Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Eva
Torres
;
María D
Duque
;
Marta
López-Querol
;
Martin C
Taylor
;
Lieve
Naesens
;
Chunlong
Ma
;
Lawrence H
Pinto
;
Francesc X
Sureda
;
John M
Kelly
;
Santiago
Vázquez
;
(2012)
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Bioorganic & medicinal chemistry, 20 (2).
pp. 942-948.
ISSN 0968-0896
DOI: 10.1016/j.bmc.2011.11.050
;
Lieve
Naesens
;
Chunlong
Ma
;
Lawrence H
Pinto
;
Francesc X
Sureda
;
John M
Kelly
;
Santiago
Vázquez
;
(2012)
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Bioorganic & medicinal chemistry, 20 (2).
pp. 942-948.
ISSN 0968-0896
DOI: 10.1016/j.bmc.2011.11.050
The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
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