Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
Daniel J
Grint
;
Kevin
Wing
;
Elizabeth
Williamson
;
Helen I
McDonald
;
Krishnan
Bhaskaran
;
David
Evans
;
Stephen Jw
Evans
;
Alex J
Walker
;
George
Hickman
;
Emily
Nightingale
;
+26 more...
Anna
Schultze
;
Christopher T
Rentsch
;
Chris
Bates
;
Jonathan
Cockburn
;
Helen J
Curtis
;
Caroline E
Morton
;
Sebastian
Bacon
;
Simon
Davy
;
Angel Ys
Wong
;
Amir
Mehrkar
;
Laurie
Tomlinson
;
Ian J
Douglas
;
Rohini
Mathur
;
Paula
Blomquist
;
Brian
MacKenna
;
Peter
Ingelsby
;
Richard
Croker
;
John
Parry
;
Frank
Hester
;
Sam
Harper
;
Nicholas J
DeVito
;
Will
Hulme
;
John
Tazare
;
Ben
Goldacre
;
Liam
Smeeth
;
Rosalind M
Eggo
;
(2021)
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
Eurosurveillance, 26 (11).
pp. 10-15.
ISSN 1025-7917
DOI: 10.2807/1560-7917.ES.2021.26.11.2100256
;
Kevin
Wing
;
Elizabeth
Williamson
;
Helen I
McDonald
;
Krishnan
Bhaskaran
;
David
Evans
;
Stephen Jw
Evans
;
Alex J
Walker
;
George
Hickman
;
Emily
Nightingale
;
+26 more...
Anna
Schultze
;
Christopher T
Rentsch
;
Chris
Bates
;
Jonathan
Cockburn
;
Helen J
Curtis
;
Caroline E
Morton
;
Sebastian
Bacon
;
Simon
Davy
;
Angel Ys
Wong
;
Amir
Mehrkar
;
Laurie
Tomlinson
;
Ian J
Douglas
;
Rohini
Mathur
;
Paula
Blomquist
;
Brian
MacKenna
;
Peter
Ingelsby
;
Richard
Croker
;
John
Parry
;
Frank
Hester
;
Sam
Harper
;
Nicholas J
DeVito
;
Will
Hulme
;
John
Tazare
;
Ben
Goldacre
;
Liam
Smeeth
;
Rosalind M
Eggo
;
(2021)
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
Eurosurveillance, 26 (11).
pp. 10-15.
ISSN 1025-7917
DOI: 10.2807/1560-7917.ES.2021.26.11.2100256
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.
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