Miltefosine: issues to be addressed in the future.
Berman, J;
Bryceson, ADM;
Croft, S;
Engel, J;
Gutteridge, W;
Karbwang, J;
Sindermann, H;
Soto, J;
Sundar, S;
Urbina, JA;
(2006)
Miltefosine: issues to be addressed in the future.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 Su.
S41-S44.
ISSN 0035-9203
DOI: https://doi.org/10.1016/j.trstmh.2006.02.009
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Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions.
