich.) Hochst.
[Conference or Workshop Item]
https://researchonline.lshtm.ac.uk/id/eprint/6181
Full text not available from this repository.
Asres, K;
Bucar, F;
Knauder, E;
Yardley, V;
Kendrick, H;
Croft, SL;
(2001)
In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle.
Phytotherapy research, 15 (7).
pp. 613-617.
ISSN 0951-418X
DOI: https://doi.org/10.1002/ptr.897
Full text not available from this repository.
Bailey, Nigel JC;
Wang, Yulan;
Sampson, Julia;
Davis, Wendy;
Whitcombe, Ian;
Hylands, Peter J;
Croft, Simon L;
Holmes, Elaine;
(2004)
Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics.
Journal of pharmaceutical and biomedical analysis, 35 (1).
pp. 117-126.
ISSN 0731-7085
DOI: https://doi.org/10.1016/j.jpba.2003.12.024
Full text not available from this repository.
Bal, Gunther;
Van der Veken, Pieter;
Antonov, Dimitri;
Lambeir, Anne-Marie;
Grellier, Philippe;
Croft, Simon L;
Augustyns, Koen;
Haemers, Achiel;
(2003)
Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity.
Bioorganic & medicinal chemistry letters, 13 (17).
pp. 2875-2878.
ISSN 0960-894X
DOI: https://doi.org/10.1016/s0960-894x(03)00579-1
Full text not available from this repository.
Baschong, Werner;
Wittlin, Sergio;
Inglis, Kirstine A;
Fairlamb, Alan H;
Croft, Simon L;
Kumar, TR Santha;
Fidock, David A;
Brun, Reto;
(2011)
Triclosan is minimally effective in rodent malaria models.
Nature medicine, 17 (1).
pp. 33-34.
ISSN 1078-8956
DOI: https://doi.org/10.1038/nm0111-33
Full text not available from this repository.
Berman, J;
Bryceson, ADM;
Croft, S;
Engel, J;
Gutteridge, W;
Karbwang, J;
Sindermann, H;
Soto, J;
Sundar, S;
Urbina, JA;
(2006)
Miltefosine: issues to be addressed in the future.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 Su.
S41-S44.
ISSN 0035-9203
DOI: https://doi.org/10.1016/j.trstmh.2006.02.009
Full text not available from this repository.
Blackie, Margaret AL;
Beagley, Paul;
Croft, Simon L;
Kendrick, Howard;
Moss, John R;
Chibale, Kelly;
(2007)
Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.
Bioorganic & medicinal chemistry, 15 (20).
pp. 6510-6516.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2007.07.012
Full text not available from this repository.
Burza, S;
Croft, SL;
Boelaert, M;
(2018)
Leishmaniasis.
Elsevier.
DOI: https://doi.org/10.1016/S0140-6736(18)31204-2
Full text not available from this repository.
Camacho, MDR;
Phillipson, JD;
Croft, SL;
Solis, PN;
Marshall, SJ;
Ghazanfar, SA;
(2003)
Screening of plant extracts for antiprotozoal and cytotoxic activities.
Journal of ethnopharmacology, 89 (2-3).
pp. 185-191.
ISSN 0378-8741
DOI: https://doi.org/10.1016/s0378-8741(03)00269-1
Full text not available from this repository.
Cameron, Angus;
Read, Jon;
Tranter, Rebecca;
Winter, Victoria J;
Sessions, Richard B;
Brady, R Leo;
Vivas, Livia;
Easton, Anna;
Kendrick, Howard;
Croft, Simon L;
+12 more...
Barros, David;
Lavandera, Jose Luis;
Martin, José Julio;
Risco, Felix;
García-Ochoa, Silvestre;
Gamo, Fracisco Javier;
Sanz, Laura;
Leon, Luisa;
Ruiz, Jose R;
Gabarró, Raquel;
Mallo, Araceli;
Gómez de las Heras, Federico;
(2004)
Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.
The Journal of biological chemistry, 279 (30).
pp. 31429-31439.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M402433200
Full text not available from this repository.
Carrico, Dora;
Ohkanda, Junko;
Kendrick, Howard;
Yokoyama, Kohei;
Blaskovich, Michelle A;
Bucher, Cynthia J;
Buckner, Frederick S;
Van Voorhis, Wesley C;
Chakrabarti, Debopam;
Croft, Simon L;
+3 more...
Gelb, Michael H;
Sebti, Saïd M;
Hamilton, Andrew D;
(2004)
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry, 12 (24).
pp. 6517-6526.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2004.09.020
Full text not available from this repository.
Chauvière, Gérard;
Bouteille, Bernard;
Enanga, Bertin;
de Albuquerque, Cristina;
Croft, Simon L;
Dumas, Michel;
Périé, Jacques;
(2003)
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
Journal of medicinal chemistry, 46 (3).
pp. 427-440.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm021030a
Full text not available from this repository.
Chen, J;
Kuznetsova, L;
Chibale, K;
Clarkson, C;
Smith, P;
Croft, SL;
Ojima, I;
(2003)
Design, synthesis, and evaluation of taxanes as potential antimalarial agents.
[Conference or Workshop Item]
https://researchonline.lshtm.ac.uk/id/eprint/14865
Full text not available from this repository.
Chibale, K;
Haupt, H;
Kendrick, H;
Yardley, V;
Saravanamuthu, A;
Fairlamb, AH;
Croft, SL;
(2001)
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.
Bioorganic & medicinal chemistry letters, 11 (19).
pp. 2655-2657.
ISSN 0960-894X
DOI: https://doi.org/10.1016/s0960-894x(01)00528-5
Full text not available from this repository.
Conners, Rebecca;
Schambach, Felix;
Read, Jon;
Cameron, Angus;
Sessions, Richard B;
Vivas, Livia;
Easton, Anna;
Croft, Simon L;
Brady, R Leo;
(2005)
Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.
Molecular and biochemical parasitology, 142 (2).
pp. 137-148.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2005.03.015
Full text not available from this repository.
Cottrell, Denise M;
Capers, Jeffrey;
Salem, Manar M;
DeLuca-Fradley, Kate;
Croft, Simon L;
Werbovetz, Karl A;
(2004)
Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles.
Bioorganic & medicinal chemistry, 12 (11).
pp. 2815-2824.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2004.03.054
Full text not available from this repository.
Croft, SL;
(2001)
Monitoring drug resistance in leishmaniasis.
Tropical medicine & international health, 6 (11).
pp. 899-905.
ISSN 1360-2276
DOI: https://doi.org/10.1046/j.1365-3156.2001.00754.x
Full text not available from this repository.
Croft, SL;
(2001)
From natural products to drugs.
Current opinion in infectious diseases, 14 (6).
pp. 717-718.
ISSN 0951-7375
DOI: https://doi.org/10.1097/00001432-200112000-00009
Full text not available from this repository.
Croft, SL;
(2003)
Antiprotozoals.
In: Finch, RG; Greenwood, D; Norrby, SR; Whitley, RJ, (eds.)
Antibiotic and Chemotherapy.
Churchill Livingstone, London, pp. 452-471.
https://researchonline.lshtm.ac.uk/id/eprint/15630
Full text not available from this repository.
Croft, SL;
Buffett, P;
(2015)
Leishmaniasis.
