Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.

Rao, Srinivasa PS; Gould, Matthew K; Noeske, Jonas; Saldivia, Manuel; Jumani, Rajiv S; Ng, Pearly S; René, Olivier; Chen, Yen-Liang; Kaiser, Marcel; Ritchie, Ryan; +32 more... Francisco, Amanda Fortes; Johnson, Nila; Patra, Debjani; Cheung, Harry; Deniston, Colin; Schenk, Andreas D; Cortopassi, Wilian A; Schmidt, Remo S; Wiedemar, Natalie; Thomas, Bryanna; Palkar, Rima; Ghafar, Nahdiyah A; Manoharan, Vanessa; Luu, Catherine; Gable, Jonathan E; Wan, Kah Fei; Myburgh, Elmarie; Mottram, Jeremy C; Barnes, Whitney; Walker, John; Wartchow, Charles; Aziz, Natasha; Osborne, Colin; Wagner, Juergen; Sarko, Christopher; Kelly, John M; Manjunatha, Ujjini H; Mäser, Pascal; Jiricek, Jan; Lakshminarayana, Suresh B; Barrett, Michael P; Diagana, Thierry T; (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380 (6652). pp. 1349-1356. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.adh0614

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