Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
Bonsignori, Mattia;
Montefiori, David C;
Wu, Xueling;
Chen, Xi;
Hwang, Kwan-Ki;
Tsao, Chun-Yen;
Kozink, Daniel M;
Parks, Robert J;
Tomaras, Georgia D;
Crump, John A;
+7 more...Kapiga, Saidi H;
Sam, Noel E;
Kwong, Peter D;
Kepler, Thomas B;
Liao, Hua-Xin;
Mascola, John R;
Haynes, Barton F;
(2012)
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
Journal of virology, 86 (8).
pp. 4688-4692.
ISSN 0022-538X
DOI: https://doi.org/10.1128/JVI.07163-11
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Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.