In: Goldman, L; Schafer, AI, (eds.)
Goldman’s Cecil Medicine, 25th ed.
Elsevier-Saunders, pp. 2120-2025.
https://researchonline.lshtm.ac.uk/id/eprint/2950079
Full text not available from this repository.
Croft, SL;
Olliaro, P;
(2011)
Leishmaniasis chemotherapy--challenges and opportunities.
Clinical microbiology and infection, 17 (10).
pp. 1478-1483.
ISSN 1198-743X
DOI: https://doi.org/10.1111/j.1469-0691.2011.03630.x
Full text not available from this repository.
Croft, SL;
Seifert, K;
(2010)
Antiprotozoal agents.
In: Finch, RogerG; Greenwood, David; Whitley, RichardJ; Norrby, SRagnar, (eds.)
Antibiotic and Chemotherapy: Expert Consult (9th Edition).
Saunders.
ISBN 0702040649
https://researchonline.lshtm.ac.uk/id/eprint/2264
Full text not available from this repository.
Croft, SL;
Sutherland, C;
(2001)
Antiprotozoan drugs.
In: UNSPECIFIED, (ed.)
Encyclopedia of Life Sciences.
Nature Publishing Group, London, p. 10.
https://researchonline.lshtm.ac.uk/id/eprint/17863
Full text not available from this repository.
Croft, SL;
Vivas, L;
Brooker, S;
(2003)
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 9 (4).
pp. 518-533.
ISSN 1020-3397
https://researchonline.lshtm.ac.uk/id/eprint/13879
Full text not available from this repository.
Croft, Simon;
(2001)
Antimalarial Chemotherapy: Mechanisms of Action, Resistance and New Directions in Drug Discovery.
Drug discovery today, 6 (22).
1151-.
ISSN 1359-6446
DOI: https://doi.org/10.1016/s1359-6446(01)02035-9
Full text not available from this repository.
Croft, Simon L;
Coombs, Graham H;
(2003)
Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs.
Trends in parasitology, 19 (11).
pp. 502-508.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2003.09.008
Full text not available from this repository.
Croft, Simon L;
Seifert, Karin;
Duchêne, Michael;
(2003)
Antiprotozoal activities of phospholipid analogues.
Molecular and biochemical parasitology, 126 (2).
pp. 165-172.
ISSN 0166-6851
DOI: https://doi.org/10.1016/s0166-6851(02)00283-9
Full text not available from this repository.
Croft, Simon L;
Sundar, Shyam;
Fairlamb, Alan H;
(2006)
Drug resistance in leishmaniasis.
Clinical microbiology reviews, 19 (1).
pp. 111-126.
ISSN 0893-8512
DOI: https://doi.org/10.1128/CMR.19.1.111-126.2006
Full text not available from this repository.
Croft, Simon L;
Ward, Steven;
(2015)
The Nobel Prize in Medicine 2015: Two drugs that changed global health.
Science translational medicine, 7 (316).
316ed14-.
ISSN 1946-6234
DOI: https://doi.org/10.1126/scitranslmed.aad5868
Full text not available from this repository.
Croft, Simon L;
Yardley, Vanessa;
(2002)
Chemotherapy of leishmaniasis.
Current pharmaceutical design, 8 (4).
pp. 319-342.
ISSN 1381-6128
DOI: https://doi.org/10.2174/1381612023396258
Full text not available from this repository.
Croft, Simon L;
Yardley, Vanessa;
Kendrick, Howard;
(2002)
Drug sensitivity of Leishmania species: some unresolved problems.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 Sup (SUPPL.).
S127-S129.
ISSN 0035-9203
DOI: https://doi.org/10.1016/s0035-9203(02)90063-5
Full text not available from this repository.
Das, Shantanabha;
Freier, Anja;
Boussoffara, Thouraya;
Das, Sushmita;
Oswald, Detlef;
Losch, Florian O;
Selka, Melanie;
Sacerdoti-Sierra, Nina;
Schönian, Gabriele;
Wiesmüller, Karl-Heinz;
+10 more...
Seifert, Karin;
Schroff, Matthias;
Juhls, Christiane;
Jaffe, Charles L;
Roy, Syamal;
Das, Pradeep;
Louzir, Hechmi;
Croft, Simon L;
Modabber, Farrokh;
Walden, Peter;
(2014)
Modular multiantigen T cell epitope-enriched DNA vaccine against human leishmaniasis.
Science translational medicine, 6 (234).
234ra56-.
ISSN 1946-6234
DOI: https://doi.org/10.1126/scitranslmed.3008222
Full text not available from this repository.
Daunes, S;
D'Silva, C;
Kendrick, H;
Yardley, V;
Croft, SL;
(2001)
QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives.
Journal of medicinal chemistry, 44 (18).
pp. 2976-2983.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm000502n
Full text not available from this repository.
Dellai, Afef;
Appel, Jon;
Bouraoui, Abderrahman;
Croft, Simon;
Nefzi, Adel;
(2013)
Antimalarial and cytotoxic activities of chiral triamines.
Bioorganic & medicinal chemistry letters, 23 (16).
pp. 4579-4582.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2013.06.035
Full text not available from this repository.
Dujardin, Jean-Claude;
González-Pacanowska, Dolores;
Croft, Simon L;
Olesen, Ole F;
Späth, Gerald F;
(2010)
Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas.
Trends in parasitology, 26 (8).
pp. 395-403.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2010.04.012
Full text not available from this repository.
Escobar, P;
Yardley, V;
Croft, SL;
(2001)
Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice.
Antimicrobial agents and chemotherapy, 45 (6).
pp. 1872-1875.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.45.6.1872-1875.2001
Full text not available from this repository.
Escobar, Patricia;
Matu, Sangeeta;
Marques, Cláudia;
Croft, Simon L;
(2002)
Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B.
Acta tropica, 81 (2).
pp. 151-157.
ISSN 0001-706X
DOI: https://doi.org/10.1016/s0001-706x(01)00197-8
Full text not available from this repository.
Fattorusso, Caterina;
Campiani, Giuseppe;
Kukreja, Gagan;
Persico, Marco;
Butini, Stefania;
Romano, Maria Pia;
Altarelli, Maria;
Ros, Sindu;
Brindisi, Margherita;
Savini, Luisa;
+10 more...
Novellino, Ettore;
Nacci, Vito;
Fattorusso, Ernesto;
Parapini, Silvia;
Basilico, Nicoletta;
Taramelli, Donatella;
Yardley, Vanessa;
Croft, Simon;
Borriello, Marianna;
Gemma, Sandra;
(2008)
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Journal of medicinal chemistry, 51 (5).
pp. 1333-1343.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm7012375
Full text not available from this repository.
Fidock, David A;
Rosenthal, Philip J;
Croft, Simon L;
Brun, Reto;
Nwaka, Solomon;
(2004)
Antimalarial drug discovery: efficacy models for compound screening.
Nature reviews Drug discovery, 3 (6).
pp. 509-520.
ISSN 1474-1776
DOI: https://doi.org/10.1038/nrd1416
Full text not available from this repository.
Garnier, Tracy;
Brown, Marc B;
Lawrence, M Jayne;
Croft, Simon L;
(2006)
In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis.
