Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
Jung, M; Lee, K; Jung, H; Kendrick, H; Yardley, V
; Croft, SL and
(2004)
Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
Bioorganic & medicinal chemistry letters, 14 (8).
pp. 2001-2003.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2003.12.104
; Croft, SL and
(2004)
Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
Bioorganic & medicinal chemistry letters, 14 (8).
pp. 2001-2003.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2003.12.104
(+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.
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