Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Julieta
Coro
;
Richard
Atherton
;
Susan
Little
;
Hayley
Wharton
;
Vanessa
Yardley
;
Amaury
Alvarez
;
Margarita
Súarez
;
Rolando
Pérez
;
Hortensia
Rodríguez
;
(2006)
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorganic & medicinal chemistry letters, 16 (5).
pp. 1312-1315.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.11.060
;
Amaury
Alvarez
;
Margarita
Súarez
;
Rolando
Pérez
;
Hortensia
Rodríguez
;
(2006)
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorganic & medicinal chemistry letters, 16 (5).
pp. 1312-1315.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.11.060
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC(50) values ranging between 0.3 and 4 microM for the most active compounds.
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