Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Gemma, S; Kukreja, G; Fattorusso, C; Persico, M; Romano, MP; Altarelli, M; Savini, L; Campiani, G; Fattorusso, E; Basilico, N; +3 more...Taramelli, D; Yardley, V
; Butini, S and
(2006)
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters, 16 (20).
pp. 5384-5388.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2006.07.060
; Butini, S and
(2006)
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters, 16 (20).
pp. 5384-5388.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2006.07.060
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
Full text not available from this repository.
Downloads