Basilico, Nicoletta; Parapini, Silvia; D'Alessandro, Sarah; Misiano, Paola; Romeo, Sergio; Dondio, Giulio; Yardley, Vanessa; Vivas, Livia; Nasser, Shereen; Rénia, Laurent; +5 more... Russell, Bruce M; Suwanarusk, Rossarin; Nosten, François; Sparatore, Anna; Taramelli, Donatella; (2023) Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities. Biomolecules, 13 (5). p. 836. ISSN 2218-273X DOI: https://doi.org/10.3390/biom13050836

Braillard, Stéphanie; Keenan, Martine; Breese, Karen J; Heppell, Jacob; Abbott, Michael; Islam, Rafiqul; Shackleford, David M; Katneni, Kasiram; Crighton, Elly; Chen, Gong; +28 more... Patil, Rahul; Lee, Given; White, Karen L; Carvalho, Sandra; Wall, Richard J; Chemi, Giulia; Zuccotto, Fabio; González, Silvia; Marco, Maria; Deakyne, Julianna; Standing, David; Brunori, Gino; Lyon, Jonathan J; Castañeda-Casado, Pablo; Camino, Isabel; Martinez Martinez, Maria S; Zulfiqar, Bilal; Avery, Vicky M; Feijens, Pim-Bart; Van Pelt, Natascha; Matheeussen, An; Hendrickx, Sarah; Maes, Louis; Caljon, Guy; Yardley, Vanessa; Wyllie, Susan; Charman, Susan A; Chatelain, Eric; (2023) DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1. Science translational medicine, 15 (726). eadh9902-. ISSN 1946-6234 DOI: https://doi.org/10.1126/scitranslmed.adh9902

Van Bocxlaer, Katrien; Dixon, Jodie; Platteeuw, Johannes J; Van Den Heuvel, Dennie; Mcarthur, Kerri-Nicola; Harris, Andy; Alavijeh, Mo; Croft, Simon L; Yardley, Vanessa; (2023) Efficacy of oleylphosphocholine in experimental cutaneous leishmaniasis. The Journal of antimicrobial chemotherapy, 78 (7). pp. 1723-1731. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dkad162

Mowbray, Charles E; Braillard, Stéphanie; Glossop, Paul A; Whitlock, Gavin A; Jacobs, Robert T; Speake, Jason; Pandi, Bharathi; Nare, Bakela; Maes, Louis; Yardley, Vanessa; +12 more... Freund, Yvonne; Wall, Richard J; Carvalho, Sandra; Bello, Davide; Van den Kerkhof, Magali; Caljon, Guy; Gilbert, Ian H; Corpas-Lopez, Victoriano; Lukac, Iva; Patterson, Stephen; Zuccotto, Fabio; Wyllie, Susan; (2021) DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. Journal of Medicinal Chemistry, 64 (21). pp. 16159-16176. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.1c01437

Sanderson, Lisa; da Silva, Marcelo; Sekhar, Gayathri N; Brown, Rachel C; Burrell-Saward, Hollie; Fidanboylu, Mehmet; Liu, Bo; Dailey, Lea Ann; Dreiss, Cécile A; Lorenz, Chris; +6 more... Christie, Mark; Persaud, Shanta J; Yardley, Vanessa; Croft, Simon L; Valero, Margarita; Thomas, Sarah A; (2021) Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug. PLoS neglected tropical diseases, 15 (4). e0009276-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0009276

Intakhan, Nuchpicha; Chanmol, Wetpisit; Somboon, Pradya; Bates, Michelle D; Yardley, Vanessa; Bates, Paul A; Jariyapan, Narissara; (2020) Antileishmanial Activity and Synergistic Effects of Amphotericin B Deoxycholate with Allicin and Andrographolide against Leishmania martiniquensis In Vitro. PATHOGENS, 9 (1). p. 49. ISSN 2076-0817 DOI: https://doi.org/10.3390/pathogens9010049

O'Keeffe, Alec; Hale, Christine; Cotton, James A; Yardley, Vanessa; Gupta, Kapish; Ananthanarayanan, Abhishek; Murdan, Sudaxshina; Croft, Simon L; (2020) Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs. Microorganisms, 8 (6). p. 831. DOI: https://doi.org/10.3390/microorganisms8060831

Riezk, A; (2020) Insights into the application of chitosan as an anti-leishmanial compound. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04656180

Riezk, Alaa; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L; (2020) Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis. Molecules, 25 (17). p. 4002. DOI: https://doi.org/10.3390/molecules25174002

Clark, David J; Moore, Catherine M; Flanagan, Marc; Bocxlaer, Katrien Van; Piperaki, Evangelia-Theophano; Yardley, Vanessa; Croft, Simon L; Tyson, John; Whitehouse, Sam P; O'Halloran, Jonathan; +2 more... Krishna, Sanjeev; Staines, Henry M; (2019) An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture. BioTechniques, 68 (2). pp. 79-84. ISSN 0736-6205 DOI: https://doi.org/10.2144/btn-2019-0086

