Novel Developments in the Epidemic of Human Immunodeficiency Virus and Tuberculosis Coinfection


Anandaiah, A; Dheda, K; Keane, J; Koziel, H; Moore, DAJ; Patel, NR; (2011) Novel Developments in the Epidemic of Human Immunodeficiency Virus and Tuberculosis Coinfection. American journal of respiratory and critical care medicine, 183 (8). pp. 987-997. ISSN 1073-449X DOI: https://doi.org/10.1164/rccm.201008-1246CI

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Abstract

Tuberculosis (TB) disease remains one of the highest causes of mortality in HIV-infected individuals, and HIV-TB coinfection continues to grow at alarming rates, especially in sub-Saharan Africa. Surprisingly, a number of important areas regarding coinfection remain unclear. For example, increased risk of TB disease begins early in the course of HIV infection; however, the mechanism by which HIV increases this risk is not well understood. In addition, there is lack of consensus on the optimal way to diagnose latent TB infection and to manage active disease in those who are HIV infected. Furthermore, effective point-of-care testing for TB disease remains elusive. This review discusses key areas in the epidemiology, pathogenesis, diagnosis, and management of active and latent TB in those infected with HIV, focusing attention on issues related to high-and low-burden areas. Particular emphasis is placed on controversial areas where there are gaps in knowledge and on future directions of study.

Item Type: Article
Keywords: tuberculosis, HIV, diagnosis, management, epidemiology, HIV-INFECTED PATIENTS, ISONIAZID PREVENTIVE THERAPY, RECONSTITUTION, INFLAMMATORY SYNDROME, MULTIDRUG-RESISTANT TUBERCULOSIS, ACTIVE, ANTIRETROVIRAL THERAPY, DRUG-SUSCEPTIBILITY ASSAY, GAMMA RELEASE ASSAY, SUB-SAHARAN AFRICA, CELL-BASED ASSAYS, CD4 T-CELLS
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
PubMed ID: 21177884
Web of Science ID: 289955600012
URI: http://researchonline.lshtm.ac.uk/id/eprint/761

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