The Journal of pharmacy and pharmacology, 58 (8).
pp. 1043-1054.
ISSN 0022-3573
DOI: https://doi.org/10.1211/jpp.58.8.0004
Full text not available from this repository.
Garnier, Tracy;
Croft, Simon L;
(2002)
Topical treatment for cutaneous leishmaniasis.
Current opinion in investigational drugs (London, England, 3 (4).
pp. 538-544.
ISSN 1472-4472
https://researchonline.lshtm.ac.uk/id/eprint/16580
Full text not available from this repository.
Garnier, Tracy;
Mäntylä, Antti;
Järvinen, Tomi;
Lawrence, Jayne;
Brown, Marc;
Croft, Simon;
(2007)
In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs.
The Journal of antimicrobial chemotherapy, 60 (4).
pp. 802-810.
ISSN 0305-7453
DOI: https://doi.org/10.1093/jac/dkm303
Full text not available from this repository.
Garnier, Tracy;
Mäntylä, Antti;
Järvinen, Tomi;
Lawrence, M Jayne;
Brown, Marc B;
Croft, Simon L;
(2007)
Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis.
The Journal of pharmacy and pharmacology, 59 (1).
pp. 41-49.
ISSN 0022-3573
DOI: https://doi.org/10.1211/jpp.59.1.0006
Full text not available from this repository.
Gemma, Sandra;
Campiani, Giuseppe;
Butini, Stefania;
Joshi, Bhupendra P;
Kukreja, Gagan;
Coccone, Salvatore Sanna;
Bernetti, Matteo;
Persico, Marco;
Nacci, Vito;
Fiorini, Isabella;
+14 more...
Novellino, Ettore;
Taramelli, Donatella;
Basilico, Nicoletta;
Parapini, Silvia;
Yardley, Vanessa;
Croft, Simon;
Keller-Maerki, Sonja;
Rottmann, Matthias;
Brun, Reto;
Coletta, Massimiliano;
Marini, Stefano;
Guiso, Giovanna;
Caccia, Silvio;
Fattorusso, Caterina;
(2009)
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
Journal of medicinal chemistry, 52 (2).
pp. 502-513.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm801352s
Full text not available from this repository.
Gemma, Sandra;
Campiani, Giuseppe;
Butini, Stefania;
Kukreja, Gagan;
Coccone, Salvatore Sanna;
Joshi, Bhupendra P;
Persico, Marco;
Nacci, Vito;
Fiorini, Isabella;
Novellino, Ettore;
+12 more...
Fattorusso, Ernesto;
Taglialatela-Scafati, Orazio;
Savini, Luisa;
Taramelli, Donatella;
Basilico, Nicoletta;
Parapini, Silvia;
Morace, Giulia;
Yardley, Vanessa;
Croft, Simon;
Coletta, Massimiliano;
Marini, Stefano;
Fattorusso, Caterina;
(2008)
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Journal of medicinal chemistry, 51 (5).
pp. 1278-1294.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm701247k
Full text not available from this repository.
Ghosh, Subhash;
Chan, Julian MW;
Lea, Christopher R;
Meints, Gary A;
Lewis, Jared C;
Tovian, Zev S;
Flessner, Ryan M;
Loftus, Timothy C;
Bruchhaus, Iris;
Kendrick, Howard;
+5 more...
Croft, Simon L;
Kemp, Robert G;
Kobayashi, Seiki;
Nozaki, Tomoyoshi;
Oldfield, Eric;
(2004)
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Journal of medicinal chemistry, 47 (1).
pp. 175-187.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm030084x
Full text not available from this repository.
Gokhale, Nikhil H;
Padhye, Subhash B;
Billington, David C;
Rathbone, Daniel L;
Croft, Simon L;
Kendrick, Howard D;
Anson, Christopher E;
Powell, Annie K;
(2003)
Synthesis and characterization of copper(II) complexes of pyridine-2-carboxamidrazones as potent antimalarial agents.
Inorganica chimica acta, 349.
pp. 23-29.
ISSN 0020-1693
DOI: https://doi.org/10.1016/s0020-1693(03)00047-1
Full text not available from this repository.
Gokhale, Nikhil H;
Padhye, Subhash B;
Croft, Simon L;
Kendrick, Howard D;
Davies, Wendy;
Anson, Christopher E;
Powell, Annie K;
(2003)
Transition metal complexes of buparvaquone as potent new antimalarial agents. 1. Synthesis, X-ray crystal-structures, electrochemistry and antimalarial activity against Plasmodium falciparum.
Journal of inorganic biochemistry, 95 (4).
pp. 249-258.
ISSN 0162-0134
DOI: https://doi.org/10.1016/s0162-0134(03)00134-x
Full text not available from this repository.
Gokhale, Nikhil H;
Shirisha, K;
Padhye, Subhash B;
Croft, Simon L;
Kendrick, Howard D;
Mckee, Vickie;
(2006)
Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
Bioorganic & medicinal chemistry letters, 16 (2).
pp. 430-432.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2005.09.061
Full text not available from this repository.
Grant, Karen M;
Dunion, Morag H;
Yardley, Vanessa;
Skaltsounis, Alexios-Leandros;
Marko, Doris;
Eisenbrand, Gerhard;
Croft, Simon L;
Meijer, Laurent;
Mottram, Jeremy C;
(2004)
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.
Antimicrobial agents and chemotherapy, 48 (8).
pp. 3033-3042.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.48.8.3033-3042.2004
Full text not available from this repository.
Gros, Ludovic;
Castillo-Acosta, Victor Manuel;
Jiménez Jiménez, Carmen;
Sealey-Cardona, Marco;
Vargas, Sofia;
Manuel Estévez, Antonio;
Yardley, Vanessa;
Rattray, Lauren;
Croft, Simon L;
Ruiz-Perez, Luis M;
+3 more...
Urbina, Julio A;
Gilbert, Ian H;
González-Pacanowska, Dolores;
(2006)
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.
Antimicrobial agents and chemotherapy, 50 (8).
pp. 2595-2601.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.01508-05
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Gros, Ludovic;
Lorente, Silvia Orenes;
Jimenez, Carmen Jimenez;
Yardley, Vanessa;
Rattray, Lauren;
Wharton, Hayley;
Little, Susan;
Croft, Simon L;
Ruiz-Perez, Luis M;
Gonzalez-Pacanowska, Dolores;
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Gilbert, Ian H;
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Evaluation of azasterols as anti-parasitics.
Journal of medicinal chemistry, 49 (20).
pp. 6094-6103.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm060290f
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Guerin, Philippe J;
Olliaro, Piero;
Sundar, Shyam;
Boelaert, Marleen;
Croft, Simon L;
Desjeux, Philippe;
Wasunna, Monique K;
Bryceson, Anthony DM;
(2002)
Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.
The Lancet infectious diseases, 2 (8).
pp. 494-501.
ISSN 1473-3099
DOI: https://doi.org/10.1016/s1473-3099(02)00347-x
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Guglielmo, Stefano;
Bertinaria, Massimo;
Rolando, Barbara;
Crosetti, Marco;
Fruttero, Roberta;
Yardley, Vanessa;
Croft, Simon L;
Gasco, Alberto;
(2009)
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.
