Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
Peña, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa
; Croft, Simon; and Serra, Gloria
(2012)
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
Bioorganic & medicinal chemistry letters, 22 (15).
pp. 4994-4997.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2012.06.028
; Croft, Simon; and Serra, Gloria
(2012)
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
Bioorganic & medicinal chemistry letters, 22 (15).
pp. 4994-4997.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2012.06.028
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
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