Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
Bornman, Liza;
Campbell, Sarah J;
Fielding, Katherine;
Bah, Boubacar;
Sillah, Jackson;
Gustafson, Per;
Manneh, Kebba;
Lisse, Ida;
Allen, Angela;
Sirugo, Giorgio;
+7 more...Sylla, Aissatou;
Aaby, Peter;
McAdam, Keith PWJ;
Bah-Sow, Oumou;
Bennett, Steve;
Lienhardt, Christian;
Hill, Adrian VS;
(2004)
Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
The Journal of infectious diseases, 190 (9).
pp. 1631-1641.
ISSN 0022-1899
DOI: https://doi.org/10.1086/424462
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Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.