European journal of medicinal chemistry, 44 (12).
pp. 5071-5079.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2009.09.012
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Hayhoe, Simon;
McCrossan, Maria;
Smith, Aden;
Ellis, David;
Croft, Simon;
Mei, Man Fong;
(2002)
Single-use acupuncture needles: scanning electron-microscopy of needle-tips.
Acupuncture in medicine, 20 (1).
pp. 11-18.
ISSN 0964-5284
DOI: https://doi.org/10.1136/aim.20.1.11
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Haynes, Richard K;
Fugmann, Burkhard;
Stetter, Jörg;
Rieckmann, Karl;
Heilmann, Hans-Dietrich;
Chan, Ho-Wai;
Cheung, Man-Ki;
Lam, Wai-Lun;
Wong, Ho-Ning;
Croft, Simon L;
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Vivas, Livia;
Rattray, Lauren;
Stewart, Lindsay;
Peters, Wallace;
Robinson, Brian L;
Edstein, Michael D;
Kotecka, Barbara;
Kyle, Dennis E;
Beckermann, Bernhard;
Gerisch, Michael;
Radtke, Martin;
Schmuck, Gabriele;
Steinke, Wolfram;
Wollborn, Ute;
Schmeer, Karl;
Römer, Axel;
(2006)
Artemisone--a highly active antimalarial drug of the artemisinin class.
Angewandte Chemie (International ed in English), 45 (13).
pp. 2082-2088.
ISSN 1433-7851
DOI: https://doi.org/10.1002/anie.200503071
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Haynes, Richard K;
Ho, Wing-Yan;
Chan, Ho-Wai;
Fugmann, Burkhard;
Stetter, Jörg;
Croft, Simon L;
Vivas, Livia;
Peters, Wallace;
Robinson, Brian L;
(2004)
Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity.
Angewandte Chemie (International ed in English), 43 (11).
pp. 1381-1385.
ISSN 1433-7851
DOI: https://doi.org/10.1002/anie.200352343
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Haynes, Richard K;
Wong, Ho-Ning;
Lee, Kin-Wo;
Lung, Chung-Man;
Shek, Lai Yung;
Williams, Ian D;
Croft, Simon L;
Vivas, Livia;
Rattray, Lauren;
Stewart, Lindsay;
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Wong, Vincent KW;
Ko, Ben CB;
(2007)
Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities.
ChemMedChem, 2 (10).
pp. 1464-1479.
ISSN 1860-7179
DOI: https://doi.org/10.1002/cmdc.200700065
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Hudock, Michael P;
Sanz-Rodríguez, CE;
Song, Yongcheng;
Chan, Julian MW;
Zhang, Yonghui;
Odeh, Sarah;
Kosztowski, Thomas;
Leon-Rossell, Annette;
Concepción, JL;
Yardley, Vanessa;
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Croft, Simon L;
Urbina, Julio A;
Oldfield, Eric;
(2006)
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Journal of medicinal chemistry, 49 (1).
pp. 215-223.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm0582625
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Jeganathan, Sinthujah;
Sanderson, Lisa;
Dogruel, Murat;
Rodgers, Jean;
Croft, Simon;
Thomas, Sarah A;
(2011)
The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers.
The Journal of pharmacology and experimental therapeutics, 336 (2).
pp. 506-515.
ISSN 0022-3565
DOI: https://doi.org/10.1124/jpet.110.172981
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Jung, Mankil;
Lee, Kyunghoon;
Jung, Hochul;
Kendrick, Howard;
Yardley, Vanessa;
Croft, Simon L;
(2004)
Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
Bioorganic & medicinal chemistry letters, 14 (8).
pp. 2001-2003.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2003.12.104
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Jung, Mankil;
Lee, Kyunghoon;
Kendrick, Howard;
Robinson, Brian L;
Croft, Simon L;
(2002)
Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid.
Journal of medicinal chemistry, 45 (22).
pp. 4940-4944.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm020244p
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Kayser, O;
Kiderlen, A;
Croft, SL;
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Natural Products as potential antiparasitic drugs.
In: Rahman, Atta-, Yr, (ed.)
Studies in Natural Product Chemistry 26.
Elsevier, pp. 779-848.
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Kayser, O;
Kiderlen, AF;
Croft, SL;
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Natural products as antiparasitic drugs.
Parasitology research, 90 Sup.
S55-S62.
ISSN 0932-0113
DOI: https://doi.org/10.1007/s00436-002-0768-3
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Kayser, O;
Olbrich, C;
Croft, SL;
Kiderlen, AF;
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Formulation and biopharmaceutical issues in the development of drug delivery systems for antiparasitic drugs.
Parasitology research, 90 Sup.
S63-S70.
ISSN 0932-0113
DOI: https://doi.org/10.1007/s00436-002-0769-2
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Kayser, O;
Olbrich, C;
Yardley, V;
Kiderlen, AF;
Croft, SL;
(2003)
Formulation of amphotericin B as nanosuspension for oral administration.
International journal of pharmaceutics, 254 (1).
pp. 73-75.
ISSN 0378-5173
DOI: https://doi.org/10.1016/s0378-5173(02)00686-5
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Kayser, Oliver;
Kiderlen, Albrecht F;
Croft, Simon L;
(2003)
Antileishmanial activity of two gamma-pyrones from Podolepsis hieracioides (Asteraceae).
Acta tropica, 86 (1).
pp. 105-107.
ISSN 0001-706X
DOI: https://doi.org/10.1016/s0001-706x(02)00258-9
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Larabi, Malika;
Yardley, Vanessa;
Loiseau, Philippe M;
Appel, Martine;
Legrand, Philippe;
Gulik, Annette;
Bories, Christian;
Croft, Simon L;
Barratt, Gillian;
(2003)
Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B.
Antimicrobial agents and chemotherapy, 47 (12).
pp. 3774-3779.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.47.12.3774-3779.2003
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Laurent, Thierry;
Rijal, Suman;
Yardley, Vanessa;
Croft, Simon;
De Doncker, Simonne;
Decuypere, Saskia;
Khanal, Basudha;
Singh, Rupa;
Schönian, Gabriele;
Kuhls, Katrin;
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Chappuis, François;
Dujardin, Jean-Claude;
(2006)
Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal.
Infection, genetics and evolution, 7 (2).
pp. 206-212.
ISSN 1567-1348
DOI: https://doi.org/10.1016/j.meegid.2006.08.005
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Liu, Mei;
Wilairat, Prapon;
Croft, Simon L;
Tan, Agnes Lay-Choo;
Go, Mei-Lin;
(2003)
Structure-activity relationships of antileishmanial and antimalarial chalcones.
Bioorganic & medicinal chemistry, 11 (13).
pp. 2729-2738.
ISSN 0968-0896
DOI: https://doi.org/10.1016/s0968-0896(03)00233-5
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Liu, Mei;
Wilairat, Prapon;
Croft, Simon L;
Tan, Agnes Lay-Choo;
Go, Mei-Lin;
(2004)
Corrigendum to “Structure–activity relationships of antileishmanial and antimalarial chalcones” (Bioorg. Chem. 2003, 11, 2729–2738].
