Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.

Stella Peña ; Laura Scarone ; Eduardo Manta ; Lindsay Stewart ; Vanessa Yardley ORCID logo ; Simon Croft ORCID logo ; Gloria Serra ; (2012) Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. Bioorganic & medicinal chemistry letters, 22 (15). pp. 4994-4997. ISSN 0960-894X DOI: 10.1016/j.bmcl.2012.06.028
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The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
Item Type Article
ISI 306481100015
Date Deposited 08 Dec 2015 20:04

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