Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Grint, DJORCID logo; Wing, KORCID logo; Williamson, EORCID logo; McDonald, HIORCID logo; Bhaskaran, KORCID logo; Evans, D; Evans, SJORCID logo; Walker, AJ; Hickman, G; Nightingale, EORCID logo; +26 more...Schultze, AORCID logo; Rentsch, CTORCID logo; Bates, C; Cockburn, J; Curtis, HJ; Morton, CE; Bacon, S; Davy, S; Wong, AYORCID logo; Mehrkar, A; Tomlinson, LORCID logo; Douglas, IJORCID logo; Mathur, RORCID logo; Blomquist, P; MacKenna, B; Ingelsby, P; Croker, R; Parry, J; Hester, F; Harper, S; DeVito, NJ; Hulme, W; Tazare, JORCID logo; Goldacre, BORCID logo; Smeeth, LORCID logo; Eggo, RMORCID logo and (2021) Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Eurosurveillance, 26 (11). pp. 10-15. ISSN 1025-7917 DOI: 10.2807/1560-7917.ES.2021.26.11.2100256
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The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.


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