Bioorganic & medicinal chemistry, 12 (6).
p. 1569.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2004.01.023
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Lorente, Silvia Orenes;
Jimenez, Carmen Jimenez;
Gros, Ludovic;
Yardley, Vanessa;
de Luca-Fradley, Kate;
Croft, Simon L;
A Urbina, Julio;
Ruiz-Perez, Luis M;
Pacanowska, Dolores Gonzalez;
Gilbert, Ian H;
(2005)
Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics.
Bioorganic & medicinal chemistry, 13 (18).
pp. 5435-5453.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2005.06.012
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Lorente, Silvia Orenes;
Rodrigues, Juliany CF;
Jiménez Jiménez, Carmen;
Joyce-Menekse, Miranda;
Rodrigues, Carlos;
Croft, Simon L;
Yardley, Vanessa;
de Luca-Fradley, Kate;
Ruiz-Pérez, Luis M;
Urbina, Julio;
+3 more...
de Souza, Wanderley;
González Pacanowska, Dolores;
Gilbert, Ian H;
(2004)
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
Antimicrobial agents and chemotherapy, 48 (8).
pp. 2937-2950.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.48.8.2937-2950.2004
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Luna, Katherine Paola;
Hernández, Indira Paola;
Rueda, César Mauricio;
Zorro, María Magdalena;
Croft, Simon L;
Escobar, Patricia;
(2009)
In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.
Biomedica, 29 (3).
pp. 448-455.
ISSN 0120-4157
DOI: https://doi.org/10.7705/biomedica.v29i3.15
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Luque-Ortega, JR;
Rivero-Lezcano, OM;
Croft, SL;
Rivas, L;
(2001)
In vivo monitoring of intracellular ATP levels in Leishmania donovani promastigotes as a rapid method to screen drugs targeting bioenergetic metabolism.
Antimicrobial agents and chemotherapy, 45 (4).
pp. 1121-1125.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.45.4.1121-1125.2001
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Maes, L;
Cos, P;
Croft, SL;
(2013)
The relevance of susceptibility tests, breakpoints and markers.
In: Pont-Sucre, A; Diaz, E; Padron-Nieves, M, (eds.)
Drug resistance in Leishmania parasites.
Springer-Verlag, Wien, pp. 407-429.
https://researchonline.lshtm.ac.uk/id/eprint/2939183
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Magaraci, Filippo;
Jimenez, Carmen Jimenez;
Rodrigues, Carlos;
Rodrigues, Juliany CF;
Braga, Marina Vianna;
Yardley, Vanessa;
de Luca-Fradley, Kate;
Croft, Simon L;
de Souza, Wanderley;
Ruiz-Perez, Luis M;
+3 more...
Urbina, Julio;
Gonzalez Pacanowska, Dolores;
Gilbert, Ian H;
(2003)
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.
Journal of medicinal chemistry, 46 (22).
pp. 4714-4727.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm021114j
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Martin, MB;
Grimley, JS;
Lewis, JC;
Heath, HT;
Bailey, BN;
Kendrick, H;
Yardley, V;
Caldera, A;
Lira, R;
Urbina, JA;
+4 more...
Moreno, SN;
Docampo, R;
Croft, SL;
Oldfield, E;
(2001)
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Journal of medicinal chemistry, 44 (6).
pp. 909-916.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm0002578
Full text not available from this repository.
Martin, Michael B;
Sanders, John M;
Kendrick, Howard;
de Luca-Fradley, Kate;
Lewis, Jared C;
Grimley, Joshua S;
Van Brussel, Erin M;
Olsen, Jeffrey R;
Meints, Gary A;
Burzynska, Agnieszka;
+3 more...
Kafarski, Pawel;
Croft, Simon L;
Oldfield, Eric;
(2002)
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.
Journal of medicinal chemistry, 45 (14).
pp. 2904-2914.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm0102809
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Mohamed-Ahmed, Abeer HA;
Brocchini, Stephen;
Croft, Simon L;
(2012)
Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis.
Current opinion in infectious diseases, 25 (6).
pp. 695-702.
ISSN 0951-7375
DOI: https://doi.org/10.1097/QCO.0b013e328359eff2
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Mohamed-Ahmed, Abeer HA;
Les, Karolina A;
Seifert, Karin;
Croft, Simon L;
Brocchini, Stephen;
(2013)
Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).
Molecular pharmaceutics, 10 (3).
pp. 940-950.
ISSN 1543-8384
DOI: https://doi.org/10.1021/mp300339p
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Mohamed-Ahmed, Abeer HA;
Seifert, Karin;
Yardley, Vanessa;
Burrell-Saward, Hollie;
Brocchini, Stephen;
Croft, Simon L;
(2013)
Antileishmanial activity, uptake, and biodistribution of an amphotericin B and poly(α-Glutamic Acid) complex.
Antimicrobial agents and chemotherapy, 57 (10).
pp. 4608-4614.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.02343-12
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Muriithi, Mary W;
Abraham, W-R;
Addae-Kyereme, Jonathan;
Scowen, Ian;
Croft, Simon L;
Gitu, Peter M;
Kendrick, Howard;
Njagi, ENM;
Wright, Colin W;
(2002)
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.
Journal of natural products, 65 (7).
pp. 956-959.
ISSN 0163-3864
DOI: https://doi.org/10.1021/np0106182
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Murray, PJ;
Kranz, M;
Ladlow, M;
Taylor, S;
Berst, F;
Holmes, AB;
Keavey, KN;
Jaxa-Chamiec, A;
Seale, PW;
Stead, P;
+4 more...
Upton, RJ;
Croft, SL;
Clegg, W;
Elsegood, MR;
(2001)
The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin.
Bioorganic & medicinal chemistry letters, 11 (6).
pp. 773-776.
ISSN 0960-894X
DOI: https://doi.org/10.1016/s0960-894x(01)00049-x
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Mäntylä, Antti;
Garnier, Tracy;
Rautio, Jarkko;
Nevalainen, Tapio;
Vepsälainen, Jouko;
Koskinen, Ari;
Croft, Simon L;
Järvinen, Tomi;
(2004)
Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone.
Journal of medicinal chemistry, 47 (1).
pp. 188-195.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm030868a
Full text not available from this repository.
Mäntylä, Antti;
Rautio, Jarkko;
Nevalainen, Tapio;
Vepsälainen, Jouko;
Juvonen, Risto;
Kendrick, Howard;
Garnier, Tracy;
Croft, Simon L;
Järvinen, Tomi;
(2004)
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives.
Bioorganic & medicinal chemistry, 12 (13).
pp. 3497-3502.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2004.04.032
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Nan, A;
Nanayakkara, NP;
Walker, LA;
Yardley, V;
Croft, SL;
Ghandehari, H;
(2001)
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs.
Journal of controlled release, 77 (3).
pp. 233-243.
ISSN 0168-3659
DOI: https://doi.org/10.1016/s0168-3659(01)00514-4
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Nan, Anjan;
Croft, Simon L;
Yardley, Vanessa;
Ghandehari, Hamidreza;
(2004)
Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis.
Journal of controlled release, 94 (1).
pp. 115-127.
ISSN 0168-3659
DOI: https://doi.org/10.1016/j.jconrel.2003.09.012
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Nanayakkara, NP Dhammika;
Ager, Arba L;
Bartlett, Marilyn S;
Yardley, Vanessa;
Croft, Simon L;
Khan, Ikhlas A;
McChesney, James D;
Walker, Larry A;
(2008)
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.
