Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Coro, J; Atherton, R; Little, S; Wharton, H; Yardley, V
; Alvarez, A; Súarez, M; Pérez, R; Rodríguez, H and
(2006)
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorganic & medicinal chemistry letters, 16 (5).
pp. 1312-1315.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.11.060
; Alvarez, A; Súarez, M; Pérez, R; Rodríguez, H and
(2006)
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorganic & medicinal chemistry letters, 16 (5).
pp. 1312-1315.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.11.060
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC(50) values ranging between 0.3 and 4 microM for the most active compounds.
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