Riezk, Alaa; Raynes, John G; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L; (2019) Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro. Antimicrobial agents and chemotherapy, 64 (3). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01772-19

Van Bocxlaer, Katrien; Caridha, Diana; Black, Chad; Vesely, Brian; Leed, Susan; Sciotti, Richard J; Wijnant, Gert-Jan; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles E; +2 more... Ioset, Jean-Robert; Croft, Simon L; (2019) Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis. International Journal for Parasitology: Drugs and Drug Resistance, 11. pp. 129-138. ISSN 2211-3207 DOI: https://doi.org/10.1016/j.ijpddr.2019.02.002

Wijnant, Gert-Jan; Croft, Simon L; de la Flor, Raul; Alavijeh, Mo; Yardley, Vanessa; Braillard, Stéphanie; Mowbray, Charles; Van Bocxlaer, Katrien; (2019) Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis. Antimicrobial agents and chemotherapy, 63 (9). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00829-19

Guo, Minshan; Wang, Ke; Qiao, Ning; Yardley, Vanessa; Li, Mingzhong; (2018) Investigating Permeation Behavior of Flufenamic Acid Cocrystals Using a Dissolution and Permeation System. Molecular pharmaceutics, 15 (9). pp. 4257-4272. ISSN 1543-8384 DOI: https://doi.org/10.1021/acs.molpharmaceut.8b00670

Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Braillard, Stephanie; Chatelain, Eric; +5 more... Wan, Baojie; Franzblau, Scott G; Ma, Zhenkun; Cooper, Christopher B; Denny, William A; (2018) Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. Journal of medicinal chemistry, 61 (6). pp. 2329-2352. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.7b01581

Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J; Merchant, Tejal; Croft, Simon L; +2 more... Jacobs, Robert T; Wring, Stephen A; (2018) Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles. Antimicrobial agents and chemotherapy, 62 (5). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02419-17

Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Fortes Francisco, Amanda; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Murdan, Sudaxshina; Croft, Simon L; (2018) Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. Antimicrobial agents and chemotherapy, 62 (10). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00631-18

Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Alavijeh, Mo; Silva-Pedrosa, Rita; Antunes, Sandra; Mauricio, Isabel; Murdan, Sudaxshina; Croft, Simon L; (2018) Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome® and AmBisome® in murine cutaneous leishmaniasis. International journal for parasitology Drugs and drug resistance, 8 (2). pp. 223-228. ISSN 2211-3207 DOI: https://doi.org/10.1016/j.ijpddr.2018.04.001

Yardley, V; Koniordou, M; (2018) Chapter 4: Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis. In: UNSPECIFIED, (ed.) Drug Discovery for Leishmaniasis. Royal Society of Chemistry, pp. 55-76. ISBN 9781782628897 DOI: https://doi.org/10.1039/9781788010177 Full text not available from this repository.

Basilico, Nicoletta; Parapini, Silvia; Sparatore, Anna; Romeo, Sergio; Misiano, Paola; Vivas, Livia; Yardley, Vanessa; Croft, Simon L; Habluetzel, Annette; Lucantoni, Leonardo; +8 more... Renia, Laurent; Russell, Bruce; Suwanarusk, Rossarin; Nosten, Francois; Dondio, Giulio; Bigogno, Chiara; Jabes, Daniela; Taramelli, Donatella; (2017) In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial. Molecules (Basel, Switzerland), 22 (12). p. 2102. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules22122102

Bhambra, AS; Ruparelia, KC; Tan, HL; Tasdemir, D; Burrell-Saward, H; Yardley, V; Beresford, KJ; Arroo, RR; (2017) Synthesis and antitrypanosomal activities of novel pyridylchalcones. European journal of medicinal chemistry, 128. pp. 213-218. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2017.01.027

Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; +5 more... Wan, B; Wang, Y; Ma, Z; Cooper, CB; Denny, WA; (2017) 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 60 (10). pp. 4212-4233. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.7b00034

Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Harris, Andy; Murdan, Sudaxshina; Croft, Simon L; (2017) Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis. Antimicrobial agents and chemotherapy, 62 (3). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02009-17

Wijnant, Gert-Jan; Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L; (2017) Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. Antimicrobial agents and chemotherapy, 61 (8). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00358-17

Daunes, S; Yardley, V; Croft, SL; D'Silva, C; (2016) Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. Bioorganic & medicinal chemistry. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2016.12.016

Khan, Nazma Habib; Bari, Arfan Ul; Hashim, Rizwan; Khan, Inamullah; Muneer, Akhtar; Shah, Akram; Wahid, Sobia; Yardley, Vanessa; O'Neil, Brighid; Sutherland, Colin J; (2016) Cutaneous Leishmaniasis in Khyber Pakhtunkhwa Province of Pakistan: Clinical Diversity and Species-Level Diagnosis. The American journal of tropical medicine and hygiene, 95 (5). pp. 1106-1114. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.16-0343

