Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.

Stephen RC Howie ; Gerard AJ Morris ; Rafal Tokarz ; Bernard E Ebruke ; Eunice M Machuka ; Readon C Ideh ; Osaretin Chimah ; Ousman Secka ; John Townend ; Michel Dione ; +11 more... Claire Oluwalana ; Malick Njie ; Mariatou Jallow ; Philip C Hill ; Martin Antonio

; Brian Greenwood

; Thomas Briese ; Kim Mulholland

; Tumani Corrah ; W Ian Lipkin ; Richard A Adegbola ; (2014) Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples. Clinical infectious diseases, 59 (5). pp. 682-685. ISSN 1058-4838 DOI: 10.1093/cid/ciu384

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Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae.