Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo.
Blackie, Margaret AL;
Yardley, Vanessa;
Chibale, Kelly;
(2010)
Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo.
Bioorganic & medicinal chemistry letters, 20 (3).
pp. 1078-1080.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2009.12.030
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Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo efficacy of PQ, and salts thereof, have been determined in Plasmodium berghei ANKA and Plasmodium yoelii. Phenylequine hydrochloride has shown an ED(50) of 0.81 in P. yoelii (cf chloroquine ED(50)=1.31).