Tegazzini, Diana; Díaz, Rosario; Aguilar, Fernando; Peña, Imanol; Presa, Jesús L; Yardley, Vanessa; Martin, Julio J; Coteron, Jose M; Croft, Simon L; Cantizani, Juan; (2016) A Replicative In Vitro Assay for Drug Discovery against Leishmania donovani. Antimicrobial agents and chemotherapy, 60 (6). pp. 3524-3532. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01781-15

Thompson, Andrew M; O'Connor, Patrick D; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; +3 more... Wang, Yuehong; Ma, Zhenkun; Denny, William A; (2016) Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 59 (6). pp. 2530-2550. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.5b01699

Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L; (2016) Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model. The Journal of pharmacy and pharmacology, 68 (7). pp. 862-872. ISSN 0022-3573 DOI: https://doi.org/10.1111/jphp.12548

Van Bocxlaer, Katrien; Yardley, Vanessa; Murdan, Sudaxshina; Croft, Simon L; (2016) Drug permeation and barrier damage in Leishmania-infected mouse skin. The Journal of antimicrobial chemotherapy, 71 (6). pp. 1578-1585. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dkw012 Full text not available from this repository.

Yizengaw, Endalew; Getahun, Mulusew; Tajebe, Fitsumbrhan; Cruz Cervera, Edward; Adem, Emebet; Mesfin, Getnet; Hailu, Asrat; Van der Auwera, Gert; Yardley, Vanessa; Lemma, Mulualem; +10 more... Skhedy, Ziv; Diro, Ermias; Yeshanew, Arega; Melkamu, Roma; Mengesha, Bewketu; Modolell, Manuel; Munder, Markus; Müller, Ingrid; Takele, Yegnasew; Kropf, Pascale; (2016) Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions. Frontiers in immunology, 7 (NOV). 517-. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2016.00517

Bhambra, Avninder S; Edgar, Mark; Elsegood, Mark RJ; Li, Yuqi; Weaver, George W; Arroo, Randolph RJ; Yardley, Vanessa; Burrell-Saward, Hollie; Krystof, Vladimir; (2015) Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes. European journal of medicinal chemistry, 108. pp. 347-353. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2015.11.043 Full text not available from this repository.

Carvalho, Luis; Martínez-García, Marta; Pérez-Victoria, Ignacio; Manzano, José Ignacio; Yardley, Vanessa; Gamarro, Francisco; Pérez-Victoria, José M; (2015) The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei. Antimicrobial agents and chemotherapy, 59 (10). pp. 6151-6160. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00879-15 Full text not available from this repository.

Corware, Karina; Yardley, Vanessa; Mack, Christopher; Schuster, Steffen; Al-Hassi, Hafid; Herath, Shanthi; Bergin, Philip; Modolell, Manuel; Munder, Markus; Müller, Ingrid; +1 more... Kropf, Pascale; (2014) Protein energy malnutrition increases arginase activity in monocytes and macrophages. Nutrition & metabolism, 11 (1). 51-. ISSN 1743-7075 DOI: https://doi.org/10.1186/1743-7075-11-51

Gupta, Suman; Yardley, Vanessa; Vishwakarma, Preeti; Shivahare, Rahul; Sharma, Bhawna; Launay, Delphine; Martin, Denis; Puri, Sunil K; (2014) Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis. The Journal of antimicrobial chemotherapy, 70 (2). pp. 518-527. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dku422 Full text not available from this repository.

Les, Karolina Alicja; Mohamed-Ahmed, Abeer HA; Balan, Sibu; Choi, Ji-won; Martin, Denis; Yardley, Vanessa; Powell, Keith; Godwin, Antony; Brocchini, Steve; (2014) Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases. Polymer chemistry, 5 (3). pp. 1037-1048. ISSN 1759-9954 DOI: https://doi.org/10.1039/c3py01051a Full text not available from this repository.

Peña, S; Fagundez, C; Medeiros, A; Comini, M; Scarone, L; Sellanes, D; Manta, E; Tulla-Puche, J; Albericio, F; Stewart, L; +2 more... Yardley, V; Serra, G; (2014) Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents. MedChemComm, 5 (9). pp. 1309-1316. ISSN 2040-2503 DOI: https://doi.org/10.1039/c4md00135d Full text not available from this repository.

Sanderson, Lisa; Yardley, Vanessa; Croft, Simon L; (2014) Activity of anti-cancer protein kinase inhibitors against Leishmania spp. The Journal of antimicrobial chemotherapy, 69 (7). pp. 1888-1891. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dku069 Full text not available from this repository.

Baiocco, Paola; Poce, Giovanna; Alfonso, Salvatore; Cocozza, Martina; Porretta, Giulio Cesare; Colotti, Gianni; Biava, Mariangela; Moraca, Francesca; Botta, Maurizio; Yardley, Vanessa; +4 more... Fiorillo, Annarita; Lantella, Antonella; Malatesta, Francesco; Ilari, Andrea; (2013) Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. ChemMedChem, 8 (7). pp. 1175-1183. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.201300176 Full text not available from this repository.

