A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Wilkinson, Eduan
; Giovanetti, Marta; Tegally, Houriiyah; San, James E; Lessells, Richard; Cuadros, Diego; Martin, Darren P; Rasmussen, David A; Zekri, Abdel-Rahman N; Sangare, Abdoul K; +292 more...Ouedraogo, Abdoul-Salam; Sesay, Abdul K; Priscilla, Abechi; Kemi, Adedotun-Sulaiman; Olubusuyi, Adewunmi M; Oluwapelumi, Adeyemi OO; Hammami, Adnène; Amuri, Adrienne A; Sayed, Ahmad; Ouma, Ahmed EO; Elargoubi, Aida; Ajayi, Nnennaya A; Victoria, Ajogbasile F; Kazeem, Akano; George, Akpede; Trotter, Alexander J; Yahaya, Ali A; Keita, Alpha K; Diallo, Amadou; Kone, Amadou; Souissi, Amal; Chtourou, Amel; Gutierrez, Ana V; Page, Andrew J; Vinze, Anika; Iranzadeh, Arash; Lambisia, Arnold; Ismail, Arshad; Rosemary, Audu; Sylverken, Augustina; Femi, Ayoade; Ibrahimi, Azeddine; Marycelin, Baba; Oderinde, Bamidele S; Bolajoko, Bankole; Dhaala, Beatrice; Herring, Belinda L; Njanpop-Lafourcade, Berthe-Marie; Kleinhans, Bronwyn; McInnis, Bronwyn; Tegomoh, Bryan; Brook, Cara; Pratt, Catherine B; Scheepers, Cathrine; Akoua-Koffi, Chantal G; Agoti, Charles N; Peyrefitte, Christophe; Daubenberger, Claudia; Morang'a, Collins M; Nokes, D James; Amoako, Daniel G; Bugembe, Daniel L; Park, Danny; Baker, David; Doolabh, Deelan; Ssemwanga, Deogratius; Tshiabuila, Derek; Bassirou, Diarra; Amuzu, Dominic SY; Goedhals, Dominique; Omuoyo, Donwilliams O; Maruapula, Dorcas; Foster-Nyarko, Ebenezer; Lusamaki, Eddy K; Simulundu, Edgar; Ong'era, Edidah M; Ngabana, Edith N; Shumba, Edwin; El Fahime, Elmostafa; Lokilo, Emmanuel; Mukantwari, Enatha; Philomena, Eromon; Belarbi, Essia; Simon-Loriere, Etienne; Anoh, Etilé A; Leendertz, Fabian; Ajili, Faida; Enoch, Fakayode O; Wasfi, Fares; Abdelmoula, Fatma; Mosha, Fausta S; Takawira, Faustinos T; Derrar, Fawzi; Bouzid, Feriel; Onikepe, Folarin; Adeola, Fowotade; Muyembe, Francisca M; Tanser, Frank; Dratibi, Fred A; Mbunsu, Gabriel K; Thilliez, Gaetan; Kay, Gemma L; Githinji, George; van Zyl, Gert; Awandare, Gordon A; Schubert, Grit; Maphalala, Gugu P; Ranaivoson, Hafaliana C; Lemriss, Hajar; Anise, Happi; Abe, Haruka; Karray, Hela H; Nansumba, Hellen; Elgahzaly, Hesham A; Gumbo, Hlanai; Smeti, Ibtihel; Ayed, Ikhlas B; Odia, Ikponmwosa; Ben Boubaker, Ilhem Boutiba; Gaaloul, Imed; Gazy, Inbal; Mudau, Innocent; Ssewanyana, Isaac; Konstantinus, Iyaloo; Lekana-Douk, Jean B; Makangara, Jean-Claude C; Tamfum, Jean-Jacques M; Heraud, Jean-Michel; Shaffer, Jeffrey G; Giandhari, Jennifer; Li, Jingjing; Yasuda, Jiro; Mends, Joana Q; Kiconco, Jocelyn; Morobe, John M; Gyapong, John O; Okolie, Johnson C; Kayiwa, John T; Edwards, Johnathan A; Gyamfi, Jones; Farah, Jouali; Nakaseegu, Joweria; Ngoi, Joyce M; Namulondo, Joyce; Andeko, Julia C; Lutwama, Julius J; O'Grady, Justin; Siddle, Katherine; Adeyemi, Kayode