Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.

Peña, S; Scarone, L; Manta, E; Stewart, L; Yardley, VORCID logo; Croft, SORCID logo; Serra, G and (2012) Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. Bioorganic & medicinal chemistry letters, 22 (15). pp. 4994-4997. ISSN 0960-894X DOI: 10.1016/j.bmcl.2012.06.028
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The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).

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