Mohamed-Ahmed, Abeer HA; Seifert, Karin; Yardley, Vanessa; Burrell-Saward, Hollie; Brocchini, Stephen; Croft, Simon L; (2013) Antileishmanial activity, uptake, and biodistribution of an amphotericin B and poly(α-Glutamic Acid) complex. Antimicrobial agents and chemotherapy, 57 (10). pp. 4608-4614. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02343-12 Full text not available from this repository.

Peña, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa; Croft, Simon; Serra, Gloria; (2012) Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. Bioorganic & medicinal chemistry letters, 22 (15). pp. 4994-4997. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.06.028 Full text not available from this repository.

Kobarfard, Farzad; Yardley, Vanessa; Little, Susan; Daryaee, Fereidoon; Chibale, Kelly; (2011) Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity. Chemical biology & drug design, 79 (3). pp. 326-331. ISSN 1747-0277 DOI: https://doi.org/10.1111/j.1747-0285.2011.01278.x Full text not available from this repository.

Müller, Tobias; Johann, Laure; Jannack, Beate; Brückner, Margit; Lanfranchi, Don Antoine; Bauer, Holger; Sanchez, Cecilia; Yardley, Vanessa; Deregnaucourt, Christiane; Schrével, Joseph; +3 more... Lanzer, Michael; Schirmer, R Heiner; Davioud-Charvet, Elisabeth; (2011) Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. Journal of the American Chemical Society, 133 (30). pp. 11557-11571. ISSN 0002-7863 DOI: https://doi.org/10.1021/ja201729z Full text not available from this repository.

Abazid, Nizar; (2010) Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.01742275

Blackie, Margaret AL; Yardley, Vanessa; Chibale, Kelly; (2010) Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. Bioorganic & medicinal chemistry letters, 20 (3). pp. 1078-1080. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2009.12.030 Full text not available from this repository.

Haque, Ashraful; Stanley, Amanda C; Amante, Fiona H; Rivera, Fabian de Labastida; Zhou, Yonghong; Kuns, Rachel D; Yardley, Vanessa; Sakaguchi, Shimon; Hill, Geoffrey R; Engwerda, Christian R; (2010) Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. Journal of immunology (Baltimore, Md, 184 (5). pp. 2583-2592. ISSN 0022-1767 DOI: https://doi.org/10.4049/jimmunol.0903080 Full text not available from this repository.

Yang, Mei; Arai, Chika; Bakar Md, Abu; Lu, Jun; Ge, Jian-Feng; Pudhom, Khanitha; Takasu, Kiyosei; Kasai, Kazuki; Kaiser, Marcel; Brun, Reto; +3 more... Yardley, Vanessa; Itoh, Isamu; Ihara, Masataka; (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm9013086 Full text not available from this repository.

Yardley, Vanessa; Gamarro, Francisco; Croft, Simon L; (2010) Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. Antimicrobial agents and chemotherapy, 54 (12). pp. 5356-5358. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00985-10 Full text not available from this repository.

Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, Bhupendra P; Kukreja, Gagan; Coccone, Salvatore Sanna; Bernetti, Matteo; Persico, Marco; Nacci, Vito; Fiorini, Isabella; +14 more... Novellino, Ettore; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Yardley, Vanessa; Croft, Simon; Keller-Maerki, Sonja; Rottmann, Matthias; Brun, Reto; Coletta, Massimiliano; Marini, Stefano; Guiso, Giovanna; Caccia, Silvio; Fattorusso, Caterina; (2009) Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of medicinal chemistry, 52 (2). pp. 502-513. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm801352s Full text not available from this repository.

Guglielmo, Stefano; Bertinaria, Massimo; Rolando, Barbara; Crosetti, Marco; Fruttero, Roberta; Yardley, Vanessa; Croft, Simon L; Gasco, Alberto; (2009) A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. European journal of medicinal chemistry, 44 (12). pp. 5071-5079. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2009.09.012 Full text not available from this repository.

Coro, Julieta; Little, Susan; Yardley, Vanessa; Suárez, Margarita; Rodríguez, Hortensia; Martín, Nazario; Perez-Pineiro, Rolando; (2008) Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). Archiv der Pharmazie, 341 (11). pp. 708-713. ISSN 0365-6233 DOI: https://doi.org/10.1002/ardp.200800011 Full text not available from this repository.

Decuypere, S; Vanaerschot, M; Rijal, S; Yardley, V; Maes, L; de Doncker, S; Chappuis, F; Dujardin, J-C; (2008) Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation. Parasitology, 135 (2). pp. 183-194. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182007003782

Fattorusso, Caterina; Campiani, Giuseppe; Kukreja, Gagan; Persico, Marco; Butini, Stefania; Romano, Maria Pia; Altarelli, Maria; Ros, Sindu; Brindisi, Margherita; Savini, Luisa; +10 more... Novellino, Ettore; Nacci, Vito; Fattorusso, Ernesto; Parapini, Silvia; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; Croft, Simon; Borriello, Marianna; Gemma, Sandra; (2008) Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. Journal of medicinal chemistry, 51 (5). pp. 1333-1343. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm7012375 Full text not available from this repository.

