Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.


Peña, S; Scarone, L; Manta, E; Stewart, L; Yardley, V; Croft, S; Serra, G; (2012) Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. Bioorganic & medicinal chemistry letters, 22 (15). pp. 4994-7. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.06.028

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Abstract

The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
PubMed ID: 22765903
Web of Science ID: 306481100015
URI: http://researchonline.lshtm.ac.uk/id/eprint/2373977

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