T; Tumedi, Kefentse A; Said, Khadija M; Hae-Young, Kim; Duedu, Kwabena O; Belyamani, Lahcen; Fki-Berrajah, Lamia; Singh, Lavanya; Martins, Leonardo de O; Tyers, Lynn; Ramuth, Magalutcheemee; Mastouri, Maha; Aouni, Mahjoub; El Hefnawi, Mahmoud; Matsheka, Maitshwarelo I; Kebabonye, Malebogo; Diop, Mamadou; Turki, Manel; Paye, Marietou; Nyaga, Martin M; Mareka, Mathabo; Damaris, Matoke-Muhia; Mburu, Maureen W; Mpina, Maximillian; Nwando, Mba; Owusu, Michael; Wiley, Michael R; Youtchou, Mirabeau T; Ayekaba, Mitoha O; Abouelhoda, Mohamed; Seadawy, Mohamed G; Khalifa, Mohamed K; Sekhele, Mooko; Ouadghiri, Mouna; Diagne, Moussa M; Mwenda, Mulenga; Allam, Mushal; Phan, My VT; Abid, Nabil; Touil, Nadia; Rujeni, Nadine; Kharrat, Najla; Ismael, Nalia; Dia, Ndongo; Mabunda, Nedio; Hsiao, Nei-Yuan; Silochi, Nelson B; Nsenga, Ngoy; Gumede, Nicksy; Mulder, Nicola; Ndodo, Nnaemeka; Razanajatovo, Norosoa H; Iguosadolo, Nosamiefan; Judith, Oguzie; Kingsley, Ojide C; Sylvanus, Okogbenin; Peter, Okokhere; Femi, Oladiji; Idowu, Olawoye; Testimony, Olumade; Chukwuma, Omoruyi E; Ogah, Onwe E; Onwuamah, Chika K; Cyril, Oshomah; Faye, Ousmane; Tomori, Oyewale; Ondoa, Pascale; Combe, Patrice; Semanda, Patrick; Oluniyi, Paul E; Arnaldo, Paulo; Quashie, Peter K; Dussart, Philippe; Bester, Phillip A; Mbala, Placide K; Ayivor-Djanie, Reuben; Njouom, Richard; Phillips, Richard O; Gorman, Richmond; Kingsley, Robert A; Carr, Rosina AA; El Kabbaj, Saâd; Gargouri, Saba; Masmoudi, Saber; Sankhe, Safietou; Lawal, Salako B; Kassim, Samar; Trabelsi, Sameh; Metha, Samar; Kammoun, Sami; Lemriss, Sanaâ; Agwa, Sara HA; Calvignac-Spencer, Sébastien; Schaffner, Stephen F; Doumbia, Seydou; Mandanda, Sheila M; Aryeetey, Sherihane; Ahmed, Shymaa S; Elhamoumi, Siham; Andriamandimby, Soafy; Tope, Sobajo; Lekana-Douki, Sonia; Prosolek, Sophie; Ouangraoua, Soumeya; Mundeke, Steve A; Rudder, Steven; Panji, Sumir; Pillay, Sureshnee; Engelbrecht, Susan; Nabadda, Susan; Behillil, Sylvie; Budiaki, Sylvie L; van der Werf, Sylvie; Mashe, Tapfumanei; Aanniz, Tarik; Mohale, Thabo; Le-Viet, Thanh; Schindler, Tobias; Anyaneji, Ugochukwu J; Chinedu, Ugwu; Ramphal, Upasana; Jessica, Uwanibe; George, Uwem; Fonseca, Vagner; Enouf, Vincent; Gorova, Vivianne; Roshdy, Wael H; Ampofo, William K; Preiser, Wolfgang; Choga, Wonderful T; Bediako, Yaw; Naidoo, Yeshnee; Butera, Yvan; de Laurent, Zaydah R; Sall, Amadou A; Rebai, Ahmed; von Gottberg, Anne; Kouriba, Bourema; Williamson, Carolyn; Bridges, Daniel J; Chikwe, Ihekweazu; Bhiman, Jinal N; Mine, Madisa; Cotten, Matthew; Moyo, Sikhulile; Gaseitsiwe, Simani; Saasa, Ngonda; Sabeti, Pardis C; Kaleebu, Pontiano; Tebeje, Yenew K; Tessema, Sofonias K; Happi, Christian; Nkengasong, John; and de Oliveira, Tulio
(2021)
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Science, 374 (6566).
pp. 423-431.