Friebolin, Wolfgang; Jannack, Beate; Wenzel, Nicole; Furrer, Julien; Oeser, Thomas; Sanchez, Cecilia P; Lanzer, Michael; Yardley, Vanessa; Becker, Katja; Davioud-Charvet, Elisabeth; (2008) Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 51 (5). pp. 1260-1277. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm7009292 Full text not available from this repository.

Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Coccone, Salvatore Sanna; Joshi, Bhupendra P; Persico, Marco; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; +12 more... Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Morace, Giulia; Yardley, Vanessa; Croft, Simon; Coletta, Massimiliano; Marini, Stefano; Fattorusso, Caterina; (2008) Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. Journal of medicinal chemistry, 51 (5). pp. 1278-1294. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm701247k Full text not available from this repository.

Musonda, Chitalu C; Yardley, Vanessa; de Souza, Renata C Carvalho; Ncokazi, Kanyile; Egan, Timothy J; Chibale, Kelly; (2008) Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. Organic & biomolecular chemistry, 6 (23). pp. 4446-4451. ISSN 1477-0520 DOI: https://doi.org/10.1039/b813007h Full text not available from this repository.

Nanayakkara, NP Dhammika; Ager, Arba L; Bartlett, Marilyn S; Yardley, Vanessa; Croft, Simon L; Khan, Ikhlas A; McChesney, James D; Walker, Larry A; (2008) Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. Antimicrobial agents and chemotherapy, 52 (6). pp. 2130-2137. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00645-07 Full text not available from this repository.

Nanayakkara, NP; Ager, AL; Bartlett, MS; Yardley, V; Croft, SL; Khan, IA; McChesney, JD; Walker, LA; (2008) Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichloropheno xy]quinoline succinate. Antimicrobial agents and chemotherapy, 52 (6). pp. 2130-2137. ISSN 0066-4804 DOI: https://doi.org/10.1128/aac.00645-07 Full text not available from this repository.

October, Natasha; Watermeyer, Nicholas D; Yardley, Vanessa; Egan, Timothy J; Ncokazi, Kanyile; Chibale, Kelly; (2008) Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity. ChemMedChem, 3 (11). pp. 1649-1653. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.200800172 Full text not available from this repository.

Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, Gagan; Joshi, Bhupendra P; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Ernesto; Nacci, Vito; +6 more... Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Morace, Giulia; Yardley, Vanessa; Fattorusso, Caterina; (2007) Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. Journal of medicinal chemistry, 50 (4). pp. 595-598. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm061429p Full text not available from this repository.

Gemma, Sandra; Kukreja, Gagan; Campiani, Giuseppe; Butini, Stefania; Bernetti, Matteo; Joshi, Bhupendra P; Savini, Luisa; Basilico, Nicoletta; Taramelli, Donatella; Yardley, Vanessa; +5 more... Bertamino, Alessia; Novellino, Ettore; Persico, Marco; Catalanotti, Bruno; Fattorusso, Caterina; (2007) Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. Bioorganic & medicinal chemistry letters, 17 (13). pp. 3535-3539. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.04.077 Full text not available from this repository.

Khrizman, Alexander; Moulthrop, Jason S; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Moyna, Guillermo; (2007) Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives. Bioorganic & medicinal chemistry letters, 17 (15). pp. 4183-4186. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.05.044 Full text not available from this repository.

Khrizman, Alexander; Slack, Rachel D; Remsing, Richard C; Little, Susan; Yardley, Vanessa; Moyna, Guillermo; (2007) Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. Archiv der Pharmazie, 340 (11). pp. 569-576. ISSN 0365-6233 DOI: https://doi.org/10.1002/ardp.200700143 Full text not available from this repository.

Musonda, Chitalu C; Little, Susan; Yardley, Vanessa; Chibale, Kelly; (2007) Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. Bioorganic & medicinal chemistry letters, 17 (17). pp. 4733-4736. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.06.070 Full text not available from this repository.

Rijal, Suman; Yardley, Vanessa; Chappuis, François; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Boelaert, Marleen; De Doncker, Simonne; Croft, Simon; Dujardin, Jean-Claude; (2007) Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome? Microbes and infection / Institut Pasteur, 9 (4). pp. 529-535. ISSN 1286-4579 DOI: https://doi.org/10.1016/j.micinf.2007.01.009 Full text not available from this repository.

Too, Kathleen; Brown, Daniel M; Bongard, Emily; Yardley, Vanessa; Vivas, Livia; Loakes, David; (2007) Anti-malarial activity of N6-modified purine analogues. Bioorganic & medicinal chemistry, 15 (16). pp. 5551-5562. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2007.05.038 Full text not available from this repository.

Bauer, Holger; Fritz-Wolf, Karin; Winzer, Andreas; Kühner, Sebastian; Little, Susan; Yardley, Vanessa; Vezin, Hervé; Palfey, Bruce; Schirmer, R Heiner; Davioud-Charvet, Elisabeth; (2006) A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. Journal of the American Chemical Society, 128 (33). pp. 10784-10794. ISSN 0002-7863 DOI: https://doi.org/10.1021/ja061155v Full text not available from this repository.

