In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Yardley, Vanessa;
Khan, Anis A;
Martin, Michael B;
Slifer, Teri R;
Araujo, Fausto G;
Moreno, Silvia NJ;
Docampo, Roberto;
Croft, Simon L;
Oldfield, Eric;
(2002)
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Antimicrobial agents and chemotherapy, 46 (3).
pp. 929-931.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.46.3.929-931.2002
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The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.