Antimicrobial agents and chemotherapy, 52 (6).
pp. 2130-2137.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00645-07
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Nanayakkara, NP;
Ager, AL;
Bartlett, MS;
Yardley, V;
Croft, SL;
Khan, IA;
McChesney, JD;
Walker, LA;
(2008)
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichloropheno xy]quinoline succinate.
Antimicrobial agents and chemotherapy, 52 (6).
pp. 2130-2137.
ISSN 0066-4804
DOI: https://doi.org/10.1128/aac.00645-07
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Ohkanda, J;
Lockman, JW;
Yokoyama, K;
Gelb, MH;
Croft, SL;
Kendrick, H;
Harrell, MI;
Feagin, JE;
Blaskovich, MA;
Sebti, SM;
+1 more...
Hamilton, AD;
(2001)
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters, 11 (6).
pp. 761-764.
ISSN 0960-894X
DOI: https://doi.org/10.1016/s0960-894x(01)00055-5
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Ohkanda, Junko;
Buckner, Frederick S;
Lockman, Jeffrey W;
Yokoyama, Kohei;
Carrico, Dora;
Eastman, Richard;
de Luca-Fradley, Kate;
Davies, Wendy;
Croft, Simon L;
Van Voorhis, Wesley C;
+3 more...
Gelb, Michael H;
Sebti, Saïd M;
Hamilton, Andrew D;
(2004)
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry, 47 (2).
pp. 432-445.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm030236o
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Oldfield, E;
Martin, MB;
Croft, SL;
Rodriguez, N;
Montalvetti, A;
Bailey, BN;
Docampo, R;
Urbina, JA;
Khan, AA;
Slifer, TR;
+2 more...
Araujo, FG;
Moreno, SNJ;
(2001)
Bisphosphonates as novel chemotherapeutic agents.
[Conference or Workshop Item]
https://researchonline.lshtm.ac.uk/id/eprint/16588
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Onyeibor, Onyeka;
Croft, Simon L;
Dodson, Hilary I;
Feiz-Haddad, Mohammad;
Kendrick, Howard;
Millington, Nicola J;
Parapini, Silvia;
Phillips, Roger M;
Seville, Scott;
Shnyder, Steven D;
+2 more...
Taramelli, Donatella;
Wright, Colin W;
(2005)
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
Journal of medicinal chemistry, 48 (7).
pp. 2701-2709.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm040893w
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Orenes Lorente, Silvia;
Gómez, Rosario;
Jiménez, Carmen;
Cammerer, Simon;
Yardley, Vanessa;
de Luca-Fradley, Kate;
Croft, Simon L;
Ruiz Perez, Luis M;
Urbina, Julio;
Gonzalez Pacanowska, Dolores;
+1 more...
Gilbert, Ian H;
(2005)
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.
Bioorganic & medicinal chemistry, 13 (10).
pp. 3519-3529.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2005.02.060
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Parveen, Seheli;
Khan, Mohammed OF;
Austin, Susan E;
Croft, Simon L;
Yardley, Vanessa;
Rock, Peter;
Douglas, Kenneth T;
(2005)
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.
Journal of medicinal chemistry, 48 (25).
pp. 8087-8097.
ISSN 0022-2623
DOI: https://doi.org/10.1021/jm050819t
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Pez, Didier;
Leal, Isabel;
Zuccotto, Fabio;
Boussard, Cyrille;
Brun, Reto;
Croft, Simon L;
Yardley, Vanessa;
Ruiz Perez, Luis M;
Gonzalez Pacanowska, Dolores;
Gilbert, Ian H;
(2003)
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.
Bioorganic & medicinal chemistry, 11 (22).
pp. 4693-4711.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2003.08.012
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Peña, Stella;
Scarone, Laura;
Manta, Eduardo;
Stewart, Lindsay;
Yardley, Vanessa;
Croft, Simon;
Serra, Gloria;
(2012)
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
Bioorganic & medicinal chemistry letters, 22 (15).
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ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2012.06.028
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Pérez-Victoria, F Javier;
Sánchez-Cañete, María P;
Seifert, Karin;
Croft, Simon L;
Sundar, Shyam;
Castanys, Santiago;
Gamarro, Francisco;
(2006)
Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.
Drug resistance updates, 9 (1-2).
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ISSN 1368-7646
DOI: https://doi.org/10.1016/j.drup.2006.04.001
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Ramírez, Irama;
Carabot, Alfredo;
Meléndez, Pablo;
Carmona, Juan;
Jimenez, Manuel;
Patel, Asmita V;
Crabb, Trevor A;
Blunden, Gerald;
Cary, Peter D;
Croft, Simon L;
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Costa, Manuel;
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Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira.
Phytochemistry, 64 (2).
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ISSN 0031-9422
DOI: https://doi.org/10.1016/s0031-9422(03)00241-3
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Ren, H;
Grady, S;
Gamenara, D;
Heinzen, H;
Moyna, P;
Croft, SL;
Kendrick, H;
Yardley, V;
Moyna, G;
(2001)
Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds.
Bioorganic & medicinal chemistry letters, 11 (14).
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DOI: https://doi.org/10.1016/s0960-894x(01)00308-0
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Ren, Hongyu;
Grady, Shannon;
Banghart, Matthew;
Moulthrop, Jason S;
Kendrick, Howard;
Yardley, Vanessa;
Croft, Simon L;
Moyna, Guillermo;
(2003)
Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines.
European journal of medicinal chemistry, 38 (11-12).
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ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2003.07.004
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Rijal, Suman;
Yardley, Vanessa;
Chappuis, François;
Decuypere, Saskia;
Khanal, Basudha;
Singh, Rupa;
Boelaert, Marleen;
De Doncker, Simonne;
Croft, Simon;
Dujardin, Jean-Claude;
(2007)
Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome?
Microbes and infection / Institut Pasteur, 9 (4).
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ISSN 1286-4579
DOI: https://doi.org/10.1016/j.micinf.2007.01.009
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Saha, B;
Tonkal, AMDJ;
Croft, S;
Roy, S;
(2004)
Mast cells at the host-pathogen interface: host-protection versus immune evasion in leishmaniasis.
Clinical and experimental immunology, 137 (1).
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ISSN 0009-9104
DOI: https://doi.org/10.1111/j.1365-2249.2004.02505.x
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Salmon-Chemin, L;
Buisine, E;
Yardley, V;
Kohler, S;
Debreu, MA;
Landry, V;
Sergheraert, C;
Croft, SL;
Krauth-Siegel, RL;
Davioud-Charvet, E;
(2001)
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
Journal of medicinal chemistry, 44 (4).
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ISSN 0022-2623
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Sanderson, Lisa;
Yardley, Vanessa;
Croft, Simon L;
(2014)
Activity of anti-cancer protein kinase inhibitors against Leishmania spp.
The Journal of antimicrobial chemotherapy, 69 (7).
pp. 1888-1891.
ISSN 0305-7453
DOI: https://doi.org/10.1093/jac/dku069
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Santos, Djalma AP dos;
Vieira, Paulo C;
Silva, M Fátima das GF da;
Fernandes, João B;
Rattray, Lauren;
Croft, Simon L;
(2009)
Antiparasitic activities of acridone alkaloids from Swinglea glutinosa (Bl.) Merr.