Coro, Julieta; Atherton, Richard; Little, Susan; Wharton, Hayley; Yardley, Vanessa; Alvarez, Amaury; Súarez, Margarita; Pérez, Rolando; Rodríguez, Hortensia; (2006) Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. Bioorganic & medicinal chemistry letters, 16 (5). pp. 1312-1315. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2005.11.060 Full text not available from this repository.

Croft, Simon L; Seifert, Karin; Yardley, Vanessa; (2006) Current scenario of drug development for leishmaniasis. The Indian journal of medical research, 123 (3). pp. 399-410. ISSN 0971-5916 https://researchonline.lshtm.ac.uk/id/eprint/11722

Ferreira, Cara L; Ewart, Charles B; Barta, Cheri A; Little, Susan; Yardley, Vanessa; Martins, Candice; Polishchuk, Elena; Smith, Peter J; Moss, John R; Merkel, Michael; +2 more... Adam, Michael J; Orvig, Chris; (2006) Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates. Inorganic chemistry, 45 (20). pp. 8414-8422. ISSN 0020-1669 DOI: https://doi.org/10.1021/ic061166p Full text not available from this repository.

Gemma, Sandra; Kukreja, Gagan; Fattorusso, Caterina; Persico, Marco; Romano, Maria P; Altarelli, Maria; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Ernesto; Basilico, Nicoletta; +3 more... Taramelli, Donatella; Yardley, Vanessa; Butini, Stefania; (2006) Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorganic & medicinal chemistry letters, 16 (20). pp. 5384-5388. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2006.07.060 Full text not available from this repository.

Gros, Ludovic; Castillo-Acosta, Victor Manuel; Jiménez Jiménez, Carmen; Sealey-Cardona, Marco; Vargas, Sofia; Manuel Estévez, Antonio; Yardley, Vanessa; Rattray, Lauren; Croft, Simon L; Ruiz-Perez, Luis M; +3 more... Urbina, Julio A; Gilbert, Ian H; González-Pacanowska, Dolores; (2006) New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action. Antimicrobial agents and chemotherapy, 50 (8). pp. 2595-2601. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01508-05 Full text not available from this repository.

Gros, Ludovic; Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Yardley, Vanessa; Rattray, Lauren; Wharton, Hayley; Little, Susan; Croft, Simon L; Ruiz-Perez, Luis M; Gonzalez-Pacanowska, Dolores; +1 more... Gilbert, Ian H; (2006) Evaluation of azasterols as anti-parasitics. Journal of medicinal chemistry, 49 (20). pp. 6094-6103. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm060290f Full text not available from this repository.

Hudock, Michael P; Sanz-Rodríguez, CE; Song, Yongcheng; Chan, Julian MW; Zhang, Yonghui; Odeh, Sarah; Kosztowski, Thomas; Leon-Rossell, Annette; Concepción, JL; Yardley, Vanessa; +3 more... Croft, Simon L; Urbina, Julio A; Oldfield, Eric; (2006) Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. Journal of medicinal chemistry, 49 (1). pp. 215-223. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm0582625 Full text not available from this repository.

Laurent, Thierry; Rijal, Suman; Yardley, Vanessa; Croft, Simon; De Doncker, Simonne; Decuypere, Saskia; Khanal, Basudha; Singh, Rupa; Schönian, Gabriele; Kuhls, Katrin; +2 more... Chappuis, François; Dujardin, Jean-Claude; (2006) Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal. Infection, genetics and evolution, 7 (2). pp. 206-212. ISSN 1567-1348 DOI: https://doi.org/10.1016/j.meegid.2006.08.005 Full text not available from this repository.

Musonda, Chitalu C; Gut, Jiri; Rosenthal, Philip J; Yardley, Vanessa; Carvalho de Souza, Renata C; Chibale, Kelly; (2006) Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorganic & medicinal chemistry, 14 (16). pp. 5605-5615. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2006.04.035 Full text not available from this repository.

Tasdemir, Deniz; Brun, Reto; Yardley, Vanessa; Franzblau, Scott G; Rüedi, Peter; (2006) Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. Chemistry & biodiversity, 3 (11). pp. 1230-1237. ISSN 1612-1872 DOI: https://doi.org/10.1002/cbdv.200690124 Full text not available from this repository.

Tasdemir, Deniz; Kaiser, Marcel; Brun, Reto; Yardley, Vanessa; Schmidt, Thomas J; Tosun, Fatma; Rüedi, Peter; (2006) Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial agents and chemotherapy, 50 (4). pp. 1352-1364. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.50.4.1352-1364.2006 Full text not available from this repository.

Yardley, Vanessa; Ortuno, Nimer; Llanos-Cuentas, Alejandro; Chappuis, Francois; Doncker, Simonne De; Ramirez, Luis; Croft, Simon; Arevalo, Jorge; Adaui, Vanessa; Bermudez, Hernan; +2 more... Decuypere, Saskia; Dujardin, Jean-Claude; (2006) American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility? The Journal of infectious diseases, 194 (8). pp. 1168-1175. ISSN 0022-1899 DOI: https://doi.org/10.1086/507710 Full text not available from this repository.

