Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Sandra
Gemma
;
Gagan
Kukreja
;
Caterina
Fattorusso
;
Marco
Persico
;
Maria P
Romano
;
Maria
Altarelli
;
Luisa
Savini
;
Giuseppe
Campiani
;
Ernesto
Fattorusso
;
Nicoletta
Basilico
;
+3 more...
Donatella
Taramelli
;
Vanessa
Yardley
;
Stefania
Butini
;
(2006)
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters, 16 (20).
pp. 5384-5388.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2006.07.060
;
Stefania
Butini
;
(2006)
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters, 16 (20).
pp. 5384-5388.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2006.07.060
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
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