Tracking the establishment of local endemic populations of an emergent enteric pathogen.
Holt, Kathryn E;
Thieu Nga, Tran Vu;
Thanh, Duy Pham;
Vinh, Ha;
Kim, Dong Wook;
Vu Tra, My Phan;
Campbell, James I;
Hoang, Nguyen Van Minh;
Vinh, Nguyen Thanh;
Minh, Pham Van;
+20 more...Thuy, Cao Thu;
Nga, Tran Thi Thu;
Thompson, Corinne;
Dung, Tran Thi Ngoc;
Nhu, Nguyen Thi Khanh;
Vinh, Phat Voong;
Tuyet, Pham Thi Ngoc;
Phuc, Hoang Le;
Lien, Nguyen Thi Nam;
Phu, Bui Duc;
Ai, Nguyen Thi Thuy;
Tien, Nguyen Manh;
Dong, Nguyen;
Parry, Christopher M;
Hien, Tran Tinh;
Farrar, Jeremy J;
Parkhill, Julian;
Dougan, Gordon;
Thomson, Nicholas R;
Baker, Stephen;
(2013)
Tracking the establishment of local endemic populations of an emergent enteric pathogen.
Proceedings of the National Academy of Sciences of the United States of America, 110 (43).
pp. 17522-17527.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.1308632110
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