Journal of the Brazilian Chemical Society, 20 (4).
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Seifert, Karin;
Croft, Simon L;
(2006)
In vitro and in vivo interactions between miltefosine and other antileishmanial drugs.
Antimicrobial agents and chemotherapy, 50 (1).
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ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.50.1.73-79.2006
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Seifert, Karin;
Escobar, Patricia;
Croft, Simon L;
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In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent.
The Journal of antimicrobial chemotherapy, 65 (3).
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ISSN 0305-7453
DOI: https://doi.org/10.1093/jac/dkp500
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Seifert, Karin;
Juhls, Christiane;
Salguero, Francisco J;
Croft, Simon L;
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Sequential chemoimmunotherapy of experimental visceral leishmaniasis using a single low dose of liposomal amphotericin B and a novel DNA vaccine candidate.
Antimicrobial agents and chemotherapy, 59 (9).
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DOI: https://doi.org/10.1128/AAC.00273-15
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Seifert, Karin;
Lemke, Andreas;
Croft, Simon L;
Kayser, Oliver;
(2007)
Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivatives.
Antimicrobial agents and chemotherapy, 51 (12).
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ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00465-07
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Seifert, Karin;
Matu, Sangeeta;
Javier Pérez-Victoria, F;
Castanys, Santiago;
Gamarro, Francisco;
Croft, Simon L;
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Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).
International journal of antimicrobial agents, 22 (4).
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ISSN 0924-8579
DOI: https://doi.org/10.1016/s0924-8579(03)00125-0
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Seifert, Karin;
Munday, Jane;
Syeda, Tahmina;
Croft, Simon L;
(2011)
In vitro interactions between sitamaquine and amphotericin B, sodium stibogluconate, miltefosine, paromomycin and pentamidine against Leishmania donovani.
The Journal of antimicrobial chemotherapy, 66 (4).
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Seifert, Karin;
Pérez-Victoria, F Javier;
Stettler, Marianne;
Sánchez-Cañete, María P;
Castanys, Santiago;
Gamarro, Francisco;
Croft, Simon L;
(2007)
Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo.
International journal of antimicrobial agents, 30 (3).
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ISSN 0924-8579
DOI: https://doi.org/10.1016/j.ijantimicag.2007.05.007
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Sindermann, H;
Croft, SL;
Engel, KR;
Bommer, W;
Eibl, HJ;
Unger, C;
Engel, J;
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Miltefosine (Impavido): the first oral treatment against leishmaniasis.
Medical microbiology and immunology, 193 (4).
pp. 173-180.
ISSN 0300-8584
DOI: https://doi.org/10.1007/s00430-003-0201-2
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Stuart, Ken;
Brun, Reto;
Croft, Simon;
Fairlamb, Alan;
Gürtler, Ricardo E;
McKerrow, Jim;
Reed, Steve;
Tarleton, Rick;
(2008)
Kinetoplastids: related protozoan pathogens, different diseases.
The Journal of clinical investigation, 118 (4).
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ISSN 0021-9738
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Van Bocxlaer, Katrien;
Yardley, Vanessa;
Murdan, Sudaxshina;
Croft, Simon L;
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Drug permeation and barrier damage in Leishmania-infected mouse skin.
The Journal of antimicrobial chemotherapy, 71 (6).
pp. 1578-1585.
ISSN 0305-7453
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Vivas, L;
Rattray, L;
Stewart, LB;
Robinson, BL;
Fugmann, B;
Haynes, RK;
Peters, W;
Croft, SL;
(2007)
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.
The Journal of antimicrobial chemotherapy, 59 (4).
pp. 658-665.
ISSN 0305-7453
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Vivas, Livia;
Easton, Anna;
Kendrick, Howard;
Cameron, Angus;
Lavandera, Jose-Luis;
Barros, David;
de las Heras, Federico Gomez;
Brady, R Leo;
Croft, Simon L;
(2005)
Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase.
Experimental parasitology, 111 (2).
pp. 105-114.
ISSN 0014-4894
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Vivas, Livia;
Rattray, Lauren;
Stewart, Lindsay;
Bongard, Emily;
Robinson, Brian L;
Peters, Wallace;
Croft, Simon L;
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Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo.
Acta tropica, 105 (3).
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ISSN 0001-706X
DOI: https://doi.org/10.1016/j.actatropica.2007.12.005
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Wright, CW;
Addae-Kyereme, J;
Breen, AG;
Brown, JE;
Cox, MF;
Croft, SL;
Gökçek, Y;
Kendrick, H;
Phillips, RM;
Pollet, PL;
(2001)
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.
Journal of medicinal chemistry, 44 (19).
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Wube, AA;
Bucar, F;
Gibbons, S;
Asres, K;
Rattray, L;
Croft, SL;
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Antiprotozoal activity of sesquiterpenes from Warburgia ugandensis towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro.
Planta medica, 74 (9).
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Wube, Abraham Abebe;
Bucar, Franz;
Asres, Kaleab;
Gibbons, Simon;
Rattray, Lauren;
Croft, Simon L;
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Antimalarial compounds from Kniphofia foliosa roots.
Phytotherapy research, 19 (6).
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ISSN 0951-418X
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Wube, Abraham Abebe;
Bucar, Franz;
Gibbons, Simon;
Asres, Kaleab;
Rattray, Lauren;
Croft, Simon L;
(2010)
Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro.
Phytotherapy research, 24 (10).
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ISSN 0951-418X
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Xu, J;
Bergquist, R;
Qian, YJ;
Wang, Q;
Yu, Q;
Peeling, R;
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China-Africa and China-Asia Collaboration on Schistosomiasis Control: A SWOT Analysis.
Adv Parasitol, 92.
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Yardley, Vanessa;
Gamarro, Francisco;
Croft, Simon L;
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Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.
Antimicrobial agents and chemotherapy, 54 (12).
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ISSN 0066-4804
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Yardley, Vanessa;
Khan, Anis A;
Martin, Michael B;
Slifer, Teri R;
Araujo, Fausto G;
Moreno, Silvia NJ;
Docampo, Roberto;
Croft, Simon L;
Oldfield, Eric;
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In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Antimicrobial agents and chemotherapy, 46 (3).
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ISSN 0066-4804
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Yardley, Vanessa;
Ortuno, Nimer;
Llanos-Cuentas, Alejandro;
Chappuis, Francois;
Doncker, Simonne De;
Ramirez, Luis;
Croft, Simon;
Arevalo, Jorge;
Adaui, Vanessa;
Bermudez, Hernan;
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Decuypere, Saskia;
Dujardin, Jean-Claude;
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American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?
The Journal of infectious diseases, 194 (8).
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ISSN 0022-1899
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del Rayo Camacho, M;
Phillipson, JD;
Croft, SL;
Kirby, GC;
Warhurst, DC;
Solis, PN;
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Terpenoids from Guarea rhophalocarpa.
Phytochemistry, 56 (2).
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del Rayo Camacho, Maria;
Phillipson, J David;
Croft, Simon L;
Marley, Dereck;
Kirby, Geoffrey C;
Warhurst, David C;
(2002)
Assessment of the Antiprotozoal Activity of <i>Galphimia </i><i>g</i><i>lauca </i>and the Isolation of New Nor-secofriedelanes and Nor-friedelanes.
