Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.
Catherine
Fagundez
;
Diver
Sellanes
;
Stella
Peña
;
Laura
Scarone
;
Anna CC
Aguiar
;
Juliana O
de Souza
;
Rafael VC
Guido
;
Lindsay
Stewart
;
Vanessa
Yardley
;
Sabine
Ottilie
;
+4 more...
Elizabeth A
Winzeler
;
Francisco-J
Gamo
;
Laura M
Sanz
;
Gloria L
Serra
;
(2019)
Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.
ACS medicinal chemistry letters, 10 (1).
pp. 137-141.
ISSN 1948-5875
DOI: 10.1021/acsmedchemlett.8b00543
;
Sabine
Ottilie
;
+4 more...
Elizabeth A
Winzeler
;
Francisco-J
Gamo
;
Laura M
Sanz
;
Gloria L
Serra
;
(2019)
Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.
ACS medicinal chemistry letters, 10 (1).
pp. 137-141.
ISSN 1948-5875
DOI: 10.1021/acsmedchemlett.8b00543
Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well as liver stage are presented. The synthesis, parasitological characterization, physicochemical properties, in vivo evaluation, and mice pharmacokinetics are described.
-
picture_as_pdf - Fagundez-etal-2019-Synthesis-Profiling-and-in-Vivo-Evaluation-of-Cyclopeptides.pdf
-
subject - Accepted Version
-
copyright - Available under Copyright the publishers
Downloads