Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Grint, Daniel JORCID logo; Wing, KevinORCID logo; Williamson, ElizabethORCID logo; McDonald, Helen IORCID logo; Bhaskaran, KrishnanORCID logo; Evans, David; Evans, Stephen JwORCID logo; Walker, Alex J; Hickman, George; Nightingale, EmilyORCID logo; +26 more...Schultze, AnnaORCID logo; Rentsch, Christopher TORCID logo; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel YsORCID logo; Mehrkar, Amir; Tomlinson, LaurieORCID logo; Douglas, Ian JORCID logo; Mathur, RohiniORCID logo; Blomquist, Paula; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, JohnORCID logo; Goldacre, BenORCID logo; Smeeth, LiamORCID logo; and Eggo, Rosalind MORCID logo (2021) Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Eurosurveillance, 26 (11). pp. 10-15. ISSN 1025-7917 DOI: 10.2807/1560-7917.ES.2021.26.11.2100256
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The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.


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