Baliani, Alessandro; Bueno, Gorka Jimenez; Stewart, Mhairi L; Yardley, Vanessa; Brun, Reto; Barrett, Michael P; Gilbert, Ian H; (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. Journal of medicinal chemistry, 48 (17). pp. 5570-5579. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm050177+ Full text not available from this repository.

Decuypere, S; Vandesompele, J; Yardley, V; De Donckeri, S; Laurent, T; Rijal, S; Llanos-Cuentas, A; Chappuis, F; Arevalo, J; Dujardin, JC; (2005) Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. Parasitology, 131 (Pt 3). pp. 321-329. ISSN 0031-1820 DOI: https://doi.org/10.1017/s0031182005007808

Decuypere, Saskia; Rijal, Suman; Yardley, Vanessa; De Doncker, Simonne; Laurent, Thierry; Khanal, Basudha; Chappuis, François; Dujardin, Jean-Claude; (2005) Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal. Antimicrobial agents and chemotherapy, 49 (11). pp. 4616-4621. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.49.11.4616-4621.2005 Full text not available from this repository.

Lee, Brittany; Bauer, Holger; Melchers, Johannes; Ruppert, Thomas; Rattray, Lauren; Yardley, Vanessa; Davioud-Charvet, Elisabeth; Krauth-Siegel, R Luise; (2005) Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. Journal of medicinal chemistry, 48 (23). pp. 7400-7410. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm0504860 Full text not available from this repository.

Lorente, Silvia Orenes; Jimenez, Carmen Jimenez; Gros, Ludovic; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; A Urbina, Julio; Ruiz-Perez, Luis M; Pacanowska, Dolores Gonzalez; Gilbert, Ian H; (2005) Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasitics. Bioorganic & medicinal chemistry, 13 (18). pp. 5435-5453. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2005.06.012 Full text not available from this repository.

Orenes Lorente, Silvia; Gómez, Rosario; Jiménez, Carmen; Cammerer, Simon; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; Ruiz Perez, Luis M; Urbina, Julio; Gonzalez Pacanowska, Dolores; +1 more... Gilbert, Ian H; (2005) Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. Bioorganic & medicinal chemistry, 13 (10). pp. 3519-3529. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2005.02.060 Full text not available from this repository.

Parveen, Seheli; Khan, Mohammed OF; Austin, Susan E; Croft, Simon L; Yardley, Vanessa; Rock, Peter; Douglas, Kenneth T; (2005) Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. Journal of medicinal chemistry, 48 (25). pp. 8087-8097. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm050819t Full text not available from this repository.

Yardley, Vanessa; Croft, Simon L; De Doncker, Simonne; Dujardin, Jean-Claude; Koirala, Siddhartha; Rijal, Suman; Miranda, Cesar; Llanos-Cuentas, Alejandro; Chappuis, Francois; (2005) The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine. The American journal of tropical medicine and hygiene, 73 (2). pp. 272-275. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.2005.73.272

Grant, Karen M; Dunion, Morag H; Yardley, Vanessa; Skaltsounis, Alexios-Leandros; Marko, Doris; Eisenbrand, Gerhard; Croft, Simon L; Meijer, Laurent; Mottram, Jeremy C; (2004) Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrobial agents and chemotherapy, 48 (8). pp. 3033-3042. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.48.8.3033-3042.2004 Full text not available from this repository.

Jung, Mankil; Lee, Kyunghoon; Jung, Hochul; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L; (2004) Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives. Bioorganic & medicinal chemistry letters, 14 (8). pp. 2001-2003. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2003.12.104 Full text not available from this repository.

Lorente, Silvia Orenes; Rodrigues, Juliany CF; Jiménez Jiménez, Carmen; Joyce-Menekse, Miranda; Rodrigues, Carlos; Croft, Simon L; Yardley, Vanessa; de Luca-Fradley, Kate; Ruiz-Pérez, Luis M; Urbina, Julio; +3 more... de Souza, Wanderley; González Pacanowska, Dolores; Gilbert, Ian H; (2004) Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. Antimicrobial agents and chemotherapy, 48 (8). pp. 2937-2950. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.48.8.2937-2950.2004 Full text not available from this repository.

Nan, Anjan; Croft, Simon L; Yardley, Vanessa; Ghandehari, Hamidreza; (2004) Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis. Journal of controlled release, 94 (1). pp. 115-127. ISSN 0168-3659 DOI: https://doi.org/10.1016/j.jconrel.2003.09.012 Full text not available from this repository.

del Rayo Camacho, Maria; Phillipson, J David; Croft, Simon L; Yardley, Vanesa; Solis, Pablo N; (2004) In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins. Planta medica, 70 (1). pp. 70-72. ISSN 0032-0943 DOI: https://doi.org/10.1055/s-2004-815460 Full text not available from this repository.

