Items where Author is "Wilkinson, SR"
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Number of items: 23.
Article
Bot, C;
Hall, BS;
Bashir, N;
Taylor, MC;
Helsby, NA;
Wilkinson, SR;
(2010)
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.
Antimicrobial agents and chemotherapy, 54 (10).
pp. 4246-52.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00800-10
Full text not available from this repository.
Bromley, EV;
Taylor, MC;
Wilkinson, SR;
Kelly, JM;
(2004)
The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal.
International journal for parasitology, 34 (1).
pp. 63-71.
ISSN 0020-7519
DOI: https://doi.org/10.1016/j.ipara.2003.09.004
Full text not available from this repository.
Logan, FJ;
Taylor, MC;
Wilkinson, SR;
Kaur, H;
Kelly, JM;
(2007)
The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.
The Biochemical journal, 407 (3).
pp. 419-26.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20070766
Full text not available from this repository.
Obado, SO;
Taylor, MC;
Wilkinson, SR;
Bromley, EV;
Kelly, JM;
(2005)
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature.
Genome research, 15 (1).
pp. 36-43.
ISSN 1088-9051
DOI: https://doi.org/10.1101/gr.2895105
Patel, S;
Hussain, S;
Harris, R;
Sardiwal, S;
Kelly, JM;
Wilkinson, SR;
Driscoll, PC;
Djordjevic, S;
(2010)
Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
The Biochemical journal, 425 (3).
pp. 513-22.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20091167
Full text not available from this repository.
Piacenza, L;
Irigoin, F;
Alvarez, MN;
Peluffo, G;
Taylor, MC;
Kelly, JM;
Wilkinson, SR;
Radi, R;
(2007)
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.
The Biochemical journal, 403 (2).
pp. 323-34.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20061281
Full text not available from this repository.
Piacenza, L;
Peluffo, G;
Alvarez, MN;
Kelly, JM;
Wilkinson, SR;
Radi, R;
(2008)
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite.
The Biochemical journal, 410 (2).
pp. 359-68.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20071138
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-758.
ISSN 0066-4804
DOI: https://doi.org/10.1128/aac.01360-06
Full text not available from this repository.
Prathalingham, SR;
Wilkinson, SR;
Horn, D;
Kelly, JM;
(2007)
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
Antimicrobial agents and chemotherapy, 51 (2).
pp. 755-8.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.01360-06
Full text not available from this repository.
Schnick, C;
Polley, SD;
Fivelman, QL;
Ranford-Cartwright, LC;
Wilkinson, SR;
Brannigan, JA;
Wilkinson, AJ;
Baker, DA;
(2009)
Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages.
Molecular microbiology, 71 (2).
pp. 533-545.
ISSN 0950-382X
DOI: https://doi.org/10.1111/j.1365-2958.2008.06544.x
Taylor, MC;
Kaur, H;
Blessington, B;
Kelly, JM;
Wilkinson, SR;
(2008)
Validation of spermidine synthase as a drug target in African trypanosomes.
The Biochemical journal, 409 (2).
pp. 563-9.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20071185
Full text not available from this repository.
Wilkinson, SM;
Meyer, DJ;
Taylor, MC;
Bromley, EV;
Miles, MA;
Kelly, JM;
(2002)
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.
The Journal of biological chemistry, 277 (19).
pp. 17062-17071.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M111126200
Full text not available from this repository.
Wilkinson, SR;
Horn, D;
Prathalingam, R;
Kelly, JM;
(2003)
RNAi identifies two hydroperoxide metabolising enzymes that are essential to the bloodstream form of the African trypanosome.
The Journal of biological chemistry, 278 (34).
pp. 31640-6.
ISSN 0021-9258
DOI: https://doi.org/10.1074/jbc.M303035200
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2009)
Trypanocidal drugs: mechanisms, resistance and new targets.
Expert reviews in molecular medicine, 11.
ISSN 1462-3994
DOI: https://doi.org/10.1017/S1462399409001252
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2003)
The role of glutathione peroxidases in trypanosomatids.
Biological chemistry, 384 (4).
pp. 517-25.
ISSN 1431-6730
DOI: https://doi.org/10.1515/BC.2003.060
Full text not available from this repository.
Wilkinson, SR;
Obado, SO;
Mauricio, IL;
Kelly, JM;
(2002)
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America, 99 (21).
pp. 13453-8.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.202422899
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Ahmed, A;
Horn, D;
Kelly, JM;
(2006)
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
Free radical biology & medicine, 40 (2).
pp. 198-209.
ISSN 0891-5849
DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022
Full text not available from this repository.
Wilkinson, SR;
Prathalingam, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
(2005)
Vitamin C biosynthesis in trypanosomes: A role for the glycosome.
Proceedings of the National Academy of Sciences of the United States of America, 102.
pp. 11645-11650.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0504251102
Full text not available from this repository.
Wilkinson, SR;
Taylor, MC;
Horn, D;
Kelly, JM;
Cheeseman, I;
(2008)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America, 105 (13).
pp. 5022-7.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0711014105
Full text not available from this repository.
Wilkinson, SR;
Taylor, MC;
Touitha, S;
Mauricio, IL;
Meyer, DJ;
Kelly, JM;
(2002)
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.
The Biochemical journal, 364 (Pt 3).
pp. 787-94.
ISSN 0264-6021
DOI: https://doi.org/10.1042/BJ20020038
Full text not available from this repository.
Wilkinson, SR;
and Kelly, JM;
(2009)
Trypanocidal drugs: mechanisms, resistance and new targets.
Expert reviews in molecular medicine, 11 (e31).
pp. 1-24.
ISSN 1462-3994
http://researchonline.lshtm.ac.uk/id/eprint/4897
Full text not available from this repository.
Book Section
Kelly, JM;
Taylor, MC;
Wilkinson, SR;
(2005)
Trypanosoma cruzi.
In: Fuchs, J; Podda, M; Goethe, JW, (eds.)
Encyclopedia of Diagnostic Genomics and Proteomics.
Marcel Dekker, Inc., New York, USA, pp. 1297-1301.
http://researchonline.lshtm.ac.uk/id/eprint/15644
Full text not available from this repository.
Wilkinson, SR;
Kelly, JM;
(2003)
How does Trypanosoma cruzi survive the toxic effects of reactive oxygen species?
In: Kelly, JM, (ed.)
Molecular Mechanisms in the Pathogenesis of Chagas? Disease.
Landes Bioscience, Georgetown, Texas, USA, pp. 56-71.
http://researchonline.lshtm.ac.uk/id/eprint/15542
Full text not available from this repository.