ISSN 0036-8075
DOI: 10.1126/science.abj4336
; Giovanetti, Marta; Tegally, Houriiyah; San, James E; Lessells, Richard; Cuadros, Diego; Martin, Darren P; Rasmussen, David A; Zekri, Abdel-Rahman N; Sangare, Abdoul K; +292 more...Ouedraogo, Abdoul-Salam; Sesay, Abdul K; Priscilla, Abechi; Kemi, Adedotun-Sulaiman; Olubusuyi, Adewunmi M; Oluwapelumi, Adeyemi OO; Hammami, Adnène; Amuri, Adrienne A; Sayed, Ahmad; Ouma, Ahmed EO; Elargoubi, Aida; Ajayi, Nnennaya A; Victoria, Ajogbasile F; Kazeem, Akano; George, Akpede; Trotter, Alexander J; Yahaya, Ali A; Keita, Alpha K; Diallo, Amadou; Kone, Amadou; Souissi, Amal; Chtourou, Amel; Gutierrez, Ana V; Page, Andrew J; Vinze, Anika; Iranzadeh, Arash; Lambisia, Arnold; Ismail, Arshad; Rosemary, Audu; Sylverken, Augustina; Femi, Ayoade; Ibrahimi, Azeddine; Marycelin, Baba; Oderinde, Bamidele S; Bolajoko, Bankole; Dhaala, Beatrice; Herring, Belinda L; Njanpop-Lafourcade, Berthe-Marie; Kleinhans, Bronwyn; McInnis, Bronwyn; Tegomoh, Bryan; Brook, Cara; Pratt, Catherine B; Scheepers, Cathrine; Akoua-Koffi, Chantal G; Agoti, Charles N; Peyrefitte, Christophe; Daubenberger, Claudia; Morang'a, Collins M; Nokes, D James; Amoako, Daniel G; Bugembe, Daniel L; Park, Danny; Baker, David; Doolabh, Deelan; Ssemwanga, Deogratius; Tshiabuila, Derek; Bassirou, Diarra; Amuzu, Dominic SY; Goedhals, Dominique; Omuoyo, Donwilliams O; Maruapula, Dorcas; Foster-Nyarko, Ebenezer; Lusamaki, Eddy K; Simulundu, Edgar; Ong'era, Edidah M; Ngabana, Edith N; Shumba, Edwin; El Fahime, Elmostafa; Lokilo, Emmanuel; Mukantwari, Enatha; Philomena, Eromon; Belarbi, Essia; Simon-Loriere, Etienne; Anoh, Etilé A; Leendertz, Fabian; Ajili, Faida; Enoch, Fakayode O; Wasfi, Fares; Abdelmoula, Fatma; Mosha, Fausta S; Takawira, Faustinos T; Derrar, Fawzi; Bouzid, Feriel; Onikepe, Folarin; Adeola, Fowotade; Muyembe, Francisca M; Tanser, Frank; Dratibi, Fred A; Mbunsu, Gabriel K; Thilliez, Gaetan; Kay, Gemma L; Githinji, George; van Zyl, Gert; Awandare, Gordon A; Schubert, Grit; Maphalala, Gugu P; Ranaivoson, Hafaliana C; Lemriss, Hajar; Anise, Happi; Abe, Haruka; Karray, Hela H; Nansumba, Hellen; Elgahzaly, Hesham A; Gumbo, Hlanai; Smeti, Ibtihel; Ayed, Ikhlas B; Odia, Ikponmwosa; Ben Boubaker, Ilhem Boutiba; Gaaloul, Imed; Gazy, Inbal; Mudau, Innocent; Ssewanyana, Isaac; Konstantinus, Iyaloo; Lekana-Douk, Jean B; Makangara, Jean-Claude C; Tamfum, Jean-Jacques M; Heraud, Jean-Michel; Shaffer, Jeffrey G; Giandhari, Jennifer; Li, Jingjing; Yasuda, Jiro; Mends, Joana Q; Kiconco, Jocelyn; Morobe, John M; Gyapong, John O; Okolie, Johnson C; Kayiwa, John T; Edwards, Johnathan A; Gyamfi, Jones; Farah, Jouali; Nakaseegu, Joweria; Ngoi, Joyce M; Namulondo, Joyce; Andeko, Julia C; Lutwama, Julius J; O'Grady, Justin; Siddle, Katherine; Adeyemi, Kayode T; Tumedi, Kefentse A; Said, Khadija M; Hae-Young, Kim; Duedu, Kwabena O; Belyamani, Lahcen; Fki-Berrajah, Lamia; Singh, Lavanya; Martins, Leonardo de