Kayser, O; Olbrich, C; Yardley, V; Kiderlen, AF; Croft, SL; (2003) Formulation of amphotericin B as nanosuspension for oral administration. International journal of pharmaceutics, 254 (1). pp. 73-75. ISSN 0378-5173 DOI: https://doi.org/10.1016/s0378-5173(02)00686-5 Full text not available from this repository.

Larabi, Malika; Yardley, Vanessa; Loiseau, Philippe M; Appel, Martine; Legrand, Philippe; Gulik, Annette; Bories, Christian; Croft, Simon L; Barratt, Gillian; (2003) Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B. Antimicrobial agents and chemotherapy, 47 (12). pp. 3774-3779. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.47.12.3774-3779.2003 Full text not available from this repository.

Lawn, SD; Yardley, V; Vega-Lopez, F; Watson, J; Lockwood, DN; (2003) New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 (4). pp. 443-445. ISSN 0035-9203 DOI: https://doi.org/10.1016/s0035-9203(03)90084-8 Full text not available from this repository.

Magaraci, Filippo; Jimenez, Carmen Jimenez; Rodrigues, Carlos; Rodrigues, Juliany CF; Braga, Marina Vianna; Yardley, Vanessa; de Luca-Fradley, Kate; Croft, Simon L; de Souza, Wanderley; Ruiz-Perez, Luis M; +3 more... Urbina, Julio; Gonzalez Pacanowska, Dolores; Gilbert, Ian H; (2003) Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi. Journal of medicinal chemistry, 46 (22). pp. 4714-4727. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm021114j Full text not available from this repository.

Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L; Yardley, Vanessa; Ruiz Perez, Luis M; Gonzalez Pacanowska, Dolores; Gilbert, Ian H; (2003) 2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase. Bioorganic & medicinal chemistry, 11 (22). pp. 4693-4711. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2003.08.012 Full text not available from this repository.

Ren, Hongyu; Grady, Shannon; Banghart, Matthew; Moulthrop, Jason S; Kendrick, Howard; Yardley, Vanessa; Croft, Simon L; Moyna, Guillermo; (2003) Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European journal of medicinal chemistry, 38 (11-12). pp. 949-957. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2003.07.004 Full text not available from this repository.

Croft, Simon L; Yardley, Vanessa; (2002) Chemotherapy of leishmaniasis. Current pharmaceutical design, 8 (4). pp. 319-342. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612023396258 Full text not available from this repository.

Croft, Simon L; Yardley, Vanessa; Kendrick, Howard; (2002) Drug sensitivity of Leishmania species: some unresolved problems. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 Sup (SUPPL.). S127-S129. ISSN 0035-9203 DOI: https://doi.org/10.1016/s0035-9203(02)90063-5 Full text not available from this repository.

Yardley, Vanessa; Khan, Anis A; Martin, Michael B; Slifer, Teri R; Araujo, Fausto G; Moreno, Silvia NJ; Docampo, Roberto; Croft, Simon L; Oldfield, Eric; (2002) In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial agents and chemotherapy, 46 (3). pp. 929-931. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.46.3.929-931.2002 Full text not available from this repository.

Asres, K; Bucar, F; Knauder, E; Yardley, V; Kendrick, H; Croft, SL; (2001) In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. Phytotherapy research, 15 (7). pp. 613-617. ISSN 0951-418X DOI: https://doi.org/10.1002/ptr.897 Full text not available from this repository.

Chibale, K; Haupt, H; Kendrick, H; Yardley, V; Saravanamuthu, A; Fairlamb, AH; Croft, SL; (2001) Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. Bioorganic & medicinal chemistry letters, 11 (19). pp. 2655-2657. ISSN 0960-894X DOI: https://doi.org/10.1016/s0960-894x(01)00528-5 Full text not available from this repository.

Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL; (2001) QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives. Journal of medicinal chemistry, 44 (18). pp. 2976-2983. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm000502n Full text not available from this repository.

Escobar, P; Yardley, V; Croft, SL; (2001) Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. Antimicrobial agents and chemotherapy, 45 (6). pp. 1872-1875. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.45.6.1872-1875.2001 Full text not available from this repository.

Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; +4 more... Moreno, SN; Docampo, R; Croft, SL; Oldfield, E; (2001) Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. Journal of medicinal chemistry, 44 (6). pp. 909-916. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm0002578 Full text not available from this repository.

Nan, A; Nanayakkara, NP; Walker, LA; Yardley, V; Croft, SL; Ghandehari, H; (2001) N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. Journal of controlled release, 77 (3). pp. 233-243. ISSN 0168-3659 DOI: https://doi.org/10.1016/s0168-3659(01)00514-4 Full text not available from this repository.

Ren, H; Grady, S; Gamenara, D; Heinzen, H; Moyna, P; Croft, SL; Kendrick, H; Yardley, V; Moyna, G; (2001) Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds. Bioorganic & medicinal chemistry letters, 11 (14). pp. 1851-1854. ISSN 0960-894X DOI: https://doi.org/10.1016/s0960-894x(01)00308-0 Full text not available from this repository.

Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E; (2001) 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. Journal of medicinal chemistry, 44 (4). pp. 548-565. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm001079l Full text not available from this repository.