Journal of natural products, 65 (10).
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del Rayo Camacho, Maria;
Phillipson, J David;
Croft, Simon L;
Marley, Dereck;
Kirby, Geoffrey C;
Warhurst, David C;
(2002)
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
Journal of natural products, 65 (10).
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ISSN 0163-3864
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del Rayo Camacho, Maria;
Phillipson, J David;
Croft, Simon L;
Rock, Peter;
Marshall, Sarah J;
Schiff, Paul L;
(2002)
In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei.
Phytotherapy research, 16 (5).
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ISSN 0951-418X
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del Rayo Camacho, Maria;
Phillipson, J David;
Croft, Simon L;
Yardley, Vanesa;
Solis, Pablo N;
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In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins.
Planta medica, 70 (1).
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dos Santos, Djalma AP;
de C Braga, Patricia A;
da Silva, M Fátima das GF;
Fernandes, João B;
Vieira, Paulo C;
Magalhães, Aderbal F;
Magalhães, Eva G;
Marsaioli, Anita J;
de S Moraes, Valéria R;
Rattray, Lauren;
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Croft, Simon L;
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Anti-African trypanocidal and antimalarial activity of natural flavonoids, dibenzoylmethanes and synthetic analogues.
The Journal of pharmacy and pharmacology, 61 (2).
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ISSN 0022-3573
DOI: https://doi.org/10.1211/jpp/61.02.0017
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van Baren, C;
Anao, I;
Lira, PD;
Debenedetti, S;
Houghton, P;
Croft, S;
Martino, V;
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Triterpenic acids and flavonoids from Satureja parvifolia. Evaluation of their antiprotozoal activity.
Zeitschrift fur Naturforschung C, Journal of biosciences, 61 (3-4).
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ISSN 0939-5075
https://researchonline.lshtm.ac.uk/id/eprint/11723
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Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates.
PhD thesis, London School of Hygiene & Tropical Medicine.
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Ashwin, Helen;
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Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis.
Wellcome open research, 3.
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Gamo, Francisco-Javier;
Ferrer, Santiago B;
Hui, Raymond;
Bousema, Teun;
Angulo-Barturén, Iñigo;
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Osborne, Simon A;
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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nature communications, 8 (1).
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Emerging paradigms in anti-infective drug design.
Parasitology, 141 (1).
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Barrett, Michael P;
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Management of trypanosomiasis and leishmaniasis.
British medical bulletin, 104 (1).
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Basilico, Nicoletta;
Parapini, Silvia;
Sparatore, Anna;
Romeo, Sergio;
Misiano, Paola;
Vivas, Livia;
Yardley, Vanessa;
Croft, Simon L;
Habluetzel, Annette;
Lucantoni, Leonardo;
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Renia, Laurent;
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Suwanarusk, Rossarin;
Nosten, Francois;
Dondio, Giulio;
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In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.
Molecules (Basel, Switzerland), 22 (12).
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Burrell-Saward, H;
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Development of an imaging model of a CNS infection with African trypanosomes.
PhD thesis, London School of Hygiene & Tropical Medicine.
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Burrell-Saward, H;
Harris, AJ;
de LaFlor, R;
Sallam, H;
Alavijeh, MS;
Ward, TH;
Croft, SL;
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Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human african trypanosomiasis.
International journal of antimicrobial agents, 50 (2).
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Burrell-Saward, Hollie;
Rodgers, Jean;
Bradley, Barbara;
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A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
The Journal of antimicrobial chemotherapy, 70 (2).
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den Boer, Margriet;
Burza, Sakib;
Chapman, Lloyd AC;
Chaskopoulou, Alexandra;
Coleman, Michael;
Courtenay, Orin;
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Croft, Simon;
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Dilger, Erin;
Foster, Geraldine;
Garlapati, Rajesh;
Haines, Lee;
Harris, Angela;
Hemingway, Janet;
Hollingsworth, T Déirdre;
Jervis, Sarah;
Medley, Graham;
Miles, Michael;
Paine, Mark;
Picado, Albert;
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de Vlas, Sake J;
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Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India.
Parasites & vectors, 9 (1).
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Caridha, Diana;
Vesely, Brian;
van Bocxlaer, Katrien;
Arana, Byron;
Mowbray, Charles E;
Rafati, Sima;
Uliana, Silvia;
Reguera, Rosa;
Kreishman-Deitrick, Mara;
Sciotti, Richard;
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Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis.
International Journal for Parasitology: Drugs and Drug Resistance, 11.
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ISSN 2211-3207
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Clark, David J;
Moore, Catherine M;
Flanagan, Marc;
Bocxlaer, Katrien Van;
Piperaki, Evangelia-Theophano;
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Tyson, John;
Whitehouse, Sam P;
O'Halloran, Jonathan;
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Krishna, Sanjeev;
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An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture.
BioTechniques, 68 (2).
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Kinetoplastida: new therapeutic strategies.
Parasite (Paris, France), 15 (3).
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Croft, SL;
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Essentials of antimicrobial pharmacology. Ed. P.H. Axelsen. Humana Press, 2001. Pp. 141. $24.50 pb. ISBN 0 896 03842 4. [Book Review].
Epidemiology and infection, 128 (2).
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Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense.
Bioorganic & medicinal chemistry.
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DrPH thesis, London School of Hygiene & Tropical Medicine.
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Medley, Graham F;
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Costs and outcomes of active and passive case detection for visceral leishmaniasis (Kala-Azar) to inform elimination strategies in Bihar, India.
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Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis.
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Ganguly, Nirmal K;
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Biomedicine and biotechnology: public health impact.
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Strategies towards ending the burden of neglected infectious diseases - Assessing the success of the Product Development Partnership model and its approaches.
PhD thesis, London School of Hygiene & Tropical Medicine.
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Chemical and bioassay techniques to authenticate quality of the anti-leishmanial drug miltefosine.
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Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis.
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PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
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PhD thesis, London School of Hygiene & Tropical Medicine.
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Antimicrobial agents and chemotherapy, 64 (3).
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Christie, Mark;
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Thomas, Sarah A;
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Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.
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Innovations for the elimination and control of visceral leishmaniasis.
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A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani.
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Vesely, Brian;
Leed, Susan;
Sciotti, Richard J;
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Yardley, Vanessa;
Braillard, Stéphanie;
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Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis.
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Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.
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New pharmacokinetic and PK/PD drug development methodologies for cutaneous leishmaniasis.
PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine.
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Wijnant, Gert-Jan;
Croft, Simon L;
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Alavijeh, Mo;
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Restricted
Croft, Simon L;
Chatelain, Eric;
Barrett, Michael P;
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Antileishmanial and antitrypanosomal drug identification.
EMERGING TOPICS IN LIFE SCIENCES, 1 (6).
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DOI: https://doi.org/10.1042/ETLS20170103
Item availability may be restricted.
Tempone, Andre G;
Pieper, Pauline;
Borborema, Samanta ET;
Thevenard, Fernanda;
Lago, Joao Henrique G;
Croft, Simon L;
Anderson, Edward A;
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ISSN 0265-0568
DOI: https://doi.org/10.1039/d0np00078g
Item availability may be restricted.