O; Tyers, Lynn; Ramuth, Magalutcheemee; Mastouri, Maha; Aouni, Mahjoub; El Hefnawi, Mahmoud; Matsheka, Maitshwarelo I; Kebabonye, Malebogo; Diop, Mamadou; Turki, Manel; Paye, Marietou; Nyaga, Martin M; Mareka, Mathabo; Damaris, Matoke-Muhia; Mburu, Maureen W; Mpina, Maximillian; Nwando, Mba; Owusu, Michael; Wiley, Michael R; Youtchou, Mirabeau T; Ayekaba, Mitoha O; Abouelhoda, Mohamed; Seadawy, Mohamed G; Khalifa, Mohamed K; Sekhele, Mooko; Ouadghiri, Mouna; Diagne, Moussa M; Mwenda, Mulenga; Allam, Mushal; Phan, My VT; Abid, Nabil; Touil, Nadia; Rujeni, Nadine; Kharrat, Najla; Ismael, Nalia; Dia, Ndongo; Mabunda, Nedio; Hsiao, Nei-Yuan; Silochi, Nelson B; Nsenga, Ngoy; Gumede, Nicksy; Mulder, Nicola; Ndodo, Nnaemeka; Razanajatovo, Norosoa H; Iguosadolo, Nosamiefan; Judith, Oguzie; Kingsley, Ojide C; Sylvanus, Okogbenin; Peter, Okokhere; Femi, Oladiji; Idowu, Olawoye; Testimony, Olumade; Chukwuma, Omoruyi E; Ogah, Onwe E; Onwuamah, Chika K; Cyril, Oshomah; Faye, Ousmane; Tomori, Oyewale; Ondoa, Pascale; Combe, Patrice; Semanda, Patrick; Oluniyi, Paul E; Arnaldo, Paulo; Quashie, Peter K; Dussart, Philippe; Bester, Phillip A; Mbala, Placide K; Ayivor-Djanie, Reuben; Njouom, Richard; Phillips, Richard O; Gorman, Richmond; Kingsley, Robert A; Carr, Rosina AA; El Kabbaj, Saâd; Gargouri, Saba; Masmoudi, Saber; Sankhe, Safietou; Lawal, Salako B; Kassim, Samar; Trabelsi, Sameh; Metha, Samar; Kammoun, Sami; Lemriss, Sanaâ; Agwa, Sara HA; Calvignac-Spencer, Sébastien; Schaffner, Stephen F; Doumbia, Seydou; Mandanda, Sheila M; Aryeetey, Sherihane; Ahmed, Shymaa S; Elhamoumi, Siham; Andriamandimby, Soafy; Tope, Sobajo; Lekana-Douki, Sonia; Prosolek, Sophie; Ouangraoua, Soumeya; Mundeke, Steve A; Rudder, Steven; Panji, Sumir; Pillay, Sureshnee; Engelbrecht, Susan; Nabadda, Susan; Behillil, Sylvie; Budiaki, Sylvie L; van der Werf, Sylvie; Mashe, Tapfumanei; Aanniz, Tarik; Mohale, Thabo; Le-Viet, Thanh; Schindler, Tobias; Anyaneji, Ugochukwu J; Chinedu, Ugwu; Ramphal, Upasana; Jessica, Uwanibe; George, Uwem; Fonseca, Vagner; Enouf, Vincent; Gorova, Vivianne; Roshdy, Wael H; Ampofo, William K; Preiser, Wolfgang; Choga, Wonderful T; Bediako, Yaw; Naidoo, Yeshnee; Butera, Yvan; de Laurent, Zaydah R; Sall, Amadou A; Rebai, Ahmed; von Gottberg, Anne; Kouriba, Bourema; Williamson, Carolyn; Bridges, Daniel J; Chikwe, Ihekweazu; Bhiman, Jinal N; Mine, Madisa; Cotten, Matthew; Moyo, Sikhulile; Gaseitsiwe, Simani; Saasa, Ngonda; Sabeti, Pardis C; Kaleebu, Pontiano; Tebeje, Yenew K; Tessema, Sofonias K; Happi, Christian; Nkengasong, John; and de Oliveira, Tulio
(2021)
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Science, 374 (6566).
pp. 423-431.
ISSN 0036-8075
DOI: 10.1126/science.abj4336
The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories. We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots, the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants.
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