<ns4:p><ns4:bold>Background:</ns4:bold> The coronavirus disease 2019 (COVID-19) vaccination programme in England was extended to include all adolescents and children by April 2022. The aim of this paper is to describe trends and variation in vaccine coverage in different clinical and demographic groups amongst adolescents and children in England.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> With the approval of NHS England, a cohort study was conducted of 3.21 million children and adolescents’ records in general practice in England, <ns4:italic>in situ</ns4:italic> and within the infrastructure of the electronic health record software vendor TPP using OpenSAFELY. Vaccine coverage across various demographic (sex, deprivation index and ethnicity) and clinical (risk status) populations is described.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Coverage is higher amongst adolescents than it is amongst children, with 53.5% adolescents and 10.8% children having received their first dose of the COVID-19 vaccine. Within those groups, coverage varies by ethnicity, deprivation index and risk status; there is no evidence of variation by sex.</ns4:p><ns4:p> <ns4:bold>Conclusion: </ns4:bold>First dose COVID-19 vaccine coverage is shown to vary amongst various demographic and clinical groups of children and adolescents.</ns4:p>