An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets.

Ward, Daniel; Higgins, Matthew; Phelan, Jody E; Hibberd, Martin L; Campino, Susana; Clark, Taane G; (2021) An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets. GENOME MEDICINE, 13 (1). 4-. ISSN 1756-994X DOI: https://doi.org/10.1186/s13073-020-00822-6

Abstract

During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: http://genomics.lshtm.ac.uk/immuno (online); https://github.com/dan-ward-bio/COVID-immunoanalytics (source code).

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology
Research Centre	Covid-19 Research Centre for the Mathematical Modelling of Infectious Diseases
PubMed ID	33413610
Elements ID	155174